Kokarboksilaza - instructions for use, analogs, reviews and release forms (injections in ampoules for intravenous and intramuscular injections of hydrochloride) drug for the treatment of acidosis and coma in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Cocarboxylase. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Cocarboxylase in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Co-carboxylase in the presence of existing structural analogs.Use for the treatment of acidosis, diabetic coma and hepatic and renal failure in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Cocarboxylase - coenzyme, formed in the body of thiamine. Has a metabolic action, activates tissue metabolism. In the body it is phosphorylated to form mono-, di- and triphosphoric esters; kokarboksilaza is a part of the enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, promotes the formation of acetyl-coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids.

Improves the absorption of glucose, trophic nervous tissue, contributes to the normalization of the functions of the cardiovascular system.

Deficiency of cocarboxylase causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and an acidotic coma.

Composition

Cocarboxylase hydrochloride + excipients.

Indications

• metabolic acidosis;
• Hyperglycemic coma and acidosis in diabetes mellitus;
• liver failure;
• kidney failure;
• respiratory acidosis in chronic, cardiopulmonary insufficiency;
• respiratory insufficiency;
• chronic circulatory failure;
• IHD;
• myocardial infarction and postinfarction cardiosclerosis (as part of complex therapy);
• acute alcohol poisoning;
• chronic alcoholism;
• poisoning with digitalis, barbiturates;
• intoxication with infectious diseases: diphtheria, scarlet fever, typhus and paratyphus (in complex therapy);
• peripheral neuritis.

In children during the newborn period:

• perinatal hypoxic encephalopathy;
• respiratory insufficiency;
• pneumonia;
• sepsis;
• hypoxia;
• acidosis.

Forms of release

Lyophilizate for the preparation of solution for intravenous and intramuscular injection (injections in ampoules for injections).

There are no other medicinal forms, be they pills or candles.

Instructions for use and usage diagram

Adults are given intramuscularly or intravenously. The dose is 50-200 mg per day. In diabetes (acidosis, coma) daily dose can be 0.1-1 g. Frequency and duration of use depends on the indications.

Children - in / m, in / in (drip (dropper) or jet), the newborn - sublingual. Children under 3 months - 25 mg per day, from 4 months to 7 years - 25-50 mg per day, from 8 to 18 years - 50-100 mg per day. Duration of treatment - from 3-7 to 15 days.

Side effect

• allergic reactions (hives, itching);
• hyperemia, itching and swelling at the injection site.

Contraindications

• hypersensitivity to cocarboxylase.

Application in pregnancy and lactation

Concerning the effectiveness and harmlessness of the use of cocarboxylase during pregnancy, medical studies have not yet been conducted. Therefore, there is no reliable data on the contraindication of cocarboxylase at this time. Consultation of the doctor is necessary.

Use in children

The application is possible according to the dosing regimen.

special instructions

Without features.

Drug Interactions

Strengthens cardiotonic action of cardiac glycosides and improves their tolerability.

Analogues of the drug Cocarboxylase

Structural analogs for the active substance:

• Cocarboxylase Imprus;
• Ferein cocarboxylase;
• Elar's cocarboxylase;
• Cocarboxylase hydrochloride.

Analogues for the pharmacological group (funds for the treatment of acidosis):

• Alpha D3 Teva;
• Dimephosphone;
• Kalinor;
• Quintasol;
• Sodium bicarbonate;
• Composite sodium lactate;
• Stylamine;
• Trometamol N.

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