Priority - instructions for use, reviews, analogues and release forms (lyophilizate for the preparation of solution for injection) inoculations for the prevention of measles, mumps and rubella in adults, children and pregnancy. Composition and complications after vaccination

In this article, you can read the instructions for using the drug Priority. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Prioryx inoculation in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Prioriics in the presence of available structural analogues.Use for the prevention of measles, mumps and rubella in adults, children, as well as during pregnancy and lactation. Composition and complications after vaccination.

Priority - live combined attenuated vaccine against measles, mumps and rubella. The attenuated vaccine strains of the measles virus (Schwarz), mumps (RIT 4385, Jeryl Lynn derivative) and rubella (Wistar RA 27/3) are cultured separately in the chicken embryo (measles and mumps) and diploid human cells (rubella virus).

Clinical studies have shown the high efficacy of the Priori vaccine. Antibodies to measles virus were detected in 98% of the vaccinated, 96.1% in the mumps virus and 99.3% in the rubella virus. One year after vaccination, all seropositive individuals retained a protective titer of antibodies to measles virus and rubella virus and 88.4% had a mumps virus.

A certain degree of protection against measles disease can be achieved by administering the vaccine to non-immunized individuals within 72 hours after they have been exposed to measles.

Composition

The attenuated vaccine strain of measles virus (Schwarz) + The attenuated vaccine strain of the mumps virus (RIT4385, Jeryl Lynn derivative) + The attenuated vaccine strain of the rubella virus (Wistar RA 27/3) + excipients.

Indications

• prevention of measles, mumps and rubella from the age of 12 months.

Forms of release

Lyophilizate for the preparation of solution for intramuscular and subcutaneous injection (injections in ampoules for injections).

Instructions for use and how to use them

The vaccine is administered subcutaneously in a dose of 0.5 ml; intramuscular administration of the vaccine is permitted. Do not use intravenous vaccine!

In accordance with the Calendar of Preventive Inoculations of Russia, Prioriks are administered to children aged 12 months followed by booster vaccination at the age of 6 years. In addition, Prioryx can be administered to girls at age 13, who were not vaccinated before or received only one inoculation with monovalent or combination vaccines against measles, rubella and mumps.

Rules for the preparation of solution

Immediately before use, the contents of the supplied syringe or ampoule with a solvent at the rate of 0.5 ml per dose are added to the vial with the preparation. The bottle is shaken thoroughly until completely dissolved. The dissolution time of the preparation should not exceed 1 min. The dissolved preparation is a clear liquid from light orange to light red color.If the solution looks different or there are foreign particles, the vaccine is not used.

A new sterile needle should be used to administer the drug. When using the vaccine in multi-dose packs, a new syringe and needle should be used each time to take the drug.

Dissolved drug in multi-dose pack should be used during the working day (for no more than 8 hours) if stored in a refrigerator (at a temperature of 2 to 8 degrees Celsius). The drug should be removed from the bottle with strict adherence to aseptic rules.

In no circumstances are Prioryx vaccines given intravenously.

Side effect

• upper respiratory tract infection;
• otitis media;
• lymphadenopathy;
• increased parotid glands;
• diarrhea;
• vomiting;
• anorexia;
• unusual crying;
• nervousness;
• insomnia;
• febrile convulsions;
• cough;
• bronchitis;
• rash;
• allergic reactions;
• conjunctivitis;
• redness at the injection site;
• pain and swelling at the injection site;
• increased temperature (rectal above 38 degrees Celsius, axillary / oral cavity: above 37.5 degrees Celsius);
• meningitis;
• thrombocytopenia, thrombocytopenic purpura;
• transverse myelitis;
• acute primary idiopathic polyneuritis (Guillain-Barre syndrome);
• peripheral neuritis;
• encephalitis;
• erythema multiforme;
• anaphylactic reactions;
• arthralgia;
• arthritis;
• Kawasaki syndrome;
• transient painful short-term swelling of the testicles;
• development korepodobnogo a syndrome.

Accidental intravenous administration can cause severe reactions, even shock. In such cases, appropriate emergency medical care is required.

In general, the profile of adverse reactions was similar after the administration of the first dose of vaccine and revaccination. However, pain at the injection site was observed in 1-10% of cases after the first, vaccination, and after revaccination - in more than 10% of cases.

Contraindications

• primary and secondary immunodeficiencies (however, the drug can be used in people with asymptomatic HIV infection, as well as in AIDS patients);
• acute diseases and exacerbations of chronic diseases (with mild ARVI, acute intestinal diseases vaccination is allowed immediately after the temperature normalization);
• pregnancy;
• allergic reactions to the previous administration of the drug;
• hypersensitivity to neomycin,any other ingredient of the vaccine and chicken eggs (however, the history of contact neuronin-induced contact dermatitis and an allergic reaction to non-anaphylactic chicken eggs is not a contraindication to vaccination).

Application in pregnancy and lactation

The Prioryx vaccine is contraindicated in pregnancy.

It is possible to use the vaccine during breastfeeding after assessing the potential benefits and potential risks.

Vaccination of women of childbearing age is carried out in the absence of pregnancy and only if the woman agrees to be prevented from conception within 3 months after vaccination.

special instructions

Care should be taken when administering the vaccine to people with allergic diseases and convulsions in a personal and family history. It should be borne in mind that after the introduction of the vaccine in connection with the possible risk of developing allergic reactions of immediate type, the patient should be under medical supervision for 30 minutes. Places of vaccination should be provided with anti-shock therapy, incl. a solution of epinephrine (adrenaline) 1: 1000.

make sure before administration of the vaccine, the alcohol or other disinfectant has evaporated from the skin surface and the vial stopper, as these substances can inactivate attenuated viruses in the vaccine.

Drug Interactions

Priorix vaccine may be administered simultaneously (in one day) and DT DTP vaccines, live and inactivated poliomyelitis vaccine, vaccine against Haemophilus influenzae type b, hepatitis B vaccine, provided the injection of drugs in different syringes at different sites. Other live viral vaccines are prescribed with an interval of at least 1 month.

Priority should not be confused with other vaccines in the same syringe.

Priorix may be used for re-vaccination in persons previously vaccinated with another combination vaccine against measles, mumps and rubella or corresponding monotherapies.

If necessary setting TST it should be carried out or simultaneously with the vaccination or 6 weeks after her as measles (and possibly mumps) vaccine process may cause a temporary decrease in skin sensitivity to tuberculin that will cause a false negative result.

Analogues of Prioriks

Analogues for the pharmacological group (funds for the treatment and prevention of measles, rubella and mumps):

• Vaccine parotitic-measles alive;
• Vaccine mumps culture alive;
• Vaccine against measles, mumps and rubella live attenuated;
• Vaccine against rubella live attenuated;
• Rubella vaccine is a viable live culture;
• Rubella vaccine culture live attenuated;
• Isoprinosine;
• The human immunoglobulin is normal;
• Retinol acetate solution in oil;
• Retinol acetate solution for injection in oil;
• Retinol palmitate;
• Ruvax;
• Rudivax;
• Hervewax;
• Erespal.

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