Dazolik - instructions for use, analogs, reviews and release forms (500 mg tablets, suspension) for the treatment of trichomoniasis and giardiasis in adults, children and pregnancy. Composition and interaction with alcohol

In this article, you can read the instructions for using the drug Dazolik. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Dazolik in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Dazolik in the presence of existing structural analogues. Use to treat trichomoniasis and giardiasis in adults, children, as well as during pregnancy and lactation.Composition and interaction of the drug with alcohol.

Dazolik - antiprotozoal drug, a derivative of 5-nitroimidazole. The mechanism of action is in the biochemical reduction of 5-nitro Ornidazole intracellular transport proteins of anaerobic bacteria and protozoa. The recovered 5-nitro ornidazole interacts with DNA microbial cells by inhibiting synthesis of nucleic acids, which leads to the death of the bacteria.

It is active against Trichomonas vaginalis (tihomonady), Giardia lamblia, Entamoeba histolytica, and also against anaerobic bacteria (Bacteroides spp. (Including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp. , Clostridium spp.). Orniferous microorganisms are not sensitive to ornidazole.

Composition

Ornidazole + auxiliary substances.

Pharmacokinetics

Absorption from the gastrointestinal tract is high. Bioavailability is 90%. The connection with plasma proteins is less than 15%. Penetrates into most tissues, it passes through the blood-brain barrier (BBB) ​​and the placental barrier. Excreted in breast milk. Metabolized in the liver by hydroxylation, oxidation and glucuronation. Displayed as metabolites kidney (60-70%) and feces (20-25%), about 5% of the dose is excreted unchanged.

Indications

• trichomoniasis;
• amebiasis, amoebic dysentery, extraintestinal amoebiasis (including amoebic liver abscess);
• giardiasis;
• prevention of infections caused by anaerobic bacteria, in operations on the colon and in gynecology.

Forms of release

The tablets covered with a cover of 500 mg.

Suspension for oral administration (in vials or sachets).

Tablets are vaginal (sometimes mistakenly called candles).

Instructions for use and reception scheme

Tablets are taken orally after a meal.

For trichomoniasis, adults are prescribed 1.5 g once or 1 g in combination with intravaginal administration of 500 mg (vaginal tablets) overnight. You can treat for 5 days, appointing 500 mg orally 2 times a day (morning and evening), also with the appointment of 1 vaginal tablet of 500 mg per night. Children dose set at a rate of 25 mg / kg body weight once.

For amoebic dysentery adults and children weighing more than 35 kg per 1.5 grams once a day, with a body weight of more than 60 kg - 2 grams per day. Children older than 3 years and with a body weight of less than 35 kg daily dose is set at the rate of 40 mg / kg body weight. The course of treatment is 3 days.

In other forms of amebiasis, adults and children over 12 years of age - 500 mg twice a day for 5-10 days.Children older than 3 years and weighing less than 35 kg - 25 mg / kg body weight once for 5-10 days.

With giardiasis, adults and children weighing more than 35 kg - 1.5 g once a day, children over 3 years old and weighing less than 35 kg - 40 mg / kg per day. Duration of treatment is 1-2 days.

To prevent infections caused by anaerobic bacteria, appoint 0.5-1 g before the operation and 0.5 g 2 times a day after the operation for 3-5 days.

Side effect

• drowsiness;
• headache;
• dizziness;
• tremor;
• stiff muscles;
• violation of coordination of movements;
• convulsions;
• fatigue;
• temporary loss of consciousness;
• sensory or mixed peripheral neuropathy;
• perversion of taste sensations;
• nausea;
• allergic reactions.

Contraindications

• children under 3 years (for tablets);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in the first trimester of pregnancy and during lactation (breastfeeding).

Use in children

Contraindicated in children under 3 years (for tablets).

special instructions

In the treatment of trichomoniasis, simultaneous treatment of both sex partners should be carried out.

With caution should apply the drug for diseases of the central nervous system (incl.epilepsy, multiple sclerosis), liver disease, alcoholism, pregnancy and lactation.

Impact on the ability to drive vehicles and manage mechanisms

Because Ornidazole has a depressing effect on the central nervous system, it should not be used during the management of vehicles or other work that requires a clear coordination of movements.

Drug Interactions

When combined, Dazolik enhances the effect of indirect anticoagulants of the coumarin series, prolongs the miorelaksiruyuschee effect of vecuronium bromide.

Compatible with ethanol (alcohol) (does not inhibit acetaldehyde), unlike other imidazole derivatives (metronidazole).

Analogues of the drug Dazolik

Structural analogs for the active substance:

• Avrazor;
• Gairo;
• Quinizole;
• Lornisol;
• Ornidazole;
• Ornion;
• Ornisid;
• Ornisid Forte;
• Tiberal.

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