Aspirin - instructions for use, reviews, analogs and forms of release (tablets in the dosage of 100 mg, 500 mg, oops, cardio, effervescent) of the drug for the dilution of blood, pain and heat in adults, children and pregnancy

Aspirin - instructions for use, reviews, analogs and forms of release (tablets in the dosage of 100 mg, 500 mg, oops, cardio, effervescent) of the drug for the dilution of blood, pain and heat in adults, children and pregnancy

In this article, you can read the instructions for using the drug Aspirin. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Aspirin in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Aspirin in the presence of existing structural analogues. Use to dilute blood, relieve pain and heat in adults, children, as well as during pregnancy and lactation.Various forms of aspirin - cardio (cardiac form), oops and form of release in the form of effervescent tablets to reduce the harmful effect on the mucosa of the gastrointestinal tract.


Aspirin - Non-steroidal anti-inflammatory drug. Antiaggregant. The mechanism of antiplatelet effect of Acetylsalicylic acid (ASA - active substance Aspirin) is irreversible inhibition of cyclooxygenase (COX-1), which blocks the synthesis of thromboxane A2 and suppresses platelet aggregation. The antiaggregant effect is most pronounced in platelets, because they are not able to re-synthesize cyclooxygenase. It is believed that ASA has other mechanisms for suppressing platelet aggregation, which expands its use in various vascular diseases.


ASA also has an anti-inflammatory, analgesic and antipyretic effect, which is due to inhibition of cyclooxygenase enzymes involved in the synthesis of protaglandins.




When ingested quickly absorbed mainly from the proximal part of the small intestine and to a lesser extent from the stomach. The presence of food in the stomach significantly alters the absorption of acetylsalicylic acid.


About 80% of salicylic acid binds to blood plasma proteins. Salicylates easily penetrate into many tissues and body fluids, including. in spinal, peritoneal and synovial fluid. In small amounts, salicylates are found in the brain tissue, traces - in bile, sweat, feces. Rapidly penetrates the placental barrier, in small quantities excreted in breast milk.


Penetration into the joint cavity is accelerated in the presence of hyperemia and edema and slows down in the proliferative phase of inflammation.


It is excreted mainly by active secretion in the renal tubules in unchanged form (60%) and in the form of metabolites. In newborns, the elimination of salicylate is much slower than in adults.



  • rheumatism;
  • rheumatoid arthritis;
  • infectious-allergic myocarditis;
  • fever (fever) with infectious and inflammatory diseases;
  • pain syndrome of mild and moderate intensity of various genesis (including neuralgia, myalgia, headache);
  • prevention of thrombosis and embolism (the so-called blood thinning);
  • primary and secondary prevention of myocardial infarction;
  • prevention of cerebral circulation disorders by ischemic type.


Forms of release


Tablets of 100 mg and 500 mg.


Tablets of 100 mg and 300 mg (Aspirin cardio).


Effervescent water-soluble forms of aspirin tablets - 500 mg (Upsarin UPCA, Aspirin 1000).


Instructions for use and dosage


Individually. For adults, a single dose varies from 40 mg to 1 g, daily from 150 mg to 8 g; multiplicity of application - 2-6 times a day.


Adult single dose - 100 mg, the recommended daily dose - 300 mg (3 tablets a day). Aspirin should be taken after meals, with plenty of water. The course of treatment should not exceed 7-10 days in the absence of undesirable side effects. Longer therapy requires consultation of the attending physician.


The appointment of Aspirin to children is possible only after consulting a doctor, taking into account the possible risk of developing Reye's syndrome - a very rare, life-threatening condition, accompanied by the development of encephalopathy and fatty liver degeneration. Recommended doses for children: from 2 to 3 years - 100 mg / day (1 table), from 4 to 6 years - 200 mg / day (2 tablets), from 7 to 9 years - 300 mg / day (3 tables .).


Side effect

  • nausea, vomiting;
  • anorexia;
  • pain in epigastrium;
  • diarrhea;
  • occurrence of erosive-ulcerative lesions, bleeding from the gastrointestinal tract;
  • abnormal liver function;
  • dizziness;
  • headache;
  • noise in ears;
  • thrombocytopenia, anemia, and leukopenia;
  • impaired renal function;
  • nephrotic syndrome;
  • skin rash;
  • angioedema;
  • bronchospasm;
  • "Aspirin triad" (combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and drugs of pyrazolone series);
  • Reye's syndrome.



  • erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
  • gastrointestinal bleeding;
  • "aspirin triad";
  • the presence in the anamnesis of indications for urticaria, rhinitis caused by the intake of acetylsalicylic acid and other NSAIDs;
  • hemophilia;
  • hemorrhagic diathesis;
  • hypoprothrombinemia;
  • exfoliating aortic aneurysm;
  • portal hypertension;
  • deficiency of vitamin K;
  • hepatic and / or renal insufficiency;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • Reye's syndrome;
  • Children's age (under 15 years - the risk of developing Reye's syndrome in children with hyperthermia in the presence of viral diseases);
  • 1 and 3 trimesters of pregnancy;
  • lactation period;
  • hypersensitivity to acetylsalicylic acid and other salicylates.


Application in pregnancy and lactation


Contraindicated in the use of 1 and 3 trimesters of pregnancy. In the 2nd trimester of pregnancy, one-time administration is possible on strict indications.


Has a teratogenic effect: when applied in 1 trimester leads to the development of cleavage of the upper sky, in the 3rd trimester - causes inhibition of labor (inhibition of prostaglandin synthesis), premature closure of the arterial duct in the fetus, hyperplasia of pulmonary vessels and hypertension in the small circulation.


Aspirin is excreted in breast milk, which increases the risk of bleeding in the child due to impaired platelet function, so do not use acetylsalicylic acid in the mother during lactation.


special instructions


They are used with caution in patients with liver and kidney disease, with bronchial asthma, erosive and ulcerative lesions and bleeding from the gastrointestinal tract in an anamnesis, with increased bleeding or concomitant anticonvolution therapy, decompensated chronic heart failure.


Aspirin even in small doses reduces the excretion of uric acid from the body, which can cause an acute attack of gout in predisposed patients. When performing long-term therapy and / or using acetylsalicylic acid in high doses, it is necessary to observe the doctor and regularly check the level of hemoglobin.


The use of acetylsalicylic acid as an anti-inflammatory agent in a daily dose of 5-8 is restricted in connection with a high probability of side effects from the gastrointestinal tract.


Before surgical intervention, to reduce bleeding during surgery and in the postoperative period, it is necessary to cancel the intake of salicylates for 5-7 days.


During prolonged therapy, a general blood test and examination of feces for latent blood should be performed.


The use of aspirin in pediatrics is contraindicated, since in the case of viral infection in children under the influence of acetylsalicylic acid, the risk of developing Reye syndrome increases. Symptoms of Reye's syndrome are prolonged vomiting, acute encephalopathy, enlargement of the liver.


Duration of treatment (without consulting a physician) should not exceed 7 days with an appointment as an analgesic and more than 3 days as an antipyretic.


During treatment, the patient should refrain from drinking alcohol.


Drug Interactions


With simultaneous application of antacids containing magnesium and / or aluminum hydroxide, slow down and reduce absorption of aspirin.


With the simultaneous use of calcium channel blockers, drugs that limit the intake of calcium or increase the excretion of calcium from the body, the risk of bleeding increases.


With simultaneous use with aspirin, the action of Heparin and indirect anticoagulants, hypoglycemic agents of sulfonylurea derivatives, insulin, methotrexate, phenytoin, valproic acid is enhanced.


When used simultaneously with glucocorticosteroids, the risk of ulcerogenic action and the occurrence of gastrointestinal bleeding increases.


With simultaneous use, the effectiveness of diuretics (spironolactone, furosemide) decreases.


With the simultaneous use of other NSAIDs, the risk of side effects increases. Acetylsalicylic acid can reduce plasma concentrations of indomethacin, piroxicam.


When used simultaneously with gold preparations, acetylsalicylic acid can induce liver damage.


With the simultaneous use, the effectiveness of uricosuric agents decreases (including probenecid, sulfinpyrazone, benzbromarone).


With the simultaneous use of acetylsalicylic acid and alendronate sodium, the development of severe esophagitis is possible.


With the simultaneous use of griseofulvin, absorption of acetylsalicylic acid may be impaired.


With the simultaneous use of dipyridamole, it is possible to increase Cmax salicylate in blood plasma and AUC.


With simultaneous use with acetylsalicylic acid, the concentrations of digoxin, barbiturates and lithium salts in blood plasma increase.


With the simultaneous use of salicylates in high doses with inhibitors of carbonic anhydrase, intoxication with salicylates is possible.


Acetylsalicylic acid in doses less than 300 mg per day has a negligible effect on the efficacy of Captopril and enalapril. With the use of acetylsalicylic acid in high doses, a decrease in the efficacy of captopril and Enalapril is possible.


With simultaneous use of Caffeine increases the rate of absorption, concentration in the blood plasma and bioavailability of acetylsalicylic acid.


With simultaneous use of Metoprolol may increase Cmax salicylate in blood plasma.


When pentazocine is used against the background of long-term use of aspirin in high doses, there is a risk of developing serious adverse reactions from the kidneys.


With simultaneous use of phenylbutazone reduces uricosuria caused by acetylsalicylic acid.


With the simultaneous use of ethanol (alcohol) can enhance the negative effect of aspirin on the digestive tract.


Analogues of the drug Aspirin


Structural analogs for the active substance:

  • Anopyrine;
  • ASA cardio;
  • Aspicor;
  • Aspen;
  • Aspirin 1000;
  • Aspirin Cardio;
  • Acercar;
  • Acentene;
  • Acetylsalicylic acid;
  • Acetylsalicylic acid Cardio;
  • Acylpyrine;
  • Acsbyrin;
  • Bufferin;
  • Zorex Morning;
  • KardiASK;
  • Collorite;
  • Myristin;
  • Taspir;
  • Trombo ACC;
  • Thrombopol;
  • Walsh-Asalgin;
  • Upsarin of the UPSA.

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Reviews (19):
To sweat with a cold I drink aspirin with milk, as my mother did in childhood, this sweating begins, the next morning I get up-to-date.
Yes, prescribe aspirin as an antipyretic is understandable, although children can not be for Reino.But here to use for dilution of blood pure aspirin it already looks like the last century, because now there are many drugs that have a similar effect, but they do not affect the gastric mucosa and cause ulcers and gastritis. The same cardiomagnet, trombo ass.
A long dose of Aspirin can adversely affect vision. This conclusion was made by American scientists after observing a sample of 5,000 patients (men and women) who regularly took Aspirin and underwent a vision test. However, the study still requires clarification and at this time the benefit of taking Aspirin in particular for the prevention of cardiovascular disease exceeds the potential harm, therefore, it is not yet planned to make any changes in the clinical practice of using this medication.
Sometimes people take aspirin for any reason or even when there is no reason to take it. In fact, this is not such an inoffensive medicine as it seems. Therefore, I would not advise taking aspirin without first consulting with a doctor,because there can be very adverse effects of such treatment.
I take aspirin york more than 3 years for 2 tablets and helps from the head and the temperature relieves.
The drug aspirin york normal, 1-2 tablets and the head passes .. helps me with stress.
Advise, please, what else liquefies the blood - except aspirin (burned them mucous), and without it I can not sleep? I have intracranial pressure !?
richch5When the aspirin group does not fit according to the testimony, then I look toward Warfarin. But this is a serious drug and just will not be appointed.

I just do not understand why you need Aspirin with increased intracranial pressure? Try if that different types of cardioaspirin in the shells that do not act on the stomach, and dissolve in the intestine (the same Cardiomagnet and many others), this option will be softer than Warfarin.
So I have a question, why with intracranial? Is it like a painkiller. About the shell I agree, only, in my opinion, the cardiomagnum without the envelope is coming. I know for sure that in Trombo Assa there is - my father drinks it.
Alla, The man needed a "dilution", but without aspirin. He received his answer. People for years drink ordinary Aspirin, without any attachments cardio or shells and feel great. These are not the dosages to burn something in the gastrointestinal mucosa. Especially if the income of the patient does not allow you to assign something more expensive, albeit shell. Let him drink primitive and live than suffer from disability due to the fact that he could not buy expensive for financial reasons and received no timely prevention.
Tell me, please, can as a result of taking aspirin for two months to cause iron deficiency anemia? (Patient age, diagnosed with a heart attack, flicker, hypertension). Sorry for the incorrect question. Anticoagulants can somehow influence the level of hemoglobin in the blood? While in the hospital at the middle of the treatment, she suddenly showed up,iron deficiency anemia, before it was a course of injections of heparin subcutaneously, and on time its termination coincided with the news of the fall of hemoglobin and the beginning of therapy with drugs for its return to normal indices. Unfortunately, I can not give specific indicators of hemoglobin level. They were not informed of what was wrong.
Natalia 08042015, Something I do not understand you, then Aspirin, then Heparin. Or was this medication prescribed for the patient? In response, it is better to specify the duration of administration and dosage immediately. If acetylsalicylic acid was in the cardiac dosage (100 mg or a quarter of the standard Aspirin tablet), then it does not have a particular effect on germs of hemopoiesis and in two months anemia can not develop exactly, anemia also does not develop from Heparin. In general, it is more like a non-medicinal form of anemia, so it is necessary to look for what was the cause of this phenomenon, perhaps it is temporary, maybe something with a valvular heart apparatus. There are many reasons ...
During treatment in the hospital, they went parallel for a while - cardiomagnesium and heparin subcutaneously. I do not know the dosage of both drugs, as well as the level to which hemoglobin fell, in our district hospital it is not accepted that relatives of patients "climb into the process of treatment" and even the patients themselves try to give information on a minimum.
Heparin was subcutaneously for 5 days for 4 injections a day. The next day, which was the 8th day from the day of hospitalization, found out that my mother had lost hemoglobin level, they learned by chance, only because she was started to do new injections intramuscularly - to increase hemoglobin. As far as she could understand, such injections are done with a serious decrease in hemoglobin. In the extract from the epicrisis in the paragraph about the analyzes, on the basis of which the diagnosis is made, is "Hb 111". This is the tolerable level of hemoglobin for her age (75), do you think?
As for aspirin, now it is prescribed to him in a dosage of 100 mg, there was more in the hospital.
After discharge for a while, she was slightly livelier, and now she is again suspected of iron deficiency anemia. Tomorrow another blood test and a doctor's appointment are scheduled.
Before hospitalization she had bronchitis, she had a severe cough and a fever, sometimes higher than 38 degrees. Now there is no fever and no cough.
Natalia 08042015, There is no concept of tolerable hemoglobin level, there is a norm and deviations from the norm. Your mother has a deviation from the norm. According to the description of your problem, most likely not associated with taking any medications, since the time of the onset of the disease and the first intake of these drugs, not much time passed, but the presence of cardiac problems could well affect the change in hemoglobin level in the blood. So in your case it is necessary to continue the treatment of anemia, its degree is really small, so that you can probably quickly restore the required hemoglobin level to your mom.
The tooth hurt during feeding. At night I took 1 tablet of aspirin. I did not know that I should not take this pill ...
I take aspirin in each case for 30 years.You need physical work - aspirin, you need mental work - aspirin, something is sick - aspirin. I am already 60 years old and have no problems!
Review of the visitor to the Directory Regina moved to the required section:
In general, the old folk way tested aspirin with analgin, sweated and no temperature.
Can you take aspirin while driving?
Love, Can. No restrictions on the subject of reducing the reaction rate or other side effects that may interfere with driving, does not appear after Aspirin.

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