Oftan - instructions for use, analogs, reviews and release forms (eye drops Katachrom, Dexamethasone, Timolol, Idu, Eye Gel Timogel) drugs for cataract, glaucoma, scleritis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Oftan. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Oftan in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Oftan in the presence of existing structural analogues.Use for treatment of cataract, glaucoma, scleritis and iridocyclitis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Oftan - a combined preparation that improves the energy metabolism of the lens (Oftan Katakhrom).

Cytochrome C plays an important role in biochemical oxidation-reduction processes in the tissues of the eyeball and is an antioxidant.

Adenosine, the precursor of ATP, takes part in the metabolic processes of the lens.

Nicotinamide stimulates the synthesis of nicotinamide-dinucleotide, cofactor dehydrogenases.

Oftan Dexamethasone

Synthetic fluorinated glucocorticosteroid (GCS) for topical application in ophthalmology. The drug has a pronounced anti-inflammatory and anti-allergic effect.

Dexamethasone interacts with specific protein receptors in target tissues, thereby regulating the expression of corticosteroid-dependent genes and further influencing protein synthesis. Stabilizes the lysosomal enzymes of leukocyte membranes and inhibits the release of enzymes. It inhibits the synthesis of kinins, mitosis and migration of leukocytes. Inhibits the synthesis of antibodies and disrupts the recognition of the antigen.All these mechanisms are involved in suppressing the inflammatory response in tissues in response to mechanical, chemical or immune damage.

The duration of anti-inflammatory action after instillation of 1 drop of the drug is 4-8 hours.

Oftan Timogel

Antiglaukomny drug, non-selective beta-blocker. Reduces increased intraocular pressure by reducing the production of aqueous humor. Like other beta-blockers, Timolol has a negligible effect on the system of outflow of intraocular fluid. Has a weak anesthetic effect and does not affect pupil size and accommodation.

Oftan Timolol

Antiglaukomny drug, non-selective beta-blocker. Has no internal sympathomimetic and membrane-stabilizing activity. With topical application in the form of eye drops, timolol reduces both normal and increased intraocular pressure by reducing the formation of intraocular fluid. Does not affect the size of the pupil and accommodation.

Composition

Cytochrome C + Adenosine + Nicotinamide + auxiliary substances (Oftan Kathahrom).

Dexamethasone sodium phosphate + excipients (Oftan Dexamethasone).

Timolola maleate + auxiliary substances (Oftan Timolol and Oftan Timogel).

Idoxuridine + auxiliary substances (Oftan Idu).

Pharmacokinetics

When topical application of cytochrome C is not absorbed into the systemic circulation. Adenosine penetrates well through the cornea. Cytochrome C is completely metabolized in the body in the same ways as amino acids, and gem is broken down to bilirubin, which is excreted in bile. Adenosine is metabolized practically in all tissues with the formation of inosine, xanthine and urate, which are excreted in the urine. Ribose, which is part of the adenosine molecule, is metabolized to glyceraldehyde-3-phosphate, and then to pyruvate, and finally cleaved in the Krebs cycle. Nicotinamide is partially metabolized to nicotinic acid. Both compounds are methylated to form N-methyl nicotinamide, which is further cleaved in the liver. Unchanged nicotinamide and metabolites are excreted in the urine.

About 60-70% of Dexamethasone entering the systemic circulation communicates with plasma proteins. Metabolites are excreted through the intestine.

When topical application of timolol maleate quickly penetrates through the cornea.After instillation of eye drops, the maximum concentration of timolol in the aqueous humor of the eye is achieved after 1-2 hours. 80% of timolol, used in the form of eye drops, enters the systemic bloodstream by absorption through the vessels of the conjunctiva, the nasal mucosa and the lacrimal tract. The excretion of timolol metabolites is mainly carried out by the kidneys.

Indications

Oftan Kathahrom

• cataract of different genesis.

Oftan Dexamethasone

• neogenic forms of conjunctivitis, keratitis, keratoconjunctivitis and blepharitis;
• scleritis and episcleritis;
• irit, iridocyclitis and other uveitis of various genesis;
• superficial corneal damage of various etiologies (chemical, physical or immune mechanisms) after complete corneal epithelialization;
• inflammation of the posterior segment of the eye (choroiditis, chorioretinitis);
• edema, inflammation (including in the postoperative period);
• sympathetic ophthalmia;
• allergic conjunctivitis or keratoconjunctivitis.

Oftan Timolol

• increased intraocular pressure (ophthalmic hypertension);
• open-angle glaucoma;
• glaucoma on the aphakic eye and other types of secondary glaucoma;
• as an additional means to reduce intraocular pressure in closed-angle glaucoma (in combination with miotics);
• Congenital glaucoma (with ineffectiveness of other agents).

Oftan Ida

• keratitis and keratoconjunctivitis caused by the Herpes simplex virus (the surface form of herpes).

Forms of release

Eye drops (Oftan Katachrom, Dexamethasone, Timolol, Ida).

Eye gel (Oftan Timogel).

Instructions for use and how to use them

Cataracts

Assign 1-2 drops in the conjunctival sac 3 times a day.

When using the vial for the first time, turn the lid of the vial down while pressing down and then open the vial.

Drops of Dexamethasone

In acute conditions, 1-2 drops are prescribed per conjunctival sac every 1-2 hours.

After reducing inflammation, the drug is instilled in 1-2 drops in the conjunctival sac 3-5 times a day.

The duration of treatment should not exceed 2-3 weeks.

The decision on the duration of treatment is based on objective data, including the effectiveness of the drug, the severity of clinical symptoms and the possible risk of side effects.

Timolol Drops

At the beginning of treatment, 1-2 drops are prescribed to the affected eye in the form of drops of the eye 0.25% or drops of the eye 0.5% 2 times a day.

If intraocular pressure with normal use is normalized, you should lower the dose to 1 drop 1 time per day in the morning.

Oftan Timolol treatment is usually carried out for a long time. A break in treatment or a change in the dosage of the drug is carried out only on the instructions of the attending physician.

Ida drops

Conjunctival. 1 drop in the conjunctival cavity every hour during the day and every 2 hours at night; after steady improvement - every 2 hours in the afternoon and every 4 hours at night. Treatment continues for 3-5 days after complete healing, which is confirmed by the lack of staining of the cornea with fluorescin.

The course of treatment is no more than 21 days.

Side effect

• short-term burning sensation and tingling of the eyes;
• allergic reactions;
• blurring of vision;
• irritation and congestion hyperemia;
• contact dermatitis;
• nausea;
• arterial hypotension;
• dizziness;
• dyspnea;
• feeling of heat and pulsation in the temples;
• fainting (due to the vasodilator effect of nicotinic acid);
• the development of secondary glaucoma and steroid cataract (Oftan Dexamethasone).

Contraindications

• bronchial asthma or other severe chronic obstructive airway disease;
• sinus bradycardia;
• AV-blockade of 2 and 3 degrees;
• Decompensated heart failure;
• dystrophic processes in the cornea;
• children and adolescents under 18 years (due to the lack of data on the effectiveness and safety of the drug in children and adolescents);
• hypersensitivity to the components of the drug;
• increased intraocular pressure (Dexamethasone);
• glaucoma (dexamethasone);
• pregnancy;
• lactation.

Application in pregnancy and lactation

There is no sufficient experience of using Oftan Kathahrom during pregnancy and lactation (breastfeeding).

It is possible to use Oftan Katahrom during pregnancy and lactation as prescribed by the doctor and in cases when the expected benefit of therapy for the mother exceeds the potential risk for the fetus or infant.

In view of the potential carcinogenicity, teratogenicity and mutagenicity, Oftan Idu should not be used during pregnancy and breastfeeding.

Use in children

Contraindicated in children and adolescents under 18 years (due to the lack of data on the effectiveness and safety of the drug in children and adolescents).

special instructions

During the period of treatment with Oftan Catachrom, soft contact lenses should not be worn. the preservative can be deposited in them and have an adverse effect on the tissues of the eye. Before using Oftan Kathamroch, contact lenses should be removed and re-installed after 15 minutes after instillation of the drug.

Oftan Dexamethasone contains a preservative of benzalkonium chloride, which can be absorbed by soft contact lenses and cause a change in their color and have an adverse effect on the tissues of the eye. If you need to use contact lenses during treatment with Oftan Dexamethasone, they should be removed before using the drug and, if necessary, should be installed no earlier than 15 minutes after instillation.

If treatment with Oftan Dexamethasone lasts for more than 2 weeks, it is necessary to regularly monitor the intraocular pressure and the condition of the cornea.

Impact on the ability to drive vehicles and manage mechanisms

Patients who, after instillation of the drug, have a short-term eye irritation, should avoid driving vehicles, working with machinery, machines or some other equipment requiring good visual acuity, immediately after the application of eye drops.

Drug Interactions

There was no clinically significant interaction of Oftan-Catachrom with other drugs.

The combined use of Oftan Timolol with eye drops containing adrenaline can cause a dilated pupil.

With the simultaneous use of eye drops containing epinephrine and pilocarpine, it is possible to increase the decrease in intraocular pressure of Oftan Timolol.

Arterial hypotension and bradycardia can increase with simultaneous application of Ophthalmic Timolol with calcium antagonists, reserpine and systemic beta-blockers.

Interaction with other drugs is mainly due to the participation in the excretion of dexamethasone isoenzyme CYP3A4. Dexamethasone induces the isoenzyme CYP3A4, thus, reducing the effectiveness of calcium channel blockers, quinidine and erythromycin.In the usual topical regimen, the dose of the drug is not sufficient to induce induction or saturation of the liver enzymes.

Analogues of the medicinal product Oftan

There are no structural analogs to the active substance of the drug Oftan.

Analogues on the curative effect (remedies for the treatment of senile cataract):

• Vita Iodurol;
• Vitafakol;
• Indocide;
• Quinax;
• Multimax;
• Naklof;
• Oftan Katachrom;
• Polivit Geriatric;
• Strix forte;
• Taufon;
• Focus.

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