Paracetamol - instructions for use, analogs, reviews and release forms (tablets 200, 325 and 500 mg, suspension and syrup for children, suppositories) for antipyretic and analgesic effect in adults, children and during pregnancy

In this article, you can read the instructions for using the drug Paracetamol. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Paracetamol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Paracetamol in the presence of existing structural analogs.Use as an antipyretic and analgesic in adults, children, as well as during pregnancy and lactation.

Paracetamol - non-narcotic analgesic, blocks COX1 and COX2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX, which explains the almost complete absence of anti-inflammatory effect. The absence of a blocking effect on the synthesis of Pg in peripheral tissues causes the absence of a negative effect on water-salt metabolism (Na + and water retention) and the mucous membrane of the gastrointestinal tract.

Pharmacokinetics

Penetrates through the BBB. Less than 1% of the dose of paracetamol taken by the lactating mother penetrates into breast milk. Metabolised in the liver. It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged.

Indications

Applied in adults and children from 3 months to 12 years as:

• antipyretic agents for acute respiratory infections, influenza, childhood infections, post-reaction reactions and other conditions accompanied by fever;
• painkiller with pain syndrome of mild and moderate intensity, including: headache and toothache, muscle pain, neuralgia, pain with injuries and burns.

Forms of release

Tablets 200, 325 and 500 mg.

Syrup 125 mg (for children).

Suspension for ingestion 120 mg (pediatric form of paracetamol).

Rectal suppositories for adults and children - 50, 100, 250 and 500 mg.

Instructions for use and dosage

Inside. Adults and adolescents over 12 years: 1-2 tablets up to 4 times a day (not more than 4 g per day).

Children: at the age of 6-12 years - 0.5-1 table. 4 times a day, up to 6 years (from 3 months) - 10 mg / kg.

The dosage of syrups, suspensions and suppositories is calculated on the basis of the norms given above in terms of the active substance.

Side effect

• allergic reactions (including skin rash, itching, angioedema);
• disorders of hematopoiesis (anemia, thrombocytopenia, methemoglobinemia).

Contraindications

• hypersensitivity;
• the period of newborns (up to 1 month).

Carefully:

• renal and hepatic impairment;
• benign hyperbilirubinemia (including Gilbert's syndrome)
• viral hepatitis;
• blood diseases (leukopenia, thrombocytopenia);
• early infancy (up to 3 months).

special instructions

Paracetamol should not be used concomitantly with other paracetamol-containing drugs, as this can cause an overdose of paracetamol. When using the drug for more than 5-7 days, it is necessary to monitor the peripheral blood and the functional state of the liver. Paracetamol distorts the results of laboratory studies of glucose and uric acid in the blood plasma.

Drug Interactions

Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which makes it possible to develop a hepatotoxic effect with small overdoses. Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects. When taken together with salicylates, the nephrotoxic effect of paracetamol increases. The combination with chloramphenicol leads to an increase in the toxic properties of the latter. Strengthens the effect of anticoagulants of indirect action and reduces the effectiveness of uricosuric drugs.

Analogues of the drug Paracetamol

Structural analogs for the active substance:

• Akamol-Teva;
• Aldolor;
• Apap;
• Acetaminophen;
• Children's Panadol;
• Children's Tylenol;
• Ithymol;
• Kalpol;
• Xoomapar;
• Lupocet;
• Mexalen;
• Pamol;
• Panadol;
• Perfalgan;
• Prohodol;
• Sanidol;
• Strymol;
• Tylenol;
• Febricet;
• Cefekon D;
• Efferalgan.

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