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Finlepsin - instructions for use, analogs, reviews and release forms (200 mg tablets and 400 mg retard) drugs for the treatment of epilepsy and neuralgia in adults, children and pregnancy. Interaction with alcohol

Finlepsin - instructions for use, analogs, reviews and release forms (200 mg tablets and 400 mg retard) drugs for the treatment of epilepsy and neuralgia in adults, children and pregnancy. Interaction with alcohol

In this article, you can read the instructions for using the drug Finlepsin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Finlepsin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Finlepsin in the presence of existing structural analogues. Use for the treatment of epilepsy and neuralgia in adults, children, as well as during pregnancy and lactation.Interaction of the drug with alcohol.

 

Finlepsin antiepileptic agent, derivative of tricyclic iminostilbene. It is believed that anticonvulsant action is associated with a decrease in the ability of neurons to maintain a high frequency of development of repeated action potentials through inactivation of sodium channels. In addition, it seems that inhibition of the release of neurotransmitters by blocking the presynaptic sodium channels and the development of action potentials, which in turn reduces the synaptic transmission, is important.

 

Has a moderate antimanic, antipsychotic effect, as well as analgesic effect with neurogenic pain. The mechanisms of action may involve GABA receptors, which may be associated with calcium channels; Also, apparently, the effect of Carbamazepine (the active ingredient of Finlepsin) on systems of neurotransmitter modulators is important.

 

The antidiuretic effect of carbamazepine may be associated with a hypothalamic effect on the osmoreceptors, which is mediated through the secretion of ADH, and is also due to direct action on the renal tubules.

 

Composition

 

Carbamazepine + excipients.

 

Pharmacokinetics

 

When taking the drug inside Finlepsin slowly, but almost completely absorbed from the digestive tract (eating does not significantly affect the speed and degree of absorption). In the spinal fluid and saliva, concentrations are proportional to the amount of the active substance unbound with proteins (20-30%). It penetrates the placental barrier and is excreted in breast milk (the concentration is 25-60% of that in the blood plasma). Metabolised in the liver. Carbamazepine can induce its own metabolism. After a single oral intake of 72% of the dose is excreted in the urine and 28% with feces; while about 2% are excreted in the urine in the form of unchanged carbamazepine, about 1% - in the form of a metabolite.

 

Indications

  • epilepsy: primary generalized seizures (with the exception of absences), partial forms of epilepsy (simple and complex seizures), secondary generalized seizures;
  • neuralgia of the trigeminal nerve;
  • idiopathic neuropathy of the glossopharyngeal nerve;
  • pain in diabetic polyneuropathy;
  • epileptiform cramps in multiple sclerosis, spasms of facial muscles with trigeminal neuralgia, tonic convulsions, paroxysmal dysarthria and ataxia,paroxysmal paresthesia and attacks of pain;
  • alcohol abstinence syndrome (anxiety, convulsions, hyperexcitability, sleep disturbances);
  • psychotic disorders (affective and schizoaffective disorder, psychosis, impaired function of the limbic system).

 

Forms of release

 

Tablets 200 mg, 400 mg (retard).

 

Instructions for use and dosage

 

Pills

 

Install individually. When ingested for adults and adolescents 15 years and older, the initial dose is 100-400 mg. If necessary, and taking into account the clinical effect, the dose is increased by no more than 200 mg per day at intervals of 1 week. Frequency of admission is 1-4 times a day. The maintenance dose is usually 600-1200 mg per day in several doses. The duration of treatment depends on the indications, the effectiveness of treatment, the patient's reaction to therapy.

 

Children under the age of 6 years are administered 10-20 mg / kg per day in 2-3 divided doses; if necessary and taking into account the tolerability dose is increased by no more than 100 mg per day at intervals of 1 week; the maintenance dose is usually 250-350 mg per day and does not exceed 400 mg per day. Children aged 6-12 years - 100 mg twice a day on the first day, then increase the dose by 100 mg per day at intervals of 1 week.until the optimum effect is obtained; the maintenance dose is usually 400-800 mg per day.

 

Maximum doses: when ingested by adults and adolescents 15 years and older - 1.2 grams per day, children - 1 g per day.

 

Retard tablets

 

Tablets are taken orally during or after a meal, with a sufficient amount of liquid. If necessary, the tablet (as well as its half or quarter) can be pre-dissolved in water or in juice (while retaining the ability to prolong the release of the active substance).

 

The average range of doses is 400-1200 mg per day, the frequency of administration is 1-2 times a day. The maximum daily dose is 1600 mg.

 

In epilepsy, whenever possible, Finlepsin retard should be given as a monotherapy. Treatment begins with the application of a small daily dose, which is then slowly increased until an optimal effect is achieved.

 

The admission Finlepsin to the already conducted antiepileptic therapy should be carried out gradually, while the doses of the drugs used do not change or, if necessary, correct.

 

If you miss a dose of the next dose, take the missed dose immediately, as soon as it is noticed, while you can not take a double dose of the drug.

 

For adults, the initial dose is 200-400 mg per day, then the dose is slowly increased to achieve the optimal therapeutic effect. The maintenance dose is 800-1200 mg per day (in 1-2 divided doses).

 

The initial dose for children aged 6 to 15 years is 200 mg per day, then the dose is gradually increased by 100 mg per day until the optimal effect is achieved.

 

Supportive doses for children aged 6-10 years - 400-600 mg per day (in 2 divided doses), for children aged 11-15 years - 600-1000 mg per day (in 2 divided doses).

 

The duration of application depends on the indication and the individual reaction of the patient to the drug.

 

The decision to transfer a patient to the use of the drug Finlepsin retard, the duration of its use or the withdrawal of treatment is made by the doctor individually. The dose of the drug can be reduced or completely canceled no earlier than after a 2-3-year total absence of seizures. Cancellation of the drug is carried out gradually, reducing the dose for 1-2 years, under the control of EEG. In this case, children with a decrease in the daily dose should take into account the increase in body weight with age.

 

With neuralgia of the trigeminal nerve, idiopathic glossopharyngeal neuralgia, the initial dose is 200-400 mg per day in 2 divided doses.The initial dose is increased until the pain disappears completely, on average to 400-800 mg per day. After that, in a certain part of the patients, therapy can be continued at a lower maintenance dose of 400 mg per day.

 

With pain in diabetic neuropathy, the drug is prescribed 200 mg in the morning and 400 mg in the evening. In exceptional cases, the drug Finlepsin retard can be prescribed in a dose of 600 mg 2 times a day.

 

In the treatment of alcohol abstinence in a hospital, the average daily dose is 600 mg (200 mg in the morning and 400 mg in the evening). In severe cases, in the early days, the dose can be increased to 1200 mg per day in 2 divided doses.

 

If necessary, the preparation Finlepsin retard can be combined with other drugs used to treat alcohol withdrawal, except sedatives and hypnotics. During the treatment, the content of carbamazepine in the blood plasma must be regularly monitored. In connection with the development of adverse reactions from the side of the central nervous system and the autonomic nervous system, patients are carefully monitored in a hospital.

 

With epileptiform cramps in multiple sclerosis, the average daily dose is 200-400 mg 2 times a day.

 

For the treatment and prevention of psychosis, the initial dose and maintenance dose is 200-400 mg per day. If necessary, the dose can be increased to 400 mg twice a day.

 

Side effect

  • dizziness;
  • ataxia;
  • drowsiness;
  • headache;
  • involuntary movements;
  • nystagmus;
  • paresthesia;
  • muscle weakness;
  • hallucinations;
  • depression;
  • feeling tired;
  • aggressive behavior;
  • impaired consciousness;
  • activation of psychosis;
  • violation of taste;
  • conjunctivitis;
  • noise in ears;
  • nausea, vomiting;
  • dry mouth;
  • diarrhea or constipation;
  • decreased appetite;
  • stomach ache;
  • glossitis;
  • stomatitis;
  • bradycardia;
  • arrhythmias;
  • AV-blockade with syncope;
  • collapse;
  • heart failure;
  • manifestations of coronary insufficiency;
  • thrombophlebitis;
  • thromboembolism
  • leukopenia, eosinophilia, thrombocytopenia, leukocytosis, agranulocytosis, aplastic anemia, erythrocyte aplasia, megaloblastic anemia, reticulocytosis, hemolytic anemia;
  • fluid retention;
  • edema;
  • increase in body weight;
  • increased cholesterol and triglycerides;
  • gynecomastia or galactorrhea;
  • thyroid dysfunction;
  • impaired renal function;
  • interstitial nephritis;
  • kidney failure;
  • pneumonitis or pneumonia;
  • skin rash;
  • itching;
  • lymphadenopathy;
  • fever;
  • arthralgia.

 

Contraindications

  • AV blockade;
  • previous mielodepression;
  • intermittent porphyria in the anamnesis;
  • simultaneous administration of MAO inhibitors and lithium preparations;
  • increased sensitivity to carbamazepine.

 

Application in pregnancy and lactation

 

If necessary, use during pregnancy (especially in the first trimester) and during lactation should carefully weigh the expected benefit of treatment for the mother and the risk to the fetus or child. In this case, Finlepsin is recommended only in the form of monotherapy in the lowest effective doses.

 

Women of childbearing age during the treatment with carbamazepine are recommended to use non-hormonal contraceptives.

 

Use in children

 

The drug is prescribed for children older than 6 years.

 

special instructions

 

Finlepsin is not used in atypical or generalized small epileptic seizures, myoclonic or atonic epileptic seizures. Do not use to relieve normal pain; as a preventive agent during long periods of remission of trigeminal neuralgia.

 

They are used with caution in case of concomitant diseases of the cardiovascular system, expressed violations of the liver and / or kidney function, diabetes mellitus, increased intraocular pressure, with a history of hematological reactions to other drugs, hyponatremia, urinary retention, hypersensitivity to tricyclic antidepressants , with a history of interrupting the course of treatment with carbamazepine, as well as children and elderly patients.

 

Treatment should be carried out under the supervision of a doctor. With long-term treatment, it is necessary to monitor the blood picture, the functional state of the liver and kidneys, the concentration of electrolytes in the blood plasma, and conduct an ophthalmological examination. It is recommended to periodically determine the level of carbamazepine in the blood plasma to monitor the effectiveness and safety of treatment.

 

At least 2 weeks before the initiation of therapy with Finlepsin, treatment with MAO inhibitors should be discontinued.

 

During the treatment period, do not drink alcohol. Finlepsin reduces the tolerance of ethanol (alcohol).

 

Impact on the ability to drive vehicles and manage mechanisms

 

During treatment, one should refrain from engaging in potentially dangerous activities that require increased attention, speed of psychomotor reactions.

 

Drug Interactions

 

With the simultaneous use of Finlepsin stimulates the metabolism of anticoagulants, folic acid.

 

With simultaneous application with valproic acid, a decrease in Finlexin concentration and a significant decrease in the concentration of valproic acid in the blood plasma are possible. This increases the concentration of the carbamazepine-epoxide metabolite (probably due to the inhibition of its conversion to carbamazepine-10,11-trans-diol), which also has anticonvulsant activity, so the effects of this interaction can be leveled, but more often there are side reactions - blurred vision, dizziness, vomiting, weakness, nystagmus. With the simultaneous use of valproic acid and carbamazepine, the development of a hepatotoxic effect is possible (apparently due to the formation of a secondary metabolite of valproic acid, which has a hepatotoxic effect).

 

With the simultaneous use of valpromide reduces the metabolism in the liver of carbamazepine and its metabolite carbamazepine-epoxide due to inhibition of the enzyme epoxide hydrolase. This metabolite has anticonvulsant activity, but with a significant increase in the concentration in the blood plasma can have toxic effects.

 

With simultaneous use with verapamil, diltiazem, isoniazid, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazolum, desipramine, nicotinamide (in adults, only in high doses), erythromycin, troleandomycin, josamycin, clarithromycin; with azoles (including with itraconazole, ketoconazole, fluconazole), terfenadine, loratadine, an increase in the concentration of carbamazepine in the blood plasma is possible with a risk of side effects (dizziness, drowsiness, ataxia, diplopia).

 

When used simultaneously with hexamidine, the anticonvulsant effect of carbamazepine is weakened; with hydrochlorothiazide, Furosemide - it is possible to reduce the sodium content in the blood; with hormonal contraceptives - it is possible to weaken the effect of contraceptives and to develop acyclic bleeding.

 

With simultaneous use with thyroid hormones, an increase in the elimination of thyroid hormones is possible; with Clonazepam - it is possible to increase the clearance of clonazepam and decrease the clearance of carbamazepine; with lithium preparations - the mutual enhancement of neurotoxic action is possible.

 

At simultaneous application with the primidonum reduction of concentration Finplepsina in a blood plasma is possible. There are reports that primidone may increase the concentration in the plasma of the pharmacologically active metabolite - carbamazepine-10,11-epoxide.

 

With simultaneous application with ritonavir, the side effect of carbamazepine may be increased; with sertraline - may decrease sertraline concentration; with theophylline, rifampicin, cisplatinum, doxorubicin - a decrease in the concentration of carbamazepine in the blood plasma; with Tetracycline - possibly weakening the effects of carbamazepine.

 

With concomitant use with felbamate, a decrease in Finlexin concentration in the blood plasma is possible, but an increase in the concentration of the active metabolite of carbamazepine-epoxide, with a decrease in the concentration of felbamate in the plasma.

 

With simultaneous use with phenytoin, phenobarbital, the concentration of carbamazepine in the blood plasma decreases. Possible mutual weakening of anticonvulsant action, and in rare cases - its amplification.

 

Analogues of the drug Finleshesin

 

Structural analogs for the active substance:

  • Actinerval;
  • Apo Carbamazepine;
  • Zagreton;
  • Zeptol;
  • Carbaleptin retard;
  • Carbamazepine;
  • Carbapine;
  • Carbasan retard;
  • Mazepine;
  • Stasepine;
  • Storilate;
  • Tegretol;
  • Finlepsin retard;
  • Epial.

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Reviews (23):
Guests
Ladushka
Finlepsin is a wonderful medicine that helped me endure and give birth to a healthy son. I suffer from epilepsy, there are periodic seizures. At first she took Lamictal, Wimpat, Carbamazepine, but because of these drugs I had drowsiness. Then the neurologist prescribed me to drink Finlepsin 1200 mg per day. In parallel, I take folic acid, tk. Finlepsin removes it from the body. My bouts stopped. The general condition has improved - there is no irritability, drowsiness.The mood is always excellent! The child was born absolutely healthy.

I continue to take the drug and now. It does not affect the ability to drive, which can not but rejoice me! The main thing is to take the drug all the time so that the attacks do not return.
Guests
GOBLIN
Finlepsin is either a monstrous remedy, or I was not properly dosed by a doctor. After a two-day intake (1 tablet twice a day), the head was spinning. Periodically - dips in memory, a violation of consciousness. After calling the doctor, I recommended simply cancel. Yes, finlepsin was prescribed to me along with sleeping pills. Be very careful when taking finplepsin.
Guests
Adelaide Mikhailovna
I started taking finlepsin 200 mg twice a day with inflammation of the trigeminal nerve. On the second day of the reception, an allergy started in the form of red spots all over the body and unbearable itching.
Guests
Nika
Yes, the same garbage. After reception the head turns, small red maculae have appeared and constantly pulls in a dream, I accept on a floor of a tablet 2 times a day (an inflammation of an occipital nerve).
Guests
Alya
Have appointed or nominated finlepsin at a neuralgia, the pain has passed or has taken place after the first reception, on drowsiness it is possible to close eyes, at neuralgia to have a sleep it is useful after sleepless nights with a pain and even on a giddiness, and here with diseases of heart it is necessary to begin even from half of a tablet, it was necessary to cancel a preparation for the second day because of Pts. heart palpitations.
Guests
silceva elena vasilevna
Fenlepsin started taking after a doctor. What happened to me. The first day is all right, the second as if everywhere the pulse beats, and the heart seems to pop up. It's scary, and what to do as his trigeminal nerve is cured. I'm crying, but I'm drinking myself.
Guests
wife
After the techniques he became angry, sharply excitable, very nervous-irritable, but confusion passed.
Guests
Irina
Have appointed the daughter on a floor of a tablet 2 times a day. On the third day, memory began to disappear, the chamarache went, hallucinations began.
Guests
sergey2
Swollen lymph nodes. Her erection was gone. Difficulty with urination.Vision has fallen and there is still a lot to be done with it. Death to the one who invented it!
Guests
Natasha Crossstitch
Any drug can cause allergies, loss of erection, drowsiness, dementia, vomiting, diarrhea, etc. etc. Sorry for such a set of extraordinary physiological processes that our body can reward us. Well, that's his reaction to all sorts of tablets, syrups, potions ... I was just helped by the drug with glossopharyngeal neuralgia. It hurt for a long time, painfully, reached such a point that I just did not want to live another day. By the way, I could not diagnose it for almost 3 years, apparently because there are many symptoms that are different (pain in the throat when swallowing, in the neck, in the ear, in the jaw, and at the same time a whole set of neurological disorders, in the form of dizziness, fainting , weakness, drowsiness ... okay, I will not, each of us has his own sores). Finlepsin brought me back to life! Lord, where was that doctor who appointed me to him, and where was the fenglinsin himself these three years of my torment. I also had dizziness from him, there was a bit of pressure in my eyes, a little nausea.I'm ready to endure it, if only my former pains would not return. This is compared to them - just insignificant. He saved me - do not exaggerate at all. The drug of course, special, it's not a simple analgin or ascorbic, no! It is not sold without a prescription (in my city, at least). He has just a huge amount of pills, note that he is drinking at a special rate, which is simply very important to observe (and not as we used to - threw the pill into his mouth, helped - it means he stopped drinking, did not help - well, the fuck with her, another drink). But to whom he is vitally important, and that many drink it all his life (for example, with epilepsy). If to whom also has not approached or suits - means not your preparation, there are analogues. Health to all!
Visitors
ktyjr
The doctor diagnosed bilateral neuralgia of the first branch of the trigeminal nerve (although two other neuropathologists denied neuralgia due to the pains of both sides of the face). I do not understand the "diagnostic" subtleties, I just wanted to get rid of the pain. Finlepsin helped. Although some side effects were: drowsiness, dizziness, a sense of "flight".Probably "was not cured," because during hypothermia, mild pains in the forehead, eye, nose and upper jaw areas are renewed. I try not to "run" them. I do warming compresses, I take diclofenac (ointment and pills). But in winter frost I hope Finlepsin will help again. The drug is not easy, but everything depends, apparently, on individual tolerance.
Guests
Tanya
A year and a half ago, in the summer I was stretched. the right side of the face, woke up in the morning, did not know what was happening to me. I thought that it was a mild paralysis. Finlepsin saved me, I drank one tablet in the morning and in the evening for 10 days and everything went away. Yes, I do not argue, there were pobochki. Terrible drowsiness, pulse pulse in the head. All muscles are relaxed, it was hard to talk, walk. But believe me, this is something with how finlepsin helps. My mother suffered from epilepsy, drank them for 20 years and recovered. The most important thing is to choose the dosage for yourself, as the doctor will say. A pobochki with regular use will pass, be sure. All of health!
Guests
Jargal
My father has epileptic seizures. After taking finplepsin it got worse.Dips in the memory of nausea, seizures became frequent.
Guests
FGHk
One of my friends for 20 years took finlepsin and unfortunately he not only helped him, but also caused epilepsy in all its glory. If the cause of the appointment was the diagnosis of asthenic syndrome (as explained by the depletion of the nervous system), now now throughout life, a person suffers from seizures, convulsions, memory dips and much more, so it's better to check everything 100 times before deciding to take a drug that you probably do not need. As it turned out later, when this man once again went to the hospital, where he was examined by the professor, he could not take this drug at all, and the man had been sitting there for 20 years at that time. Here we have "doctors", ruined all health.
Guests
alpha
Epilepsy I have 20 years. There was carbamazepine first seizure once every 2 weeks after every 2 days of incapacity. Finlepsin eased the situation - 1 time in 2 months, Finlepsin retard brought the run to 2 years - the family sighed calmly. Outwardly, there are no manifestations.It is clear that the stove-buds are planted, but from 2 evils choose what you like. Russian carbaleptin retard dumped in 2 days.
Guests
Danil
He took the drug for 2 years, appointed a neurologist, suffered panic attacks, dizziness and was lost in space. He transferred the medicine normally, led a full-fledged way of life, well, when he decided to give up: I was dizzy, my head was spinning and I could not work. He suffered a couple of weeks, pierced Cortexin's course and everything went away.
Guests
NANULE
I have a mild depression. Has addressed to the psychotherapist, she has appointed to me Finlepsin on 100 mg in the morning and in the evening. I accept 3 days already. I hardly walk, I want to sleep all day, absolutely nothing I want to do. Only sleep and sleep.
Guests
Vladimir.
After a stroke, suffered 15 years ago, there was a complication, episindrom. Epileptic seizures and seizures were more frequent during a sharp change in weather and atmospheric pressure. The general state is oppressive, memory failures, bad mood. On appointment, the doctor drank Finplepsin 15 days for 2 tablets 200 mg per day and 15 days at the end for 1 tablet a day.The general state of health is normal, the seizures have decreased, the mood is not very good, and the memory is completely gone. We will look for an alternative.
Guests
Nazir
There were faints of an incomprehensible nature. Doctors believed that this is a small epileptic seizure. As he began to drink Finlepsin 100 mg 3 times a day, everything immediately passed.
Guests
Anara
I took finlepsin for two weeks according to the scheme prescribed by the doctor. Result: headaches daily, lymph node enlargement, temperature. The doctor immediately canceled. Now I'm waiting for further appointments or instructions from the doctor. But definitely, I do not want to drink anymore.
Guests
Tatyana
At me the diagnosis a pinch of a trigeminal nerve. Have written out finlepsin + still nyxes 4 in one + diclofenac. The pains were dulled after a shot-cocktail, and after finlepsin 1 tab. at night 200 mg before the cessation of pain, I sit in some kind of prostration easy, hunting to lie down, fog in my head. But what I want to say, in comparison with the pains that I experienced, these are mere trifles. Of course, strict observation of the doctor is necessary.I, say, was told to come to the reception after a course of injections (5 times), you need to comply with the regime. I will definitely go.
Guests
Alla
I have neuralgia of the trigeminal nerve, I sat, called, under the conditioner. The pain was very strong. Literally a day later, almost all passed. I drank a month, I decided that it was enough, everything was fine. And immediately the pain returned. Run to the doctor and she "calmed me" that I drink it all winter. Here also I drink finlepsin 4 months. Pain almost does not bother. I feel good. Tablets are super! Only one side effect was manifested - a buzz in the ears. I hope to pass when I stop drinking. Good health to everyone.
Guests
Zina
Carbamazepine, an analogue of finlepsin, I have been taking it for 5 years already and it helps me a lot, improves mood, cleans delusions, calms and all these medicines should accumulate in the body for a couple of weeks, and then there is a curative effect.

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