Ambroxol - instructions for use, reviews, analogs and formulations (tablets 15 mg and 30 mg, syrup) of a drug for cough and sputum control in adults, children (including infants and newborns) and during pregnancy. Inhalation

In this article, you can read the instructions for using the drug Ambroxol. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of specialists on the use of Ambroxol in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Ambroxol in the presence of existing structural analogues.Use to treat cough and get rid of sputum for various diseases of the respiratory tract in adults, children, as well as during pregnancy and lactation.

Ambroxol - mucolytic agent with expectorant action. Stimulates the serous cells of the glands of the bronchial mucosa, increasing the content of mucous secretions and, thus, changes the disturbed ratio of serous and mucous components of sputum. This activates the hydrolyzing enzymes, and increases the release of lysosomes from Clara cells, which leads to a decrease in the viscosity of sputum. Ambroxol increases the content of surfactant in the lungs, which is associated with increased synthesis and secretion in the alveolar pneumocytes, as well as with disruption of its disintegration. Increases mucocellar sputum transport. Slightly suppresses cough.

Pharmacokinetics

Absorption is high. Penetrates through the blood-brain barrier, placental barrier, excreted in breast milk. It is excreted by the kidneys: 90% in the form of water-soluble metabolites, in unchanged form - 5%.

Indications

Diseases of the respiratory tract with the formation of viscous sputum:

• acute and chronic bronchitis
• pneumonia
• chronic obstructive pulmonary disease (COPD)
• bronchial asthma with difficulty in sputum discharge
• bronchoectatic disease
• cystic fibrosis;
• Respiratory distress syndrome in newborns and premature infants.

Forms of release

Tablets 15 mg and 30 mg.

Syrup (the ideal children's form of the drug).

Instructions for use and dosing regimen

Pills

Inside, during meals, with a small amount of liquid.

Adults and children over 12 years of age are prescribed - 30 mg 3 times daily for the first 2-3 days, then 30 mg twice a day or 15 mg (half a tablet) 3 times a day.

Children 6-12 years - 15 mg (half a tablet) 2-3 times a day.

It is not recommended to use without medical appointment for more than 4-5 days.

Syrup

Inside adults and children over 12 years old - 30 mg 2-3 times a day.

Dosage regimen for children under 12 years of age:

5-12 years - 15 mg - 2-3 times a day;

2-5 years - 7.5 mg - 3 times a day;

up to 2 years - 7.5 mg - 2 times a day.

In the form of inhalations for adults and children older than 5 years - 15-22.5 mg 1-2 times a day.

Parenterally (intramuscularly, intravenously), adults - 15 mg, in severe cases - 30 mg 2-3 times a day; children - 1.2-1.6 mg / kg 3 times a day.

For the treatment of respiratory distress syndrome in preterm and newborn children, ambroxol is administered iv or IM at a dose of 10 mg / kg per day, the frequency of administration is 3-4 times a day,If necessary, the dose can be gradually increased to 30 mg / kg per day.

Side effect

• skin rash;
• hives;
• angioedema;
• allergic contact dermatitis;
• anaphylactic shock;
• weakness;
• headache;
• diarrhea;
• dry mouth and respiratory tract;
• rhinorrhea;
• constipation;
• dysuria;
• abdominal pain;
• nausea, vomiting.

Contraindications

• hypersensitivity;
• children's age till 6 years;
• pregnancy (1 term).

Application in pregnancy and lactation

The drug is not recommended for use during the first trimester of pregnancy. If necessary, use of ambroxol in 2-3 trimesters of pregnancy and during breast-feeding should evaluate the potential benefits for mother and possible risk to the fetus / baby.

special instructions

Do not combine with antitussive drugs that make it difficult to withdraw phlegm.

Drug Interactions

Joint use with antitussive drugs leads to difficulty in getting away from sputum while reducing the cough.

Increases penetration into the bronchial secretion of amoxicillin, cefuroxime, Erythromycin and doxycycline.

Analogues of Ambroxol

Structural analogs for the active substance:

• Ambrogen;
• AmbroGEXAL;
• Ambroxol Vramed;
• Ambroxol retard;
• Ambroxol-Verte;
• Ambroxol-Vial;
• Ambroxol-Richter;
• Ambroxol-Teva;
• Ambroxol-Hemofarm;
• Ambrolan;
• Ambrosan;
• Ambrosol;
• Bronoxoxol;
• Bronchorus;
• Dephlegmine;
• Bronchovern drops;
• Lazolangin;
• Lazolvan;
• Medox;
• Mucobron;
• Neo-Bronhol;
• Remebroks;
• Suprima-kof;
• Fervex from coughing;
• Flavamed;
• Haliksol.

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