Ferrum Lek - instructions for use, analogs, testimonials and release forms (syrup or drops, 100 mg chewable tablets, injections for injection) drugs for the treatment of anemia and iron deficiency in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Ferrum Lek. Comments from visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Ferrum Lek in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ferrum Lek with available structural analogues.Use to treat anemia and iron deficiency in adults, children (including infants), as well as during pregnancy and lactation. Composition of the preparation.

Ferrum Lek - anti-anemic drug. In the preparation of Ferrum Lek, iron is in the form of a complex iron compound (3) hydroxide polymaltozate.

The molecular mass of the complex is so great (about 50 kDa) that its diffusion through the mucosa of the gastrointestinal tract is 40 times slower than the diffusion of bivalent iron. The complex is stable and under physiological conditions does not release iron ions. The iron of multinuclear active zones of the complex is connected in a structure similar to the structure of a natural iron-ferritin compound. Due to this similarity, the iron of this complex is absorbed only by active absorption. Iron-binding proteins located on the surface of the intestinal epithelium absorb iron (3) from the complex through competitive ligand exchange. Absorbed iron is mainly deposited in the liver where it binds to ferritin. Later in the bone marrow it is included in the hemoglobin. The iron complex (3) hydroxyl polymaltozate does not possess the prooxidant properties inherent in iron salts (2).

Composition

Iron (3) hydroxide polymaltosate + auxiliary substances.

Pharmacokinetics

The absorption of iron, measured by hemoglobin level in erythrocytes, is inversely proportional to the dose taken (the higher the dose, the lower the absorption). There is a statistically negative correlation between the degree of iron deficiency and the amount of absorbed iron (the greater the iron deficiency, the better the absorption). Most iron is absorbed in the duodenum and jejunum. The remaining (unabsorbed) iron is excreted with feces. His excretion with exfoliating cells of the epithelium of the gastrointestinal tract and skin, as well as with sweat, bile and urine, is approximately 1 mg of iron per day. In women during menstruation, there is an additional loss of iron, which must be taken into account.

After intramuscular injection of iron quickly enters the bloodstream: 15% of the dose - after 15 minutes, 44% of the dose - after 30 minutes.

Indications

• treatment of latent iron deficiency;
• treatment of iron deficiency anemia;
• prevention of iron deficiency in pregnancy;
• Conditions in which the treatment with iron for oral administration is ineffective or unrealizable (for the injection form).

Forms of release

Syrup (sometimes mistakenly called drops).

Tablets chewing 100 mg.

Solution for intramuscular injection (injections in ampoules for injection).

Instructions for use and reception scheme

Syrup and tablets

The drug is recommended to be taken during or immediately after a meal. Chewable tablets can be chewed or swallowed whole. The daily dose can be divided into several receptions or taken for 1 time.

Doses and duration of treatment depend on the degree of iron deficiency.

The syrup can be mixed with fruit or vegetable juices or added to baby food. The measuring spoon enclosed in the packaging is used to accurately dispense the syrup.

With iron deficiency anemia, the duration of treatment is about 3-5 months. After normalizing the level of hemoglobin should continue taking the drug for several more weeks to replenish the iron stores in the body.

Children under the age of 1 year are prescribed 2.5-5 ml (1 / 2-1 measuring spoon) of syrup per day.

Children aged 1 to 12 years - 5-10 ml (1-2 measuring spoons) of syrup per day.

Children over 12 years of age, adults and mothers who breastfeed - 1-3 tablets of chewing or 10-30 ml (2-6 measuring spoons) of syrup per day.

Pregnant women are prescribed 2-3 tablets of chewing or 20-30 ml (4-6 measuring spoons) of syrup until the hemoglobin level is normalized. After this, you should continue to take 1 tablet of chewing or 10 ml (2 measuring spoons) of syrup per day, at least until the end of pregnancy to replenish the iron stores in the body.

With latent iron deficiency, the duration of treatment is about 1-2 months.

Children aged 1 to 12 years - 2.5-5 ml (1 / 2-1 measuring spoon) syrup per day.

Children over 12 years, adults and mothers who breastfeed - 1 tablet chewing or 5-10 ml (1-2 measuring spoons) syrup per day.

Pregnant women are prescribed 1 tablet of chewing or 5-10 ml (1-2 measuring spoons) of syrup per day.

Ampoules

The drug in the form of a solution can be administered only intramuscularly. Intravenous administration of the drug is not allowed!

Before the introduction of the first therapeutic dose, each patient should be given a test dose of 1 / 4-1 / 2 ampoules (25-50 mg iron) for an adult and 1/2 day dose for children. In the absence of adverse reactions within 15 minutes after administration, the remainder of the initial daily dose is administered.

The doses of the drug Ferrum Lek are selected individually according to the total iron deficiency calculated according to the following formula:

Total iron deficiency (mg) = body weight (kg) × (calculated Hb (g / l) - detected Hb (g / l)) × 0.24 + deposited iron (mg).

With a body weight of up to 35 kg: a calculated level of Hb = 130 g / l, deposited iron = 15 mg / kg of body weight.

With a body weight of more than 35 kg: the calculated level of Hb = 150 g / l, deposited iron = 500 mg.

Factor 0.24 = 0.0034 × 0.07 × 1000 (iron content in Hb = 0.34%, total blood volume = 7% of body weight, factor 1000 - transfer from g to mg).

Calculation of the total dosage for iron compensation due to blood loss

With a known amount of lost blood, the introduction of 200 mg of iron (2 ampoules) leads to an increase in hemoglobin equivalent to 1 blood unit (400 ml with a hemoglobin content of 150 g / l).

The amount of iron that needs to be refunded (mg) = the number of lost blood units x 200 or the required number of ampoules = the number of blood units lost x 2.

At a known final level of hemoglobin, the above formula is used, given that the deposited iron is not required to be replenished.

The amount of iron to be reimbursed (mg) = body weight (kg) × (calculated Hb (g / l) - detected Hb (g / l)) x 0.24

Conventional doses of Ferrum Lek

Adults and elderly patients are prescribed 100-200 mg (1-2 ampoules), depending on the level of hemoglobin; Children - 3 mg / kg per day (0.06 ml / kg body weight per day).

The maximum daily intake for adults is 200 mg (2 ampoules); for children - 7 mg / kg per day (0.14 ml / kg of body weight per day).

Rules of drug administration

The drug is injected intramuscularly alternately into the right and left buttocks.

In order to reduce pain and avoid dyeing of the skin, the following rules should be observed:

the drug should be injected into the upper outer quadrant of the buttocks, using a needle 5-6 cm long;

before injection after disinfection of the skin, the subcutaneous tissues should be moved down by 2 cm to prevent subsequent outflow of the preparation;

after administration of the drug, subcutaneous tissue should be released, and the injection site should be pressed and held in this position for 1 minute.

Before applying the solution for the / m injections of the ampoule should be carefully examined. Use only ampoules containing a homogeneous solution without sediment. A solution for intravenous injections should be used immediately after opening the ampoule.

Side effect

• feeling of heaviness;
• feeling of overflow and pressure in the epigastric region;
• nausea;
• constipation;
• diarrhea;
• staining of stool in dark color (black stool) is noted, which is caused by excretion of unsweetened iron and has no clinical significance.

Contraindications

• excess iron in the body (eg, hemochromatosis);
• impairment of iron utilization (eg, anemia caused by lead intoxication, sidero-achestic anemia);
• anemia not related to iron deficiency (eg, hemolytic anemia, megaloblastic anemia caused by a lack of cyanocobalamin);
• Osler-Randu-Weber syndrome;
• infectious diseases of the kidneys in acute stage;
• uncontrolled hyperparathyroidism;
• decompensated cirrhosis of the liver;
• infectious hepatitis;
• 1 trimester of pregnancy;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

During controlled trials, when the drug was used in the 2nd and 3rd trimester of pregnancy, there was no adverse effect on the mother or fetus. There was no adverse effect on the fetus when using the drug in the first trimester of pregnancy.

Use in children

Possible use according to the indications and in doses that take into account the age of the patient. Children under the age of 12 years, in connection with the need to prescribe the drug in low doses, preferably in the form of a syrup.

special instructions

Tablets chewing and syrup do not cause tooth enamel staining.

The drug in the injectable form should be used only in a hospital.

When appointing Ferrum Lek patients with diabetes should take into account that 1 tablet chewing and 1 ml of syrup contains 0.04 XE.

In cases of anemia caused by an infectious or malignant disease, iron accumulates in the reticulo-endothelial system, from which it is mobilized and utilized only after the cure of the underlying disease.

The drug does not affect the results of fecal occult blood tests (selectively for hemoglobin).

Impact on the ability to drive vehicles and manage mechanisms

Does not affect the ability to concentrate.

Drug Interactions

Ferrum Lek for intramuscular injections should not be used concomitantly with iron preparations for oral administration.

Simultaneous application of the preparation of Ferrum Lek with ACE inhibitors can cause an increase in the systemic effects of parenteral iron preparations.

Analogues of the drug Ferrum Lek

Structural analogs for the active substance:

• Iron polymaltose;
• Maltofer;
• Fenyuls Complex;
• Ferri.

Analogues for the pharmacological group (remedies for the treatment of iron deficiency):

• Aktiferrin compositum;
• Aloe syrup with iron;
• Biovital elixir;
• Biofer;
• Venofer;
• Vitrum Superstress;
• Vitrum Cirkus;
• Hemofer;
• Gino Tardiferon;
• Likferr 100;
• Maltofer;
• Maltofer Foul;
• Multi Tabs Active;
• Pikovit Complex;
• Sorbifer Durules;
• Special Merz sweets;
• Stress formula with iron;
• Supradin Kids Junior;
• Tardiferon;
• Totem;
• Ferlatum;
• Ferretab Comp .;
• Ferrinate;
• Ferro Folgamma;
• Ferrograduum;
• Ferronal;
• Ferrum Lek;
• Heferol;
• Enfamil with iron.

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