Fenkarol - instructions for use, analogs, testimonials and release forms (tablets 10 mg and 25 mg, powder for the preparation of solution) drugs for the treatment of allergies in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Fenkarol. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Fenkarol in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Fenkarol in the presence of existing structural analogues. Use for the treatment of allergies (pollinosis, dermatosis and other allergic manifestations and diseases) in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Fenkarol - blocker of histamine H1 receptors.Prevents development and facilitates the course of allergic reactions. Has antiallergic, antiexudative and antipruritic action, preventing the development of allergic inflammation in the tissue. Weaken the effect of histamine, reduce its effect on vascular permeability (reducing permeability, has anti-edematous effect), reduces its bronchospastic effect and spasmogenic effect on the smooth muscles of the intestine, weakens the hypotensive effect of histamine. Hifenadine (the active substance of the drug Fenkarol) reduces the content of histamine in the tissues (associated with the ability to activate diamino oxidase - an enzyme that inactivates histamine). At course treatment, the antihistamine effect of hifenadine does not decrease. Has a moderate antiserotonin effect, shows a weak m-cholinoblocking activity. Does not exert a depressing effect on the central nervous system.

Composition

Hifenadine hydrochloride + excipients.

Pharmacokinetics

Fenkarol is rapidly absorbed from the digestive tract, absorption is 45%, and after 30 minutes it is found in the tissues of the body. Has low lipophilicity, poorly penetrates the blood-brain barrier.The highest concentration of active substance is found in the liver, slightly less in the lungs and kidneys, the lowest in the brain (less than 0.05%, which explains the absence of depressing effect on the central nervous system). Hyphenadine is metabolized in the liver. Metabolites are excreted by the kidneys and intestines. An unabsorbed part of the drug is excreted through the intestine.

Indications

• Pollinosis;
• acute and chronic urticaria;
• angioedema;
• allergic rhinitis;
• dermatoses (including eczema, psoriasis, atopic dermatitis, skin itching).

Forms of release

Tablets 10 mg and 25 mg.

Powder for solution for oral administration 10 mg.

There are no other forms, be it syrup or drops,.

Instructions for use and dosage

Pills

The drug is taken orally after a meal.

The dosage regimen of the preparation coincides with all indications for use. The dosing of hifenadine may be affected by the severity of the allergic reaction, the individual sensitivity of the patient, as well as the severity of possible side effects.

Adults appoint 25-50 mg 3-4 times a day. The maximum daily dose is 200 mg. The course of treatment is 10-20 days. If necessary, repeat the treatment.

Children aged 3 to 7 years - 10 mg twice a day; at the age from 7 to 12 years - 10-15 mg 2-3 times a day; over 12 years - 25 mg 2-3 times a day. The course of treatment is 10-15 days.

Powder for solution

Adults inside - 25-50 mg 3-4 times a day. The course of treatment is on average 10-20 days. If necessary, repeat the treatment.

The maximum dose for adults is 200 mg per day.

Children under the age of 3 years - 5 mg 2-3 times a day, at the age of 3-7 years - 10-15 mg 2-3 times a day.

Side effect

• dryness of the oral mucosa;
• nausea, vomiting;
• drowsiness, headache;
• allergic reactions.

Contraindications

• pregnancy;
• lactation period (breastfeeding);
• Children's age up to 3 years (for tablets);
• deficiency of sugar / isomaltase, intolerance to fructose, glucose / galactose malabsorption, t. the preparation contains sucrose;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

It is not recommended for use in pregnancy, especially in the first trimester. If you need to use during pregnancy, you should carefully weigh the ratio of expected benefits to the mother and the risk to the fetus.

If it is necessary to treat the drug, breastfeeding should be discontinued.

Use in children

The drug is prescribed for children aged 2 years and older.

special instructions

With caution should prescribe the drug for diseases of the gastrointestinal tract, liver and kidneys.

Absence of expressed m-holinoblokiruyuschey effect allows you to prescribe the drug to patients who are contraindicated antihistamines that have m-cholinoblocking activity.

Impact on the ability to drive vehicles and manage mechanisms

Persons whose profession requires an increased concentration of attention and speed of psychomotor reactions should first be determined (by short-term appointment), whether the drug does not have a sedative effect.

Drug Interactions

Possessing weak m-holinoblokiruyuschimi properties, the drug can reduce the motility of the gastrointestinal tract, which increases the absorption of slowly absorbed drugs (for example, anticoagulants indirect effects - coumarins).

Analogues of the drug Fenkarol

There are no structural analogs to the active substance of Fenkarol.

Analogues for the pharmacological group (H1 antihistamines):

• Aviomarine;
• Allergodyl;
• Allergoferon;
• Allertec;
• Astemizole;
• Bonin;
• Vibrocil;
• Histaglobin;
• Histalong;
• Histafen;
• Gifast;
• Desloratadine;
• Diazoline;
• Diacin;
• Diphenhydramine;
• Diphenhydramine hydrochloride;
• Donormil;
• Zincet;
• Zirtek;
• Zodak;
• Kestin;
• Clallergine;
• Clargotil;
• Claridol;
• Claritin;
• Clemastine;
• Cold storage;
• Koldar;
• Xizal;
• Levocetirizine Teva;
• Loratadine;
• Lotharen;
• Mebhydrogen;
• Parliamentary;
• Pipolphen;
• Polynadym;
• Primalan;
• Rapido;
• Rupafin;
• Sowentol;
• Suprastin;
• Suprastinex;
• Tavegil;
• Telfast;
• Trexile;
• Fexadine;
• Fexofenadine;
• Femizol;
• Pheniramine maleate;
• Fenistil;
• Chloropyramine;
• Cetirizine;
• Cetirinax;
• Cetrin;
• Erespal;
• Erius;
• Erolin.

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