Orthofen - instructions for use, reviews, analogs and forms of release (tablets 25 mg, ointment or gel 2%, injections in injections) for the treatment of arthritis and gout in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Orthophene. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Orthofen in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Orthophene in the presence of existing structural analogues. Use to treat arthritis, gout and other inflammatory diseases in adults, children, as well as during pregnancy and lactation. Composition of the preparation.
Orthophene - non-steroidal anti-inflammatory drug (NSAID), a derivative of phenylacetic acid. Has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect. The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (by inhibiting the synthesis of prostaglandins in the central and peripheral nervous system).
Inhibits the synthesis of proteoglycan in the cartilage.
When rheumatic diseases reduces pain in joints at rest and during movement, as well as morning stiffness and swelling of the joints, contributes to an increase in the volume of movements. Reduces post-traumatic and post-operative pain, as well as inflammatory edema.
Suppresses the aggregation of platelets. With long-term use has a desensitizing effect.
With topical application in ophthalmology reduces swelling and pain in inflammatory processes of non-infectious etiology.
Composition
Diclofenac sodium + auxiliary substances.
Pharmacokinetics
After oral administration, it is absorbed from the digestive tract. The intake of food slows the rate of absorption, the degree of absorption does not change. With rectal administration, absorption is slower. Do not cumulate. Penetrates into the synovial fluid. It is metabolized to a great extent with the formation of several metabolites, among which two are pharmacologically active, but to a lesser extent than diclofenac. Approximately 60% of the dose is excreted as metabolites kidneys, less than 1% is excreted in the urine in an unmodified form, the remaining part is output as metabolites in the bile.
Indications
- articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout);
- degenerative and chronic inflammatory diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, periarthropathies);
- post-traumatic inflammation of soft tissues and musculoskeletal system (stretching, bruising);
- pain in the spine;
- neuralgia;
- myalgia;
- arthralgia;
- pain syndrome and inflammation after surgery and trauma;
- pain syndrome with gout;
- migraine;
- algodismenorea;
- pain syndrome with adnexitis, proctitis;
- colic (biliary and renal);
- pain syndrome in infectious and inflammatory diseases of ENT organs.
For topical application:
- inhibition of miosis during surgery for cataract;
- prevention of cystoid macular edema associated with removal and implantation of the lens;
- inflammatory processes of the eye of non-infectious nature;
- posttraumatic inflammatory process with penetrating and non-penetrating injuries of the eyeball.
Forms of release
The tablets covered with a cover of 25 mg.
Ointment for external use 2% (sometimes mistakenly called cream or gel).
Solution for intramuscular injection (injections in ampoules for injection).
Instructions for use and how to use them
For oral administration for adults, a single dose is 25-50 mg 2-3 times a day. Frequency depends on the dosage form used, the severity of the disease and is 1-3 times a day, rectally - once a day. For the treatment of acute conditions or relief of an exacerbation of a chronic process, intramuscularly administered at a dose of 75 mg.
For children over 6 years and adolescents, the daily dose is 2 mg / kg.
External apply in a dose of 2-4 g (depending on the area of the painful area) to the affected area 3-4 times a day.
When used in ophthalmology, the frequency and duration of administration are determined individually.
The maximum daily intake for adults with oral administration is 150 mg per day.
Side effect
- nausea, vomiting;
- anorexia;
- pain and discomfort in the epigastric region;
- flatulence;
- constipation;
- diarrhea;
- erosive and ulcerative lesions;
- bleeding and perforation of the gastrointestinal tract;
- exacerbation of ulcerative colitis;
- dizziness;
- headache;
- excitation;
- insomnia;
- irritability;
- feeling tired;
- paresthesia;
- impaired vision (vagueness, diplopia);
- noise in ears;
- sleep disorders;
- convulsions;
- tremor;
- mental disorders;
- depression;
- Anemia, leukopenia, thrombocytopenia, agranulocytosis;
- impaired renal function;
- in predisposing patients, edema is possible;
- hair loss;
- skin rash;
- itching;
- photosensitization;
- burning at the injection site;
- formation of an infiltrate, abscess;
- necrosis of adipose tissue;
- painful defecation (with rectal administration).
Contraindications
- erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
- "aspirin triad";
- disorders of hematopoiesis of unknown etiology;
- hypersensitivity to diclofenac and the components of the dosage form used, or other NSAIDs.
Application in pregnancy and lactation
Application in pregnancy and during lactation is possible in cases where the potential benefit to the mother exceeds the potential risk to the fetus or newborn.
Use in children
It is not recommended for use in children under the age of 6 years.
special instructions
With special care apply for diseases of the liver, kidneys, gastrointestinal tract in history, dyspeptic phenomena, bronchial asthma, arterial hypertension, heart failure, immediately after serious surgical interventions, as well as in elderly patients.
With the history of allergic reactions to NSAIDs and orthophanes, orthophanes are used only in urgent cases. In the process of treatment, systematic monitoring of liver and kidney function, and peripheral blood patterns are necessary.
Rectal use in patients with anorectal disease or anorectal hemorrhage in the anamnesis is not recommended. Outer should be used only on intact skin areas.
Avoid contact with Diclofenac in the eyes (with the exception of eye drops) or mucous membranes. Patients using contact lenses should use eye drops no earlier than 5 minutes after removing the lenses.
During the period of treatment with dosage forms for systemic use, alcohol consumption is not recommended.
Impact on the ability to drive vehicles and manage mechanisms
During the treatment period, the speed of psychomotor reactions may decrease. If vision deteriorates after application of eye drops, do not drive and engage in other potentially hazardous activities.
Drug Interactions
With the simultaneous use of antihypertensive medications with Orthophenum, their effect may be weakened.
There are isolated reports of seizures in patients taking both NSAIDs and antibiotics of the quinolone series.
When used simultaneously with glucocorticosteroids (GCS), the risk of side effects from the digestive system is increased.
With the simultaneous use of diuretics, a decrease in the diuretic effect is possible. With simultaneous use with potassium-sparing diuretics, an increase in the concentration of potassium in the blood is possible.
With simultaneous use with other NSAIDs, an increased risk of side effects may occur.
There are reports of the development of hypoglycemia or hyperglycemia in patients with diabetes mellitus who used orthophane concomitantly with hypoglycemic drugs.
With simultaneous use with acetylsalicylic acid, a decrease in the concentration of diclofenac in the blood plasma is possible.
Although clinical studies have not established the effect of diclofenac on the effect of anticoagulants, individual cases of bleeding are described with the simultaneous use of diclofenac and warfarin.
With simultaneous use, an increase in the concentration of digoxin, lithium and phenytoin in the blood plasma is possible.
Absorption of diclofenac from the digestive tract decreases with simultaneous application with colestyramine, to a lesser extent - with colestipol.
With simultaneous use, it is possible to increase the concentration of Methotrexate in the blood plasma and increase its toxicity.
With simultaneous use of Orthofen may not affect the bioavailability of morphine, but the concentration of the active metabolite of morphine may remain elevated in the presence of diclofenac, which increases the risk of side effects of the metabolite of morphine, including. respiratory depression.
With simultaneous use with pentazocine, the case of the development of a large convulsive fit is described; with rifampicin - a decrease in the concentration of diclofenac in the blood plasma; with Ceftriaxone - the excretion of ceftriaxone with bile increases; with cyclosporine - it is possible to increase the nephrotoxicity of cyclosporine.
Analogues of the drug Orthophene
Structural analogs for the active substance:
- Artrex;
- Beliefed;
- Voltaren;
- Voltaren Emulgel;
- Diklak Lipogel;
- Diklak;
- Diklo-F;
- Diklobene;
- Dicluberl;
- Diqlovit;
- Diklogen;
- Diclomax;
- Diclomelan;
- Diclonac;
- Diclonate;
- Dicloran;
- Diclorium;
- Diclofen;
- Diclofenac;
- Diclofenac Long;
- Diclofenacol;
- Diphene;
- Dorosan;
- Naklof;
- Naklofen;
- Naklofen Duo;
- Orthophene injection 2.5%;
- Orthofer;
- Orthoflex;
- Rapten Duo;
- Rapent Rapid;
- Revmavek;
- Redwood retard;
- Remetan;
- Sanfinak;
- SwissSet;
- Tabuk-Di;
- Feloran;
- Feloran retard;
- Flotac.
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