Kestin - instructions for use, reviews, analogs and formulations (10 mg and 20 mg tablets, syrup or drops) of the drug for the treatment of urticaria, rhinitis and other manifestations of allergy in adults, children and pregnancy. Composition and alcohol

In this article, you can read the instructions for using the drug Kestin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Kestin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Kestin analogs in the presence of existing structural analogs.Use for the treatment of urticaria, rhinitis and other manifestations of allergy in adults, children, as well as during pregnancy and lactation. Composition and interaction of the drug with alcohol.

Kestin - antiallergic drug. After taking the drug inside, the expressed antiallergic effect begins after 1 hour and lasts for 48 hours. After a 5-day course of treatment with Kestin, antihistamine activity persists for 72 hours due to the action of active metabolites. The drug has no pronounced anticholinergic and sedative effect. There was no effect of Kestin's preparation on the QT-interval of the ECG in a dose of 100 mg, exceeding the recommended daily dose by 5-10 times.

Composition

Ebastin + auxiliary substances.

Pharmacokinetics

After oral administration, it is rapidly absorbed and almost completely metabolized in the liver, becoming an active metabolite of carabastine. Fatty foods accelerate absorption (concentration in the blood increases to 50%). Eating does not affect the clinical effects of Kestin. Does not penetrate the blood-brain barrier. It is excreted by the kidneys - 60-70%, in the form of conjugates.

Indications

• allergic rhinitis seasonal and / or all-the-year-round (caused by household, pollen, epidermal, food, drug allergens);
• urticaria (can be caused by domestic, pollen, epidermal, food, insect, drug allergens, exposure to the sun, cold, etc.);
• allergic diseases and conditions due to increased release of histamine.

Forms of release

Tablets coated with 10 mg and 20 mg.

Liofilized tablets 20 mg.

Syrup (sometimes mistakenly called drops).

Instructions for use and dosing regimen

Pills

Inside, regardless of food intake.

Adults and children over 12 years are prescribed 10-20 mg (1-2 tablets) of the drug once a day.

If the liver function is impaired, the daily dose should not exceed 10 mg.

Tablets lyophilized

The drug is designed for resorption in the oral cavity, regardless of food intake.

Adults, children and adolescents over 15 years of age are prescribed 20 mg (1 lyophilized tablet) once a day. The course of treatment is determined by the disappearance of the symptoms of the disease.

In elderly patients, dose adjustment is not required.

In patients with impaired renal function, dose adjustment is not required.

With minor and moderate hepatic insufficiency, the drug can be used in a usual dose. In severe liver dysfunction do not exceed the daily dose of Ebastin 10 mg.

Special precautions for handling:

1. To avoid damage to the tablets, do not remove the tablet from the blister by pressing. Open the package by gently lifting the free edge of the protective film.
2. Remove the protective film.
3. Gently squeeze the drug without touching it.

Carefully remove the tablet and put it on the tongue, where it will quickly dissolve. No need to drink with water or other liquid. Eating does not affect the effect of the drug.

Syrup

• Children from 6 to 12 years: 5 mg (5 ml) once a day.
• Children from 12 to 15 years: 10 mg (10 ml) once a day.
• Adults and children over 15 years are prescribed 10-20 mg (10-20 ml) once a day.

A daily dose of 20 mg is given on the recommendation of a doctor.

Kestin is taken regardless of food intake.

Side effect

• headache;
• drowsiness;
• dryness of the oral mucosa;
• dyspepsia;
• nausea;
• insomnia;
• abdominal pain;
• asthenic syndrome;
• sinusitis;
• rhinitis.

Contraindications

• hypersensitivity to the components of the drug;
• pregnancy, lactation;
• children under 12 years (tablets), up to 15 years (lyophilized tablets);
• lactase deficiency
• lactose intolerance
• glucose-galactose malabsorption.

Application in pregnancy and lactation

Kestin is contraindicated during pregnancy and lactation.

Use in children

Tablets are contraindicated for children under 12 years. Tablets lyophilized are contraindicated for children under the age of 15 years. Syrup is used with caution in children under 6 years of age.

special instructions

Use with caution in patients with increased QT-interval, hypokalemia, with renal and / or liver failure.

Impact on the ability to drive vehicles and manage mechanisms

In the event of side effects from the central nervous system, it is possible to minimize the ability of patients to drive vehicles and engage in other potentially dangerous activities requiring increased concentration of attention and speed of psychomotor reactions.

Drug Interactions

It is not recommended to use Kestin simultaneously with Ketoconazole and Erythromycin (increased risk of QT-interval prolongation).

Kestin does not interact with theophylline, indirect anticoagulants, cimetidine, diazepam, ethanol (alcohol), and ethanol-containing drugs.

Analogues of the drug Kestin

Kestin does not have a structural analogue for the active substance. The drug contains a unique active substance Ebastin.

Analogues on the curative effect (remedies for urticaria):

• Allergies;
• Arthromax;
• Asmawal;
• Astemizole;
• Berlikort;
• Hydrocortisone;
• Histaglobin;
• Histalong;
• Histafen;
• Decortin;
• Dexamethasone;
• Diazoline;
• Diacin;
• Dimebon;
• Zaditen;
• Zirtek;
• Zodak;
• Calcium chloride;
• Kenakorth;
• Clargotil;
• Claridol;
• Claritin;
• Clarifer;
• Clemastine;
• Xizal;
• Lomilan;
• Loratadine;
• Lordestin;
• Lorinden;
• Lotharen;
• Noblessite;
• NovoPassit;
• Oxycort;
• Parliamentary;
• Pipolphen;
• Prednisolone;
• Primalan;
• Rivtagil;
• Suprastin;
• Suprastinex;
• Tavegil;
• Telfast;
• Tranexam;
• Fenistil;
• Fenkarol;
• Fortecortin;
• Celeston;
• Cetirizine;
• Cetrin;
• Erolin.

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