Efferlangan - instructions for use, testimonials, analogues and forms of release (suppositories 80 mg, 150 mg and 300 mg, tablets effervescent 500 mg of UFSA and with vitamin C, children's syrup, solution 3%) drugs for pain in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Efferalgan. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Effergangan in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Effergangan with available structural analogues. Use to treat pain and reduce temperature in adults, children (including infants and newborns), as well as during pregnancy and lactation. Composition of the preparation.

Efferalgan - An analgesic-antipyretic. Has analgesic and antipyretic effect. Inhibits COX-1 and COX-2 mainly in the central nervous system, affecting the centers of pain and thermoregulation. In inflamed tissues, cellular peroxidases neutralize the effect of Paracetamol on COX, which explains the almost complete lack of anti-inflammatory effect.

It has no negative effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa due to the absence of influence on the synthesis of prostaglandins in peripheral tissues.

Composition

Paracetamol + auxiliary substances.

Pharmacokinetics

Absorption of Effergangan is complete and rapid. The distribution of paracetamol in tissues is rapid. There are comparable concentrations of the drug in the blood, saliva and plasma. The association with plasma proteins is low (10-25%). Penetrates through the blood-brain barrier (BBB). Metabolism occurs in the liver. It is excreted by the kidneys in the form of metabolites, mainly conjugates. In unchanged form, less than 5% is output.

Indications

• as an antipyretic agent in acute respiratory infections, influenza, childhood infections, post-vaccination reactions and other conditions accompanied by fever;
• pain syndrome of mild to moderate intensity: headache, toothache, migraine, neuralgia, muscle pain, back pain, pain with injuries and burns, sore throat, algodismenorea.

Forms of release

Syrup for children 30 mg.

Tablets effervescent 500 mg Efferalgan UPSA.

Candles rectal 80 mg, 150 mg and 300 mg.

Solution for oral administration (for children) 3%.

Tablets are effervescent with vitamin C.

Instructions for use and dosage

Rectal Candles

The drug is used rectally. After releasing the suppository from the package, enter the child in the anus (preferably after a cleansing enema or spontaneous bowel movement).

The average single dose of Effergangan depends on the weight of the child and is 10-15 mg / kg 3-4 times a day. The maximum daily dose is 60 mg / kg.

Children aged 5 to 10 years (with a body weight of 20 to 30 kg) are given 1 suppository (300 mg) 3-4 times a day at intervals of 4-6 hours. Do not use more than 4 suppositories per day.

Children aged 6 months to 3 years (with a body weight of 10 to 14 kg) are administered 1 suppository rectal (150 mg) 3-4 times a day at intervals of 4-6 hours. Do not use more than 4 suppositories per day.

Children aged 3 to 5 months (with a body weight of 6 to 8 kg) are administered 1 suppository rectal (80 mg) 3-4 with an interval of 4-6 hours.Do not use more than 4 candles per day.

Duration of treatment is 3 days when used as an antipyretic and up to 5 days - as an analgesic.

Effervescent tablets

The tablet should be dissolved in a glass of water (200 ml) and drunk.

Assign inside of 0.5-1 g (1-2 tablets) 2-3 times a day at intervals of not less than 4 hours.

The maximum single dose is 1 g (2 tablets), daily - 4 g (8 tablets).

Duration of treatment (without consulting a doctor) is no more than 5 days when used as an analgesic and 3 days - as an antipyretic.

Syrup

The average single dose depends on the weight of the child and is 10-15 mg / kg of body weight 3-4 times a day. The maximum daily dose should not exceed 60 mg / kg of body weight. The interval between doses of the drug should be 4-6 hours. Follow regular intervals between taking the drug.

For convenience and accuracy of dosing should use a measuring spoon. On the measuring spoon, there are divisions indicating the child's body weight: 4, 6, 8, 10, 12, 14 or 16 kg. Undetected divisions correspond to the intermediate body weight: 5, 7, 9, 11, 13 or 15 kg.

Children with body weight from 4 to 16 kg

Fill the measuring spoon to the mark corresponding to the mass of the child's body, or to the mark closest to the weight of the child's body. For example, if the body weight of the child is from 4 to 5 kg, fill the measuring spoon up to the mark corresponding to 4 kg. If necessary, the drug should be taken every 4-6 hours.

Children with body weight from 16 to 32 kg

Fill the measuring spoon to the mark corresponding to 10 kg, then refill the measuring spoon until the label so as to obtain the total weight of the child's body. For example, if the body weight of the child is from 18 to 19 kg, fill the measuring spoon to the mark corresponding to 10 kg, then re-fill the measuring spoon up to the mark of 8 kg. If necessary, the drug should be taken every 4-6 hours.

Side effect

• skin rash;
• itching;
• angioedema;
• anaphylactic shock;
• anemia, thrombocytopenia, methemoglobinemia;
• diarrhea;
• abdominal pain;
• nausea, vomiting;
• tenesmus.

Contraindications

• severe violations of liver function;
• severe renal dysfunction;
• blood diseases;
• chronic alcoholism;
• deficiency of glucose-6-phosphate dehydrogenase;
• 1 and 3 trimesters of pregnancy;
• lactation period (breastfeeding);
• Children under 15 years of age (for effervescent tablets, you must use special children's form of the drug: syrup or suppositories) (body weight less than 50 kg);
• children's age up to 1 month (for Efferalgan solution);
• Children's age up to 3 months (for rectal suppositories containing 80 mg of paracetamol);
• children's age up to 6 months (for rectal suppositories containing 150 mg of paracetamol);
• children's age to 5 years (for rectal suppositories containing 300 mg of paracetamol);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Contraindicated use of the drug in the first and third trimester of pregnancy and lactation (breastfeeding).

special instructions

With continued febrile syndrome in the presence of paracetamol for more than 3 days, and a painful syndrome - more than 5 days, a doctor's consultation is required.

Distorts the indicators of laboratory tests in quantitative determination of uric acid in the plasma.

In order to avoid toxic damage to the liver, Efferalgan should not be combined with taking alcoholic beverages, and also to people who are prone to chronic alcohol consumption.

The risk of liver damage increases in patients with alcoholic hepatosis.

When the drug is used for a long time, it is necessary to monitor the pattern of peripheral blood and the functional state of the liver.

Efferalgan in effervescent tablets contains 412.4 mg of sodium in 1 tablet, which should be taken into account by patients on a strict low-salt diet. The tablets contain sorbitol, so the drug should not be used with fructose intolerance, low absorption of glucose and galactose, isomaltase deficiency.

Drug Interactions

Inducers of microsomal oxidation in the liver (phenytoin, ethanol (alcohol), barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of paracetamol, which allows the development of severe intoxication with a slight drug overdose.

Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic effects of paracetamol.

Efferalgan reduces the effectiveness of uricosuric drugs.

When used simultaneously with paracetamol, ethanol (alcohol) promotes the development of acute pancreatitis.

Analogues of the Efferalgan drug

Structural analogs for the active substance:

• Akamol Teva;
• Aldolor;
• Apap;
• Acetaminophen;
• Daleron;
• Children's Panadol;
• Children's Tylenol;
• Ithymol;
• Kalpol;
• Xoomapar;
• Lupocet;
• Mexalen;
• Pamol;
• Panadol;
• Panadol junior;
• Panadol tablets are soluble;
• Paracetamol;
• Perfalgan;
• Prohodol;
• Child passed through;
• Sanidol;
• Strymol;
• Tylenol;
• Tylenol for infants;
• Febricet;
• Cefekon D.

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