Azafen - instructions for use, analogs, reviews and release forms (25 mg tablets, 150 mg MB modified release) antidepressant drug for the treatment of depression, affective disorders in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Azafen. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Azafen in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Azafen in the presence of existing structural analogues.Use for the treatment of depression and affective disorders in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

Azafen - Tricyclic antidepressant. Blocking the reverse neuronal capture of monoamines by presynaptic membranes, increases their content in the synaptic cleft, which leads to relief of the symptoms of depression. Timoleptic action of the drug is combined with sedative activity and anxiolytic effect. In contrast to tricyclic antidepressants it does not possess anticholinergic properties, does not affect the activity of MAO, does not have cardiotoxic effect.

Composition

Pipofezin + excipients.

Pharmacokinetics

Quickly and completely absorbed from the digestive tract. Bioavailability is about 80%. In tablets, the azafen MB active substance is enclosed in a special carrier matrix, which ensures the gradual release of pipophazine in the digestive tract. The released pypofezin quickly and almost completely absorbed from the digestive tract. Binding to plasma proteins - 90%. To a large extent, it undergoes biotransformation in the liver with the formation of inactive metabolites.The study showed that pipiphezin is not a substrate for the isoenzymes CYP2C9, CYP2C19, CYP2D6 and CYP3A4, but is mainly metabolized by CYP1A2. At repeated receptions of fluctuation of concentration of a preparation in a blood plasma in an interval between two doses are smoothed out. It is excreted mainly by the kidneys.

Indications

• depressive disorders of mild and moderate severity (including depressive states in chronic somatic diseases).

Forms of release

Tablets 25 mg.

Modified release tablets 150 mg (Azafen MB).

Instructions for use and dosing regimen

The initial dose for adults is 25-50 mg in 2 divided doses (morning and lunch). With good tolerability, the dose is gradually increased to 150-200 mg per day (3-4 doses, the last intake before bedtime), in some cases up to 400 mg per day. The optimal daily dose is 150-200 mg, the maximum daily dose is 400-500 mg. When the desired effect is achieved, they pass to maintenance doses of 25-75 mg per day. The course of treatment is up to 1 year (not less than 1-1.5 months).

After establishing the optimal daily dose using Azafen tablets of 25 mg, prescribe Azafen MB (tabletswith modified release) 150 mg 1 time (morning) or 2 times (morning and evening), taking into account the effectiveness and tolerability.

Side effect

• headache;
• dizziness;
• nausea, vomiting;
• allergic reactions.

Contraindications

• severe hepatic and / or renal insufficiency;
• simultaneous administration of MAO inhibitors;
• pregnancy;
• lactation period (breastfeeding);
• hypersensitivity to the drug.

Application in pregnancy and lactation

The drug Azafen is contraindicated in pregnancy and lactation.

Use in children

Caution should be given to the drug in childhood (not enough data on safety of use).

special instructions

After the transfer from therapy with MAO inhibitors to Azafen, an interval of 2 weeks is necessary.

Periodic monitoring of liver and kidney function is necessary.

During the period of treatment, alcohol is not allowed.

With caution should prescribe the drug for chronic heart failure, myocardial infarction, with IHD, condition after acute cerebrovascular accident, infectious diseases, diabetes, in childhood (not enough data on safety of use).

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, patients should refrain from engaging in potentially hazardous activities requiring increased attention and speed of psychomotor reactions, for example, vehicle management.

Drug Interactions

With the simultaneous use of Azafen potentiates the effects of ethanol (alcohol) and other drugs, depressing the central nervous system, antihistamines and anticoagulants.

Reduces the effectiveness of anticonvulsant therapy.

The study showed that pipiphezin is not an inhibitor or inducer of the isoenzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4, so it is unlikely that the drug Azafen will interact with the drugs that are the substrates of these isoenzymes. Fluvoxamine, propafenone, mexiletine, ciprofloxacin, being inhibitors of CYP1A2, can increase the concentration of pipophezin in the blood plasma.

Analogues of the drug Azafen

Structural analogs for the active substance:

• Azafen MV;
• Pipofezin.

Analogues for the pharmacological group (antidepressants):

• Agomelatine;
• Adress;
• Azona;
• Aleval;
• Amizole;
• Amitriptyline;
• Anaphranil;
• Asentra;
• Valdoxane;
• Velaxin;
• Velafax;
• Venlaksor;
• Venlafaxine;
• Heptor;
• Daplex;
• Depres;
• Depenone;
• Deprim;
• Deprim forte;
• Doxepine;
• Duloxetine;
• Zoloft;
• Ixelles;
• Kaliksta;
• Clomipramine;
• Coaxyl;
• Lerivon;
• Maprotiline;
• Melipramine;
• Mirtazonal;
• Mirtalan;
• Nerustin;
• Oprah;
• Paxil;
• Paroxetine;
• Pirazidol;
• Plizil;
• Prozac;
• Profluzak;
• Rexetin;
• Seralin;
• The Siozam;
• Triptysole;
• Trittico;
• Févarine;
• Fluxonil;
• Fluoxetine;
• Framex;
• Cipralex;
• Citalopram;
• Elivel;
• Escitalopram;
• Ephevelone;
• Epevelon retard.

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