Vinpotropil - instructions for use, reviews, analogs and formulations (tablets 10 mg + 800 mg, capsules 5 mg + 400 mg, injections in ampoules for injection 1 mg + 80 mg) of the drug for the treatment of stroke in adults, children and pregnancy

In this article, you can read the instructions for using the drug Vinpotropil. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Vinpotropil in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Vinpotropil analogs in the presence of existing structural analogues. Use to treat the effects of stroke, tinnitus, migraine in adults, children, as well as during pregnancy and lactation.

Vinpotropil - Nootropic combined preparation, also has vasodilating properties. Improves cerebral circulation, causes a slight decrease in systemic blood pressure. Increases the resistance of brain cells to hypoxia, facilitates transportation of oxygen and substrates provide energy to tissues (due to reduction of affinity of erythrocytes for oxygen and enhancing the absorption of glucose metabolism and transition to aerobic processes). It promotes the accumulation of cAMP and ATP in tissues, an increase in the content of catecholamines in the brain tissues. The vasodilatory effect is associated with a direct relaxing effect on the smooth muscle of vessels predominantly of the brain. The drug does not cause steal phenomenon and increases blood flow to ischemic brain area, without affecting the blood supply intact areas. Improves microcirculation in the brain due to a decrease in platelet aggregation, decrease in blood viscosity, increase in the deformability of erythrocytes.

Has a positive effect on metabolic processes in brain cells, increases the concentration of ATP in the brain tissue, enhances the synthesis of ribonucleic acids and phospholipids, and glucose utilization.It improves the integrative activity of the brain, facilitates the consolidation of memory, facilitates the learning process, changes the rate of spread of excitation in the brain. Strengthens alpha and beta activity, reduces delta activity on the EEG, reduces the severity of the vestibular nystagmus, improves hemispheric connections and synaptic conductivity in neocortical structures, increases mental activity, enhances cerebral blood flow, and does not have sedative or psychostimulating effects.

The effect of the drug develops gradually.

Composition

Vinpocetine + Piracetam + auxiliary substances.

Pharmacokinetics

Vinpocetine

After taking the drug inside, Vinpocetine is well absorbed from the digestive tract, bioavailability is about 50-70%. The therapeutic concentration in the blood plasma varies from 10 to 20 ng / ml.

Pyracetam

After taking the drug inside is well absorbed from the digestive tract, bioavailability is about 95%. It penetrates the blood-brain barrier (GEB), accumulates in the brain tissues 1-4 hours after ingestion. From the cerebrospinal fluid is derived much slower than from other tissues and body fluids.It is not practically biotransformed in the body and is excreted by 2/3 in kidneys unchanged for 30 hours.

Indications

• insufficiency of cerebral circulation (the recovery period of ischemic and hemorrhagic stroke, encephalopathy of various origins);
• Parkinsonism of vascular genesis (Parkinson's disease);
• intoxication;
• brain trauma and other CNS diseases, accompanied by a decrease in intellectual-mnestic functions;
• psychoorganic syndrome with predominance of asthenia and adynamia;
• asthenic syndrome;
• Labyrinthopathy, Meniere's syndrome, tinnitus;
• prevention of migraine;
• prevention of kinetosis.

Forms of release

Capsules 5 mg + 400 mg.

The tablets covered with a cover of 10 mg + 800 mg.

Concentrate for the preparation of a solution for infusions 1 mg + 80 mg (injections in ampoules for injection).

Instructions for use and dosage

Capsules

Adults and adolescents over 14 years of age are prescribed 1-2 capsules 3 times a day. The maintenance dose is 1 capsule 3 times a day.

Duration of treatment is from 2-3 weeks to 2-6 months.

Capsules should be taken without chewing, before eating, squeezed with enough water.

Pills

Inside, regardless of food intake.

For patients 18 years and older: 1 tablet 2-3 times a day, with plenty of water. The last reception is 4 hours before bedtime. Duration of treatment is from 2-3 weeks to 2-6 months. Before the drug cancellation dose is recommended to gradually reduce (possibly using Vinpotropil in another dosage form: capsules containing 5 mg vinpocetine and 400 mg piracetam).

The course of treatment and dosage is determined by the attending physician.

Ampoules

Intravenously drip (in the form of a dropper). 2-3 ampoules of the drug, previously diluted in 500 ml of infusion solution (0.9% solution of sodium chloride or solutions containing dextrose) 1 time per day (the infusion rate should not exceed 80 cap / min). The course of treatment is 10-14 days. If necessary, it can be repeated after 6-8 weeks.

After achieving the improvement, they switch to taking the drug inside in the oral dosage form.

Side effect

• changes on the ECG (depression of the ST segment, prolongation of the Q-T interval);
• tachycardia;
• extrasystole;
• lability of blood pressure (blood pressure) (more often decrease);
• motor disinhibition;
• irritability;
• depression;
• asthenia;
• dizziness;
• headache;
• sleep disturbance (insomnia, increased drowsiness);
• mental agitation;
• disturbance of balance;
• exacerbation of epilepsy;
• anxiety;
• hallucinations;
• confusion of consciousness;
• extrapyramidal disorders;
• decreased ability to concentrate;
• nausea, vomiting;
• heartburn;
• diarrhea, constipation;
• abdominal pain;
• decreased appetite;
• gastralgia;
• weight gain;
• increased sweating;
• vertigo;
• dermatitis;
• itching;
• hives;
• hyperemia of the skin;
• hypersensitivity;
• anaphylactic reactions;
• angioedema;
• pain in the injection site;
• thrombophlebitis;
• fever;
• general weakness (may be a manifestation of the underlying disease);
• increased sexual activity.

Contraindications

• pregnancy, lactation;
• severe cardiac rhythm disturbances;
• ischemic heart disease (severe course);
• hemorrhagic stroke;
• severe chronic renal failure (CC less than 20 ml / min);
• liver failure;
• the patient's age is up to 14 years (for capsules and tablets) and up to 18 years (for injections);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Vinpotropil is not recommended for use during pregnancy and lactation.

Use in children

The drug is contraindicated for children under 14 years (for capsules and tablets) and up to 18 years (for injections).

special instructions

It is recommended to monitor the kidney function indefinitely (especially in patients with CRF) - with Nitrogen content and creatinine concentration, while in patients with liver diseases - the functional state of the liver.

With prolonged therapy in elderly patients, regular monitoring of renal function is recommended, if necessary, correlate the dose depending on the concentration of creatinine.

Use Vinpotropil with caution in case of hemostasis, extensive surgical interventions, severe bleeding, chronic renal failure (KK 20-80 ml / min).

It penetrates the hemodialysis apparatus through the filter membranes. In the case of the initial extension of the Q-T interval, and also with simultaneous use with drugs extending the Q-T interval, periodic ECG monitoring is necessary during the treatment period.

Before cancellation, the dose of Vinpotropil should be reduced gradually.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

The solution of vinpocetine is pharmaceutically incompatible with heparin, solutions containing amino acids. It is possible to intensify the hypotensive effect with simultaneous application with methyldopa (blood pressure control is necessary). The solution of piracetam is pharmaceutically compatible with Dextrose solutions (5%, 10%, 20%), fructose (5%, 10%, 20%), 0.9% sodium chloride solution, Ringer's solution, 20% mannitol solution, hydroxyethyl starch (6% , 10%).

Vinpotropil increases the risk of hemorrhagic complications against Heparin therapy, the effectiveness of thyroid hormones, antipsychotic drugs (neuroleptics), indirect anticoagulants (against a background of high doses of pyracetam). When used simultaneously with drugs that stimulate the central nervous system, excessive stimulation of the central nervous system is possible. Weaken the effect of anticonvulsants (reduces the convulsive threshold).When administered with neuroleptics reduces the risk of extrapyramidal disorders.

Analogues of the drug Vinpotropil

Structural analogues of the active ingredient have no Vinpotropil. The drug contains a unique combination of active substances, which has no analogues.

Analogues for the pharmacological group (nootropics):

• Amylonosar;
• Bilobil;
• Gamma-aminobutyric acid;
• Gamalon;
• Gliatilin;
• Glycine;
• Glycine forte;
• Glutamic acid;
• Gopantam;
• Hopantenic acid;
• Divaza;
• Idebenon;
• Intelland;
• Cavinton;
• Quinel;
• Combbitropyl;
• Cortexin;
• Cortexin for children;
• Qudesan;
• Lucetsam;
• Meclofenoxate hydrochloride;
• Mexidol;
• Mexiprim;
• Mexicin;
• Memotropized;
• Metostabil;
• Minisem;
• Neuromet;
• Noben;
• NooCam;
• Hoenopt;
• Nootropil;
• Noophen;
• Noocetam;
• Omaron;
• Pantogam;
• Pantokaltsin;
• Pikamilon;
• Piraben;
• Piracesine;
• Piracetam;
• Recognan;
• Semax;
• Stamine;
• Tenoten;
• Tenoten for children;
• Thiocetam;
• Fezam;
• Fenibut;
• Phenotropil;
• Choline alphoscerate;
• Holilitil;
• Cebrilysin;
• Ceraxon;
• Cerebrosolate;
• Cerebrolysin;
• Cerepro;
• Cereton;
• Citicolin sodium;
• Encephabol;
• The escotrope;
• Ethylthiobenzimidazole hydrobromide.

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