Milk thistle - instructions for use, reviews, analogs and forms of release (tablets 500 mg, capsules 300 mg, powder, oil) drugs for the treatment of cirrhosis, hepatitis and other liver diseases in adults, children and pregnancy. Composition
In this article, you can read the instructions for using the drug Milk thistle. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Milk thistle in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of milk thistle in the presence of existing structural analogues. Use for the treatment of cirrhosis, hepatitis, fatty degeneration and other liver diseases in adults, children,as well as during pregnancy and lactation. Composition of the preparation.
Milk thistle - Herbaceous plant of the family Compositae. As a medicinal raw material, ripe fruits are used - Fructus Silybi mariani. The fruit contains a group of flavonoid compounds, designated as silymarin (Silimari). Of silymarin, three separate isomeric compounds, silybinin, silidianin, and silicistrin-have a phenylchromanone structure and have some degree of hepatoprotective effect.
Clinically, these compounds manifest themselves in the improvement of subjective and objective symptoms and normalization of indicators of the functional state of the liver (transaminase, bilirubin). This leads to an improvement in the general condition, a reduction in complaints related to digestion, and in patients with impaired digestion due to hepatic disease leads to better appetite and weight gain.
Composition
Extract of milk thistle spotted (silymarin) + auxiliary substances.
Pharmacokinetics
Interacts with free radicals in the liver and reduces their toxicity. Interrupting the process of lipid peroxidation, prevents further destruction of cellular structures.In damaged hepatocytes stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA polymerase A), stabilizes cell membranes, prevents the loss of cellular components and intracellular enzymes (transaminases), accelerates the regeneration of liver cells. It inhibits the penetration into the cells of some hepatotoxic substances (poison fungus pale toadstool). Subjected to enterohepatic circulation. Metabolised in the liver by conjugation. It is excreted mainly with bile in the form of glucuronides and sulfates, in an insignificant degree with urine. Do not cumulate. After repeated oral administration of 140 mg 3 times a day, a stable concentration is achieved.
It improves the general condition of patients with liver diseases, reduces subjective complaints, normalizes laboratory indicators (activity of transaminases, gamma-glutamyltransferase, alkaline phosphatase, bilirubin level). Long-term use significantly increases the survival rate of patients suffering from cirrhosis of the liver.
Indications
- toxic liver damage (alcoholism, intoxication with halogenated hydrocarbons, heavy metal compounds, medicinal liver damage) and their prevention;
- chronic hepatitis;
- cirrhosis of the liver (as part of complex therapy);
- state after infectious and toxic hepatitis;
- dystrophy and fatty liver;
- correction of lipid metabolism disorders.
Forms of release
Capsules 300 mg.
Tablets 500 mg.
Powder.
Oil for internal use (made by squeezing out milk thistle seeds).
Instructions for use and how to use them
Butter
Adults and children over 12 years of age on 0.5 teaspoon 2 times a day during meals. The course of admission is 30 days.
Capsules
Adults and children over 12 years of age 5 capsules 2 times a day with meals. The course of admission is 30 days.
Side effect
- diarrhea;
- allergic reactions;
- children's age till 12 years;
- hypersensitivity to the components of the drug.
Contraindications
- hypersensitivity.
Application in pregnancy and lactation
There is no evidence of adverse effects of the drug on reproductive function in animals. During pregnancy and during breastfeeding it can be used for medical reasons and if the benefit of treatment with the drug exceeds the risk to the fetus.
Use in children
Contraindicated in children under 12 years.
special instructions
Treatment of Milk thistle can not replace a diet or a refusal of anything in case of liver damage (for example, from alcohol).
With caution should be used in patients with hormonal disorders (endometriosis, uterine myoma, breast carcinoma, ovaries and uterus, prostate carcinoma) because of the possible estrogen-like action of silymarin.
In patients with impaired digestion due to hepatic disease, it leads to better appetite and weight gain. It is mistakenly believed that the drug can be used for weight loss, but this is not true, the metabolic processes in the diseased organism are normalized.
In folk medicine, oil, seeds, cake and cake are widely used, remaining after extruding the oil from the seeds of milk thistle.
Impact on the ability to drive vehicles and manage mechanisms
Milk thistle does not adversely affect the ability to drive vehicles and work with machines.
Drug Interactions
With the combined use of milk thistle with oral hormonal contraceptives and drugs intended for hormone replacement therapy, it is possible to reduce the effects of the latter.
Silymarin may enhance the effects of diazepam, alprazolam, ketoconazole, lovastatin, vinblastine because of its inhibitory effect on the microsomal enzymes of the cytochrome P450 system.
Analogues of the drug Thistle
Structural analogs for the active substance:
- Karsil;
- Karsil Forte;
- Legalon;
- Silegon;
- Silibinin;
- Sylimar;
- Silymarin.
Analogues for the pharmacological group (hepatoprotectors):
- Antraliv;
- Berlition;
- Bondjigar;
- Brentzialle forte;
- Vitanorm;
- HepaMerz;
- Gepabene;
- Hepatosan;
- Hepatofalk the plant;
- Hepafor;
- Heptor;
- Heptral;
- Heptrog;
- Glutargin;
- Dipan;
- Covechol;
- Karsil;
- Laennek;
- Legalon;
- Liv 52;
- Livedoksa;
- Livolife Forte;
- Lipoic acid;
- Maxar;
- Methionine;
- Metrop;
- Moliksan;
- Octolipen;
- Ornitsetil;
- Progepar;
- Resalute Pro;
- Ropren;
- Sibektan;
- Silegon;
- Silymarin;
- Sirepard;
- Thiolipone;
- Tiotriazolin;
- Tyqveol;
- Urdoks;
- Ursodez;
- Ursodeoxycholic acid;
- Ursodex;
- Ursuliv;
- Ursor;
- Ursosan;
- Ursofalk;
- Phosphogliv;
- Phosphogliv Forte;
- Phosphontsiale;
- Hepabos;
- Holudexan;
- Exxhol;
- Erbisol;
- Eslidine;
- Essentiale;
- Essentiale forte N;
- Essential phospholipids;
- The Essler;
- Essliver forte.
Similar medicines:
Other medicines:
- Lokren - instructions for use, reviews, analogs and formulations (20 mg tablets) of the drug for the treatment of angina pectoris and pressure reduction in adults, children and pregnancy. Composition and interaction with alcohol
- Barbovale - instructions for use, analogs, reviews and release forms (drops or tablets) of a sedative medication for the treatment of insomnia, neuroses and hysteria in adults, children and pregnancy. Composition
- Indap - instructions for use, analogs, reviews and release forms (capsules or tablets 2.5 mg) of a diuretic for the treatment of edema and pressure in adults, children and pregnancy