Preductal - instructions for use, reviews, analogs and formulations (tablets 20 mg and 35 mg MB MP) of a medicament for the treatment of coronary heart disease in adults, including during pregnancy and lactation
In this article, you can read the instructions for using the drug Preductal. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Preductal in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Preductal in the presence of existing structural analogues. Use for the treatment of coronary heart disease and prevention of angina attacks in adults, children, as well as in pregnancy and lactation.
Preductal MB - prevents a decrease in the intracellular content of ATP by maintaining the energy metabolism of cells in a state of hypoxia. Thus, the drug ensures the normal functioning of membrane ion channels, transmembrane transfer of potassium and sodium ions and preservation of cellular homeostasis.
Trimetazidine (the active ingredient of the drug Preductal) slows the oxidation of fatty acids by selective inhibition of long chain 3-ketoacetyl-CoA thiolase, which leads to an increase in glucose oxidation and the restoration of conjugation between glycolysis and oxidative decarboxylation and causes myocardial protection from ischemia. Switching of oxidation of fatty acids to glucose oxidation underlies antianginal action of trimetazidine.
It has been experimentally confirmed that Preductal has the following properties:
- maintains the energy metabolism of the heart and neurosensory organs during ischemia;
- reduces the magnitude of intracellular acidosis and the degree of changes in the transmembrane ion flow that occurs with ischemia;
- lowers the level of migration and infiltration of polynucleated neutrophils in ischemic and reperfusion tissues of the heart;
- reduces the size of myocardial damage;
- does not directly affect the parameters of hemodynamics.
In patients suffering from angina, Preductal:
- increases coronary reserve, thereby slowing the development of ischemia caused by physical exertion, starting from the 15th day of therapy;
- limits severe fluctuations in blood pressure caused by physical exertion, without any significant changes in heart rate;
- significantly reduces the frequency of angina attacks and the need for short-acting nitroglycerin;
- improves the contractile function of the left ventricle in patients with ischemic dysfunction.
In clinical studies of 2 months, it was shown that adding Presedtal MV 35 mg to Atenolol at a dose of 50 mg after 12 hours resulted in a significant slowdown in the onset of ischemic depression in the ST segment during exercise tests.
Pharmacokinetics
After taking the drug, the drug is rapidly absorbed. Eating does not affect the pharmacokinetic properties of the drug. It is excreted from the body mainly by the kidneys in unchanged form.
Indications
- cardiology: prolonged therapy of IHD, prevention of attacks of stable angina (monotherapy or as part of combination therapy);
- ENT diseases: treatment of cochlear-vestibular disorders of ischemic nature, such as dizziness, tinnitus, hearing impairment;
- ophthalmology: chorioretinal disorders with ischemic component.
Forms of release
Tablets coated with 20 mg and 35 mg (Preductal MR).
Instructions for use and dosing regimen
Preductal MV is prescribed 1 tablet 2 times a day during meals in the morning and in the evening. The duration of therapy is set individually.
Tablets I take inwards whole, without chewing and washing down with water.
Side effect
- stomach ache;
- diarrhea;
- dyspepsia;
- nausea, vomiting;
- dizziness;
- headache;
- extrapyramidal symptoms (tremor, rigidity, akinesia), reversible after drug withdrawal;
-
a feeling of palpitations;
-
extrasystole;
-
tachycardia;
-
marked decrease in blood pressure;
-
Orthostatic hypotension, which may be accompanied by general weakness, dizziness or loss of balance, especially with the simultaneous use of antihypertensive drugs;
- flushes of blood to the skin of the face;
- skin rash;
- itching;
- hives;
- asthenia.
Contraindications
- marked renal failure (CC less than 15 ml / min);
- hypersensitivity to the components of the drug;
- children and adolescents under the age of 18.
Application in pregnancy and lactation
In experimental studies, the teratogenic effect of Trimetazidine has not been established. However, due to the lack of clinical data, the drug is not recommended for use in pregnancy.
It is not known whether trimetazidine is excreted in breast milk. Therefore, if it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.
Use in children
Due to the lack of sufficient clinical data, it is not recommended to prescribe the drug to children and adolescents under the age of 18 years.
Application in elderly patients
Caution should be used to prescribe Preductal MB to elderly patients over 75 years of age who may have an increase in exposure.
special instructions
Preductal MB is not intended for relief of angina attacks and is not indicated for the initial course of therapy for unstable angina or myocardial infarction at the prehospital stage or in the first days of hospitalization.
In the case of an angina attack, treatment should be reviewed and adapted (drug therapy or revascularization procedure).
MB reductase may cause or worsen symptoms of parkinsonism (tremor, akinesia, tone increase), therefore, regular monitoring of patients, especially of the elderly, should be carried out. In doubtful cases, patients should be referred to a neurologist for an appropriate examination.
When motor disorders such as Parkinsonism symptoms, restless legs syndrome, tremor, Romberg pose instability and gait unsteadiness occur, Preductal MB should be finally abolished.
Such cases are rare and symptoms usually pass after discontinuation of therapy: in most patients - within 4 months after discontinuation of the drug. If the symptoms of parkinsonism persist for more than 4 months after discontinuation of the drug, you should consult a neurologist.
There may be cases of falls associated with instability in the Romberg position and the "shakiness" of the gait or pronounced decrease in blood pressure, especially in patients taking antihypertensive drugs.
Caution should be used to prescribe Preductal MB to patients who may have an increase in exposure:
- with renal insufficiency of moderate and severe degree;
- in elderly patients older than 75 years.
Impact on the ability to drive vehicles and manage mechanisms
In the course of clinical studies, there was no evidence of the influence of Preductal MB on hemodynamics, however, in the period of post-marketing use, cases of dizziness and drowsiness were observed, which could affect the ability to drive vehicles and carry out work requiring increased rates of physical and mental reactions.
Drug Interactions
Drug interaction of the drug Preductal MP is not described.
Analogues of the drug Preductal
Structural analogs for the active substance:
- Angiosyl retard;
- Antisthenes;
- Antistene CF;
- Vero-Trimetazidine;
- Depenorm MB;
- Carditrim;
- Metagard;
- Predizin;
- Precardard;
- Romekor;
- Rimecor MB;
- Tridoukard;
- Trimectal;
- Trimectal;
- Trimetazide;
- Trimetazidine;
- Trimetazidine MB;
- Trimetazidine-Biocom MB;
- Trimetazidine-ratopharm;
- Trimetazidine dihydrochloride;
- Trimitard MV.
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