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Amlodipine - instructions for use, analogs, reviews and release forms (5 mg and 10 mg tablets) for the treatment of blood pressure and its reduction in adults, children and pregnancy »Page 2

Amlodipine - instructions for use, analogs, reviews and release forms (5 mg and 10 mg tablets) for the treatment of blood pressure and its reduction in adults, children and pregnancy

In this article, you can read the instructions for using the drug Amlodipine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Amlodipine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of amlodipine in the presence of existing structural analogs. Use for the treatment of blood pressure and its reduction, stenocardia in adults, children, as well as during pregnancy and lactation.

 

Amlodipine - dihydropyridine derivative - slow calcium channel blocker (BCCI) of the 2nd generation, has antianginal and hypotensive action. Linking with dihydropyridine receptors, blocks calcium channels, reduces the transmembrane transition of calcium ions into the cell (mostly in smooth muscle cells of blood vessels, rather than in cardiomyocytes).

 

Antianginal effect is due to the expansion of coronary and peripheral arteries and arterioles: with angina decreases the severity of myocardial ischemia; expanding peripheral arterioles, reduces OPSS, reduces preload on the heart, reduces the need for myocardium in oxygen. Expands the main coronary arteries and arterioles in unchanged and ischemic zones of the myocardium, increases the flow of oxygen into the myocardium (especially with vasospastic angina); prevents the development of spasm of the coronary arteries (including those caused by smoking). In patients with stable angina, a single daily dose increases exercise tolerance, slows the development of angina pectoris and "ischemic" depression of the ST segment, reduces the incidence of angina attacks and the consumption of Nitroglycerin and other nitrates.

 

Has a long-term dose-dependent hypotensive effect.The hypotensive effect is due to a direct vasodilating effect on smooth muscle vessels. With arterial hypertension, a single dose provides a clinically significant decrease in blood pressure over a period of 24 hours (in the position of the patient lying down and standing). Orthostatic hypotension in the appointment of amlodipine is rare.

 

Does not cause a decrease in exercise tolerance, a fraction of the ejection of the left ventricle. Reduces the degree of myocardial hypertrophy of the left ventricle, has antiatherosclerotic and cardioprotective action in IHD. Does not affect the contractility and conductance of the myocardium, does not cause a reflex increase in heart rate, inhibits platelet aggregation, increases the rate of glomerular filtration, has a weak natriuretic effect.

 

When diabetic nephropathy does not increase the severity of microalbuminuria. Does not have any adverse effect on the metabolism and concentration of plasma lipids and can be used in the treatment of patients with bronchial asthma, diabetes and gout.

 

A significant reduction in blood pressure is observed after 6-10 h, the duration of the effect is 24 h.With prolonged therapy, the maximum decrease in blood pressure occurs 6-12 hours after taking amlodipine by mouth. If after prolonged treatment with amlodipine abolished, an effective reduction in blood pressure persists for 48 hours after the last dose. Then the blood pressure indicators gradually return to the baseline within 5-6 days.

 

Pharmacokinetics

 

After ingestion, amlodipine is slowly absorbed from the digestive tract. Food intake does not affect the absorption of amlodipine. Most of the drug in the blood (95%), binds to blood plasma proteins. Amlodipine undergoes a slow but active metabolism in the liver in the absence of a significant "first pass" effect. Metabolites do not have significant pharmacological activity. About 60% of the dose taken internally is excreted by the kidneys mainly in the form of metabolites, 10% - unchanged, and 20-25% - through the intestine, as well as breast milk.

 

The drug penetrates the blood-brain barrier. When hemodialysis is not removed.

 

In elderly patients (over 65 years), amlodipine excretion is slowed compared to young patients, but this difference is not clinically significant.

 

Indications

  • Arterial hypertension (in monotherapy or in combination with other drugs);
  • angina pectoris tension;
  • vasospastic angina (Prinzmetal angina).

 

Forms of release

 

Tablets 5 mg and 10 mg. Can be produced in combination with other dosage forms (combination drugs).

 

Instructions for use and dosing regimen

 

Inside, the initial dose for the treatment of hypertension and angina is 5 mg once a day. The maximum daily dose is 10 mg once.

 

With arterial hypertension, the maintenance dose can be 2.5-5 mg (1/2 tablets of 5 mg - 1 tablet of 5 mg) per day

 

With angina pectoris and vasospastic angina pectoris, 5-10 mg per day, once. In order to prevent attacks of angina pectoris - 10 mg per day.

 

Patients with impaired hepatic function as an antihypertensive agent Amlodipine is administered with caution, at an initial dose of 2.5 mg (1/2 tablet at 5 mg), as an antianginal agent - 5 mg.

 

Do not require dose changes with simultaneous administration with thiazide diuretics, beta-blockers and ACE inhibitors.

 

Do not require dose changes in patients with renal insufficiency.

 

Side effect

  • palpitation;
  • peripheral edema (swelling of the ankles and feet);
  • "tides" of blood to the skin of the face;
  • excessive decrease in blood pressure;
  • dyspnea;
  • vasculitis;
  • orthostatic hypotension;
  • development or exacerbation of heart failure;
  • heart rhythm disturbances (including bradycardia, ventricular tachycardia and atrial fibrillation);
  • myocardial infarction;
  • pain in the chest;
  • headache;
  • dizziness;
  • increased fatigue;
  • drowsiness;
  • asthenia;
  • paresthesia;
  • insomnia;
  • mood lability;
  • unusual dreams;
  • nervousness;
  • depression;
  • anxiety;
  • migraine;
  • increased sweating;
  • nausea;
  • stomach ache;
  • vomiting;
  • constipation or diarrhea;
  • flatulence;
  • dyspepsia;
  • anorexia;
  • dry mouth;
  • thirst;
  • increased appetite;
  • gastritis;
  • thrombocytopenic purpura, leukopenia, thrombocytopenia;
  • frequent urination;
  • painful urination;
  • impotence;
  • gynecomastia;
  • dyspnea;
  • rhinitis;
  • cough;
  • dermatitis;
  • violation of skin pigmentation;
  • itching;
  • rash (including erythematous, maculopapular rash, urticaria);
  • angioedema;
  • muscle cramps;
  • backache;
  • tinnitus;
  • Pain in the eyes;
  • chills;
  • nose bleed.

 

Contraindications

  • severe arterial hypotension (systolic blood pressure less than 90 mm Hg);
  • collapse, cardiogenic shock;
  • unstable angina (with the exception of Prinzmetal's stenocardia);
  • clinically significant aortic stenosis;
  • pregnancy and lactation;
  • age under 18 years (effectiveness and safety not studied);
  • deficiency of lactase, lactose intolerance, glucose-galactose malabsorption;
  • increased sensitivity to amlodipine, dihydropyridine derivatives and other components of the drug.

 

Application in pregnancy and lactation

 

There was no evidence of teratogenicity of amlodipine in the study on animals, but there is no clinical experience of its use in pregnancy and lactation. Therefore, amlodipine should not be given to pregnant women during lactation, as well as to women of childbearing age, unless they use reliable contraceptive methods.

 

special instructions

 

During the period of Amlodipine treatment, it is necessary to control the body weight and sodium intake, the purpose of the appropriate diet. It is necessary to maintain dental hygiene and supervision at the dentist (to prevent soreness, bleeding and gingival hyperplasia).

 

Patients with low body weight, low growth patients and patients with severe liver function impairment may need a smaller dose.

 

Despite the fact that stopping the use of amlodipine is not accompanied by the development of the "withdrawal" syndrome, it is desirable to stop the treatment, gradually reducing the dose of the drug.

 

The effectiveness and safety of the drug in hypertensive crisis is not established.

 

Impact on the ability to drive vehicles and manage mechanisms

 

There were no reports of Amlodipine's influence on driving or working with machinery. However, some patients, mainly at the beginning of treatment, may experience drowsiness and dizziness. When they occur, the patient must observe special precautions when driving and working with complex mechanisms.

 

Drug Interactions

 

Amlodipine can safely be used to treat hypertension along with thiazide diuretics, alpha-adrenoblockers, beta-blockers, or ACE inhibitors. In patients with stable angina, the drug can be combined with other antianginal agents, for example, with long-acting nitrates, beta-blockers or short-acting nitrates.

 

Amlodipine can be used simultaneously with non-steroidal anti-inflammatory drugs (especially indomethacin), antibacterial agents and hypoglycemic agents for oral administration.

 

It is possible to strengthen the anti-anginal and hypotensive action of BCCC when combined with thiazide and loop diuretics, verapamil, ACE inhibitors, beta-adrenoblockers and nitrates, as well as enhance their hypotensive effect when combined with alpha-blockers, antipsychotics.

 

Although no negative inotropic effects were usually observed in the study of amlodipine, nevertheless, some BCCCs can increase the negative inotropic effect of antiarrhythmic agents that cause prolongation of the QT interval (eg, Amiodarone and quinidine).

 

A single dose of 100 mg of Sildenafil (Viagra) in patients with essential hypertension does not affect the pharmacokinetics of amlodipine.

 

The repeated use of amlodipine in a dose of 10 mg and Atorvastatin at a dose of 80 mg is not accompanied by significant changes in the pharmacokinetics of atorvastatin.

 

Ethanol (alcohol-containing beverages): Amlodipine in single and repeated application at a dose of 10 mg does not affect the pharmacokinetics of ethanol (alcohol).

 

Antiviral agents (ritonavir) increase the plasma concentrations of BCCI, incl. amlodipine.

 

Neuroleptics and isoflurane - strengthening of hypotensive action of dihydropyridine derivatives.

 

Calcium preparations can reduce the effect of BCCC.

 

When amlodipine is used together with lithium preparations, it is possible to intensify manifestations of neurotoxicity (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus).

 

Amlodipine does not change the pharmacokinetics of cyclosporine.

 

Does not affect the concentration of serum Digoxin and its renal clearance.

 

Has no significant effect on the effect of Warfarin (prothrombin time).

 

Cimetidine does not affect the pharmacokinetics of amlodipine.

 

Grapefruit juice: simultaneous single intake of 240 mg of grapefruit juice and 10 mg of amlodipine inwards is not accompanied by a significant change in the pharmacokinetics of amlodipine.

 

Analogues of the drug Amlodipine

 

Structural analogs for the active substance:

  • Acridipine;
  • Amlovas;
  • Amlodak;
  • Amlodigamma;
  • Amlodipine Alkaloid;
  • Amlodipine Zentiva;
  • Amlodipine Cardio;
  • Amlodipine Sandoz;
  • Amlodipine-Ajio;
  • Amlodipine-Biocom;
  • Amlodipine-3T;
  • Amlodipine-Prana;
  • Amlodipine-Teva;
  • Amlodipine-Chaikafarma;
  • Amlodipine besylate;
  • Amlodipina besilat;
  • Amlodipine maleate;
  • Amlodipharm;
  • Amlocard-Sanovel;
  • Amlong;
  • Ammonorm;
  • Amrorus;
  • Amlotop;
  • Vero-Amlodipine;
  • Kalchek;
  • Cardilopin;
  • Corvadil;
  • Cordy Cor;
  • Norvasc;
  • Normodipine;
  • Omerar Cardio;
  • Stamlo;
  • Tenox.

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Reviews (192):
Guests
lads
I am 70 years old. I take amlodipine for six months. Bleeding heavily.
Guests
Olga
On the second day of using Amlodipine (5 mg at 5 pm), a headache appeared in the back of the head. As with migraines.
Guests
Natasha
Hello! In the morning I drink Amlodipine Teva 5 mg and 1.25 mg Concor. In the afternoon, the pressure decreases, there is lethargy and drowsiness. Is it possible to reduce the intake of Amlodipine Teva to 2.5 mg by dividing the tablet?
Administrators
admin
Natasha, It is possible to divide. Although in general Amlodipin is drunk at night, and in the morning you can take Concor. Something namudrili you whether with a dosage, or with a mode of reception of preparations.
Visitors
zvezdopad
Essential hypertension. In the 99th year, when examined in the clinic, a therapy was selected - Diroton 10 mg + Felodip 10 mg once a day. A year ago, Diroton replaced Lorist M with 12.5 mg (for economic reasons). The question is - can I, in my case, replace Felodip 10 mg with Amlodipine 10 mg (since the cost of Felodip is too high for me)? And if the substitution is real, then is there any dosage that exists for Felodipa?
Visitors
majad
I accept from pressure: Carvedilol 25 ml, Perindopril 4 mg and amlodipine 10 mg. Tell me, please, how are these medicines combined? Thank you.
Administrators
admin
zvezdopadThe drugs indicated in the question are not analogous to the active substance: in Amlodipine the active substance amlodipine besylate, in Felodip - felodipine.According to the pharmacological group - calcium channel blockers, these drugs are analogous. If by the rules, then of course such a substitution must be coordinated with the acting doctor, as the drugs are not absolutely equivalent, but that you will not be allowed to try to replace Felodip with amlodipine in similar dosages, because they are more similar than they are.

majad, Medicines work well with each other and even enhance the positive anti-anginal and antihypertensive effects of each other. Experience and instructions for negative side effects when using a combination of drugs should not be.
Visitors
Oksweta77
The doctor prescribed me amlodipine and wals, a month later I had a terrible urticaria. Now I pass a survey, I'm trying to find out the reason. And maybe from amlodipine such a rash? In pobochke there is a urticaria? Thank you.
Administrators
admin
Oksweta77, Month took drugs and there were no side effects? So it does not happen, look for the reason in another - food allergy, pollen, stress.
Visitors
grandfather Sasha
Hello, tell me, is it possible to combine preparations of Amlodipine and Bisoprolol and according to what scheme?
Administrators
admin
grandfather Sasha, Can. In terms of antianginal and antihypertensive effects, these drugs enhance the joint positive effect, but side effects when used in this combination are rare. Usually apply this scheme of reception: in the morning - Bisoprolol, in the evening - Amlodipine. As for specific dosages of drugs, it is better to ask the attending physician who knows the patient and his illness.
Visitors
TatianaP.
Hello! Answer me please. I write at the request of my sister. Age 60 years. Five years of taking amlodipine-teva number 5. Since the beginning of taking this drug, the pressure is kept at a normal level. But - she smoked for many years. And now, 3 months ago, she gave up this bad habit. The last 8 days the pressure is 100/60, does not feel well, is weak, and so on. Question: Is such a low pressure connected with the fact,that she quit smoking? And most importantly, can I stop taking amlodipine. If you stop taking it, then how? Lives in a small town, doctors are deficit. Answer please. Sincerely, Tatyana P.
Administrators
admin
TatianaP.Probably, the smoking factor also affected the decrease in pressure, which always affects the vessels negatively, causing spasms and a reflex increase in blood pressure in smokers. Let your sister try to cancel Amlodipine, but constantly monitors the pressure and records the figures, if the numbers begin to increase and go beyond the limits of the norm, then it is worth finding the dosage of this medication (from the current dose by the method of lowering).
Visitors
Laracka
Hello! Tell me please. I had a pressure jump of 180 to 110. Before that, the pressure was always normal at 120/80. There were pains in the heart area. Descended or went on reception to the cardiologist. Has written out Enap N in the morning and in the evening and meksidol 3 times a day it is long. I went to the therapist and appointed Amolodipine in the morning of Ko-Perineva in the evening. Twice a day erinite on the tongue.Four days I accept appointment of the therapist pressure 100/60 the head strongly hurts and the red face heart beat is strong. Maybe it's a lot of drugs for me from the pressure.
Administrators
admin
Laracka, Yes many. But I still do not understand, do you accept Enap, and Mexidol, and Ko-Pernev, and Amlodipin, or only the last two? If all 4 drugs, then you need to cancel them in pairs. If the last two - you can start with a dose adjustment, for example, to split them and monitor the pressure after that, if you increase more than 130/90, then return half of the Co-perineva or Amlodipine, etc. In general, the selection method to go to their dosage of drugs against pressure.
Guests
Tatyana or Tatyana Felorovna
Already 2 times asked a question, but received no answer. Why?
Administrators
admin
Tatyana or Tatyana Felorovna, Answers to questions are given only to registered visitors. This is written in the rules exactly on the link above the form of feedback-questions. Reviews can be left without registration.If the question is interesting to a wide range of visitors to the Directory, sometimes I answer without registration, but this is rare.
Guests
Nikolay Lysenkov
I am 67 years old. AD constantly within 165/115, I drink enalapril, the effect is negligible. One friend told me to take pills in the morning Metoprolol + Amlodipine. He is very helpful. Tell or Say please, whether it is possible to use in a combination these preparations. Sincerely.
Administrators
admin
Nikolay LysenkovThese drugs can combine, they enhance the mutual antihypertensive effect. But the appointment is familiar, if he is not your doctor, I think it's wrong. Contact your doctor for an appropriate therapy.
Visitors
Avel
Hello. The pressure of the smoker is 160/90. Began to take bisoprolol 5 mg and amlodipine 5 mg in the morning on an empty stomach. Tell me, please, can it be divided into morning and evening, and not taken only in the morning?
Administrators
admin
Avel, Bisoprolol must be taken in the morning, Amlodipine is taken in the evening.
Guests
galena
I used to wake up with a headache, every day. Began to take Amlodipine 10 mg 1/4 part in the evening, once a day. All is well. The pressure is normal. I wake up easily, without pain, but I have tortured my cough ...
Guests
Love
An excellent product. After the appointment, on the second day, everything returned to normal.
Guests
marina tretyakov
In pregnancy, I have a high blood pressure of 160-90.150-80.140-90. My doctor prescribed amlodipine 5 mg in the morning and 10 ml in the evening and another drug nifedipine 3 times a day. Has started to take pressure 140-90 and more did not fall, the head, the greater or big puffiness of the bottom extremities, the allergy strongly hurted or was ill; was sick.
Visitors
Maria M
Visitors of the site write about Amlodipine Teva, I have a medication just Amlodipine 5 mg, manufactured by Vertex St. Petersburg, its cost is only 49 rub.80 kopecks.
Maybe I'm taking the wrong medicine? In the pharmacy I was assured that this is a domestic analogue of the import, nothing worse.
Administrators
admin
Maria M, I have such an approach to this issue: you have money for expensive branded drugs - buy expensive brands, there is no money - buy domestic or Indian, Chinese counterparts or generics. It is clear that their price is lower not simply, somewhere and the active substance can be unstable in quality, and auxiliary substances can provoke an allergy, but it is better than nothing to take from drugs and not to be treated, motivating it by the fact that expensive drugs are not available by wallet. If the drug suits your function, take it calmly and do not worry any more and do not think too much.
Visitors
Alexsundra
Alexsundra, Moved your question to the drug Enap H, where it is more appropriate.
admin
Visitors
Amlodipma
Mom is 88 years old. Hypertension, diabetes ... From hypertension takes:
Morning - Indapamide - 2.5 mg; Lizinopril - 5 mg or 10 mg, depending on what pressure.
Evening - Acecardol, Amlodipine - 5 - 10 mg depending on the pressure at the moment

The pressure in her recently often rises from low to high, so we follow the dosage. Indapamide has been drinking for many years. With a good appetite grows thin, weight below the norm. Is it possible to abandon indapamide? Edema never was.

I left you a question about my grandmother, 88, widow, uch. Second World War. There is no answer. The last discussion was a year ago. A site then you have a valid one? For the sake of the question I registered. Cheating, like everywhere else?
Administrators
admin
AmlodipmaWhat deception? In fact, the administrator of the site is one and he is also a person, so every second can not answer. Many people go to meet them and answer even without registration, if the question is interesting to a wide range of readers. In addition, the reviews have pagination and you need to poke on the dvoechku below to see that there are fresh reviews and questions to the drug Amlodipine, your question will also be on the next page.

About your problem. If there is no edema and the pressure is unstable, then Indapamide can be removed from the accepted therapy regimen.

I did not see in the question of drugs that affect glucose metabolism, this is important, because it can also affect blood pressure.By the way, weight loss can also be caused by the intake of hypoglycemic drugs, or by the presence of severe pathology (oncology was checked for a long time, the stomach is okay, does not complain?).

Amlodipine is better taken in a constant dosage of 5 or 10 mg, as recommended by a doctor, but the dosage of lisinopril can be changed to the current pressure figures. Perhaps in too large variations in the intake of drugs, and the instability of pressure indicators is hidden.
Visitors
Amlodipma
Sorry - guilty with hasty conclusions! Thanks for the answer! Two days in the morning my grandmother did not take indapamide - by the evening of the third day the pressure jumped to 170/100. Maybe just a coincidence? Began to take it again ....

From diabetes it takes mannil 2 tablets (2.5) twice a day. A week ago, sugar was 9.1. Once a year (in the spring) she lies in the day hospital and gives all the tests. In general, she is a good fellow - active, agile, she does not sit idly by. But now it's losing weight and now we are afraid to experiment with indapamide ...
Administrators
admin
AmlodipmaWith such a level of sugar and in Maninila do not lose weight. From Indapamide, the effect of losing weight is also short-term and begins already at the beginning of taking this drug, and not after a while (which is exactly the case with your grandmother). Hence it is necessary to search for the cause, but here there are many things from sharply negative, to trivial diagnoses and banal malnutrition, you need to look at the medical history and examine it.

With pressure, it is necessary to choose the optimal averaging scheme and poprinimat two weeks without changes (without looking at the numbers of pressure, the main thing is that there were not too big fluctuations, threatening health). Medicines will accumulate in the body and after, as a result of daily monitoring of blood pressure, see what to add or remove in the prescribed scheme. Naturally, it is necessary to do this under the supervision of the attending physician of the patient.
Visitors
Amlodipma
Thank you very much for your advice! And we will do it.))
Visitors
ifhybh
I am 69 years old. The pressure began to rise about eight years ago. The pills began to take when the pressure became 180. Started with Enapa.Two weeks later, the strongest arrhythmia started, the pressure dropped sharply to 90. I read on the Internet and found out that it was orthostatic hypotension. Has ceased to accept tablets absolutely, while pressure did not become 210. Has bought or purchased losartan - the same effect as before. I started looking for medications on the Internet without this side effect and I found Amlodipine. I read many sites and there was no orthostatic hypotension anywhere. Has bought or purchased. She drank two weeks. The pressure dropped in the daytime to 180-190 and, behold, again the old story, barely made it home. Tell me, please: "Is there a cure without this side effect?" And then I decided for myself that I'd rather die from high blood pressure than from such a side effect. I will die from it sooner than from pressure.
Visitors
Maria M
Maria M. 2 months took amlodipine - edema on the legs, the face burns, the head is spinning. The cardiologist has replaced on arifon retard (while I accept only week), edemas have passed or have taken place.
Administrators
admin
ifhybh, You will forgive me, but to prescribe for myself at a pressure of 180 various medications myself, and then put incorrect diagnoses on the Internet or attribute side effects, allegedly from the use of drugs is the height of stupidity.Address already to the doctor (it is better to the cardiologist), hand over before reception necessary diagnostic minimum (the general and biochemical analysis of a blood, the general urine, an electrocardiogram, US of heart and kidneys) and then it is already possible to argue about something, and so you will run around in a circle while do not drive the body.
Guests
viktor 1972
I am 44 years old. 7 years ago due to high pressure the doctor prescribed to take the diroton 10, indapamide 2.5 in the morning, and amlodipine 5 in the evening. From high cholesterol took a lot of drugs, but the effect was not enough (heredity). I took these medicines for several years. Still with it I tried to clean the vessels and lower cholesterol with the help of herbs from herbs and other folk recipes (I have it 8-10.3). Two years he was on a diet. After 4 years of treatment, I felt the result. The pressure became stable, without crises. Cholesterol - 5,2. Decided to gradually stop taking all medications. 3 years it was good. But in January of this year, the first attack of rest angina occurred at night. At the moment there are 5 of them for this year. Pressure at the time of attack 200 at 120. Duration up to an hour. I started taking the same pills again a week ago, right after the last evening attack. Pressure is almost always the norm.Pulse 60-66. But there were small, almost constant pains in the chest. It may be side effects of amlodipine and it must be replaced because his doctor appointed 7 years ago, when there were no night attacks. I'm on a business trip - I'm guessing.
Administrators
admin
viktor 1972, Run to the doctor. Business trip is not a business trip, please contact the nearest medical institution, ECG and ultrasound of the heart necessarily, plus biochemical markers of the heart muscle. I think you are your self-medication (and the cancellation of prescribed medications is self-medication) until the heart attack is healed. Amlodipine to pain in the heart, in your case, has no relationship.
Visitors
gimru
Hello. Prompt, pzhl, the husband of a hypertonic from teenage age, 30 years, has got in hospital with the diagnosis predinfarktnoe a status, precisely to define or determine, that with it or him could not. Have written out with the diagnosis Hypertension 2 tbsp. Risk 2. CHF 0. Dislipidemia. Assigned: Renitec 5 mg 2 times a day, Concor 1.25 in the morning, Amlodipine 5 mg in the afternoon, Cardiomagnesium 75 mg at night, Atorvastatin 10 mg during supper.Is the prescription correct and are they combined well? Thank you!
Administrators
admin
gimru, All appointments are adequate, well combined and consistent with the diagnoses. Specific dosages of these drugs are determined initially by the attending physician and in the subsequent selection of minimally effective dosages under the control of blood pressure and heart rate (pulse).
Visitors
Anton25
Tell me, please, my mother's pressure is 160/95. She was prescribed amlodipine 5 mg once a day for the night and discharged from the hospital. She has been drinking it for a week and a half, and the pressure has not decreased either in the morning or in the evening, but it has become noticeable that the decrease of the heart rate to 50-55 Ud. Whether it is necessary to accept further this preparation or again to address to the doctor for purpose or appointment another?
Guests
Galina
I take amlodipine 10 mg at night, enalapril twice for 20 mg. Pressure above 140 does not rise. I have been taking it for two years now. However, the back began to ache heavily, joint arthrosis appeared.
Administrators
admin
Site visitor feedback boris added to the required section:
I drink amlodipine 5 mg in the morning before eating. Decreases the pressure well, but ... 5-6 hours after the reception begins running to the toilet until pain in the bladder. And it lasts 2-3 hours.

Anton25For a week and a half, the effect should already be stable. If the drug does not begin to act at all in the first week of taking it, you can already change it or change the dosage. Address to the attending physician, let him look, why the medicine did not work.

Site visitor question schkola365 moved to the required section:
I am 60 years old. He served in the army for 32 years. Before retiring at 50, a stroke occurred. All ten years he accepted Enap NL. First 10 mg, the last 2 years 20 mg. But now his head and pressure are hurting from him, an average of 180 to 110. He was at a doctor's appointment with a therapist, assigned to our site in a polyclinic. When he measured the pressure, he said that the pressure was high. I told him that there are headaches when taking Enap NL. He advised, to change the medication for Amlodipine 5 mg. Since there are many varieties of this medicine, tell me please, what should I start taking? Sincerely, Ivan Petrovich.
schkola365, No difference.I use the Russian, Slovenian, and Belarusian Amlodipines in treatment - all basically work the same way. For your pressure, I would have saved the morning intake Enap NL 20 mg and in the evening Amlodipine. True 5 mg of the latter I think is not enough, but you can try with this dosage, if the pressure decreases, but not to the optimal figures - then add. Headaches are likely from increased pressure, but if the pressure decreases, and the pain remains, you will have to change and Enap NL to something else.
Visitors
938868
Good afternoon! My husband has high blood pressure. The doctor prescribed enalapril 10 mg in the morning + indapamide, although there was never edema. In the evening, Amlodipine 5 mg + cardiomagnesium 5 mg. After receiving amlodipine, the legs in the lower part began to itch, there was a heaviness in the legs - can it be replaced with another drug?
Administrators
admin
938868, Yes it is better in your case for amlodipine to cancel (perhaps the remaining scheme will be enough to maintain the required level of blood pressure) or to replace with Moxonidine or Physiotenses, which can be taken in the evening,if the remaining tablets finally with its function can not cope.
Visitors
Vasilyeva Inna
Vasilyeva Inna, Moved your question to the drug Moxonidine, where it is more appropriate.
admin
Visitors
Vasilyeva Inna
Dd! Unfortunately, you did not understand me. I am am excited with pobochka amlodipina, namely, edemas at trophic disturbances. Than it can be replaced? Thank you!

I apologize, because I confused the first question. Instead of amlodipine, she wrote moxonidine. Excuse me.
Administrators
admin
Vasilyeva InnaSimilar to Moxonidine. With trophic ulcers and diabetes mellitus, taking Amlodipine is possible, so why replace it with me is unclear.

Peripheral edema that can cause this medicine is not more than a probability, someone appears (infrequently), someone does not. Clear contraindications to admission are specified in the instructions, and everything else can be considered as an individual reaction to taking the medicine and does not carry a direct ban.
Guests
armen
Tell me, please, does amlodipine combine with berlipril? I drink in the morning 5 mg. amlodipine and 10 mg. berlipril in the evening. I can not say that all this helps me a lot.
Visitors
afrodita8
admin, Good afternoon! Today my doctor prescribed Amlodipine 5 mg in the evening in addition to Lozap 25 mg morning. From Lozap had no effect - on the contrary, before the pressure rose only by night, and now in the morning already. A lot of pobochki, headache, dizziness, bones, cuts the eyes and there is a decrease in vision, ringing in the ears, sometimes there is incontinence of urine for no reason. For 3 months added 18 kg of weight (against the background of the selection of drugs for pressure or hormonal failure, the pulse of heart rate dropped to 55-60 and gain weight). Ankles swell for a long time, even before the onset of pressure problems. Can I drink amlodipine, which I was discharged? After all, probably all the side effects that I had with Lozap, Amlodipine only doubled. I'm afraid for vision, scare swelling and lower heart rate.
Administrators
admin
afrodita8, Amlodipine may worsen the swelling of the legs or ankles. So in your case this is a bad assignment. About Lopaz replied in the subject about this drug. I advise you to find a competent doctor who will choose individual treatment, according to your condition, until I see no systemic and individualized appointments.
Administrators
admin
armen, It is combined. Take it wrong - standardly Berlipril is taken in the morning, and Amlodipine in the evening. To say that it is the wrong reception is the ineffectiveness of your treatment, I can not without a full picture of the medical history.
Guests
Katyusha
A bad drug. Horror.
Guests
Gregory
Accepted concor and vero-amlodipine for six years felt normal, then the heart rate dropped significantly. Can I take one amlodipine? How long can I take amlodipine?
Administrators
admin
Gregory, Amlodipine can be taken without Concor, the main thing is to achieve the necessary effect of treatment. Medicines for pressure take a long time, usually for life or until canceled, will not be replaced by the attending physician.
Visitors
asolt 15
Whatever medications I was prescribed, they did not help me. At me pressure always after a dream, in the morning and after day time rest ... To me have appointed or nominated amlodipin 5 mg and bisoprolol 2,5 mg in the morning and in the evening. In the morning and after a dream during the day, the pressure is always 150 to 60, the pulse is 80-86. In the morning I get up with a pressure I drink two tablets, after an hour and does not fall, I drink a pill of corinfar or nifedipine, the pressure drops to 130.
What else to drink, I went through five therapists, but the result is this? Help.
Administrators
admin
asolt 15, I would start with a group of ACE inhibitors (Enalapril, Lysinopril and others) or angiotensin 2 receptor antagonists (Lozartan, Iberbersartan and others) with morning reception together with Bisoprolol, and at night take Amlodipine. But we must look at the concomitant diseases, the previous treatment and choose therapy, taking into account possible contraindications, so contact your doctor.
Visitors
asolt 15
Thanks, I'll try. The attending physician is not present, to whom will write down, to that and go.
Visitors
stenli
Hello. Advise. Accepted enam, enap, now switched to lisinopril 10 and amlodipine 5. The question is how are they better taken together at once or one morning and evening another? Thank you. s.u.v to you.
Administrators
admin
stenliIt will be more correct in your therapy scheme to take Lysinopril in the morning, and Amlodipine in the evening.
Visitors
asolt 15
After the amputation, my legs began to swell, I was frightened, I had to go to the doctor again.
Visitors
Sergey Borisovich
Could nasal congestion be caused by taking amlodipine? Swelling of the legs takes place.
Administrators
admin
Sergey Borisovich, Nasal congestion, runny nose from taking Amlodipine are possible. Given the additional swelling of the lower extremities, try with your doctor to choose another medicine to reduce pressure.
Visitors
Uelina Elena
Good evening.Tell me, please, my mother of 57 years, takes co-perineva (like 25 mg) and amlodipine at night and complains that at night she can not sleep, but only runs to the toilet. Could this be due to amlodipine? Can I take it in the morning?
Administrators
admin
Uelina Elena, Sometimes this effect is observed in patients taking amlodipine. In the morning, no one takes Amlodipine, it's wrong in terms of combinatorial treatment that your mom takes. You need to contact your doctor to replace it with an evening meal of this medication for another remedy or try to replace yourself with another from the group of Amlodipine: Corinfar, Nifedipine, Verapamil and see how it goes.
Visitors
ninanine
Hello. I am 66 years old. I took 4 years verapamil for 80 mg in the morning and in the evening on the appointment of a cardiologist. Recently started a tachycardia and on the ECG appeared again extrasystoles. The therapist has changed to me verapamil on allapinin on 1 tab. 2 times a day and amlodipine for 1 table. 5mg. I drink a month. There were severe headaches, a feeling of raspiraniya head, dizziness that could not even stand on their feet. If she herself drank half a pill of allapinin instead of one, then there were no side effects.But this tablet is forbidden to divide. The pressure is normal, but I arbitrarily added 2.5 mg of lisinopril. Dizziness and noise after taking amlodipine remained. I want to know whether it is possible to take lisinopril and in what dose with these medications? And can I take extra Fezam from the heads of the surroundings and noise and in what dosage?
Administrators
admin
ninanine, Lisinopril in a joint scheme with Allapinin and Amlodipin can be taken, as well as Fezam. Additional side effects when using this combination should not be. Dosages should be consulted by your doctor so that he understands which medications you take, took into account the accompanying conditions and correctly prescribed dosages based on the stage of the disease development.
Guests
Olga
Amlodipine should be drunk with diuretics?
Administrators
admin
Olga, Optional, you can without a diuretic.
Guests
Irina
I take Amlodipine a long time, in the morning and in the evening, a lover, and at lunchtime Amlodipine. All is well, but you can sometimes see a crisis and you have to drink Captopril. After taking Amlodipina, she began to notice cramps in her legs.
Visitors
tagara
Hello. My father is 86 years old. Last time, pressure, nausea, vomiting, and dizziness began to increase. He was in the hospital for veterans. After hospitalization, preparations Indapamide 0.25 mg - 1 t in the morning before meals, Pikamilon 0.05 - 3 rd, Amlodipine 5 mg - 1 t in the evening before meals are prescribed. Mildronate 0.25 mg - 2 rd, Cardiomagnesium 75 mg - 1 t after the meal. After taking the pills and treatment, the pressure is normal. But worrying is that memory is lost at times. He does not remember how they brought him home from the hospital. Sometimes (not always) loses orientation, where is located. There was drowsiness. Also speaks, that the head any heavy. This has never happened before. It is possible, of course, that these are manifestations of senile age. Tell me, please, maybe this medicine works that way. Read the side effects of amlodipine, which can be amnesia, drowsiness. And he's thin, his body weight is not big. Now I do not know whether to continue treatment with pills or not.There is no doctor in the village, but to take him to the city far away, the road is heavy. Advise what to do. Thank you. Sincerely, Marina.
Administrators
admin
tagara, If you know how to check it. The pressure at the moment I understood so is compensated and its numbers are normal, so the cancellation of drugs can cause a recurrence of the crisis, which as you described was strong enough and accompanied by nausea and even vomiting in your father and this is more dangerous than the manifestations indicated by you in the question. You can try to cancel for a couple of days Amlodipine, if you suspect it, but I did not observe the failures in memory due to the use of this medication in my practice and the instructions do not describe such effects. Most likely it is necessary to address to the neurologist for purpose or appointment of vascular preparations and nootropics because at high figures of pressure there can be problems with normal blood supply of bodies of targets (a brain, kidneys).
Guests
Galina Mihailova
I am 66 years old. Amlodipine Teva took almost 5 mg every evening and the pressure was normal, then the therapist increased the dose of 10 mg, because she was in a state of stress due to the death of her granddaughter.After 3 months, the ankles and feet of both legs began to swell, the pressure was 140-160 / 75-80. At night, sometimes there is a fluttering of the heart and a pulse of 90-100, no cardiac pain. Now the therapist canceled Amlodipine and prescribed Bisoprolol 5 mg and Ko-Perineva 2.5 + 8 mg until I take nothing. The question is, you can leave Amlodipine 5 mg and add Indapamide 2.5, because, as I read the annotations of new drugs, I'm afraid to take them. I am used to Amlodipina and at the price I like.
Administrators
admin
Galina MihailovaMost likely, you have already gotten swelling from Amlodipine (a side effect of this medication that does not respond well to treatment, and it's wrong in fact, you have to cancel it). Plus the raised or increased pressure he has ceased to lower, plus a tachycardia. So I think that the replacement of drugs is justified in your case.
Visitors
tolkacheva.2011
I am 50 years old. The therapist prescribed 1 tablet per day from Arifon's pressure and Amlodipine 10, once a day, interacting with each other and how long to take them? Thank you.
Administrators
admin
tolkacheva.2011, Normal combination. According to the instructions and experience negative side effects from such a joint reception should not be. Arifon take in the morning, and Amlodipine at night and everything should be fine.
Visitors
Vlada Belik
The husband of 68 years, accepts Amlodipine 10 mg, koperezenevu and tromboass. The doctor warned that calcium channel blockers can increase the level of sugar that we have.
Is it possible to continue taking amlodipine, since he showed himself well in terms of maintaining the pressure in the norm?
Administrators
admin
Vlada Belik, I hear for the first time that preparations of a group of calcium channel blockers promote the increase of blood sugar. In the instructions to Amlodipine, these side effects are also not indicated. Another question is that these drugs are mainly taken by patients of the older age group, and there accompanying diseases will be lured even without the influence of the drug factor. I would analyze the nutrition of your husband, turned to the endocrinologist and Amlodipine has not yet canceled.
Guests
Olga
Amlodipine very well reduces my pressure, but my ankles begin to swell.
Visitors
Dmitry1105
Hello. Prompt, it is possible to accept Amlodipin at varices (expansion of veins when I lower a hand on a cyst of a hand, on shchikolotkah too are expanded). The pressure jumps 145-165 / 100-120 and with what dosage to begin? Pulse is always around 90. Thank you.
Administrators
admin
Dmitry1105With such levels of blood pressure, you need to start with a minimum dosage, for Amlodipine it will be 5 mg at night. Varicose veins are not a contraindication to taking this medication.

Before taking any medicine, it is worth consulting with a doctor in person to determine the correct diagnosis and the appointment of competent treatment. Elevated blood pressure can be not only symptoms of hypertension, but also manifestations of many other diseases.
Guests
Aigul, 41 years old
Good afternoon. I took amlodipine 5 mg, indapamide 2.5 and valsacor 0.25.Edema was not, but from indapamide was nausea and dizziness. Now as 2 years in the morning I take amlodipine 5 mg and walsakor 0.25. The pressure is normal, but the legs swell, joints hurt. The doctor diagnosed arthritis, arthrosis.

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