Zedex - instructions for use, analogs, reviews and release forms (syrup) of the drug for treating cough for colds, flu, ARVI in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Zedex. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Zedex in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Zedexa in the presence of existing structural analogs. Use to treat cough for colds, flu, SARS in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Zedex - combined preparation with antitussive and expectorant action. Bromhexine has mucolytic (secretolitic), expectorant and weak antitussive effect. Mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. Dextromosthorfan increases the sensitivity threshold of the cough center of the medulla oblongata, without leading to the depression of the respiratory center, has an antitussive and sedative effect, does not cause an addictive effect to the drug and does not possess an analgesic effect. Ammonium chloride has expectorant properties.

Composition

Bromhexine hydrochloride + Dextromethorphan hydrobromide + Ammonium chloride + auxiliary substances.

Pharmacokinetics

All substances that make up Zedex are adsorbed into the digestive tract and enter the systemic bloodstream, binding to plasma proteins.

Dextromethorphan is absorbed very quickly in the digestive tract, and its antitussive effect is felt on average 20 minutes after Zedex administration and lasts for five hours. This substance undergoes biotransformation in the liver, almost half of the metabolites are excreted by the kidneys with urine (half-life is approximately 11 hours).

Bromhexine is almost completely absorbed and binds to plasma proteins (the maximum concentration in the blood is noted 60 minutes after admission). Metabolism by demethylation and oxidation occurs in the liver with the formation of an active metabolite of Ambroxol (stimulating the formation of sputum and having an expectorant effect). Excretion of metabolites occurs through the kidneys.

Ammonium chloride entering Zedex is transformed into pulmonary tissues with the formation of active metabolites that act on the mucosa of the respiratory tract, activating the ciliary epithelium of the bronchi.

Indications

• to alleviate the symptoms of colds, flu, ARVI, accompanied by a cough.

Forms of release

Syrup 8 mg + 10 mg + 100 mg.

Instructions for use and dosing regimen

Adults and children over 12 years - inside 2 teaspoons 2-3 times a day.

Children from 6 to 12 years - inside half or one teaspoon 3-4 times a day.

Side effect

• dyspeptic phenomena;
• exacerbation of peptic ulcer;
• allergic reactions (skin rash, rhinitis and others);
• increase in the level of transaminases in the blood serum;
• drowsiness;
• sleep disturbance;
• increased excitability (especially in children).

Contraindications

• hypersensitivity to the components of the drug;
• pregnancy and lactation;
• peptic ulcer (at the stage of exacerbation);
• simultaneous reception of other drugs containing substances that are part of Sedex;
• children's age till 6 years.

Carefully

• hepatic or renal insufficiency;
• bronchial asthma.

Application in pregnancy and lactation

Zedex is contraindicated in pregnancy and lactation.

Use in children

Contraindicated for children under 6 years. Use according to indications in children older than 6 years.

special instructions

During treatment should refrain from drinking alcohol.

Impact on the ability to drive vehicles and manage mechanisms

Be careful when doing work that requires concentration of attention, increased speed of motor and mental reactions.

Drug Interactions

Zedex can be prescribed concomitantly with other drugs used in the treatment of bronchopulmonary diseases. Zedex is not prescribed concomitantly with antitussive agents (including those containing codeine).

Bromhexine, which is part of Zedex, promotes the penetration of antibiotics (erythromycin, cephalexin,oxytracycline, ampicillin, amoxicillin) into the lung tissue, but its combined use with salicylates, phenylbutazone and oxyphenbutazone can cause severe irritation of the gastric mucosa. Alcohol, which is part of the syrup, can change the effect of other medicines.

Since the drug includes dextromethorphan, simultaneous use with MAO inhibitors is contra-indicated (it is possible to act on the CNS and expressed respiratory depression), Amiodarone (may inhibit the metabolism of dextromethorphan in the liver and increase its toxicity), antidepressants serotonin reuptake inhibitors (fluoxetine, paroxetine). Dextromethorphan can potentiate the analgesic effect of opioids.

Analogues of the drug Zedex

Zedex does not have structural analogues in terms of the composition of active substances.

Analogues on the pharmacological group (secretolitics and stimulants of the motor function of the respiratory tract):

• Altalex;
• Ambrogen;
• Ambroghexal;
• Ambroxol;
• Ambrolan;
• Ambrolore;
• Ambrosan;
• Ambrosol;
• Acestin;
• Acetylcysteine;
• ATSTS;
• Bromhexine;
• Bronkatar;
• Bronchicum;
• Bronhobos;
• Bronoxoxol;
• Bronchoplant;
• Bronchorus;
• Bronchostop;
• Bronchotil;
• Gedelix;
• Hexapneumine;
• Herbion;
• Glycyrs;
• Dephlegmine;
• Doctor IOM;
• Dr. Theiss;
• Bronhoven;
• Carbocysteine;
• Lazolvan;
• Libexin;
• Mistabrone;
• Mukaltin;
• Mukobene;
• Mucobron;
• Mukodin;
• The mukonist;
• Mukonakes;
• Mukoprint;
• Mucosol;
• Mucofitin;
• Neo Bronhol;
• Pectolvan;
• Pectosol;
• Prospan;
• Prothiazine;
• Pulmonizing;
• Reglis;
• Remebroks;
• Sinupret;
• Solvyn;
• Solutan;
• Suprima kof;
• Terpin hydrate;
• Terrone;
• Toraxol;
• Travisil;
• Tussamag;
• Tussin;
• Flavamed;
• Flegamine;
• Flexin;
• Fluimucil;
• Fluviert;
• Fluidite;
• Haliksol;
• Exomuk;
• Elmucin;
• Erdomed;
• Erdosteine;
• Ermucin.

Response of a therapist

Colds and flu are almost always accompanied by a cough. It is noticeable to facilitate the manifestation of this unpleasant, and sometimes greatly worsening of the patient's symptoms, the use of Zedex syrup will help. This is a complex preparation. By increasing the sensitivity threshold of the cough center, it exhibits an active antitussive effect. In addition, the drug accelerates sputum expectoration and mute calms. Zedex does not cause any addiction, the respiratory center is not depressed when it is taken.

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