Decaris - instructions for use, analogs, reviews and release forms (tablets of 50 mg and 150 mg) of the drug for the treatment of helminthiases (ascariasis, enterobiasis and other worms) in adults, children and in pregnancy based on levamisole
In this article, you can read the instructions for using the drug Dekaris. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Decaris in their practice. A big request is to actively add their feedback about the drug on the basis of levamisole: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Decaris with available structural analogues. Use for the treatment of helminthiases (ascariasis,enterobiasis and other worms) in adults, children, as well as during pregnancy and lactation.
Dekaris - anthelmintic preparation. Acting on the ganglion-like formations of nematodes, Decaris causes depolarizing neuromuscular paralysis of the membrane of helminth muscles, blocks succinate dehydrogenase, inhibits fumarate dehydrogenase, disrupting the course of bioenergetic processes of helminths. Thus, paralyzed nematodes are removed from the body by normal intestinal peristalsis within 24 hours after taking the drug.
Composition
Levamisole hydrochloride + excipients.
Pharmacokinetics
Decaris when taken in a dose of 50 mg is rapidly absorbed from the digestive tract. The maximum concentration in the blood plasma is determined by an average of 1.5-2 hours after taking the drug. Levamisol is subject to intensive metabolism in the liver, its main metabolites are p-hydroxy-levamisole and its glucuronide. In the unchanged form, kidneys release less than 5%, through the intestine less than 0.2% of the administered dose.
Indications
- toxoplasmosis;
- necropsy;
- ankylostomidosis;
- ascaridosis;
- strongyloidiasis;
- trichurosis;
- enterobiosis;
- trichostrongyloidosis.
Forms of release
Tablets 50 mg and 150 mg.
Instructions for use and dosing regimen
Adults receive 1 tablet 150 mg once. Children aged 3 to 6 years (10-20 kg) - 25-50 mg (0.5-1 tablet of 50 mg); children aged from 6 to 10 years (20-30 kg) 50-75 mg (1-1.5 tablets of 50 mg), children aged 10 to 14 years (30-40 kg) - 75-100 mg (1.5- 2 tablets of 50 mg) once.
The drug should be taken after a meal with a little water, in the evening. There is no need for a laxative or special diet. If necessary, taking the drug can be repeated after 7-14 days.
Side effect
- headache;
- insomnia;
- dizziness;
- a feeling of palpitations;
- convulsions;
- dyspeptic phenomena (nausea, vomiting, abdominal pain, diarrhea);
- encephalopathy 2-5 weeks after taking the drug;
- skin rash;
- convulsions;
- leukopenia, agranulocytosis;
- tremor.
Contraindications
- agranulocytosis caused by drugs (in the anamnesis);
- children under 3 years;
- the period of breastfeeding.
150 mg tablets are not prescribed for children!
Application in pregnancy and lactation
The purpose of the drug during pregnancy is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.
If you need to use the drug during breastfeeding, you should decide whether to stop breastfeeding.
special instructions
During and after taking the drug within 24 hours you should not drink alcohol.
There is insufficient evidence that levamisole, used as an anthelminthic agent, depresses the nervous system.
Effect of the drug on the ability to drive and other mechanisms
Due to the fact that when taking the drug may occur transient, mild dizziness should be used with caution when driving a car or when working with mechanisms during the entire course of treatment.
Drug Interactions
At simultaneous reception of a preparation with alcohol disulfiramoid-like phenomena are observed.
Care must be taken when applying Decaris with drugs that affect hematopoiesis.
With the simultaneous administration of the drug with coumarin-like anticoagulants, prothrombin time may increase, so it is necessary to adjust the dose of oral anticoagulant. Decaris increases the level of phenytoin in the blood, so when using them at the same time, it is necessary to control the level of phenytoin in the blood.
Decaris can not be used simultaneously with lipophilic preparations, such as carbon tetrachloride, tetrachlorethylene, chanopodium oil, chloroform or ether, since its toxicity can increase.
Analogues of the drug Decaris
Structural analogues for the active substance of the drug Decaris does not.
Analogues on the therapeutic effect (antihelminthics):
- Biltricide;
- Vermox;
- Vero-Mebendazole;
- Worming;
- Gelmodol-VM;
- Helmintox;
- A thousand-thousandth grass;
- Mebendazole;
- Medamin tablets 0.1 g;
- Nemosol;
- Nemocide;
- Tansy flowers;
- Piperazine;
- Piperazine adipate;
- Pirantel;
- Piervinium;
- Sanoxal;
- Telmox 100;
- Pumpkin seeds.
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