Cefexon D and N - instructions for use, analogs, testimonials and release forms (rectal suppositories 50 mg, 100 mg and 250 mg) medicines for the treatment of pain and lowering of temperature (antipyretic suppositories) in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Cefecon D and H. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Cefekon D and N in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cefekon D and H in the presence of existing structural analogues. Use to treat pain and reduce temperature in adults, children, as well as during pregnancy and lactation. Composition of antipyretic preparation.

Cefecon D and H - has analgesic and antipyretic effect. It blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. In the focus of inflammation, cellular peroxidases neutralize the effect of Paracetamol on cyclooxygenase, which explains the lack of significant anti-inflammatory effects.

The drug does not adversely affect the water-electrolyte metabolism (does not lead to a delay in sodium and water) and the mucosa of the gastrointestinal tract.

Composition

Paracetamol + excipients (Cefekon D).

Naproxen + Caffeine + Salicylamide + excipients (Cefekon N).

Pharmacokinetics

Quickly and highly absorbed from the digestive tract. Binding to plasma proteins - 15%. Penetrates through the blood-brain barrier (BBB). Metabolised in the liver; 80% reacts with glucuronic acid and sulfates to form inactive metabolites; 17% is hydroxylated to form active metabolites, which are then conjugated to glutathione and form inactive metabolites. With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis.Within 24 hours, 85-95% of paracetamol is excreted by the kidneys in the form of glucuronides and sulfates, unchanged - 3%.

In newborns of the first 2 days of life and in children aged 3-10 years, the main metabolite of paracetamol is paracetamol sulfate, in children 12 years and older - conjugated glucuronide. There is no significant age difference in the rate of elimination of paracetamol and in the total amount of the drug that is excreted in the urine.

Indications

As an anesthetic for pain syndrome of mild and moderate severity:

• neuralgia;
• myalgia;
• sciatica;
• lumbago;
• degenerative-dystrophic diseases of the musculoskeletal system (osteochondrosis, osteoarthritis, ankylosing spondylitis);
• headache, migraine;
• toothache;
• primary algodismenorea.

As an antipyretic agent:

• febrile syndrome with ARVI, flu, other colds, childhood infections, post-vaccination reactions and other conditions accompanied by fever.

Forms of release

Candles rectal for children 50 mg, 100 mg and 250 mg (Cefekon D).

Candles rectal (Cefekon N).

Instructions for use and how to use them

Cefekon D

The drug is used rectally.Suppositories are injected into the baby's rectum after a cleansing enema or spontaneous bowel movement.

The dosage regimen is set depending on the age and body weight. The average single dose is 10-15 mg / kg of the child's body weight. The drug in a single dose is administered 2-3 times a day, after 4-6 hours. The maximum daily dose of the drug should not exceed 60 mg / kg of body weight.

When the drug is used as an antipyretic agent, the duration of the course of treatment is 3 days; as an anesthetic - 5 days. If necessary, the doctor can extend the course of treatment.

Cefepecon H

The drug should be used after cleansing enema or spontaneous bowel movement.

Prescribe 1 suppository 1-3 times a day. The suppository is injected deep into the rectum, after which the patient must stay in bed for 30-40 minutes.

Duration of use as an anesthetic - no more than 5 days; as an antipyretic agent - no more than 3 days.

Side effect

• nausea, vomiting;
• stomach ache;
• rash on the skin and mucous membranes;
• itching;
• hives;
• angioedema;
• dizziness;
• excitation;
• drowsiness;
• noise in ears;
• slowing the speed of psychomotor reactions;
• tachycardia;
• anemia, thrombocytopenia, leukopenia, agranulocytosis;
• with prolonged use in high doses, it is possible to develop hepatotoxic and nephrotoxic (interstitial nephritis and papillary necrosis), hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia.

Contraindications

• age up to 1 month (for Cefekon D), children and adolescents under 16 years (for Cefekon N);
• peptic ulcer of the stomach and duodenum in the phase of exacerbation;
• bleeding;
• marked renal or hepatic insufficiency;
• arterial hypertension;
• organic diseases of the cardiovascular system;
• chronic heart failure;
• increased excitability;
• insomnia;
• angle-closure glaucoma;
• bronchospasm (including caused by the intake of non-steroidal anti-inflammatory drugs);
• elderly age;
• pregnancy;
• lactation (breastfeeding);
• hypersensitivity to paracetamol.

Application in pregnancy and lactation

Cefekon N is contraindicated in pregnancy and lactation.

Use in children

Cefekon D is contraindicated in children under the age of 1 month (including newborns), Cefekon N is contraindicated in children and adolescents under the age of 16 years.

special instructions

The patient should be warned about the need to see a doctor if the fever lasts more than 3 days and the pain syndrome is more than 5 days.

It should avoid simultaneous application with other paracetamolosoderzhaschimi drugs, tk. this can cause an overdose of paracetamol.

When using the drug Cefexon D and H for more than 5-7 days should monitor the peripheral blood and the functional state of the liver. Paracetamol distorts the results of laboratory studies in the quantitative determination of glucose and uric acid in plasma.

Drug Interactions

Inductors microsomal oxidation in the liver (phenytoin, ethanol (alcohol), barbiturates, flumetsinol, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol, hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes the possibility of severe toxicity, even at low overdose.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects.

When taking concomitantly with salicylates, the likelihood of developing a nephrotoxic effect increases.

When combined with paracetamol, the toxic effects of chloramphenicol are enhanced.

When combined with paracetamol, the effect of anticoagulants of indirect action increases and the effectiveness of uricosuric agents decreases.

Analogues of the drug Cefecon

Structural analogs for the active substance:

• Aldolor;
• Apap;
• Acetaminophen;
• Daleron;
• Children's Panadol;
• Children's Tylenol;
• Ithymol;
• Kalpol;
• Xoomapar;
• Lupocet;
• Mexalen;
• Pamol;
• Panadol;
• Panadol junior;
• Paracetamol;
• Perfalgan;
• Prohodol;
• Child passed through;
• Sanidol;
• Strymol;
• Tylenol;
• Tylenol for infants;
• Febricet;
• Cefekon D;
• Efferalgan.

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