Arutimol - instructions for use, analogs, reviews and release forms (eye drops 0.25% and 0.5%) of the drug for the treatment of glaucoma in adults, children and in pregnancy

In this article, you can read the instructions for using the drug Arutimol. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Arutimol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Arutimol in the presence of existing structural analogues. Use to treat glaucoma and reduce increased intraocular pressure in adults, children, as well as during pregnancy and lactation.

Arutimol - antiglaucoma preparation, non-selective blocker of beta1 and beta2-adrenergic receptors. Has no internal sympathomimetic and membrane-stabilizing activity. With topical application in the form of eye drops reduces both normal and increased intraocular pressure (IOP) by reducing the formation of intraocular fluid. Does not affect the size of the pupil and accommodation.

The effect of the drug manifests itself 20 min after instillation in the conjunctival sac. The maximum decrease in IOP occurs 1-2 hours later and persists for 24 hours.

Pharmacokinetics

With topical application of Timolol maleate (active ingredient of preparation Arutimol) is slightly subjected to systemic absorption. In an insignificant amount enters the systemic bloodstream by absorption through the vessels of the conjunctiva, the mucous membranes of the nose and the lacrimal tract. It is excreted by the kidneys in the form of metabolites.

Indications

• increased intraocular pressure (ocular hypertension);
• open-angle glaucoma;
• secondary glaucoma (including aphakic);
• closed-angle glaucoma (in combination with miotics as an additional means to reduce IOP);
• congenital glaucoma (with insufficient effectiveness of other therapeutic measures).

Forms of release

Eye drops 0.25% and 0.5%.

Instructions for use and how to use them

The drug is prescribed 1 drop of 0.25% or 0.5% eye drops 2 times a day in the conjunctival sac of the affected eye. After stabilizing IOP, the dose should be reduced to 1 drop 1 time per day.

The drug is intended for long-term use. The patient should be warned that a break in the use of the drug or a change in the dose can be carried out only on the advice of a doctor.

Side effect

• irritation, hyperemia of the conjunctiva and skin of the eyelids;
• burning and itching in the eyes;
• lacrimation;
• photophobia;
• edema of the epithelium of the cornea;
• point surface keratopathy;
• hyposthenia of the cornea;
• diplopia;
• ptosis;
• dry eyes;
• heart failure;
• bradycardia;
• bradyarrhythmia;
• a decrease in blood pressure;
• collapse;
• AV blockade;
• heart failure;
• transient disorders of cerebral circulation;
• headache;
• dizziness;
• weakness;
• depression;
• paresthesia;
• dyspnea;
• bronchospasm;
• pulmonary insufficiency;
• nausea;
• diarrhea;
• eczema;
• hives;
• rhinitis;
• violation of sexual functions;
• alopecia.

Contraindications

• chronic obstructive airways diseases (including bronchial asthma);
• sinus bradycardia;
• AV blockade of 2 or 3 degrees;
• severe heart failure;
• cardiogenic shock;
• corneal dystrophy;
• severe atrophic rhinitis;
• allergic reactions with generalized skin rashes;
• increased sensitivity to timolol and other components of the drug.

Application in pregnancy and lactation

The use of Arutimol during pregnancy and lactation (breastfeeding) is possible only if the intended benefit to the mother exceeds the potential risk to the fetus or baby. Sufficient experience in the use of the drug in these periods there, but it is established that timolol penetrates the placental barrier.

If the drug was used immediately before delivery or during breastfeeding, the newborns should be carefully monitored for several days after birth and during the entire treatment period of nursing mothers with Arutimol.

special instructions

The patient should be warned about the need to regularly visit a doctor to measure intraocular pressure andexamination of the cornea, as well as in case of development of adverse reactions.

If the patient wears soft contact lenses, then he should not use the drug Arutimol, t. the preservative can be deposited in soft contact lenses and have an adverse effect on the eye tissue.

It is necessary to remove hard contact lenses before instillation of the drug and to set them again after 15 minutes.

When translating patients for treatment with timolol, correction of refraction after effects caused by previously used miotics may be required.

In the case of an upcoming surgical intervention with the use of general anesthesia, it is necessary to cancel the drug for 48 hours.

Do not bury two beta-blockers in the eyes.

Impact on the ability to drive vehicles and manage mechanisms

Immediately after instillation of the drug, it is possible to reduce the clarity of vision and slow the speed of psychomotor reactions, which can reduce the ability to potentially dangerous activities requiring increased attention. This effect is enhanced by the simultaneous use of alcohol.

Drug Interactions

The combined use of arutymol with eye drops containing epinephrine (epinephrine) can cause a dilated pupil.

Decrease in IOP increases with simultaneous use of eye drops containing adrenaline (epinephrine) and pilocarpine.

Decrease in blood pressure and slowing of the heart rhythm can be potentiated by the combined use of Arutimol with calcium channel blockers, reserpine and beta-blockers.

Simultaneous use with insulin or oral hypoglycemic agents can lead to hypoglycemia.

Timolol increases the effect of muscle relaxants.

Analogues of the drug Arutimol

Structural analogs for the active substance:

• Glaumol;
• Glautam;
• Gullet;
• Cusimolol;
• Niolol;
• Okumed;
• Okumol;
• Okupres-E;
• Optimol;
• Oftan Timolol;
• Otrensin;
• Timadren;
• TimogeXal;
• Timolol;
• Timolol buffous;
• Timolol-AKOS;
• Timolol-Betalek;
• Timolol-DIA;
• Timolol-LENS;
• Timolol-MEZ;
• Timolol-POS;
• Timolola maleate;
• Timololong;
• Timothy;
• Timothy Depot.

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