Progesterone - instructions for use, reviews, analogs and forms of injection (injections 1% and 2.5%)) of a hormonal drug for contraception and treatment of bleeding in women, including effects during pregnancy

In this article, you can read the instructions for using the hormonal drug Progesterone. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Progesterone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Progesterone in the presence of existing structural analogues. Use to treat bleeding, habitual miscarriage and contraception in women, including during pregnancy and lactation.

Progesterone - gestagen. The hormone of the yellow body.Causes the transition of the uterine mucosa from the phase of proliferation caused by the follicular hormone to the secretory phase, and after fertilization promotes its transition into a state necessary for the development of a fertilized egg. Reduces excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the end elements of the breast. Does not have androgenic activity. Progesterone has a weak effect on protein metabolism, promotes the deposition of fats and the accumulation of glucose in the liver, and also reduces the reabsorption of sodium in the renal tubules.

Progesterone has a blocking effect on the secretion of hypothalamic factors releasing LH and FSH, inhibits the formation of pituitary gonadotropic hormones and inhibits ovulation.

Pharmacokinetics

After intramuscular injection is absorbed quickly and almost completely. Metabolised in the liver. It is excreted in the urine - 50-60% and with feces - more than 10%.

Indications

• dysfunctional uterine bleeding;
• metrorrhagia;
• amenorrhea;
• habitual miscarriage;
• contraception.

Forms of release

Solution for injection oil (injections) 1% and 2.5%.

Instructions for use and dosing regimen

Intramuscular, adult highest single dose of 0.025 g (2.5 ml of 1% or 1 ml of 2.5% of r-ra).

Dosing regimen is individual. Dose, frequency and duration of treatment are determined according to the scheme depending on the indications and the clinical situation.

Side effect

• increased blood pressure;
• edema;
• violations of the liver, jaundice;
• nausea, vomiting;
• decreased libido;
• increase in body weight;
• pain and tension in the mammary glands;
• irregular uterine bleeding;
• headache;
• depression.

Contraindications

• severe dysfunction of the liver or kidney;
• hepatitis;
• thromboembolic diseases;
• vaginal bleeding is not established genesis;
• carcinoma of the breast (with the exception of cases in which progesterone is used as part of the combination therapy of the disease).

Application in pregnancy and lactation

In cases of extreme necessity, it is possible to use progesterone in pregnancy with an established deficiency of the hormones of the yellow body

Progesterone is not used in women planning pregnancy in the near future.

special instructions

Use with caution in patients with cardiovascular disease, impaired liver or kidney function, diabetes mellitus,A bronchial asthma, an epilepsy, a migraine, depression.

Drug Interactions

Reduces the intensity of the drugs that stimulate the smooth muscles of the uterus, anabolic steroids, gonadotropic hormones in the anterior lobe of the pituitary gland.

Reduces the lactogenic effect of oxytocin.

Strengthens the action of diuretics, antihypertensive drugs, immunosuppressants.

With simultaneous use with barbiturates, a decrease in the action of progesterone is noted.

Analogues of the hormone Progesterone

Structural analogs for the active substance:

• Iprozhin;
• Krajonon;
• Prajisan;
• Projest;
• Utrozhestan.

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