Regein - instructions for use, reviews, analogs and formulations (solution, lotion or shampoo 2% and 5% for external use) of the drug for the treatment of baldness in men and women, including during pregnancy and feeding. Composition

In this article, you can read the instructions for using the drug Regeyn. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Regeyn in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Regein in the presence of existing structural analogues.Use to treat baldness in men and women, including during pregnancy and lactation. Composition of the preparation.

Regeyn - a drug for the treatment of alopecia (baldness). It has a stimulating effect on hair growth in people with androgenic alopecia. The appearance of signs of hair growth is observed after 4 months or more of the drug. The onset and severity of the effect may vary in different patients. A 5% solution of the drug stimulates hair growth more than 2% solution, which has been shown to increase the growth of cannon hair.

After drug cancellation, the growth of new hair is suspended, and within 3-4 months it is possible to restore the original appearance.

The exact mechanism of action of the drug Regein in the treatment of androgenetic alopecia is unknown.

Composition

Minoxidil + auxiliary substances.

Pharmacokinetics

With external application, Regein is poorly absorbed through normal undamaged skin: on average, less than 1.5% (0.3-4.5%) of the total applied dose enters the systemic circulation. The effect of concomitant skin diseases on the absorption of Minoxidil is unknown. The profile of the metabolic biotransformation of minoxidil after external application of the drug Regein has not been fully studied to the present.Minoxidil does not bind to blood plasma proteins, does not penetrate the blood-brain barrier (BBB). After discontinuation of the drug, approximately 95% of minoxidil, which enters the systemic circulation, is excreted within 4 days. Excreted mainly with urine by glomerular filtration.

Indications

• androgenic alopecia in men and women (to restore the hair and stabilize the process of hair loss).

Forms of release

Solution for external use 2% and 5%.

Other dosage forms, be it foam, shampoo or lotion, do not exist.

Instructions for use and how to use them

The drug is intended for external use only on the scalp. Do not apply the drug to other parts of the body.

Regain is applied to the affected areas of the scalp at a dose of 1 ml 2 times a day, starting from the center of the affected area. The drug is used in this dose, regardless of the size of the treated areas of the scalp. The total daily dose should not exceed 2 ml.

Patients who do not have cosmetically satisfactory hair growth when using a 2% solution, and patients who require faster hair growth, a 5% solution can be used.

For men, Regein is most effective in hair loss on the vertex, for women - with hair loss in the middle part.

Terms of use

Regein is applied only to the dry skin of the scalp. The method of application depends on the applicator used, as described below. If the drug is applied with the fingertips, after handling the head, hands should be thoroughly washed.

A. Pulverizer

This nozzle is suitable for applying the drug to large areas of the scalp.

1. Remove the large outer cap and inner screw cap from the vial.

2. Place the spray gun on the bottle and screw it tightly.

3. Remove the transparent cap.

4. Direct the head of the atomizer to the center of the affected area, press the valve and distribute the drug throughout the site of baldness with your fingertips. To apply a dose of a solution of 1 ml repeat this operation only 6 times.

5. Avoid inhalation of aerosol. After use, put on the bottle a transparent cap and a large outer cap.

B. Extended spray nozzle

This nozzle is suitable for applying the drug to small areas of baldness or for treating the skin underpreserved hair.

1. To use the extended nozzle on the bottle, a spray gun must be installed. Execute items A1 and A3 (see above).

2. Remove the small spray head from the spray gun, strengthen the extended spray nozzle onto the spray gun sleeve. Remove the small cap from the end of the extended nozzle.

3. Using the nozzle in the center of the area of ​​alopecia, press the spray gun 1 time, then distribute the drug with your fingertips over the entire area, lightly rubbing into the skin. To apply a dose of a solution of 1 ml repeat this operation only 6 times.

4. Avoid inhalation of aerosol. After use, you can put the cap on the end of the extended nozzle.

C. Nozzle for rubbing

This nozzle is suitable for applying the drug to small areas of alopecia.

1. Remove the large outer cap and inner screw cap from the vial.

2. Install the nozzle for rubbing on the bottle and screw it tightly.

3. Holding the bottle upright, squeeze the bottle in such a way as to fill the upper chamber to the black line. The chamber holds one full dose (1 ml of solution).

4. Turn over the vial, massage the scalp with the scalp so as to process the entire area of ​​alopecia, until the chamber is emptied.After use, put on a large outer cap on the bottle.

Clinical experience of the drug shows that the appearance of the first signs of hair growth stimulation is possible after applying the drug 2 times a day for 4 months or more. The onset and severity of hair growth, as well as the quality of the hair, can fluctuate in different patients.

According to individual reports, recovery of the initial appearance can be expected within 3-4 months after discontinuation of treatment.

Side effect

• dermatitis of the scalp;
• itching of the scalp;
• allergic contact dermatitis;
• folliculitis;
• alopecia;
• unwanted hair growth;
• seborrhea;
• nonspecific allergic reactions (skin rash, urticaria);
• swelling of the face;
• dyspnea;
• allergic rhinitis;
• headache;
• dizziness;
• neuritis;
• pain in the chest;
• fluctuations of blood pressure;
• cardiopalmus;
• changes in the rhythm of heartbeats;
• edema.

Contraindications

• children and adolescents under 18;
• age over 65;
• violation of the integrity of the scalp;
• dermatosis of the scalp;
• hypersensitivity to minoxidil and other components of the drug.

Application in pregnancy and lactation

The effect of the drug Regain on pregnancy is unknown. With systemic absorption, minoxidil is excreted in breast milk.

Reagain should not be used during pregnancy and lactation.

Use in children

Contraindicated in children and adolescents under the age of 18 years.

special instructions

Before starting treatment with Regein, patients should undergo a general examination, including the collection and study of medical history. The physician should make sure that the scalp skin is healthy.

Although the effects listed below were not observed when the Regene drug was applied to the skin, minoxidil is absorbed in small amounts through the skin in small amounts, and there is a risk of systemic side effects such as water and salt retention, generalized and local edema, pericardial effusion, pericarditis , pericardial tamponade, tachycardia, angina pectoris, increased orthostatic hypotension caused by some antihypertensive agents, for example, guanethidine and its derivatives. The appointment of the drug Regein to patients with hypertension receiving treatment with guanethidine or derivatives of guanethidine, or minoxidil, is possible only under medical supervision.

Patients should undergo periodic examinations to identify possible signs of systemic side effects of minoxidil. When systemic side effects occur, treatment should be discontinued. To treat edema and fluid retention in the body, if necessary, diuretics can be prescribed. To eliminate tachycardia and angina, beta-blockers can be prescribed. Patients with cardiovascular disease in a history should be warned that treatment with the drug Regein can cause an aggravation of these diseases.

When systemic side effects or severe skin reactions occur, patients should cancel the drug and consult a doctor.

The effect of the drug Regein in patients with a violation of the integrity of the skin and with dermatosis of the scalp at the place of application of the drug is unknown.

The safety and efficacy of Regein for patients younger than 18 years and over 65 years of age have not been established.

The composition of the drug Regein includes ethyl alcohol, which can cause inflammation and eye irritation. In case of getting the drug on sensitive surfaces (eyes, irritated skin,mucous membranes), it is necessary to wash the affected area with a large amount of cold water.

Accidental ingestion of the solution inside may lead to serious consequences. The observed symptoms mainly affect the cardiovascular system and include fluid retention, lowering blood pressure or tachycardia. Patients should be warned about the need to store Regein (as well as other medicines) in a place inaccessible to children. If the drug has become unusable or has expired, then you can not pour it into the waste water or throw it into the street; place the drug in a bag and put it in a trash can. These measures will help protect the environment.

Drug Interactions

There is a theoretical possibility of strengthening orthostatic hypotension in patients receiving concomitant treatment with peripheral vasodilators, which, however, did not receive clinical confirmation.

We can not rule out a very slight increase in minoxidil in the blood in patients with hypertension and taking minoxidil inward in the case of simultaneous use of the drug Regein, although relevant clinical studies have not been conducted.

It has been established that minoxidil for external use can interact with some other drugs for external use.

The simultaneous use of a solution of minoxidil for external use and cream containing Betamethasone (0.05%) leads to a decrease in the systemic absorption of minoxidil. Simultaneous use of cream containing Tretinoin (0.05%) leads to increased absorption of minoxidil. The simultaneous application of minoxidil to the skin and preparations for external use such as tretinoin and dithranol, which cause changes in the protective functions of the skin, may lead to an increase in the absorption of minoxidil.

Analogues of the drug Regeyn

Structural analogs for the active substance:

• Alerana;
• Alopexy;
• Generolon;
• COSILON;
• Minoxidil;
• Revasil.

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