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Indomethacin - instructions for use, reviews, analogs and formulations (candles 50 mg and 100 mg Sopharma, tablets and capsules 25 mg and 50 mg, 5% gel, 10% ointment) for the treatment of inflammation in adults, children and pregnancy »Page 2

Indomethacin - instructions for use, reviews, analogs and formulations (candles 50 mg and 100 mg Sopharma, tablets and capsules 25 mg and 50 mg, 5% gel, 10% ointment) for the treatment of inflammation in adults, children and pregnancy

In this article, you can read the instructions for using the drug Indomethacin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Indomethacin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of indomethacin in the presence of existing structural analogues.Use to treat inflammation in rheumatology and gynecology in adults, children, as well as during pregnancy and lactation.

 

Indomethacin - Non-steroidal anti-inflammatory agent, indoleacetic acid derivative. Has anti-inflammatory, analgesic and antipyretic effect. The mechanism of action is associated with inhibition of the enzyme COX, which leads to inhibition of the synthesis of prostaglandins from arachidonic acid.

 

Suppresses the aggregation of platelets.

 

When administered orally and parenterally contributes to the weakening of the pain syndrome, especially joint pain at rest and during movement, a decrease in morning stiffness and swelling of the joints, an increase in the volume of movements. The anti-inflammatory effect develops by the end of the first week of treatment.

 

With topical application removes pain, reduces swelling and erythema.

 

With external application, in addition, helps reduce morning stiffness, increase the volume of movements.

 

Pharmacokinetics

 

After ingestion indomethacin is rapidly absorbed from the digestive tract. Metabolised in the liver. Undergoes intestinal-hepatic recirculation.It is excreted in urine - 60% in the form of unchanged substance and metabolites, and with feces - 33% mainly in the form of metabolites.

 

Indications

 

For systemic use:

  • articular syndrome (including rheumatoid arthritis, arthrosis or osteoarthritis, ankylosing spondylitis, gout);
  • pain in the spine;
  • neuralgia;
  • myalgia;
  • traumatic inflammation of soft tissues and joints;
  • rheumatism;
  • diffuse connective tissue diseases;
  • dysmenorrhea.

 

As an auxiliary agent for infectious and inflammatory diseases of the ENT organs, adnexitis, prostatitis, cystitis.

 

For topical application:

  • prevention of inflammation in surgical interventions for cataracts and in the anterior segment of the eye;
  • inhibition of miosis during surgery.

 

For external use:

  • articular syndrome (including rheumatoid arthritis, arthrosis or osteoarthritis, ankylosing spondylitis, gout);
  • pain in the spine;
  • neuralgia;
  • myalgia;
  • traumatic inflammation of soft tissues and joints.

 

Forms of release

 

Candles for rectal administration 50 mg and 100 mg.

 

Tablets, coated with a shell, soluble in the intestine 25 mg.

 

Capsules 25 mg and 50 mg.

 

Ointment for external use 10%.

 

Gel for external use 5%.

 

Instructions for use and dosing regimen

 

Established individually taking into account the severity of the course of the disease. For adults with oral administration, the initial dose is 25 mg 2-3 times a day. If the clinical effect is inadequate, the dose is increased to 50 mg 3 times a day. Medicinal forms of prolonged action are applied 1-2 times a day. The maximum daily dose: 200 mg.

 

When the effect is achieved, treatment is continued for 4 weeks at the same or reduced dose. With prolonged use, the daily dose should not exceed 75 mg. Take after meals.

 

For the treatment of acute conditions or relief of an exacerbation of a chronic process, intramuscularly administered 60 mg 1-2 times a day. The duration of the IM is 7-14 days. Indomethacin is then administered orally or rectally at 50-100 mg twice a day, with the maximum daily dose not exceeding 200 mg. For maintenance treatment, rectally apply 50-100 mg once a day at night.

 

For topical application in ophthalmology dose, the frequency and duration of application are determined individually.

 

External apply 2 times a day.

 

Side effect

  • nausea, vomiting;
  • anorexia;
  • pain and discomfort in the abdomen;
  • constipation or diarrhea;
  • erosive and ulcerative lesions;
  • bleeding and perforation of the gastrointestinal tract;
  • intestinal stricture;
  • stomatitis;
  • flatulence;
  • bleeding from the sigmoid colon or from the diverticulum;
  • dizziness;
  • headache;
  • depression;
  • feeling tired;
  • anxiety;
  • fainting;
  • drowsiness;
  • convulsions;
  • peripheral neuropathy;
  • muscle weakness;
  • involuntary muscular movements;
  • sleep disorders;
  • mental disorders (depersonalization, psychotic episodes);
  • paresthesia;
  • edema;
  • increased blood pressure;
  • tachycardia;
  • pain in the chest;
  • arrhythmia;
  • arterial hypotension;
  • congestive heart failure;
  • itching;
  • hives;
  • erythema nodosum;
  • skin rash;
  • hair loss;
  • a sharp drop in blood pressure;
  • anaphylactic reactions;
  • angioedema;
  • pulmonary edema;
  • leukopenia;
  • DIC syndrome;
  • hearing impairment;
  • deafness;
  • interstitial nephritis;
  • impaired renal function;
  • hyperglycemia;
  • glucosuria;
  • vaginal bleeding;
  • tides;
  • increased sweating;
  • nose bleed;
  • increase and tension of mammary glands;
  • gynecomastia;
  • the formation of an infiltrate, an abscess (with local and intramuscular injection);
  • itching, redness, rash at the place of application.

 

Contraindications

  • increased sensitivity to indomethacin;
  • erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
  • "aspirin triad";
  • disorders of hematopoiesis;
  • severe violations of the liver and / or kidney function;
  • severe forms of chronic heart failure, arterial hypertension, pancreatitis;
  • 3 trimester of pregnancy;
  • children's age till 14 years;
  • for rectal administration: proctitis, recent bleeding from the rectum.

 

Application in pregnancy and lactation

 

Indomethacin is contraindicated in the third trimester of pregnancy. In 1 and 2 trimesters of pregnancy, as well as during lactation (breast-feeding), the use is not recommended.

 

Indomethacin in small amounts excreted in breast milk.

 

special instructions

 

They are used with caution in elderly patients, as well as in cases of liver, kidney, gastrointestinal disease history, dyspeptic symptoms at the time of application, arterial hypertension, heart failure, immediately after serious surgical interventions, with parkinsonism, epilepsy.

 

In case of anamnesis, allergic reactions to NSAIDs are used only in urgent cases.

 

During the period of treatment, systematic monitoring of liver and kidney function, a picture of peripheral blood is necessary.

 

It is not recommended simultaneous use with Acetylsalicylic acid and other NSAIDs.

 

Do not use indomethacin concomitantly with diflunizole.

 

When concomitant use of indomethacin with lithium preparations should be borne in mind the possibility of the appearance of symptoms of toxic effects of lithium.

 

When topical application should not be applied to the wound surface of the skin, and avoid contact with eyes or mucous membranes.

 

Impact on the ability to drive vehicles and manage mechanisms

 

During treatment should refrain from potentially dangerous activities associated with the need for concentration and increased speed of psychomotor reactions.

 

Drug Interactions

 

With simultaneous use of indomethacin can reduce the effects of saluretics, beta-blockers; intensify the effects of indirect anticoagulants.

 

With the simultaneous use of indomethacin and diflunizala there is a danger of severe bleeding from the gastrointestinal tract.

 

With simultaneous application with probenecid, an increase in the concentration of indomethacin in the blood plasma is possible.

 

Indomethacin can reduce tubular secretion of methotrexate, which leads to an increase in its toxicity.

 

With simultaneous use with NSAIDs, the toxicity of cyclosporine increases.

 

Indomethacin in a dose of 50 mg 3 times a day increases the concentration of lithium in blood plasma and reduces the clearance of lithium from the body in patients with mental illness.

 

With the simultaneous use of indomethacin with digoxin, an increase in Digoxin concentration in the blood plasma and an increase in the half-life of digoxin are possible.

 

Analogues of the medicinal product Indomethacin

 

Structural analogs for the active substance:

  • Indoene;
  • Indowis EU;
  • Indocollar;
  • Indomethacin (Moivide);
  • Indomethacin 100 Berlin-Chemie;
  • Indomethacin 50 Berlin-Chemie;
  • Indomethacin Sopharma;
  • Indomethacin-Acry;
  • Indomethacin-Altpharm;
  • Indomethacin-Biosynthesis;
  • Indotard;
  • Indocide;
  • Metindol retard;
  • Metindol.

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Reviews (125):
Guests
alex7121
Urologist prescribed the candles Indomethacin (Berlin Chemie), after half an hour thrown into the heat, strong weakness, pressure 170/100.The state is disgusting, a little let go in 3 hours.
Guests
Tatyana
Where are Indomethacin tablets disappearing? In some pharmacies, no longer come on sale. Since the 1990s, I've tried and still have not found anything better. I use them in emergency cases, the result is always gorgeous. Now, after the operation on the hip joint, after a long walk, your back hurts very much, one pill at night and you get up in the morning, as if nothing hurted. We have to use other, more expensive and not so effective drugs.
Guests
Tatyana
I regret very much that I did not read reviews on the sites. Now after passing all hell from these candles I write: these candles are dangerous for your life. The proctologist attributed to relieve pain in the coccyx. The first time, when I introduced the candle immediately began burning and discomfort, my head began to spin, after 5 minutes. the urge to go to the toilet began. The body rejected these candles. The symptoms stopped after the bowel was emptied and I did not attach importance to the fact that it was from a candle. The doctor recommended using only 3 candles no more.The second candle was used the next evening. And then it started in 1 hour, getting out of bed could not have been the strongest dizziness, pressure 160/80 (my normal 90/60), ice hands, noise in the ears, neck pain, leg cramps, panic attack. Who felt the panic attack understands what it is. But that this attack was provoked with a candle is a horror.

I'm 44g. I took a lot of candles from hemorrhoids, but there was no such reaction. I was alone in the house, it was all at 12 noon. It's good that there was an andipal in the house and I began to lower the pressure myself. A friend arrived in 10 minutes. and was with me. She called an ambulance from our Balashikha, but they did not answer. Caused through 112. The ambulance arrived in 2 hours. Inspection and attitude disgusting. They made a cardiogram and measured the pressure. But my insurance policy and the passport, which my friend was looking for in the house in panic, was more interested in them. Asked to inject at least diphenhydramine, so I calmed down and fell asleep. The doctor protested and injected a suprastin.

If anyone wants to try these candles my conclusion, in the medicine cabinet should be:
1. Preparations for high blood pressure.
2. Preparations are anti-allergic.
3. Tonometer
4. Nitrate.
I wish everyone good health.
Guests
Ramiz
Two days ago there was a strong stitching pain, under the scapula, as they say, or sneeze, not to cough or turn. I made a shot of diclofenac, the pain subsided a little, but the next day I returned, not so strong, but it's hard to lie down, much less turn around. I inserted a candle of Indomethacin 100 mg "Sopharma", and it began, almost what the previous sufferers describe. Increase in pressure to 150/80, with my 100/50, dizziness and so on. In the morning I woke up, I did not feel any pain, I decided to fix the effect and put in the candle 3 hours ago and now I sit like a plague, It's good that there is an error editor, otherwise I do not understand what I'm writing. But I always keep these candles in my home medicine cabinet, along with tablets from pressure, stomach, heart, nitrosprey and so on. Always helped with pain in the spine. I am 71 years old. There was a stroke, and a heart attack. Everything is the will of God, we will die from what is written in the heavenly chancery.
Guests
Lena
Oh the drug is terrible. I was prescribed by a gynecologist, such a state was, a nightmare, I thought everything was dying, ambulance doctors hardly pumped out. I went to work, almost fainted.No one helped, thought drank in the morning. She barely got to work, she was all white, she put the first shot.
Guests
Anna Tokarskih
A gynecologist prescribed candles with indomethacin, 1 time a day before bedtime. From the first reception did not understand what the matter was, terrible itching in the bikini area, by morning everything had passed, the second application, the same effect, only the itch stronger, and again in the morning everything went from the third application, the itching became unbearable and there were spotting. She told the doctor, she could not stop taking the drug, I can not tolerate these ailments, I stopped taking it and everything went away. And about dizziness and nausea, these syndromes are also present, but I'm not sure it's because of the candles, as stomach problems and I often suffer such ailment.
Guests
koshe4ka27
I hasten to share my experience of using candles with indomethacin produced in Penza, 100 mg. I 2 years did not sleep at night from severe pain in the hands / rheumatoid arthritis /. What kind of drugs did I not use ... And I drank, and pricked, and put candles. All for nothing.Only candles with indomethacin saved me from these terrible pains. The truth I put them for the second time with a short break. The first time did not help much, but did not notice the pox. But the second time I just came to light again. I think that we are all different, each with its own "bouquet" of sores, so our organisms react differently. So you need to try all sorts of drugs until you find yours. Also, doctors do.
Guests
First name
20-30 minutes after the introduction of the candle indomethacin first time in my life there was dizziness, a sense of anxiety, after another five minutes my hands trembled, there was a strong weakness in the arms and legs, strongly pale. I barely called an ambulance, I found a high blood pressure. Prayer and tablets of a paramedic - I got out. A week later I decided to check whether the medicine was in the cure. I took a third of the dose. The result: high blood pressure, severe weakness, palpitations and dizziness, which went through 2 hours after taking drugs from the pressure.
Very carefully you need to treat this drug ...
Guests
Galina
Just awful. I drank three days, I felt very bad.After the last pill was a week, and everything is bad, sick, dizzy, floating all before your eyes and a lot more.
Guests
Water
Indomethacin suppositories started taking the second course today. Last time nothing felt at all. Now I've put a candle, an hour ago, there was a noise in my ears, a light sniffle and some incomprehensible inner panic.
Guests
Chris
The second day "I leave" after this candle. Mom dear, I was scared, but I did not think it was a candle. I was treated in the hospital for a week, let go home with a prescription for this indomethacin. At night she put in - immediately poploholo, sat on the toilet this candle and not just her several times. It seemed to go away, in about 2 hours I fell asleep. In the afternoon, the next day, this carousel is all over again with a double force. It is impossible to sleep, the heart "fails", it makes you sick, the consciousness is not clear, drunk. You will not wish the enemy.
Guests
Tatyana
It seems that the drug was given anti-advertising for a great reward. I read and I wait when I start to die ... Do not scare people.I'm very hypochondriac, and you all here with your feedback will lead a person to a heart attack. I took a pill and looked at my watch. When horror begins after reception. I have coxarthrosis. Earlier I drank these tablets and ointment applied. And now I sit and wait for death. After your feedback. I have hypertension and nerves.
Guests
Irina
No one scares, but I'd rather I never took this awful drug. How could I have been ill.
Guests
choreographer
17.04.2018 at night, put this candle indomethacin in the rectum, tk. prescribed gynecologist, after 30 minutes it became very bad, noise in the ears, nausea, and the pulse slowed. I measure pressure and I have 140 to 180, my pressure is 100 to 90. I had to do an enema, I did not call an ambulance. The therapist doctor praises God in the neighborhood lives, said that if AD does not change after the enema, it is better to call an ambulance, but I went to bed, could not sleep for a long time, started to freeze terribly. Have to give them up. Had never suffered a BP.

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