Nurofen - instructions for use, reviews, analogs and formulations (200 mg tablets, fort, plus, children's syrup or suspension, 60 mg candles, 5% gel) medications for pain and fever in adults, children and pregnancy
In this article, you can read the instructions for using the drug Nurofen. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Nurofen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Nurofen in the presence of existing structural analogues. Use to treat pain and fever (fever) in adults, children, as well as during pregnancy and lactation. Children's forms and their use.
Nurofen - a non-steroidal anti-inflammatory agent, a derivative of phenylpropionic acid. Has anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due both to peripheral (indirectly, through suppression of prostaglandin synthesis) and to the central mechanism (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses the aggregation of platelets.
With external application has anti-inflammatory and analgesic effect. Reduces the morning stiffness, promotes an increase in the volume of movements in the joints.
Pharmacokinetics
After ingestion Ibuprofen (the active substance of the drug Nurofen) is rapidly absorbed from the digestive tract. Binding to plasma proteins is 90%. Slowly penetrates into the joint cavity, lingers in the synovial tissue, creating in it greater concentrations than in the plasma.Ibuprofen is excreted in the urine unchanged (no more than 1%) and in the form of conjugates, a minor part is excreted with bile.
Indications
- headache;
- migraine;
- toothache;
- neuralgia;
- myalgia;
- back pain;
- rheumatic pains;
- algodismenorea;
- fever in case of flu and ARVI.
Forms of release
The tablets covered with a cover of 200 mg.
Tablets for the preparation of fizzy drink 200 mg.
Candles rectal 60 mg (children's form of the drug).
Tablets Nurofen Fort 400 mg.
Nurofen plus tablets (contains ibuprofen + codeine).
Children's syrup or suspension with orange or strawberry taste 100 mg.
Gel for external use 5%.
Instructions for use and dosage
For adults and children over 12 years of age, the initial dose of the drug is 200 mg 3-4 times a day. To achieve a rapid clinical effect, it is possible to increase the initial dose to 400 mg three times a day. The maximum daily dose is 1200 mg.
Children aged 6 to 12 years - 200 mg not more than 4 times a day. It should be borne in mind that the drug can be administered only to children weighing over 20 kg. The interval between tablets should be at least 6 hours.
Do not take more than 6 tablets per day. The maximum dose is -1.2 g.
The tablets covered with a cover, it is necessary to wash down with water. The effervescent tablets should be dissolved in 200 ml of water (1 glass).
Candles for children
With fever and pain syndrome, the dose of the drug depends on the age and body weight of the child. A single dose is 5-10 mg / kg 3-4 times a day. The maximum daily dose is 30 mg / kg.
Children aged 3-9 months (body weight 5.5-8 kg) appoint 1 supp. (60 mg) 3 times a day with an interval of 6-8 hours, but not more than 180 mg per day.
Children aged 9 months to 2 years (body weight 8-12.5 kg) appoint 1 supp. (60 mg) 4 times a day with an interval of 6 hours, not more than 240 mg per day.
With postimmunization fever, children under 1 year of age are prescribed 1 supp. (60 mg); children over 1 year also - 1 soup. (60 mg), if necessary, after 6 hours, another 1 supp can be added. (60 mg).
Duration of treatment: no more than 3 days as an antipyretic agent, no more than 5 days as an analgesic. If the fever persists, then a doctor's consultation is necessary.
Do not exceed the indicated doses of the drug.
Suspension or syrup for children
With fever and pain syndrome, the drug is prescribed in a dose of 5-10 mg / kg of the child's body weight 3-4. The maximum daily dose should not exceed 30 mg / kg of body weight.
As an antipyretic agent the drug should not be taken more than 3 days, as an analgesic - no more than 5 days.
At a fever after an immunization prescribe a preparation in a dose of 50 mg (2.5 ml); if necessary, children older than 1 year after 6 hours may receive a second dose at the same dose. The maximum daily dose should not exceed 5 ml (100 mg).
Suspension before use should be shaken carefully.
To accurately dispense the suspension, a two-dimensional measuring spoon (2.5 ml and 5 ml) or a measuring syringe is applied to the vial.
Side effect
When Nurofen is used for 2-3 days, side effects are almost not observed. In the case of prolonged use, the following side effects may occur:
- nausea, vomiting;
- heartburn;
- anorexia;
- a feeling of discomfort in the epigastrium;
- diarrhea;
- flatulence;
- erosive and ulcerative lesions of the gastrointestinal tract (in some cases complicated by perforation and bleeding);
- abdominal pain, irritation;
- dryness and pain in the oral mucosa;
- constipation;
- headache;
- dizziness;
- insomnia, agitation, drowsiness, depression;
- confusion, hallucinations;
- blurred vision;
- dryness and irritation of the eyes;
- hearing loss, ringing or tinnitus;
- increased blood pressure;
- tachycardia;
- nephrotic syndrome;
- acute renal insufficiency;
- anemia (including hemolytic, aplastic);
- thrombocytopenia;
- thrombocytopenic purpura;
- agranulocytosis;
- leukopenia;
- skin rash, itching, urticaria, Quincke's edema, anaphylactoid reactions, anaphylactic shock;
- allergic rhinitis;
- bronchospasm, shortness of breath;
- increased sweating.
With prolonged use in high doses: ulceration of the mucous membrane of the gastrointestinal tract, bleeding (including from the gastrointestinal tract, gums, uterine, hemorrhoidal), visual impairment (violation of color vision, scotoma, amblyopia).
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation, incl. peptic ulcer of the stomach and duodenum, ulcerative colitis, peptic ulcer, Crohn's disease;
- severe heart failure;
- severe course of arterial hypertension;
- "aspirin" bronchial asthma, urticaria, rhinitis, triggered by the use of acetylsalicylic acid (salicylates) or other NSAIDs;
- diseases of the optic nerve, violation of color vision, amblyopia, scotoma;
- deficiency of glucose-6-phosphate dehydrogenase;
- hemophilia, hypocoagulation conditions;
- leukopenia;
- hemorrhagic diathesis;
- severe violations of the liver and / or kidney function;
- hearing loss, pathology of the vestibular apparatus;
- 3 trimester of pregnancy;
- lactation period (breastfeeding);
- children's age till 6 years;
- hypersensitivity to ibuprofen or to the components of the drug.
Application in pregnancy and lactation
Nurofen is contraindicated for use in the 3rd trimester of pregnancy.
The use of the drug in the first and second trimester of pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or baby.
If it is necessary to prescribe the drug during lactation, the question of stopping breastfeeding should be solved.
special instructions
If side effects occur, stop taking the medication and consult a doctor.
If the symptoms persist for 2-3 days after taking the drug, the drug should be canceled and the diagnosis clarified.
During the treatment is not recommended to use ethanol (alcohol) - increases the risk of developing gastric bleeding.
When taking effervescent tablets, patients on a hypocalic diet should take into account,that 1 tablet contains 1530 mg of potassium carbonate; patients with diabetes should take into account that 1 tablet contains 40 mg of sodium saccharinate; patients with intolerance to fructose should take into account that 1 tablet contains about 376 mg of sorbitol.
Control of laboratory indicators
During long-term use of the drug, control of the peripheral blood picture and the functional state of the liver and kidneys is necessary. When symptoms of gastropathy appear, careful monitoring including esophagogastroduodenoscopy, a general blood test (determination of hemoglobin), and analysis of feces for latent blood are shown.
Impact on the ability to drive vehicles and manage mechanisms
Patients should refrain from all activities requiring increased attention, speed of psychomotor reactions.
Drug Interactions
It is not recommended to take Nurofen concurrently with Acetylsalicylic acid and other NSAIDs.
With the simultaneous administration of ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (possibly increasing the incidence of acute coronary insufficiency after the onset of ibuprofen in patients,receiving as an antiaggregant agent small doses of acetylsalicylic acid).
When used simultaneously with anticoagulants and thrombolytic drugs (including alteplase, streptokinase, urokinase), the risk of bleeding increases.
When combined with Nurofen cefamandol, cefoperazone, cefotetan, valproic acid, pikamycin increase the frequency of hypoprothrombinemia.
When combined, cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which leads to an increased nephrotoxic effect.
Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of its hepatotoxic effects.
Drugs that block tubular secretion, with simultaneous use reduce the excretion and increase the plasma concentration of ibuprofen.
When combined, inducers of microsomal oxidation (including phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe hepatotoxic reactions.
Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action of ibuprofen.
When combined, Nurofen reduces the hypotensive activity of vasodilators, the natriuretic effect of Furosemide and hydrochlorothiazide.
Ibuprofen reduces the effectiveness of uricosuric drugs, increases the effect of indirect anticoagulants, antiaggregants and fibrinolytics.
Increases the side effects of mineralocorticoids, GCS, estrogens, ethanol (alcohol).
When combined, increases the hypoglycemic effect of oral antidiabetics (sulfonylurea derivatives) and insulin.
With simultaneous administration of antacids and colestyramine reduce the absorption of Nurofen.
When combined, ibuprofen increases the concentration in the blood of digoxin, lithium preparations, methotrexate.
Caffeine increases the analgesic effect of ibuprofen.
Analogues of the drug Nurofen
Structural analogs for the active substance:
- Advance;
- ArthroCam;
- Bonifen;
- Brufen;
- Burana;
- Deblock;
- Children's Motrin;
- Dolgit;
- Ibuprom;
- Ibuprofen;
- Ibuprofen Lannacher;
- Ibuprofen Nycomed;
- Ibuprofen-Hemofarm;
- Ibusan;
- Ibutop gel;
- Ibufen;
- Iprene;
- MIG 200;
- MIG 400;
- Nurofen for children;
- Nurofen Period;
- Nurofen UltraKap;
- Nurofen fort;
- Nurofen Express;
- Pedee;
- Solpaflex;
- Faspik.
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