Utrozhestan - instructions for use, reviews, analogs and forms of release (tablets, capsules 100 mg and 200 mg) drugs to treat infertility, habitual miscarriage, when planning in women, including during pregnancy. Side effect

In this article, you can read the instructions for using the drug Utrozhestan. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Utrozhestan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Utrozhestan in the presence of existing structural analogs.Use to treat infertility, habitual miscarriage, in pregnancy planning and menopause in women, including during pregnancy and lactation. Side effects and effects of taking the drug. Monthly after taking the medicine.

Utrozhestan - gestagenic preparation. Progesterone, the active substance of the drug Utrozestan, is a hormone of the yellow body. Binding to receptors on the surface of cells of target organs penetrates into the nucleus, where activating DNA stimulates RNA synthesis.

Promotes the transition of the mucous membrane of the uterus from the proliferation phase, caused by the follicular hormone, into the secretory phase. After fertilization promotes transition to a condition necessary for the development of a fertilized egg. Reduces excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the end elements of the breast.

Stimulating proteinolipase, increases fat stores, increases the utilization of glucose. Increasing the concentration of basal and stimulated insulin, promotes the accumulation of glycogen in the liver, increases the production of gonadotropic hormones of the pituitary gland; reduces azotemia, increases the excretion of Nitrogen in the urine.

Activates the growth of the secretory department of the mammary glands, induces lactation.

Promotes the formation of normal endometrium.

Pharmacokinetics

Ingestion

Micronized Progesterone is absorbed from the digestive tract. It is excreted in the urine in the form of metabolites, 95% of them are glucuron-conjugated metabolites, mainly 3-alpha, 5-beta-pregnanediol (pregnannione).

These metabolites, which are determined in the blood plasma and in urine, are similar to substances formed during the physiological secretion of the yellow body.

With vaginal administration

Absorption occurs quickly, progesterone accumulates in the uterus. A high level of progesterone is observed 1 h after administration. When administered at doses of more than 200 mg per day, the concentration of progesterone corresponds to 1 trimester of pregnancy. It is excreted in the urine in the form of metabolites, the main part is 3-alpha, 5-beta-pregnanediol (pregnannione).

Indications

Progesterone-deficient conditions in women, including:

for oral administration

• infertility due to luteal insufficiency;
• premenstrual tension syndrome;
• disorders of the menstrual cycle due to a violation of ovulation or anovulation;
• fibrocystic mastopathy;
• premenopause;
• replacement hormone therapy of menopause (in combination with estrogenic drugs).

for vaginal administration

1. hormone replacement therapy with progesterone deficiency in non-functioning (absent) ovaries (with egg donation);
2. support of the luteal phase during preparation for in vitro fertilization;
3. support of the luteal phase in the spontaneous or induced menstrual cycle;
4. premature menopause;
5. hormone replacement therapy (in combination with estrogen preparations);
6. infertility due to luteal insufficiency;
7. prevention of habitual or threatening abortion due to progestin failure;
8. prevention of uterine fibroids;
9. prevention of endometriosis.

Forms of release

Capsules 100 mg and 200 mg.

Forms of reception in the form of tablets, or candles do not exist, only in the form of capsules. All the rest does not belong to the original preparation of Utrozestan. Capsules of the drug can be administered intravaginally, which is an analog of the shape in the form of candles.

Instructions for use and reception scheme

The duration of therapy is set individually, depending on the clinical situation.

For oral administration

The drug should be taken orally, washed down with water. In most cases, when progesterone is deficient, the daily dose of Utrozhestan is 200-300 mg, divided into 2 doses (morning and evening).

If the luteal phase is deficient (premenstrual tension syndrome, menstrual cycle disorders, fibrocystic mastopathy, dysmenorrhea, premenopause), the daily dose of the drug is 200 or 400 mg for 10 days (usually from the 17th to the 26th day of the cycle).

With hormone replacement therapy in peri- and post-menopause, when taking estrogens, Utrozhestan is used at 200 mg per day for 10-12 days.

For intravaginal administration

With the complete absence of progesterone in women with non-functioning ovaries (donation of eggs), the drug is administered intravaginally against the background of estrogen therapy at 200 mg per day on the 13th and 14th days of the cycle, then 100 mg twice a day from 15 on the 25th day of the cycle, from the 26th day and, in case of pregnancy, the dose increases by 100 mg per day every week, reaching a maximum (600 mg per day) divided into 3 injections. This dose is usually applied for 60 days.

To maintain the luteal phase during the extracorporal fertilization cycle, it is recommended to administer intravaginally from 200 to 600 mg per day, starting from the day of injection of the chorionic gonadotropin during the 1 and 2 trimesters of pregnancy.

To maintain the luteal phase in the spontaneous or induced menstrual cycle, infertility associated with a violation of the function of the yellow body, it is recommended to administer intravaginally 200-300 mg per day, starting from the 17th day of the cycle for 10 days, in case of delay in menstruation and diagnosis pregnancy treatment should be continued.

In cases of threatened abortion or in order to prevent habitual abortions that occur against the background of progesterone deficiency, intravaginal administration of 200-400 mg daily in 2 divided doses (in the morning and in the evening) in the first and second trimester of pregnancy. Capsules are injected deep into the vagina.

Side effect

• allergic reactions;
• drowsiness;
• transient dizziness (1-3 hours after taking the drug);
• intermenstrual bleeding.

Contraindications

• propensity to thrombosis;
• acute phlebitis or thromboembolism;
• bleeding of unclear etiology from the genital tract;
• incomplete abortion;
• porphyria;
• established or suspected malignant neoplasms of the mammary glands and genital organs;
• expressed violations of the liver (for oral administration);
• Hypersensitivity to the components of the drug, incl. to peanut butter, soy.

Application in pregnancy and lactation

Utrogestan is indicated for use in the 1 and 2 trimesters of pregnancy.

With caution should be used in pregnancy (due to the risk of violations of liver function) and during lactation.

special instructions

Utrozhestan can not be used for contraception.

Impact on the ability to drive vehicles and manage mechanisms

When taking the drug inside should be careful when dealing with potentially dangerous activities that require increased attention and speed of psychomotor reactions.

Drug Interactions

When combined, Utrozestan enhances the action of diuretics, hypotensive drugs, immunosuppressants, anticoagulants.

Reduces the lactogenic effect of oxytocin.

Analogues of the drug Utrozhestan

Structural analogs for the active substance:

• Iprozhin;
• Krajonon;
• Prajisan;
• Progesterone;
• Projest;
• Utrozhestan.

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