Escapel - instructions for use, reviews, analogs and formulations (1.5 mg tablets) of the contraceptive drug for hormonal contraception in women (including during pregnancy and lactation). Side effects (discharge, bleeding)

In this article you can get acquainted with the instructions for the use of a hormonal drug Escapel. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Escapel in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Escapel in the presence of existing structural analogs.Use for hormonal contraception in women (including during pregnancy and lactation). Side effects (discharge, bleeding) of the drug.

Escapel - postcoital contraceptive for emergency contraception with pronounced gestagenic and antiestrogenic action. With the recommended dosing regimen, ovulation and fertilization are suppressed if the sexual intercourse occurred during the preovulatory phase of the menstrual cycle, i.e. in the period of greatest probability of fertilization. In addition, the regression of endometrial proliferation caused by the drug prevents the implantation of a fertilized egg. With the implantation the drug is ineffective.

If the recommended dosage regimen is followed, levonorgestrel (active substance of the Escapel preparation) does not have a significant effect on blood coagulation factors, fat and carbohydrate metabolism.

Reception of the drug Escapel is recommended to begin as soon as possible (but no later than 72 hours) after sexual intercourse, if no protective measures have been applied. The more time elapses between the sexual act and administration of the drug, the lower its efficiency (95% for the first 24 hours, 85% - from 24 to 48 hours, and 58% - from 48 to 72 hours).

Composition

Levonorgestrel + auxiliary substances.

Pharmacokinetics

After intake, Escapel is quickly and completely absorbed from the digestive tract. Absolute bioavailability is 100%. Levonorgestrel binds with albumin and globulin, binding sex hormones (SHGG). Levonorgestrel is excreted approximately equally by the kidneys and through the intestine exclusively in the form of metabolites.

Diseases of the gastrointestinal tract, which occur with a violation of absorption, reduce the absorption of the drug, which can affect its effectiveness.

Indications

• emergency (postcoital) contraception (after unprotected sex or unreliability of the contraceptive method used).

Forms of release

Tablets of 1.5 mg.

Instructions for use and reception scheme

The drug is taken orally 1.5 mg (1 tablet) as soon as possible, but no later than 72 hours after unprotected intercourse (the effectiveness of emergency contraception with delayed use of the drug is significantly reduced). If within 3 hours after taking a vomiting, Escapel should be taken again at a dose of 1.5 mg (1 tablet).

The drug can be used at any time of the menstrual cycle.In the case of an irregular menstrual cycle, pregnancy should be excluded.

After taking Escapel before the next menstrual period, local barrier methods of contraception (for example, a condom) should be used. The use of the drug with repeated unprotected intercourse during one menstrual cycle is not recommended because of the increased frequency of acyclic bleeding or bleeding.

Side effect

• hives;
• rash;
• itching;
• swelling of the face;
• nausea, vomiting;
• diarrhea;
• fatigue;
• headache;
• dizziness;
• pain in the lower abdomen;
• acyclic bleeding (bleeding);
• tenderness of the mammary glands;
• delay in menstruation (no more than 5-7 days, if menstruation is delayed for a longer period, pregnancy should be excluded).

Contraindications

• severe hepatic impairment;
• use in adolescents under 16;
• pregnancy;
• lactose intolerance, lactase deficiency or glucose / galactose malabsorption;
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

Escapel is contraindicated for use in pregnancy.Based on the available data, there was no adverse effect of the drug on the fetus on the occurrence of pregnancy against the background of the emergency contraceptive method.

Levonorgestrel is excreted in breast milk. After taking the drug, breast-feeding should be stopped for 24 hours.

special instructions

This drug is intended exclusively for emergency contraception and does not replace regular contraception. Repeated use of the drug Escapel during one menstrual cycle is not recommended.

Escapel should be taken as soon as possible, but no later than 72 hours after unprotected intercourse. The effectiveness of emergency contraception with delayed use of the drug is significantly reduced.

In most cases, Escapel does not affect the nature of the menstrual cycle. However, acyclic bleeding may occur and menstruation may be delayed for several days. If you delay menstruation for more than 5-7 days and change its nature (scanty or abundant discharge), you must exclude pregnancy. The appearance of pain in the lower abdomen, fainting can indicate ectopic (ectopic) pregnancy.

Teenagers under the age of 16 in exceptional cases (including with rape) need advice from a gynecologist, to confirm pregnancy. After emergency contraception, a gynecologist is recommended to choose the most suitable method for permanent contraception.

Emergency contraception does not protect against sexually transmitted diseases.

In case of violations of the function of the digestive tract (for example, with Crohn's disease) the effectiveness of the drug may decrease.

Impact on the ability to drive vehicles and manage mechanisms

The effect of the drug on the ability to manage motor vehicles and other mechanisms has not been studied.

Drug Interactions

With simultaneous application of the drug Escapel with inducers of liver enzymes, the metabolism of levonogestrel is accelerated.

The contraceptive effect of the Escapel drug decreases with simultaneous use with the following medicines: amprenavir, lansoprazole, nevirapine, oxycarbazepine, tacrolimus, topiramate, tretinoin, barbiturates, including primidone, phenytoin and carbamazepine, preparations containing St. John's wort, rifampicin, ritonavir, ampicillin, tetracycline, rifabutin, griseofulvin.

Escapel reduces the effectiveness of hypoglycemic and anticoagulant (coumarin derivatives, phenyldione) drugs.

Levonorgestrel increases plasma concentrations of GCS.

Preparations containing levonorgestrel may increase the risk of toxicity of cyclosporine, due to the suppression of its metabolism.

Analogues of the drug Escapel

Structural analogs for the active substance:

• Levonorgestrel;
• Microlus;
• Mirena;
• Norplant;
• Postinor;
• Eskinor-F.

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