Cyclodol - instructions for use, reviews, analogs and forms of release (2 mg tablets) medications for the treatment of Parkinson's disease, seizures and spasms in adults, children and pregnancy. Composition and side effects

In this article, you can read the instructions for using the drug Cyclodol. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Cyclodol in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cyclodol in the presence of existing structural analogues. Use to treat Parkinson's disease, seizures and spasms in adults, children, as well as during pregnancy and lactation. Composition and side effects of the drug.

Cyclodol - antiparkzonian means.Has a strong central n-anticholinergic action, as well as peripheral m-anticholinergic action. The central action contributes to the reduction or elimination of motor disorders associated with extrapyramidal disorders.

With parkinsonism, it reduces tremor, less affects rigidity and bradykinesia.

Has spasmolytic effect, which is associated with anticholinergic activity and direct myotropic action.

Composition

Trihexyphenidyl hydrochloride + excipients.

Indications

• Parkinsonism (idiopathic, postencephalitic, atherosclerotic, due to side effects of drugs, in the form of monotherapy and in combination with levodopa);
• Parkinson's disease;
• Little's disease;
• spastic paralysis associated with lesions of the extrapyramidal system.

Forms of release

Tablets 2 mg.

Instructions for use and dosage

Install individually. The initial dose is 0.5-1 mg per day. Then, if necessary, every 3-5 days the dose is gradually increased by 1-2 mg until the optimal therapeutic effect is achieved; the frequency of reception is 3-5 times a day.

When hypersalivation before starting treatment, trihexyphenidyl should be taken after meals. When developing during the treatment of dryness of the oral mucosa, trihexyphenidyl is prescribed before meals (if this does not cause nausea).

Maximum doses: when taken orally, a single dose of 10 mg, daily - 20 mg.

Side effect

• headache;
• irritability;
• rave;
• hallucinations;
• mental disorientation (mainly in patients with atherosclerosis);
• dryness of the oral mucosa;
• visual impairment;
• increased intraocular pressure;
• constipation;
• difficulty urinating;
• tachycardia;
• skin rash;
• purulent parotitis (due to xerostomia).

Contraindications

• retention of urination;
• prostate adenoma;
• glaucoma;
• atrial fibrillation;
• obstructive diseases of the digestive tract;
• pregnancy.

Application in pregnancy and lactation

Cyclodol is contraindicated in pregnancy.

Application in elderly patients

In patients over the age of 60, the dose of trihexyphenidyl is selected with extreme caution because of the high probability of hypersensitivity reactions.

special instructions

Use with caution in diseases of the heart, kidney or liver, arterial hypertension.

In patients over the age of 60, the dose of trihexyphenidyl is selected with extreme caution because of the high probability of hypersensitivity reactions.

During treatment, intraocular pressure should be monitored regularly.

With prolonged treatment, the intensity of adverse reactions due to the anticholinergic activity of trihexyphenidyl is usually reduced; it is possible to develop drug dependence.

Impact on the ability to drive vehicles and manage mechanisms

During the period of application of trihexyphenidyl it is not recommended to engage in activities requiring high concentration of attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of anticholinergic agents, anticholinergic effects may be enhanced.

With simultaneous application of Cyclodol with levodopa, correction of the dosing regimen is required (absorption and Cmax of levodopa in the blood plasma decrease).

With simultaneous application with reserpine, the antiparkinsonian effect of trihexyphenidyl decreases, The reserves of catecholamines in the central nervous system are emptied. As a result, cholinergic neurons are activated, and Parkinson's syndrome is enhanced.

With simultaneous use, it is possible to reduce the concentration of chlorpromazine in the blood plasma, which, apparently, is associated with a violation of absorption from the gastrointestinal tract.

Analogues of the drug Cyclodol

Structural analogs for the active substance:

• Apo Traygex;
• Romparkin;
• Trihexyphenidyl;
• Trihexyphenidyl hydrochloride.

Analogues on the therapeutic effect (means for treating Parkinson's disease):

• Azilect;
• Akineton;
• Duellin;
• Zimox;
• Izik;
• Cognitive;
• Creeded;
• Madopar;
• Mendileks;
• Midantan;
• Mirapex;
• On whom;
• Niar;
• Pantogam;
• Pantokaltsin;
• Parcón;
• Permax;
• Mertz PC;
• Pronoran;
• Rekvip Modabit;
• Segan;
• Selegiline;
• Sinemet;
• Stalevo;
• Tasmar;
• Tremonorm;
• Tropacin;
• Eldepril;
• Yumeks.

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