Lincomycin - instructions for use, reviews, analogs and forms of release (capsules or tablets 250 mg hydrochloride, injections in injections, ointment) of a medicament for the treatment of abscess, endocarditis in adults, children and pregnancy

In this article, you can read the instructions for using the drug Lincomycin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Lincomycin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Lincomycin in the presence of existing structural analogues.Use for the treatment of abscess, endocarditis and other infectious and inflammatory diseases in adults, children, as well as during pregnancy and lactation.

Lincomycin - antibiotic group of lincosamides. In therapeutic doses acts bacteriostatically. At higher concentrations, it has a bactericidal effect. Suppresses protein synthesis in a microbial cell.

It is active mainly in relation to aerobic Gram-positive bacteria: Staphylococcus spp. (including strains producing penicillinase), Streptococcus spp. (including Streptococcus pneumoniae / with the exception of Enterococcus faecalis), Corynebacterium diphtheriae; anaerobic bacteria Clostridium spp., Bacteroides spp.

Lincomomycin is also active against Mycoplasma spp.

To lincomycin, the majority of gram-negative bacteria, fungi, viruses, protozoa are resistant. Stability is produced slowly.

There is a cross-resistance between lincomycin and clindamycin.

Composition

Lincomycin (in the form of hydrochloride monohydrate) + auxiliary substances.

Pharmacokinetics

After oral administration, 30-40% is absorbed from the digestive tract. Eating slows down the speed and degree of absorption. Lincomycin is widely distributed in tissues (including bone) and body fluids. Penetrates through the placental barrier. Partially metabolized in the liver.It is excreted unchanged in the form of metabolites with urine, bile and feces.

Indications

• infectious-inflammatory diseases of severe course, caused by microorganisms sensitive to lincomycin, incl. sepsis, osteomyelitis, septic endocarditis, pneumonia, lung abscess, pleural empyema, wound infection;
• as an antibiotic reserve in infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin and other antibiotics;
• for topical application: purulent-inflammatory skin diseases.

Forms of release

Capsules 250 mg (sometimes mistakenly called tablets).

Solution for intravenous and intramuscular injection (injections in ampoules for injection) 300 mg / ml.

Ointment for external use.

Instructions for use and dosage

Admission to adults - 500 mg 3-4 times a day or intramuscularly - 600 mg 1-2 times a day. Intravenously drip 600 mg in 250 ml of isotonic sodium chloride solution or glucose 2-3 times a day.

Children aged 1 month to 14 years inside - 30-60 mg / kg per day; intravenously drip in a dose of 10-20 mg / kg every 8-12 hours.

When topical application is applied a thin layer on the affected areas of the skin.

Side effect

• nausea, vomiting;
• pain in epigastrium;
• diarrhea;
• glossitis;
• stomatitis;
• with prolonged use in high doses, it is possible to develop pseudomembranous colitis;
• reversible leukopenia, neutropenia, thrombocytopenia;
• hives;
• exfoliative dermatitis;
• angioedema;
• anaphylactic shock;
• candidiasis;
• phlebitis (with intravenous administration);
• decreased blood pressure, dizziness, general weakness (with rapid intravenous injection).

Contraindications

• severe violations of the liver and / or kidney function;
• pregnancy;
• lactation;
• increased sensitivity to lincomycin and clindamycin.

Application in pregnancy and lactation

Lincomycin penetrates the placental barrier, excreted in breast milk. Use during pregnancy is contraindicated. If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

special instructions

If the liver and / or kidney function is impaired, one-time dose of lincomycin should be reduced by 1/3 - 1/2 and the interval between administrations should be increased. With prolonged use, systematic monitoring of kidney and liver function is necessary.

If pseudomembranous colitis develops, lincomycin should be discontinued and Vancomycin or bacitracin should be prescribed.

Drug Interactions

At simultaneous application with penicillins, cephalosporins, chloramphenicol or Erythromycin antagonism of antimicrobial action is possible.

With simultaneous use with aminoglycosides, synergy is possible.

With simultaneous application with funds for inhalation anesthesia or muscle relaxants of peripheral action, there is an increase in neuromuscular blockade, up to the development of apnea.

The use of antidiarrheal drugs reduces the effect of lincomycin.

Pharmaceutical interaction

Pharmaceutically incompatible with ampicillin, barbiturates, theophylline, calcium gluconate, Heparin and magnesium sulfate.

Lincomycin is incompatible in one syringe or dropper with kanamycin or novobiocin.

Analogues of the drug Lincomycin

Structural analogs for the active substance:

• Linkomycin-AKOS;
• Lincomycin hydrochloride;
• Lincomycin hydrochloride in capsules 0.25 g;
• Lincomomycin hydrochloride injection 30%;
• Neloren;
• Films with lincomycin.

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