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Milk thistle - instructions for use, reviews, analogs and forms of release (tablets 500 mg, capsules 300 mg, powder, oil) drugs for the treatment of cirrhosis, hepatitis and other liver diseases in adults, children and pregnancy. Composition

Milk thistle - instructions for use, reviews, analogs and forms of release (tablets 500 mg, capsules 300 mg, powder, oil) drugs for the treatment of cirrhosis, hepatitis and other liver diseases in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Milk thistle. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Milk thistle in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of milk thistle in the presence of existing structural analogues. Use for the treatment of cirrhosis, hepatitis, fatty degeneration and other liver diseases in adults, children,as well as during pregnancy and lactation. Composition of the preparation.

 

Milk thistle - Herbaceous plant of the family Compositae. As a medicinal raw material, ripe fruits are used - Fructus Silybi mariani. The fruit contains a group of flavonoid compounds, designated as silymarin (Silimari). Of silymarin, three separate isomeric compounds, silybinin, silidianin, and silicistrin-have a phenylchromanone structure and have some degree of hepatoprotective effect.

 

Clinically, these compounds manifest themselves in the improvement of subjective and objective symptoms and normalization of indicators of the functional state of the liver (transaminase, bilirubin). This leads to an improvement in the general condition, a reduction in complaints related to digestion, and in patients with impaired digestion due to hepatic disease leads to better appetite and weight gain.

 

Composition

 

Extract of milk thistle spotted (silymarin) + auxiliary substances.

 

Pharmacokinetics

 

Interacts with free radicals in the liver and reduces their toxicity. Interrupting the process of lipid peroxidation, prevents further destruction of cellular structures.In damaged hepatocytes stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA polymerase A), stabilizes cell membranes, prevents the loss of cellular components and intracellular enzymes (transaminases), accelerates the regeneration of liver cells. It inhibits the penetration into the cells of some hepatotoxic substances (poison fungus pale toadstool). Subjected to enterohepatic circulation. Metabolised in the liver by conjugation. It is excreted mainly with bile in the form of glucuronides and sulfates, in an insignificant degree with urine. Do not cumulate. After repeated oral administration of 140 mg 3 times a day, a stable concentration is achieved.

 

It improves the general condition of patients with liver diseases, reduces subjective complaints, normalizes laboratory indicators (activity of transaminases, gamma-glutamyltransferase, alkaline phosphatase, bilirubin level). Long-term use significantly increases the survival rate of patients suffering from cirrhosis of the liver.

 

Indications

  • toxic liver damage (alcoholism, intoxication with halogenated hydrocarbons, heavy metal compounds, medicinal liver damage) and their prevention;
  • chronic hepatitis;
  • cirrhosis of the liver (as part of complex therapy);
  • state after infectious and toxic hepatitis;
  • dystrophy and fatty liver;
  • correction of lipid metabolism disorders.

 

Forms of release

 

Capsules 300 mg.

 

Tablets 500 mg.

 

Powder.

 

Oil for internal use (made by squeezing out milk thistle seeds).

 

Instructions for use and how to use them

 

Butter

 

Adults and children over 12 years of age on 0.5 teaspoon 2 times a day during meals. The course of admission is 30 days.

 

Capsules

 

Adults and children over 12 years of age 5 capsules 2 times a day with meals. The course of admission is 30 days.

 

Side effect

  • diarrhea;
  • allergic reactions;
  • children's age till 12 years;
  • hypersensitivity to the components of the drug.

 

Contraindications

  • hypersensitivity.

 

Application in pregnancy and lactation

 

There is no evidence of adverse effects of the drug on reproductive function in animals. During pregnancy and during breastfeeding it can be used for medical reasons and if the benefit of treatment with the drug exceeds the risk to the fetus.

 

Use in children

 

Contraindicated in children under 12 years.

 

special instructions

 

Treatment of Milk thistle can not replace a diet or a refusal of anything in case of liver damage (for example, from alcohol).

 

With caution should be used in patients with hormonal disorders (endometriosis, uterine myoma, breast carcinoma, ovaries and uterus, prostate carcinoma) because of the possible estrogen-like action of silymarin.

 

In patients with impaired digestion due to hepatic disease, it leads to better appetite and weight gain. It is mistakenly believed that the drug can be used for weight loss, but this is not true, the metabolic processes in the diseased organism are normalized.

 

In folk medicine, oil, seeds, cake and cake are widely used, remaining after extruding the oil from the seeds of milk thistle.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Milk thistle does not adversely affect the ability to drive vehicles and work with machines.

 

Drug Interactions

 

With the combined use of milk thistle with oral hormonal contraceptives and drugs intended for hormone replacement therapy, it is possible to reduce the effects of the latter.

 

Silymarin may enhance the effects of diazepam, alprazolam, ketoconazole, lovastatin, vinblastine because of its inhibitory effect on the microsomal enzymes of the cytochrome P450 system.

 

Analogues of the drug Thistle

 

Structural analogs for the active substance:

  • Karsil;
  • Karsil Forte;
  • Legalon;
  • Silegon;
  • Silibinin;
  • Sylimar;
  • Silymarin.

 

Analogues for the pharmacological group (hepatoprotectors):

  • Antraliv;
  • Berlition;
  • Bondjigar;
  • Brentzialle forte;
  • Vitanorm;
  • HepaMerz;
  • Gepabene;
  • Hepatosan;
  • Hepatofalk the plant;
  • Hepafor;
  • Heptor;
  • Heptral;
  • Heptrog;
  • Glutargin;
  • Dipan;
  • Covechol;
  • Karsil;
  • Laennek;
  • Legalon;
  • Liv 52;
  • Livedoksa;
  • Livolife Forte;
  • Lipoic acid;
  • Maxar;
  • Methionine;
  • Metrop;
  • Moliksan;
  • Octolipen;
  • Ornitsetil;
  • Progepar;
  • Resalute Pro;
  • Ropren;
  • Sibektan;
  • Silegon;
  • Silymarin;
  • Sirepard;
  • Thiolipone;
  • Tiotriazolin;
  • Tyqveol;
  • Urdoks;
  • Ursodez;
  • Ursodeoxycholic acid;
  • Ursodex;
  • Ursuliv;
  • Ursor;
  • Ursosan;
  • Ursofalk;
  • Phosphogliv;
  • Phosphogliv Forte;
  • Phosphontsiale;
  • Hepabos;
  • Holudexan;
  • Exxhol;
  • Erbisol;
  • Eslidine;
  • Essentiale;
  • Essentiale forte N;
  • Essential phospholipids;
  • The Essler;
  • Essliver forte.

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Reviews (67):
Guests
Alexey
Three years ago I took tests for surgery, I have been a carrier of Hepatitis B for more than 20 years! After the operation (hernia) I heard from an elderly woman that the liver cleanses the milk thistle! I took 2 tablets after each meal - about 3 years! Now he again passed the tests (medical examination at work) - Hepatitis NO !? Has handed over once again more full analysis - the Hepatitis In - Is not revealed !!! Thank God there are miracles!
Administrators
admin
Alexey, Rarely, but such miracles happen. As an option - the first diagnosis with which you then lived so much was unreliable. Although you should have passed the test for this period for hepatitis and more than once. There are a lot of options, but I'm glad that everything is fine with you now.
Guests
Alyona
Periodically, she drank it for 5 years, helped with gravity in the right side. But recently, when I drink milk thistle, my head begins to ache very badly.
Guests
vladimir
I liked it, but can I use it with alcohol?
Administrators
admin
vladimirYou can do it, but why. Simultaneously we treat a liver thirsty and cripple alcohol, you look and we leave on a zero result? It does not work out that way. And in general I'm against using drugs with alcohol.
Guests
EGOR
I accept terbinafine, milk thistle will normally be to protect the liver?
Administrators
admin
EGORIf the liver does not bother and does not manifest itself (pain in the right hypochondrium, bitterness after a meal or in the morning), it's okay, you can and milk thistle poprinimat.
Guests
Milan
Prompt, please, uzi have diagnosed a chronic cholecystitis. Is it possible to drink milk thistle with such a diagnosis?
Administrators
admin
Milan, It is possible, but why. Milk thistle acts positively on liver cells, and on the ducts (which is the basis of cholecystitis) almost does not affect.That is, to support the liver, this drug can be used, but in combination with other treatment for chronic cholecystitis.
Guests
Irina
Tell me, please, how to drink milk thistle powder, I was prescribed 1 h spoon, boil?
Administrators
admin
Irina, Milk thistle powder is taken dry, you do not need to boil anything. Usually 1 teaspoonful 3 times a day for 15-20 minutes before a meal, washed down with water.
Visitors
mamil17
Tell me, and after 30 days, when I drank a course, when can I apply it again?
Administrators
admin
mamil17, Indicate the next time the diagnoses for the treatment of which you are taking this or that drug. Usually, preparations based on milk thistle take a course for a month with a frequency of 2 times a year. That is, in your case, with the standard dosage, the next monthly course of admission should occur six months later.
Visitors
Kara
My husband drank a milk thistle for a month. He wants to lose weight.The result is a small one. Saw capsules 5 capsules 2 times a day with food + eating powder too 2 times a day. Could it be so? Will there be any consequences now? And can I drink again in a half year? If yes, in what doses should I take capsules and powder at the same time?
Administrators
admin
KaraFrom milk thistle, they get fatter. More precisely, this natural remedy regulates the balance of nutrients and they are better absorbed, which can lead to a set of excess weight, although obesity can not be explicitly obtained with such a reception scheme. I would start losing weight with a diet and increasing physical activity, these are two pillars of weight loss, if with endocrinology everything is in order.

And such a scheme as your husband drank, I would not adhere to. It is better to take one or capsule, or take the powder in the dosage that you unsubscribed. Although this is a natural remedy, but it contains oil, it means that substances (flavonoids, saponins and others) can accumulate in the liver, which can potentially lead to their overdose. And once every six months, I can repeat the course, not as intense as your husband is now.
Visitors
Cyrus
Hello, after taking postinore, the liver has increased and the second day does not return to normal. I bought a milk thistle, how it is better to take in this case and through how much the liver to decrease?
Administrators
admin
CyrusIs there any certainty that it will decrease from milk thistle? Ultrasound of the abdominal cavity and liver have been made, biochemical analyzes with determination of hepatic enzymes are handed over or the increase is diagnosed independently and approximately, that is, it really is or only seems. If everything is fine there, then you can try the milk thistle in the dosages indicated in the instructions (the form of the release, the milk thistle you bought is not indicated in the question, you can not say more specifically). It is better to consult on this issue with a doctor - therapist or gastroenterologist internally, since if the liver enlargement really is, then the question is serious.
Guests
Alan
Is anyone really helped the milk thistle?
Administrators
admin
Alan, Milk thistle, like any natural remedy, is very weak and it is necessary to take this remedy for a long time so that at least some result can be seen. And still it is necessary to take into account the degree of liver damage. If this is an elderly person who used alcohol all his life, took various medications, hepatotoxic including, or worked in harmful production, lived permanently in a large city, of course, the milk thistle will help him poorly, then to restore the structure of the liver it is better to use essential phospholipids and their analogues, as the stronger components of liver restoration. And a young man who has diffuse changes in the liver of Milk thistle is just right. One course of admission will be sufficient, and the subsequent restoration of the structure of this organ will be completed by the body itself.
Hello. I want to ask if you can take milk thistle, if there are stones in the gall bladder?
Administrators
admin
Lyudmila39275472, In your situation, it all depends on the size and number of stones,since the milk thistle despite its naturalness has a choleretic effect and thus can provoke the release of stones into the ducts (in the worst case), provoking biliary colic and other troubles caused by obstruction of the bile ducts.
Guests
Michael 41
Hello. I want to consult with you. I was found in the liver whether hemangioma, or hyperplasia - is not clear. All this against the background of fatty hepatosis of the 1st degree. Everything is asymptomatic. Is it possible to take milk thistle for liver treatment in this situation?
Administrators
admin
Michael 41Until an accurate diagnosis is made, you can take medications based on butter and Milk thistle, the harm will not be accurate, but the benefit ... There is already a controversial issue. Judging by the description of the problems of herbal medicines you will not be enough and most likely after a precise diagnosis you need to take stronger hepatoprotectors.
Guests
Nadina
Good afternoon! I want to consult. Recently, on the face and on the body appeared pigmented spots.As far as I know, it's a call about not very good liver health. Has decided to spend on drink a milk thistle. I drink for 1 tsp. powder before eating. The question is: how long should such a course of treatment take and whether the milk thistle will help in my case?
Administrators
admin
Nadina, Address better to the dermatologist. And then the causes of age spots can be a lot - problems with the liver, sun, senile spots. An amateur can hardly distinguish a particular type.

Milk thistle according to the scheme you specify can be taken within 30 days. It will not be worse for sure, but to say unequivocally that this will have an effect I can not, not enough introductory for diagnostics and to watch it is necessary to live.
Guests
Tatyana
Hello, in the instruction of milk thistle it is written, that it is necessary to accept with care, if there is an endometriosis or a myoma of a uterus. It may be worth stopping, although I would not want to, because the heaviness in the hypochondrium is due to the milk thistle.
Administrators
admin
Tatyana, This means that before taking such medications it is necessary to consult a specialist (in your case a gynecologist) in order to assess the consequences of such treatment,based on the diagnosis and course of the disease. Basically, of course, the reception of Milk thistle is allowed, but it's worthwhile to see a doctor.
Guests
Olga Lelina
I bought a capsule of milk thistle in a pharmacy in a package of 100 pieces. This amount is enough for 8 days (4 capsules 3 times a day). Decided to buy more, so as not to run afterwards, but there were no capsules in one pharmacy, I had to buy pills in order not to interrupt the course. Is there any difference that I started with capsules, then I switch to tablets, and in the future maybe capsules in the pharmacy?
Administrators
admin
Olga Lelina, Nothing wrong. These are products of vegetable origin and inside it is still the same milk thistle. Especially with herbal preparations you can not guess which form will shoot better, which producer has managed to preserve in quality all the useful things contained in the plant, that's all you will try.

Just see the dosage of tablets and capsules is different, see what disease you prescribed the doctor's doctor and look for the same diagnosis in the instructions to the tablets so that the replacement is adequate.
Guests
Leila
Tell me, but for prevention, you can drink thistle?
Administrators
admin
Leila, It is possible, if there are harmful for the liver (ecology, harmful working conditions, the reception of "heavy" drugs). If everything is good, the liver is healthy and there is no harmfulness, then it is better to buy fruits and do not think about diseases.
Administrators
admin
Visitor feedback marina moved to the required section:
After ARVI got a complication - the liver and pozh.zheleza were sick and at the same time in the house they made san.obrabotku, they breathed in this muck. I bought a meal of milk thistle for 2 ts.lozki a day during meals, after 10 days no pain, and even in addition, I lost 700 grams. the chair became daily.
Guests
Luminous
Tell me please! We were prescribed Milk Thistle when diagnosed with acute obstructive bronchitis 1 to 2 times a day for a child of 10 months, and in the instructions I do not see the need. To give him or not, I do not dare. Tell me what to do?
Administrators
admin
Luminous, Milk thistle has nothing to do with the treatment of obstructive bronchitis. Probably, the child is appointed from something else. It is worthwhile to ask what the attending physician.
Guests
Alyona
Viral hepatitis C, inactive. Can I take milk thistle in capsules for a long time? I read a lot of positive about this drug, I want to buy.
Administrators
admin
Alyona, It will not be worse for sure. As a biologically active food additive for liver maintenance, the milk thistle in any dosage form is the ideal drug, but if the liver suffers heavily, it may be necessary to take a course of stronger hepatoprotectors.
Guests
1234
Can my head hurt with milk thistle?
Administrators
admin
1234, Headaches with the use of milk thistle preparations are not typical. You can try to cancel the medicine and see what will become of the headache.
Guests
Edgard
I take the essence of fort. He, too, as you know, for the liver. Can I still take the milk thistle powder? I think they will not interfere with each other.
Administrators
admin
Edgard, Butter-oil. Both drugs have similar effects and I would stop at one thing or alternate. Also, the tactics of the appointment depend on the stage of the liver damage, if the light course - you can take herbal preparations based on milk thistle, if the situation is worse - it is better to take "chemistry".
Guests
Vitaliy
Can I take milk thistle in capsules to improve the liver, if in passing chronic pancreatitis, there is still seed oil?
Administrators
admin
Vitaliy, One does not interfere. If you are confused by this, try taking hepatoprotectors based on chemistry or essential phospholipids (Essentiale, Heptral, Ursosan, Ursofalk and others), or on the basis of herbs (Liv 52).
Visitors
Xenic
Hello. I suffer from seasonal allergies (birch pollen). The friend, works in pharmaceutics, advised before the beginning of the alerg. season drink Liverpool forte in capsules, supposedly the liver will become cleaner - the allergy will decrease. Tell me, is this true? To the allergist far, do not send.
Administrators
admin
Xenic, There are in the allergology the opinion that all problems with allergies in a person from a suffering liver. As the exact and unambiguous reasons for the occurrence of allergic diseases in humans, modern medicine does not know, then this technique takes place. About Liversil Forte I will not say, apparently some kind of dietary supplements based on milk thistle, so it will not be worse exactly. And suddenly it will help ...
Visitors
LuckyAnn
Good afternoon!
I'm 31 weeks pregnant. Today the doctor received regular results of blood tests, liver biochemistry indicators are overestimated 2 times. Diagnosis of the doctor: cholestatic hepatosis of pregnant women. Tell me, please, can I use milk thistle for treatment? If yes,then in what form and what daily dosage to apply to help the liver in this not a simple period? Earlier (a year ago) I used capsules for prevention of a monthly course.
Thanks for the help!
Administrators
admin
LuckyAnn, The dosage of the medication is guided by the attending physician, including the one who is watching your pregnancy. I can only say that the milk thistle may not be enough (after all, the herbal preparation is not always effective enough) and can connect hepatoprotectors stronger than the same Urososan, Ursofalk and other medicines. In exceptional cases, they can be used during pregnancy. Of course, it is necessary to comply with the diet (excluding fried, fatty, spicy, salty foods).
Guests
phasius
Hello. You can drink thistle extracts when planning a pregnancy?
Administrators
admin
phasiusWhen planning pregnancy, preparations based on the milk thistle can be taken. But during pregnancy, you can only on the appointment of a doctor,because the use of these funds on pregnant women is not checked and what effects can occur are unknown. Basically everything goes fine, but I also have a small sample of these patients, statistical methods on small figures often work incorrectly.
Guests
Marina A.
Hello. The ultrasound of the trouser cavity showed a change in liver size (about 2 cm) and obesity. Still at me a problem with shchitovidkoj. The doctor advised to use a powder of milk thistle once on an empty stomach, within a month. Tell me, please, what is more effective powder or tablets? Thank you.
Administrators
admin
Marina A., Tablets are more convenient to use. In all other respects, there is no particular difference in the use of any medicinal form of milk thistle.
Guests
Lera
Good morning. Has handed over analyzes on hepatitises, have revealed a hepatitis with, whether the milk thistle will help or assist? Saw a long time antibiotics and of course the biochemistry tests are very bad and do not know what to do.
Administrators
admin
Lera, Milk Thistle with Hepatitis C as a dead poultice. You need special antiviral drugs - Ribavirin, Sofosbuvir, Daklatasvir and others, which are appointed by the infectious disease doctor, to which you should be directed.
Visitors
9650071941
Hello. You are worried by Timakov Alexander Petrovich. I am 59 years old. I have constantly raised "bad cholesterol." In the last year its level is 7.05 m / mole. He was treated with statins and observed the diet prescribed by the therapist, but below 6.5 m / mol the level of "bad cholesterol" did not decrease. In principle, I always have nutritional restrictions that "can not", then I do not use them. Only now I do not use medicine. Tell me how to use milk thistle and what period. And one more question. Where can I buy a device for measuring "bad cholesterol" at home.
Visitors
fedorenkon12
Does the milk thistle help with chronic pancreatitis? If so, can it be taken with Creon?
Administrators
admin
9650071941I will not tell you about the device, it seems to me to use them conditionally and first check whether the portable devices show the same results as the usual biochemical blood test (from the vein). That is, to fix the day of taking biochemistry cholesterol values, which showed the device and compare it with stationary values. True fraction of cholesterol (HDL and LDL) household appliances did not learn to fix (but may already exist, I do not follow this topic).

Milk thistle can be considered as a biological supplement, and not as a panacea in your case, especially if the level of low-density lipids (the same bad cholesterol or LDL) could not reduce statins, it is unlikely to show significant results. But for the liver it will be good.
Administrators
admin
fedorenkon12, With Creon you can, do no harm. Benefit? The liver of thanks will say, but if there are serious problems with this organ (which is often the case with chronic pancreatitis) it is worth using more powerful drugs, for example, based on essential phospholipids (Essentiale, Essliver and others) or ursodeoxycholic acid (Ursosan, Ursosan and others).With this question, you should contact your doctor.
Visitors
Ganeva
Ganeva, Your question is transferred to the drug Atorvastatin, where it is more appropriate.
admin
Guests
Snezana
Has got thistle in capsules (has decided to clean a liver). But on the nose New Year holidays and without alcohol will not do. Can I start a course now, or is it better after the holidays?
Guests
Lusi
Good afternoon. The ultrasound revealed a bend of the gallbladder, the doctor appointed Ursosan, whether it was possible to take Urchosan instead of Ursosan, capsules 0.3 g? I bought the instruction in the pharmacy, on the box, take 1 capsule 3 times a day, the friend has the same just another manufacturer, in the instruction for 4 capsules 3 times a day. So how is it right?
Administrators
admin
Snezana, It is unprincipled. The ideal time for taking medications like thistle is still now. The negative impact of ecology, nutritional factors, alcohol or smoking is present in modern man almost always.
Administrators
admin
Lusi, Correct as described in the instructions. Milk thistle is the herb, how much active ingredient is put into the capsule, the manufacturer has to take so much and must be taken, which he indicated in the instructions to his medicine. And yes, preparations based on milk thistle will in any case be weaker than Ursosana.
Guests
Lyudmila
Tell me, please, is it possible to take milk thistle if a cyst is found on the liver? And is it possible with any drug to reduce the size of the cyst?
Guests
Tatyana
Hello. Tell me, please, can a child of 12 years with a diagnosis of hepatosis of the liver take an extract of milk thistle (in tablets) bad from the equalar? And whether there will be from it any effect?
Administrators
admin
LyudmilaIf a small cyst size is up to 1 cm, then it is possible. If it is more, internal consultation of the doctor is necessary. It is doubtful that it is the use of thistle to help get rid of the cyst, especially if it is large, but you can try. If doctors advise you for surgery, then it is unlikely that conservative treatment will have tangible results.
Administrators
admin
Tatyana, Hepatosis in children usually does not occur without any apparent cause. These are not elderly people who have similar changes in the liver due to prolonged exposure to toxins, improper lifestyle, nutrition, so you can take the milk thistle (I do not know about the specific dietary supplements, but I looked at the composition of Milk thistle extract in tablets, nothing like that is not contained) but it is necessary to eliminate the cause as a result of which the child developed hepatosis (infection, malnutrition and others), otherwise treatment will not give a special effect.
Guests
Pafnutiy
Remark - preparations of milk thistle can cause allergy, even dangerous - it would be good to make a special emphasis on this. Less dangerous are extracts, the cake is more "allergenic".
I have a question. I take 2 years of courses for 3-4 months a year, Karsil or Legalon. On ultrasound, obesity of the liver, the liver is compacted, but of normal size. In a year the same, but the liver is also increased by 2 cm. I adhere to the non-alcoholic life, fatty meow is also rare.Increased cholesterol, constantly. Whether there is a sense to continue to accept an extract of a thistle, or there is no sense? And can somehow the extract affect the heart rate? Thank you.
Administrators
admin
PafnutiyIf you take Karsil, Milk Thistle and Legalon and nothing happens, you might want to switch to preparations of essential phospholipids (Essentiale, Esliver and others) or ursodeoxycholic acid (Ursosan, Ursofalk and others). Natural and near-natural drugs help with minor or functional disorders, and if there are organic changes, then a rigid diet, weight control, treatment and periodic monitoring. The effects on the heart rate in the instructions to the milk thistle are not described from practice with a similar one also did not come across.

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