Cortisone - instructions for use, analogs, reviews and release forms (tablets 25 mg acetate) drug for the treatment of Addison's disease and insufficiency of adrenal cortex hormones in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Cortisone. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Cortisone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cortisone in the presence of existing structural analogues.Use for the treatment of hypopituitarism, Addison's disease and insufficiency of hormones of the adrenal cortex in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Cortisone - Glucocorticosteroid (GCS). Has a significant effect on carbohydrate metabolism and, to a lesser extent, on water and electrolyte metabolism. Has mineralocorticoid activity: sodium retention, loss of potassium, fluid retention in the body. Promotes the accumulation of glycogen in the liver, increases the glucose in the blood, increases the excretion of Nitrogen in the urine. Has anti-inflammatory, desensitizing and anti-allergic effect, has immunosuppressive activity.

The anti-inflammatory effect is caused by the inhibition of phospholipase A2, which leads to inhibition of the synthesis of prostaglandins, a decrease in the release of macrophage chemotactic factor, a decrease in the migration of macrophages and lymphocytes to the inflammatory focus, stabilization of lysosome membranes and prevention of lysosomal enzymes. Immunosuppressive action is associated with a decrease in the number of immunocompetent cells, with a decrease in the binding of immunoglobulins to cellular receptors,suppression of blast-transformation of B-lymphocytes, a decrease in the number of interleukins, lymphokines, circulating immunocomplexes, complement fractions.

Increases the excretion of calcium in the urine, activates lysis of bone tissue by mediated increase in the amount of calcitonin, increases the activity of osteoclasts, reduces the function of osteoblasts.

Has a catabolic effect, increases the breakdown of proteins. Lipolytic effect increases the content of fatty acids in the blood. Reduces the production of ACTH in the anterior lobe of the pituitary gland, which leads to suppression of activity and subsequent atrophy of the adrenal cortex.

Composition

Cortisone acetate + excipients.

Indications

Addison's disease;
secondary chronic insufficiency of the adrenal cortex (with hypopituitarism);
allergic, inflammatory, infectious-allergic, autoimmune diseases.

Forms of release

Tablets 25 mg.

Other medicinal forms of Cortisone, be it ointment, gel, cream, lotion or injections in injectable ampoules, did not exist in the Directory at the time of publication of the drug.

Instructions for use and dosing regimen

Individual.The daily daily dose is 10-300 mg in several doses. Maximum doses for adults: single dose - 150 mg, daily - 300 mg. Children are used in smaller doses. It should be borne in mind that the individual dose of cortisone is determined by the severity of the disease rather than the age of the patient.

Side effect

edema;
arterial hypertension;
an increase in the excretion of potassium until the development of hypokalemic alkalosis;
negative nitrogen balance;
hyperglycemia;
increased appetite;
increase in body weight;
the Itenko-Cushing syndrome;
amenorrhea;
osteoporosis;
aseptic necrosis of bones;
mental and neurological disorders;
increased intracranial pressure;
increased blood clotting and increased risk of thromboembolic complications;
hemorrhagic pancreatitis;
erosive and ulcerative lesions of the gastrointestinal tract;
perforation of an unrecognized ulcer;
hyperhidrosis;
reduction of resistance to infectious diseases.

Contraindications

peptic ulcer of the stomach and duodenum in the phase of exacerbation;
Cushing's disease;
tendency to thromboembolism;
kidney failure;
severe arterial hypertension;
systemic fungal infections;
viral infections;
the period of vaccination;
active form of tuberculosis;
glaucoma;
osteoporosis;
productive symptoms in mental illness;
hypersensitivity to cortisone.

Application in pregnancy and lactation

In pregnancy (especially 1 trimester) and lactation (breast-feeding) cortisone used with the expected therapeutic effect, negative impact on the fetus. With prolonged therapy, the possibility of fetal growth disorders is not ruled out. In the case of cortisone at the end of pregnancy, there is a risk of atrophy of the adrenal cortex in the fetus, which may require replacement therapy in the newborn.

Use in children

Children during prolonged treatment need careful monitoring of the dynamics of growth and development. Children who, during treatment were in contact with sick measles or chicken pox, prophylactically prescribe specific immunoglobulins.

special instructions

To use caution in patients with ulcerative colitis (UC), and diverticulitis, recently established intestinal anastomosis, gastric ulcer and duodenal ulcers, kidney failure,myasthenia gravis, arterial hypotension, diabetes, mental illness, hypoalbuminemia. With hypothyroidism, as well as with cirrhosis, the effect of cortisone can be enhanced. With initial emotional instability or psychotic tendencies, these phenomena can intensify.

When using cortisone in patients with herpes simplex cornea, one should keep in mind the possibility of perforation.

During treatment, it is necessary to monitor the intraocular pressure and the condition of the cornea. With sudden withdrawal of treatment, especially in the case of previous use in high doses, there is a so-called syndrome of cancellation of GCS (not due to hypocorticism): anorexia, nausea, blocking, generalized musculo-skeletal pain, general weakness. After cancellation of cortisone within a few months, relative insufficiency of the adrenal cortex may persist. If during this period there are stressful situations, prescribe (according to indications) for the time of GCS, if necessary in combination with mineralocorticoids.

Children during prolonged treatment need careful monitoring of the dynamics of growth and development.Children who, during treatment were in contact with sick measles or chicken pox, prophylactically prescribe specific immunoglobulins.

Drug Interactions

Strengthens the effect of anticoagulants, antiaggregants, side effects of non-steroidal anti-inflammatory drugs (NSAIDs), cardiac glycosides, estrogens, androgens and steroid anabolics, amphotericin B, asparaginase. Reduces the effectiveness of hypoglycemic, hypotensive and diuretics.

Analogues of the drug Cortisone

Structural analogs for the active substance:

Cortisone acetate.

Analogues for the pharmacological group (glucocorticosteroids):

Avamis;
Avecourt;
Advantan;
Acriderm;
Ambien;
Apulein;
Aurobin;
Beclomet Ishihiler;
Beclomethasone;
Belogent;
Beloderm;
Belosalik lotion;
Benacorte;
Betaderm;
Betamethasone;
Betaspan Depot;
Budesonide;
Garazon;
Hydrocortisone;
Desrinitis;
Decortin;
Dexamethasone;
Depot Medrol;
Dermovate;
Diprosalic;
Diprospan;
Canison plus;
Kenalog;
Cortisone acetate;
Kutiweit;
Lokoid;
Lorinden;
Medrol;
Methylprednisolone;
Metizred;
Momat;
Mometasone;
Nazonex;
Nasobek;
Pimafukort;
Polidex;
Polcortolone;
Prednisolone;
Prednisolone ointment 0.5%;
Pulmicort;
Sinaflan;
Triamsinolone;
Triderm;
Fliksonase;
Fluticasone propionate;
Flucinar;
Fluorocort;
Celestoderm B;
Celeston;
Elokom.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: hypopituitarism, Addison's disease, hypokorticism, insufficiency of the adrenal cortex