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Nurofen - instructions for use, reviews, analogs and formulations (200 mg tablets, fort, plus, children's syrup or suspension, 60 mg candles, 5% gel) medications for pain and fever in adults, children and pregnancy

Nurofen - instructions for use, reviews, analogs and formulations (200 mg tablets, fort, plus, children's syrup or suspension, 60 mg candles, 5% gel) medications for pain and fever in adults, children and pregnancy

In this article, you can read the instructions for using the drug Nurofen. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Nurofen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nurofen in the presence of existing structural analogues. Use to treat pain and fever (fever) in adults, children, as well as during pregnancy and lactation. Children's forms and their use.

 

Nurofen - a non-steroidal anti-inflammatory agent, a derivative of phenylpropionic acid. Has anti-inflammatory, analgesic and antipyretic effect.

 

The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due both to peripheral (indirectly, through suppression of prostaglandin synthesis) and to the central mechanism (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses the aggregation of platelets.

 

With external application has anti-inflammatory and analgesic effect. Reduces the morning stiffness, promotes an increase in the volume of movements in the joints.

 

Pharmacokinetics

 

After ingestion Ibuprofen (the active substance of the drug Nurofen) is rapidly absorbed from the digestive tract. Binding to plasma proteins is 90%. Slowly penetrates into the joint cavity, lingers in the synovial tissue, creating in it greater concentrations than in the plasma.Ibuprofen is excreted in the urine unchanged (no more than 1%) and in the form of conjugates, a minor part is excreted with bile.

 

Indications

  • headache;
  • migraine;
  • toothache;
  • neuralgia;
  • myalgia;
  • back pain;
  • rheumatic pains;
  • algodismenorea;
  • fever in case of flu and ARVI.

 

Forms of release

 

The tablets covered with a cover of 200 mg.

 

Tablets for the preparation of fizzy drink 200 mg.

 

Candles rectal 60 mg (children's form of the drug).

 

Tablets Nurofen Fort 400 mg.

 

Nurofen plus tablets (contains ibuprofen + codeine).

 

Children's syrup or suspension with orange or strawberry taste 100 mg.

 

Gel for external use 5%.

 

Instructions for use and dosage

 

For adults and children over 12 years of age, the initial dose of the drug is 200 mg 3-4 times a day. To achieve a rapid clinical effect, it is possible to increase the initial dose to 400 mg three times a day. The maximum daily dose is 1200 mg.

 

Children aged 6 to 12 years - 200 mg not more than 4 times a day. It should be borne in mind that the drug can be administered only to children weighing over 20 kg. The interval between tablets should be at least 6 hours.

 

Do not take more than 6 tablets per day. The maximum dose is -1.2 g.

 

The tablets covered with a cover, it is necessary to wash down with water. The effervescent tablets should be dissolved in 200 ml of water (1 glass).

 

Candles for children

 

With fever and pain syndrome, the dose of the drug depends on the age and body weight of the child. A single dose is 5-10 mg / kg 3-4 times a day. The maximum daily dose is 30 mg / kg.

 

Children aged 3-9 months (body weight 5.5-8 kg) appoint 1 supp. (60 mg) 3 times a day with an interval of 6-8 hours, but not more than 180 mg per day.

 

Children aged 9 months to 2 years (body weight 8-12.5 kg) appoint 1 supp. (60 mg) 4 times a day with an interval of 6 hours, not more than 240 mg per day.

 

With postimmunization fever, children under 1 year of age are prescribed 1 supp. (60 mg); children over 1 year also - 1 soup. (60 mg), if necessary, after 6 hours, another 1 supp can be added. (60 mg).

 

Duration of treatment: no more than 3 days as an antipyretic agent, no more than 5 days as an analgesic. If the fever persists, then a doctor's consultation is necessary.

 

Do not exceed the indicated doses of the drug.

 

Suspension or syrup for children

 

With fever and pain syndrome, the drug is prescribed in a dose of 5-10 mg / kg of the child's body weight 3-4. The maximum daily dose should not exceed 30 mg / kg of body weight.

 

As an antipyretic agent the drug should not be taken more than 3 days, as an analgesic - no more than 5 days.

 

At a fever after an immunization prescribe a preparation in a dose of 50 mg (2.5 ml); if necessary, children older than 1 year after 6 hours may receive a second dose at the same dose. The maximum daily dose should not exceed 5 ml (100 mg).

 

Suspension before use should be shaken carefully.

 

To accurately dispense the suspension, a two-dimensional measuring spoon (2.5 ml and 5 ml) or a measuring syringe is applied to the vial.

 

Side effect

 

When Nurofen is used for 2-3 days, side effects are almost not observed. In the case of prolonged use, the following side effects may occur:

  • nausea, vomiting;
  • heartburn;
  • anorexia;
  • a feeling of discomfort in the epigastrium;
  • diarrhea;
  • flatulence;
  • erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding);
  • abdominal pain, irritation;
  • dryness and pain in the oral mucosa;
  • constipation;
  • headache;
  • dizziness;
  • insomnia, agitation, drowsiness, depression;
  • confusion, hallucinations;
  • blurred vision;
  • dryness and irritation of the eyes;
  • hearing loss, ringing or tinnitus;
  • increased blood pressure;
  • tachycardia;
  • nephrotic syndrome;
  • acute renal insufficiency;
  • anemia (including hemolytic, aplastic);
  • thrombocytopenia;
  • thrombocytopenic purpura;
  • agranulocytosis;
  • leukopenia;
  • skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions, anaphylactic shock;
  • allergic rhinitis;
  • bronchospasm, shortness of breath;
  • increased sweating.

 

With prolonged use in high doses: ulceration of the mucous membrane of the gastrointestinal tract, bleeding (including from the gastrointestinal tract, gums, uterine, hemorrhoidal), visual impairment (violation of color vision, scotoma, amblyopia).

 

Contraindications

  • erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation, incl. peptic ulcer of the stomach and duodenum, ulcerative colitis, peptic ulcer, Crohn's disease;
  • severe heart failure;
  • severe course of arterial hypertension;
  • "aspirin" bronchial asthma, urticaria, rhinitis, triggered by the use of acetylsalicylic acid (salicylates) or other NSAIDs;
  • diseases of the optic nerve, violation of color vision, amblyopia, scotoma;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • hemophilia, hypocoagulation conditions;
  • leukopenia;
  • hemorrhagic diathesis;
  • severe violations of the liver and / or kidney function;
  • hearing loss, pathology of the vestibular apparatus;
  • 3 trimester of pregnancy;
  • lactation period (breastfeeding);
  • children's age till 6 years;
  • hypersensitivity to ibuprofen or to the components of the drug.

 

Application in pregnancy and lactation

 

Nurofen is contraindicated for use in the 3rd trimester of pregnancy.

 

The use of the drug in the first and second trimester of pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or baby.

 

If it is necessary to prescribe the drug during lactation, the question of stopping breastfeeding should be solved.

 

special instructions

 

If side effects occur, stop taking the medication and consult a doctor.

 

If the symptoms persist for 2-3 days after taking the drug, the drug should be canceled and the diagnosis clarified.

 

During the treatment is not recommended to use ethanol (alcohol) - increases the risk of developing gastric bleeding.

 

When taking effervescent tablets, patients on a hypocalic diet should take into account,that 1 tablet contains 1530 mg of potassium carbonate; patients with diabetes should take into account that 1 tablet contains 40 mg of sodium saccharinate; patients with intolerance to fructose should take into account that 1 tablet contains about 376 mg of sorbitol.

 

Control of laboratory indicators

 

During long-term use of the drug, control of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring including esophagogastroduodenoscopy, a general blood test (determination of hemoglobin), and analysis of feces for latent blood are shown.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Patients should refrain from all activities requiring increased attention, speed of psychomotor reactions.

 

Drug Interactions

 

It is not recommended to take Nurofen concurrently with Acetylsalicylic acid and other NSAIDs.

 

With the simultaneous administration of ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (possibly increasing the incidence of acute coronary insufficiency after the onset of ibuprofen in patients,receiving as an antiaggregant agent small doses of acetylsalicylic acid).

 

When used simultaneously with anticoagulants and thrombolytic drugs (including alteplase, streptokinase, urokinase), the risk of bleeding increases.

 

When combined with Nurofen cefamandol, cefoperazone, cefotetan, valproic acid, pikamycin increase the frequency of hypoprothrombinemia.

 

When combined, cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which leads to an increased nephrotoxic effect.

 

Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.

 

Drugs that block tubular secretion, with simultaneous use reduce the excretion and increase the plasma concentration of ibuprofen.

 

When combined, inducers of microsomal oxidation (including phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions.

 

Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action of ibuprofen.

 

When combined, Nurofen reduces the hypotensive activity of vasodilators, the natriuretic effect of Furosemide and hydrochlorothiazide.

 

Ibuprofen reduces the effectiveness of uricosuric drugs, increases the effect of indirect anticoagulants, antiaggregants and fibrinolytics.

 

Increases the side effects of mineralocorticoids, GCS, estrogens, ethanol (alcohol).

 

When combined, increases the hypoglycemic effect of oral antidiabetics (sulfonylurea derivatives) and insulin.

 

With simultaneous administration of antacids and colestyramine reduce the absorption of Nurofen.

 

When combined, ibuprofen increases the concentration in the blood of digoxin, lithium preparations, methotrexate.

 

Caffeine increases the analgesic effect of ibuprofen.

 

Analogues of the drug Nurofen

 

Structural analogs for the active substance:

  • Advance;
  • ArthroCam;
  • Bonifen;
  • Brufen;
  • Burana;
  • Deblock;
  • Children's Motrin;
  • Dolgit;
  • Ibuprom;
  • Ibuprofen;
  • Ibuprofen Lannacher;
  • Ibuprofen Nycomed;
  • Ibuprofen-Hemofarm;
  • Ibusan;
  • Ibutop gel;
  • Ibufen;
  • Iprene;
  • MIG 200;
  • MIG 400;
  • Nurofen for children;
  • Nurofen Period;
  • Nurofen UltraKap;
  • Nurofen fort;
  • Nurofen Express;
  • Pedee;
  • Solpaflex;
  • Faspik.

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Reviews (20):
Guests
Anek
My child is warmly helped by the temperature. Removes heat and the child falls asleep and without consequences, so that it is possible for children, it is possible for adults.
Guests
Lula
I took Nurofen's pops from the temperature, because before that, aspirin did not help and the drug was advised in the pharmacy. And the temperature, and the headache from the cold as a hand, took off. Yes, and recovered like faster from illness.
Guests
Alexey
If the main active substance of the drug Ibuprofen, then personally, for me the issue of choice is not worth it - why pay more for additional dyes and sweeteners, when you can take the original drug that helps at a temperature better than using some commercial forms of this medicine.
Guests
marina
How much is the open bottle of Nurofen syrup for children?
Administrators
admin
marinaSince the instructions do not say otherwise, the opened bottle of suspension (sometimes mistakenly called syrup) Nurofen for children is stored until the expiration date indicated on the package (3 years from the date of manufacture).

Naturally, it is necessary to observe the storage mode: in a dry, dark place at a temperature of no higher than 25 degrees. Before use, the suspension should be shaken.
Guests
Victoria
The drug nurofen has recently always been in the medicine cabinet, as a form of tablets, and in the form of ointments and gels. An excellent anti-inflammatory drug and an anesthetic for headache and not only. Very often I use ointments for rheumatoid arthritis and no troubles from side effects have been observed so far.
Guests
Max
Can I try these tablets with a tablet of Egilok? (I drink from hypertension)
Administrators
admin
Max, Nurofen as an active substance contains Ibuprofen, which is a non-steroidal anti-inflammatory drug (NSAID)? the drugs of this group reduce the hypotensive effect of the drug Egilok, then the network will either need to replace Nurofen with another drug, or adjust the dose of Egiloc, in any case the doctor must decide this question. Many hypertensive patients take risks at their own risk, adjusting the doses after the fact, but I do not advise you to do it myself.
Guests
Anastasia
Why is there no Nurofen in syrup without additives? Such allergic flavors are strawberry and orange. What came to mind? A child when he fever, he is not up to flavoring. It's good. But we stopped using because of unnecessary allergic flavors. After taking the treatment for an allergy three weeks. It would be good information came to the manufacturers. Among the mothers of friends conducted a survey. (30 interrogated, 2 are using the rest because of the "orange" and "strawberry" tastes.) The drug is effective and always helps.
Guests
Light
And we really like the suspension with fruit flavors, only these and we can drink during the temperature. We have a strawberry Nurofen in the medicine cabinet is always there, the child is not allergic to thank God, I follow both my diet and for it so that there are no problems.
Guests
Lily
Whether it is possible and how to accept children's Nurofen in a syrup to adults, older people? What will be the dosages in this case?
Administrators
admin
Lily, Dosage, which you recommended the doctor, recount for the active ingredient. In 5 ml of Nurofen suspension for children, 100 mg of ibuprofen active ingredient is contained, in the tablet it is 200 mg, which corresponds to 10 ml of the suspension. Then count as much as you need. If capsules are prescribed - see how much there is a dosage of 200 mg or 400 mg.
Visitors
natalia75
We gave the child Nurofen in syrup from an early age, from 1.5 years. Yes, there were allergic rashes, but insignificant. A child of up to six years was sick often, once every 1.5-2 months, so Nurofen had to be used repeatedly ((I regret now! Because at the age of 8 I was taken to the hospital with erosion of the gastrointestinal tract.I believe that this is partly to blame and Nurofen (read the instructions: ulceration of the mucosa of the gastrointestinal tract). Better conventional paracetamol or analogs.
Guests
Tatyana
Recently, I collided with the side effect of the child's Nurofen syrup. A child of 3.5 years caused hallucinations. The son did not recognize me, shook, the "wolf" screamed in fright. Attacks repeated several times within half an hour. Then he calmed down. I suggested that it could be a reaction to the heat, and the next time Nurofen was given again in a smaller dosage than he was supposed to be by age. The temperature dropped, but after a dream the hallucinations began again. Decided to abandon Nurofen.
Guests
Lyudmila
How much is Nurofen an adult. Tell me please. belay
Administrators
admin
Lyudmila, Nurofen in tablets 200 mg costs in Moscow in the region of 100-150 rubles. Prices in your area may vary, so find out the price and availability in the help of your region.
Guests
Saina
Hello! Is it possible at the temperature of the mother, without stopping the GW with a syrup?
Administrators
admin
Saina, Nurofen can be used shortly according to the indications of breastfeeding women, without stopping breastfeeding, without negative consequences for the child. So you can use it for 2-3 days. If you need longer, then through your doctor.
Guests
Tatyana
Can I apply nurofen to a child for a month and a half?
Administrators
admin
Tatyana, Nurofen in the form of a suspension is forbidden to use in children less than 5 kilograms of weight. And do not use candles for children less than 6 kilograms. Also in the application there is a general recommendation not to use in children under 3 months, but if you pass by weight you can try.

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