Flavamed - instructions for use, analogs, reviews and release forms (solution or syrup 15 mg, tablets 30 mg, 60 mg Forte) drug for coughing with bronchitis, pneumonia in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Flavamed. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Flavamed in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Flavameda in the presence of existing structural analogues. Use for cough treatment in bronchitis, pneumonia, bronchiectasis in adults, children, as well as during pregnancy and breast-feeding. Composition of the preparation.

Flavamed - expectorant mucolytic agent.Ambroxol (the active substance of the drug Flavamed) is an active N-demethylated metabolite of bromhexine. Has a secreto-motor, secretolitic and expectorant action. Stimulates the serous cells of the glands of the bronchial mucosa, increasing the content of mucous secretions and, thus, changes the disturbed ratio of serous and mucous components of sputum. Flavamed increases the content of mucous secretions and the release of surfactant (surfactant) in the alveoli and bronchi. Increases the motor activity of the ciliated epithelium, increases the mucocilliar transport of phlegm.

On average, when taken orally, the effect occurs after 30 minutes, the duration of the action is 6-12 hours, depending on the size of the single dose.

Composition

Ambroxol hydrochloride + excipients.

Pharmacokinetics

After oral administration, Flavamed is rapidly and almost completely absorbed from the digestive tract. Absolute bioavailability of Ambroxol when administered orally as a result of metabolism associated with the effect of the first passage through the liver decreases by approximately 1/3. The resulting metabolites (such as dibromantranilic acid, glucuronides) are excreted by the kidneys.Binding to plasma proteins is about 85% (80-90%). Ambroxol penetrates the blood-brain barrier (GEB) and placental barriers, and is also excreted in breast milk. Ambroxol is metabolized in the liver by conjugation with the formation of pharmacologically inactive metabolites. It is excreted mainly by the kidneys - 90% in the form of metabolites formed in the liver. Less than 10% of the amount excreted through the kidneys account for the proportion of ambroxol in unchanged form.

Indications

Acute and chronic diseases of the respiratory tract, accompanied by impaired secretion and transport of sputum:

• acute and chronic bronchitis;
• pneumonia;
• chronic obstructive pulmonary disease;
• bronchial asthma with difficulty in sputum discharge;
• bronchiectatic disease.

Forms of release

Solution for ingestion 15 mg (sometimes mistakenly called syrup).

Tablets 30 mg and 60 mg (Forte).

Instructions for use and dosage

Tablets and solution

Adults and children over 12 years of age during the first 2-3 days are prescribed 3 times a day for 30 mg (1 tablet or 2 measuring spoons (10 ml) solution, corresponding to 90 mg ambroxol hydrochloride per day, then 2 times a day for 30 mg (1 tablet or 2 measuring spoons), which corresponds to 60 mg of ambroxol hydrochloride per day.If necessary, 60 mg (2 tablets or 4 measuring spoons (20 ml) solution) can be prescribed to enhance the therapeutic effect 2 times a day (corresponding to 120 mg ambroxol hydrochloride per day).

Children aged 6 to 12 years: 2-3 times a day for 15 mg (1/2 tablets or 1 measuring spoon solution), which corresponds to 30-45 mg ambroksola hydrochloride per day.

Children aged 2 to 6 years, the drug is prescribed only as a solution 3 times a day for 1/2 scoops (2.5 ml), which corresponds to 22.5 mg ambroksola hydrochloride per day.

Children under 2 years: 2 1/2 teaspoons (2.5 ml) of solution, which corresponds to 15 mg of ambroxol hydrochloride per day.

With renal failure or severe liver damage, you should increase the interval between doses or reduce the dose.

The drug is taken after meals: tablets - without chewing and drinking with a sufficient amount of liquid, a solution - using a measuring spoon. Duration of application is determined individually, depending on the indications and course of the disease. Without the appointment of a doctor, Flavamed should not be taken more than 4-5 days.

Flavamed Forte

Inside adults and children over 12 years - 60 mg 1-2 times a day.

In the form of inhalations for adults and children older than 5 years - 15-22.5 mg 1-2 times a day.

Side effect

• skin rash;
• hives;
• angioedema (tablets);
• edema of the face (solution);
• hyperthermia;
• dyspnea;
• anaphylactic shock;
• diarrhea;
• dry mouth;
• constipation (tablets);
• abdominal pain;
• nausea, vomiting (tablets and solution);
• toxic epidermal necrolysis;
• Stevens-Johnson syndrome (tablets);
• weakness;
• headache;
• dysuria;
• exanthema (tablets).

Contraindications

• congenital intolerance to fructose (for solution);
• children under 6 years (for tablets);
• increased sensitivity to ambroxol or other components of the drug.

Application in pregnancy and lactation

The use of the drug in the first trimester of pregnancy is contraindicated. In the 2 and 3 trimesters of pregnancy, the drug should be taken with caution.

The use of the drug during lactation is possible only if the expected benefit from treatment for the mother exceeds the possible risk for the baby.

Use in children

Contraindicated in children under the age of 6 (tablets) and children under the age of 12 (Forte tablets).

special instructions

In severe renal failure, it is necessary to take into account the possibility of accumulation of metabolites of ambroxol formed in the liver.

To maintain the secretolytic action of ambroxol during the period of taking the drug, it is necessary to ensure the intake of liquid in the body in sufficient quantities.

Precautions should be prescribed the drug in violation of the bronchi motility and the formation of secretions in large quantities (for example, a rare syndrome of fixed cilia), in patients with renal or hepatic insufficiency, gastric ulcer and duodenal ulcers, as well as children under the age of 2 years (solution) .

Do not use with dry cough (unproductive, without spitting). In this case, the use of antitussive drugs that block the cough reflex is required.

When administering the drug to patients with diabetes should be noted that a 5 ml solution (1 scoop) contained 1.75 g of sorbitol, which corresponds to 0.15 XE.

Impact on the ability to drive vehicles and manage mechanisms

Not installed.

Drug Interactions

With the combined use of ambroxol and antitussive drugs that suppress the cough reflex,due to the weakening of the cough reflex, there can be a danger of stagnant phenomena in the bronchi.

Increases penetration into the bronchial secretion of amoxicillin, cefuroxime, Erythromycin and doxycycline.

Analogues of the drug Flavamed

Structural analogs for the active substance:

• Ambrogen;
• Ambro Hexal;
• Ambroxol;
• Ambrolan;
• Ambrolore;
• Ambrosan;
• Ambrosol;
• Bronoxoxol;
• Bronchorus;
• Dephlegmine;
• Bronchovern drops;
• Lazolangin;
• Lazolvan;
• Medox;
• Mucobron;
• Neo Bronhol;
• Remebroks;
• Suprima-kof;
• Thoraxol Solidshn Tablets;
• Fervex from coughing;
• Haliksol.

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