Lokoid - instructions for use, analogs, reviews and release forms (ointment, Lipocream and Emulsion Kremo or lotion 0.1%) hormonal medication for the treatment of psoriasis, eczema and dermatitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Lokoid. Comments of visitors of the site - consumers of this hormonal medication, as well as opinions of doctors of specialists on using Lokoid in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Lokoid in the presence of existing structural analogs. Use for the treatment of psoriasis, eczema and dermatitis in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Lokoid - synthetic non-halogenated glucocorticoid drug for external use. The esterification of the Hydrocortisone molecule with the residue of butyric acid (butyrate) made it possible to radically increase the activity of the preparation as compared to native hydrocortisone. Has a rapidly advancing anti-inflammatory, anti-edematous, antipruritic effect.

The use of Lokoid in the recommended doses does not cause suppression of the hypothalamic-pituitary-adrenal system. Although the use of the drug in high doses for a long time, especially with the use of occlusive dressings, can lead to an increase in the level of cortisol in the blood plasma, it is usually not accompanied by a decrease in the reactivity of the pituitary-adrenal system, and the withdrawal of the drug leads to a rapid normalization of cortisol production.

Composition

Hydrocortisone 17-butyrate + auxiliary substances.

Pharmacokinetics

After application, the active substance accumulates in the epidermis, mainly in the granular layer. Systemic absorption is negligible. A small amount of hydrocortisone 17-butyrate is absorbed into the systemic blood stream unchanged.Most hydrocortisone 17-butyrate is metabolized to hydrocortisone and other metabolites directly in the epidermis and, subsequently, in the liver. Metabolites and a small part of unchanged hydrocortisone 17-butyrate are excreted with the kidneys and through the intestine.

Indications

Superficial, uninfected, sensitive to local glucocorticosteroids (SCS) skin diseases:

• eczema;
• dermatitis (including atopic, contact, seborrheic);
• psoriasis.

Forms of release

Ointment for external use 0,1%.

Cream for external use 0,1% (Lokoid Lipocream).

Emulsion for external use 0.1% (Lokoid Krelo) (sometimes mistakenly called lotion).

Instructions for use and how to use them

Ointment

Outwardly.

A lokoid in the form of an ointment is used in subacute and chronic processes, especially in the presence of lichenification, infiltration, dryness.

The drug is applied to the affected areas of the skin with a thin layer 1-3 times a day. When there is a positive dynamics, the frequency of application of the drug can be reduced to 2-3 times a week. To improve penetration, the drug is applied by massaging movements.In cases of refractory disease, for example, in the localization of dense psoriatic plaques on the elbow areas, the knees, the drug can be used under occlusive dressings. The dose of the drug used during the week should not exceed 30-60 g.

Cream

Outwardly.

Lokoid Lipokrem is used in subacute and chronic processes, especially in the presence of lichenification, infiltration, dryness.

The drug is applied to the affected areas of the skin with a thin layer 1-3 times a day. When there is a positive dynamics, the frequency of application of the drug can be reduced to 2-3 times a week. To improve penetration, the drug is applied by massaging movements. In cases of refractory disease, for example, in the localization of dense psoriatic plaques on the elbow areas, the knees, the drug can be used under occlusive dressings. The dose of the drug used during the week should not exceed 30-60 g.

Emulsion

Outwardly.

Lokoid Krelo is preferably used for acute inflammation, especially for wet areas, and this dosage form is also an optimal choice for lesions of skin areas with abundant hair (for example,a hairy part of a skin of a head).

The drug is applied to the affected areas of the skin with a thin layer 1-3 times a day. When there is a positive dynamics, the frequency of application of the drug can be reduced to 2-3 times a week.

The drug can be applied with light massaging movements, if necessary, on the surface of the foci with a wetting after the application of Lokoid Krelo, an occlusive dressing is applied. Remains of Lokoid Crelo from the surface of the skin are removed with water. The dose of the drug used during the week should not exceed 30-60 g.

Side effect

• skin irritation and other local reactions, characteristic for the therapy of glucocorticosteroids (GCS);
• with long-term use, application to large surfaces and / or the use of occlusive dressings, side effects characteristic of systemic GCS can be observed.

Contraindications

• bacterial skin infections (strepto- and staphyloderma, gram-negative folliculitis);
• viral skin infections (herpes simplex, chicken pox, shingles);
• fungal skin infections;
• tuberculosis and syphilitic skin lesions;
• parasitic skin infections;
• Neoplastic skin changes (benign and malignant tumors);
• acne, rosacea, perioral dermatitis;
• postvaccination period;
• violation of the integrity of the skin (wounds, ulcers);
• hypersensitivity to the drug.

Application in pregnancy and lactation

Glucocorticosteroids (GCS) penetrate the placental barrier. Effects on the fetus can be particularly pronounced when applying Lokoid to large areas of the skin.

There is no data on the amount of hydrocortisone excreted in breast milk; it is recommended to take special care when applying Lokoid during lactation.

Use in children

Possible use in children from 6 months of age. In cases of use of the drug in children, on the face area or under occlusive dressings, the duration of the course of treatment should be reduced.

When used in children, the skin surface area on which the drug is applied should not exceed 20% of the total.

In childhood, suppression of the function of the adrenal cortex can develop faster. In addition, there may be a decrease in the excretion of growth hormone. When using the drug for a long time, it is necessary to observe the body weight, growth, plasma cortisol level.In a study in children who received 30-60 g of Lokoid per week for 4 weeks compared to 1% hydrocortisone ointment, no child showed any adrenocortical dysfunction, while the difference between hydrocortisone 17-butyrate in this indicator from the usual hydrocortisone was not observed.

special instructions

Do not apply Lokoid to the periorbital area due to the risk of developing glaucoma. With a systematic hit on the conjunctiva, there is a risk of increased intraocular pressure.

Any GCS for external use in the form of an ointment is not advisable to use on the scalp, as well as with acute inflammation (especially exudative). For the treatment of steroid-sensitive skin lesions localized in the face, folds, genitalia, as well as on skin areas with abundant hair, it is preferable to use other medicinal forms of Lokoid (cream, crelo).

The drug is preferably not used in the presence of atrophic skin changes.

The risk of local and systemic side effects increases when applied to extensive areas of damage, prolonged use, the use of occlusive dressings and in childhood.

If there is no effect within 2 weeks of continuous treatment, the diagnosis should be clarified.

As with any SCS, it is desirable to limit the duration of the drug and prescribe a course dose that is minimal enough to stop the skin process.

Impact on the ability to drive vehicles and manage mechanisms

Data on the influence of Lokoid on the ability to drive vehicles and work with mechanisms there.

Drug Interactions

There are no data on the drug interaction of Lokoid.

Analogues of the drug Lokoid

Structural analogs for the active substance:

• Acortin;
• Hydrocortisone;
• Corteid;
• Cortef;
• Latticort;
• The lokoid is a crelo;
• Lokoid lipocream;
• Solu Corteff;
• Sopolkort N.

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