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Trimetazidine - instructions for use, reviews, analogs and formulations (20 mg tablets, modified release of 35 mg Ratiofarm and Biocom MB) for the treatment of IHD in adults, children and pregnancy. Composition

Trimetazidine - instructions for use, reviews, analogs and formulations (20 mg tablets, modified release of 35 mg Ratiofarm and Biocom MB) for the treatment of IHD in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Trimetazidine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Trimetazidine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Trimetazidine with existing structural analogues.Use for the treatment and prevention of angina attacks and vascular disorders in adults, children, as well as in pregnancy and lactation. Composition of the preparation.

 

Trimetazidine - has an antihypoxic effect.

 

Directly affecting the cardiomyocytes and neurons of the brain, it optimizes their metabolism and function. The cytoprotective effect is due to an increase in the energy potential, activation of oxidative decarboxylation, and rationalization of oxygen consumption (enhancement of aerobic glycolysis and fat oxidation blockade).

 

Supports contractility of the myocardium, prevents the decrease in intracellular content of ATP and phosphocreatine. In conditions of acidosis normalizes the functioning of membrane ion channels, prevents the accumulation of calcium and sodium in cardiomyocytes, normalizes the intracellular content of potassium ions.

 

Reduces intracellular acidosis and increased phosphate content, due to myocardial ischemia and reperfusion. Prevents the damaging effect of free radicals, preserves the integrity of cell membranes,prevents the activation of neutrophils in the ischemia zone, prolongs the duration of the electrical potential, reduces the yield of creatine phosphokinase from cells and the severity of myocardial ischemic damage.

 

When angina pectoris reduces the frequency of seizures (decreases the intake of nitrates), after 2 weeks of treatment, exercise tolerance increases, blood pressure drops decrease. Improves hearing and results of vestibular samples in patients with pathology of ENT organs, reduces dizziness and tinnitus. In vascular pathology, the eye restores the functional activity of the retina.

 

Composition

 

Trimetazidine dihydrochloride + excipients.

 

Pharmacokinetics

 

After taking trimetazidine quickly and almost completely absorbed in the digestive tract. Bioavailability is 90%. Easily penetrates through the histohematological barriers. It is excreted by the kidneys (about 60% - unchanged).

 

Indications

  • IHD, prevention of angina attacks (in complex therapy);
  • chorioretinal vascular disorders;
  • dizziness of vascular origin;
  • cochlear-vestibular disorders of ischemic nature (tinnitus, hearing impairment).

 

Forms of release

 

The tablets covered with a cover of 20 mg.

 

Modified release tablets 35 mg (Biocom MB).

 

Instructions for use and dosing regimen

 

Inside, with food.

 

The recommended dosage regimen is 1 tablet (20 mg) 2-3 times a day (40-60 mg per day).

 

The course of treatment on the recommendation of a doctor.

 

Side effect

  • itching;
  • headache;
  • a strong palpitation;
  • weak diarrheal phenomena (nausea, vomiting, gastralgia).

 

Contraindications

  • renal failure (CC below 30 ml / min);
  • Parkinson's disease, Parkinson's symptoms, tremor, restless leg syndrome and other associated motor disorders;
  • pregnancy;
  • lactation period;
  • age under 18 years (effectiveness and safety not established);
  • hypersensitivity to any component of the drug;
  • in connection with the presence of lactose in the formulation, it is contraindicated in congenital lactose intolerance, with lactase deficiency, with glucose-galactose malabsorption.

 

Application in pregnancy and lactation

 

Trimetazidine is contraindicated during pregnancy and lactation.

 

Use in children

 

Contraindicated in children and adolescents under the age of 18 years (efficacy and safety not established).

 

special instructions

 

Do not use to stop angina attacks!

 

Against the background of drug treatment in patients with IHD, there is a significant decrease in the daily requirement for nitrates.

 

Impact on the ability to drive vehicles and manage mechanisms

 

The use of the drug does not affect the ability to drive a car and perform work that requires a high rate of psychomotor reactions.

 

Drug Interactions

 

There is no information.

 

Analogues of the drug Trimetazidine

 

Structural analogs for the active substance:

  • Angiosyl retard;
  • Antisthenes;
  • Vero Trimetazidine;
  • Depenorm MB;
  • Carditrim;
  • Metagard;
  • Predizin;
  • Preductal;
  • Preductal MB;
  • Precardard;
  • Romekor;
  • Rimecor MB;
  • Tridoukard;
  • Trimectal;
  • Trimectal MB;
  • Trimet;
  • Trimetazide;
  • Trimetazidine MB;
  • Trimetazidine Biocom MB;
  • Trimetazidine ratopharm;
  • Trimetazidine Teva;
  • Trimetazidine dihydrochloride;
  • Trimitard MV.

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Reviews (43):
Guests
galena
I drink it 3 weeks 26 days. With dyspnea, it became better, the pressure returned to normal, but I drink concor and wals, a cardiomonitor. For 5 years without a break, but the pressure still jumps to 180.100.80. Maybe it's time to change the drug, but doctors say if they go, then do not change, and yesterday again there was an arrhythmia that was very bad. Probably, it is necessary to go to the doctor.
Guests
Tat
I have low blood pressure, this is even lower.
Guests
Tamara Pavlova, 69 years old, Zlatoust
In 2014, she underwent stenting, there are stenoses and not one, this is against the background of angina and IHD. In May 2015, I was appointed to this day, and I accept Trimetazidine, I think it's a good drug: reduced nitrate intake, increased physical activity, and less pressure. But, the question is: how long can I take Trimetazidine?
Administrators
admin
Tamara Pavlova, 69 years old, ZlatoustAccording to the instructions, the duration of administration of the drug Trimetazidine is determined by the recommendation of the doctor who prescribes this medicine.From experience I can say that usually this drug is prescribed courses lasting 2-3 months. It will not be terrible if you take this medicine for so long, but I would go to the doctor for advice on the expediency of further admission.
Visitors
anitanka
Hello. I want to write about the drug and ask a question to the doctor. I am 41 years, an introduction - two years ago began to take bisoprolol, tachycardia, left, heart pain gone, migraine almost did not bother when you consider that before a headache 20 days per month, and now 1 day in the critical days, and only . One month ago, ECG was made, it worsened with a difference of 4 months. The cardiologist prescribed medications:
Trimectal MB 1t.-2 times
Cardiomagnet 1 a day.
Panangin 1t.-3 times
Bisoprolol was left at the same dose of 2.5 mg in the morning
Riboxin 1t.-3 times
All of the above drugs are taken before, except Trimektala, and it was all good, without deterioration, and this time I felt shortness of breath, which was not occur after heavy loads and sometimes at rest and chest pain which bothered several years. And this every day, with the beginning of taking Trimectal, I noticed, and there was also an upset stomach, which is not very related to nutrition.Two years ago, Preductal MV was already prescribed, which was canceled for the same reasons as now, shortness of breath and chest pain. Prompt please, whether it is necessary to accept further Trimektal MV or it is necessary for me to cancel it or him and to search for other preparation. The diagnosis is myocardial dystrophy, angina, IHD, mitral valve prolapse 1 tbsp.
Administrators
admin
anitankaOf course, if such side effects were already on the branded Preductal, then it is clear that its domestic analogue Trimectal could give a similar side effect (after all, the active substance trimetazidine has one). I would generally refuse to use drugs with this substance in the composition in your case.

From the analogs for the group of antihypoxants, I can advise you to agree with your attending physician the use of drugs Mexidol, Actovegin, Kudesan and their analogues. These drugs do not contain trimetazidine in the composition, but the therapeutic effect is similar to that of Trimectal-Preductal, although the latter are certainly more cardiospecific. Or do not use any additional components in the treatment. Decide with the attending physician, it is better if it is a cardiologist.
Guests
Love
Took the doctor's appointment. I noticed itching in the bladder. I thought of cystitis. Has started to treat a cystitis. The itch only intensified. Has stopped to accept trimetazidin, all has passed or has taken place. From tablets, the general condition was good, and activity appeared, and the heart does not squeeze, there is no strong fatigue, as if carrying bags. But I felt the urinary.
Visitors
anitanka
After the drug was withdrawn, the pains of the chest and dyspnea had already passed the next day. The doctor prescribed me riboxin and asparks, with the continuation of bisoprolol. After 2 months, everything has returned to normal, the pain does not disturb with shortness of breath. I thank your site for help.
Visitors
Natalia 08042015
Dear admin. Advise, please. To the father of 75 years, a hypertonia of 3 stages, a stenocardia of 4 classes, an aortal stenosis of 2 degrees (one year ago there was a stenosis of 1 degree, ie the status has worsened). There are no chest pains and shortness of breath, there are bouts of burning pain in the chest with a slight load. On the cardiogram diffuse changes in the heart and insufficiency of blood supply. Now the doctor in charge gave trimetazidine 35 for taking.Do you think that in our case it is realistic to repeat the situation described above in the post anitanka, that is, the appearance of retrosternal pains and shortness of breath? On the ultrasound of the heart he still has signs of bicuspid aortic valve, as we were told.
Administrators
admin
Natalia 08042015, Trimetazidine is more a vitamin for the heart, and not a medicine in its classical sense. In your case, the use of this drug. Side effect, it is a side effect, someone will show up, but someone does not. According to the instruction, this side effect is most likely observed within the framework of a static error, that is, in a small number of patients, because it is not even included in the description.
Visitors
Natalia 08042015
The drug takes 5 days, until all, pah-pah, is good and even as if it has already become a little easier. I would also like to ask whether trimetazidine is combined with molsidomine and how then the action will manifest itself, will it enhance the effect? The question about trimetazidine and molsidomine - in the background, only after talking with a full-time doctor.
Guests
Alexander Kaptsurazh
On the recommendation of a doctor, I regularly use trimetazidine 20 mg on a single tablet in the morning and in the evening for many years. At the same time I accept the Egilok and Sidnofarm. I think that it is in connection with this that I have an equilibrium in the body: much less frequent attacks of angina, which I immediately stop, normalized AD, the noise in my ears disappeared. And in order not to be afraid of sudden dizziness, I always walk with a cane. For my age (82 years) I consider this a normal situation. The effect of trimetazidine and its cost is acceptable.
Administrators
admin
Natalia 08042015, The combination is good. One acts as a purely medicinal preparation, the second as a vitamin for the heart (in simpler terms). Strengthening of the therapeutic effect is possible, but it is not guaranteed, since preparations of different orders and have different application points in the human body. In this regard, and the correction of doses of Trimetazidine and Molsidomine in joint use is not required.
Guests
Razumova
Whether it is possible to combine reception Lorista and Trimetazidina with the purpose of stabilization of a BP? Periodically rises to 180/100.
Administrators
admin
Razumova, Lorista lowers blood pressure. Trimetazidine has a different mechanism of action, but due to it, it is possible to reduce BP changes, so in combination these drugs have a positive effect.
Guests
Ireniv
Trimetazidine + Bisoprolol 5 mg decreased in 9 days the pressure to 112/76/84. Bad because of low pressure.
Guests
Galina
And this trimetazidine does not crush and dissolves poorly, and my whole mom does not swallow the whole pill. How can it be dissolved?
Administrators
admin
Galina, Do not crush or dissolve, because the tablet of Trimetazidine is coated with a film sheath. The only option, if not completely swallowed - is to chew and drink water. The truth for the medicinal effect in this case I can not vouch. If there is a shell, for something it is necessary.
Guests
Alice
I take trimetazidine biocomp for more than 3 months. Feeled tremor in different parts of the body, and it intensifies with each day of admission.
Visitors
Natalia 08042015
Hello, dear admin!
Tell me, please, in the informative order, how appropriate is the reception in one course of treatment of the preductal and cordyrik (nicorandil)? How much both of these drugs are also compatible with veroshpiron and cardiomagnet? A man, 75 years old, diagnosed with hypertension, angina pectoris, anemia (hemoglobin 103, erythrocytes 3.29), aortic stenosis.
Thank you very much in advance.
Feedback on the trimetazidine mono course: positively, there was a marked improvement in physical condition.
Administrators
admin
Natalia 08042015, I do not use this combination, I have enough of one in the treatment of angina pectoris. But there are no contraindications for such a combination. It should work, but it is already individual for a particular patient, it is necessary to try.
Guests
Moiseeva Lydia
With diabetes, there are no contraindications in the instructions, but now I am reducing the whole day and nothing happens. I'll try again, but I'm afraid.
Visitors
Natalia 08042015
Please, tell me,please, the use of trimetazidine can reduce the absorption of iron in anemia? 75 years old, male, iron level before taking the totem 3.3, after the course of the totem, 6.7 μmol / l. I'm very worried about him (father).

Trimetazidine is taken in parallel with the cordon. Could this combination affect the assimilation of iron in general or the assimilation of the totem product?
Administrators
admin
Natalia 08042015, Trimetazidine and Cordynyk are unlikely to have the ability to influence iron metabolism in the body. In the official literature I did not see any indication of such effects of these drugs. It is logical to assume that taking the Totem drug raised the level of iron in your dad's body, or other concomitant therapy, which in my life, as I recall, a lot. In order to adequately assess the therapeutic effect of a given drug, it is necessary not to overload the patient's body with medicines, but to give an opportunity to work already taken.
Guests
Galina Vladimirovna
Mom was prescribed Trimetazidine MV in the hospital, the doctor at the discharge insists on the continuation of the name of this medicine.Age 80 years + Parkinson's disease, which is a contraindication. But the doctor insists on taking this drug claiming that there is nothing else. Taking medications from Parkinson's tremors does not work, Mom is very ill, but continues to drink Trimetazidine MV, fearing for the heart.
Comment, please. The city is small, one general practitioner.
Administrators
admin
Galina Vladimirovna, Parkinson's disease or elderly age have never been contraindications to taking Trimetazidine MB. In addition, the question does not specify a diagnosis for which your mother was prescribed this medicine.
Guests
Galina Vladimirovna
Dear admin Yesterday, 13:02 You assert that there are no contraindications, and the instruction, enclosed, confirms the opposite. Whom to believe? I quote:
Contraindications:
- Hypersensitivity to any component of the drug;
- severe renal failure (creatinine clearance (CK) less than 30 ml / min);
- age under 18 years (effectiveness and safety not established);
- pregnancy and the period of breastfeeding;
- Parkinson's disease, symptoms of parkinsonism, tremor, restless legs syndrome and other associated motor disorders.

Carefully:
Patients with severe hepatic impairment (clinical data are limited), renal failure (QC greater than 30 mL / min.), Age over 75 years.
Thank you for clarifying this misunderstanding.
Administrators
admin
Galina Vladimirovna, It is necessary to believe, of course, instructions. I saw the time of updating instructions to Trimetazidine, now rechecked - the lines about Parkinson's disease and the phenomena of parkinsonism appeared there. Corrected in his version.

Given the age and appearance of Parkinsonism, your mother should not take this medicine. In her case, the benefits will be more likely to be assumed, and the harm is real and manifests itself with specific symptoms.
Guests
Lyudmila Nikolayevna
The doctor prescribed Trimetazidine, take a month, 1 tablet 2 times a day. But the instructions say that anyone with an essential tremor is contraindicated. I'm confused.
Administrators
admin
Lyudmila Nikolayevna, There is a tremor - do not accept, there is no tremor - reception is possible. The question is incomprehensible. About a tremor and its or his origin it is possible to take an interest at the neurologist.
Visitors
Natalia 08042015
Hello, dear admin! Please consult, if possible.
Man, 76 years old. Diagnoses of "hypertension", "angina", B12-iron deficiency. After an exacerbation of a stenocardia in reception kordinik and trimetazidin (a cordina constantly, trimetazidin month in a month). There is an unpleasant feeling of padding under the skin of the hands, even intensified in recent times, very much interferes. Can this be a side effect of trimetazidine or both drugs in combination?
Thank you very much in advance.
Sincerely.
Administrators
admin
Natalia 08042015, Or senile neuralgia, due to the death of nerve fibers, due to old age and damage to various systems and organs responsible for metabolism in nerve fibers.In guessing, you can play endlessly. Patient age, similar symptoms can cause both the drugs taken, and diseases, which at this age already abound. The drugs listed in the question may cause side effects, which manifest instantly, and not accumulative. If the patient takes these drugs for a long period of time and only now these symptoms appear, the problem is probably not in medications and neurologic consultation is required to determine the causes of the pathology that has arisen.
Visitors
Marfa
I am 60 years old. I have many diseases, the main one is Parkinson of the 3rd degree. Due to a poor cardiogram, shortness of breath and anemia, Trimetazidine is prescribed 1t 2 times a day - two weeks, Sorbifer durules and Neuromultivitis. Under the instruction of Trimetazidinum at parkinsonum it is counter-indicative ... Whether it is necessary to risk?
Administrators
admin
Marfa, It is not necessary. This is a direct contraindication, so Trimetazidine in your treatment regimen should be replaced by another medicine.Contact your doctor to find the appropriate treatment for your situation.
Visitors
Natalia 08042015
Hello, dear admin.
How much time (duration of the course with interruptions and without) can I take trimetazidine? A similar question would like to be asked on the cordon, but it is not in the directory.
Thank you in advance for your reply.
Administrators
admin
Natalia 08042015, The standard course of treatment with Trimetazidine is 2-3 months. Probably, it is possible and more, but if the effectiveness of the drug did not work in the first months, it is doubtful that it will help in the future. A Cordynic as a nitrate-like remedy can be used for a long time, sometimes for life, until it is canceled or replaced by the patient's attending physician.
Guests
Basilium 71year
The drug is basically good. At whom a tremor in arms or hand alas to accept it is impossible.
Guests
Tatyana
Hello, admin. Question to you. To me have diagnosed: Frequent atrial extrasystoles by type of Bigimenia. Have appointed or nominated Trimetazidin MB.I've been drinking for a month, but one of these days is the celebration of my jubilee. Can I drink a glass of wine while eating these pills? Or is it not worth it?
Administrators
admin
TatyanaHow to ruin your health, everyone decides for himself. Alcohol is not the product without which the body can not do without. Trimetazidine according to the instructions does not have proven reactions of interaction with alcohol.
Guests
Irina
Is trimetazidine combined with papaverine?
Administrators
admin
Irina, According to the instructions, Trimetazidine is combined with any other medicinal products and there should not be additional side effects with such a compatibility.
Guests
lads
Hello, I'm in shock. To me 52 years, never complained of heart and pressure always in norm or rate, most likely even little bit lowered. Prophilia passed in the school, according to the results of the cardiogram the doctor diagnosed myocardiological cardiosclerosis (while preliminary, because he prescribed uzi heart, kidney, shield gland, holter). Has appointed or nominated tablets trimetazidin.
Visitors
Natalia 08042015
The recall of trimetazidine is repeated, almost two years later. I hope it will be useful.
The drug really helps. Improves the condition of the heart and the general condition and well-being. The cardiologist himself noted, we see it. Almost two years in total took (now a long break) father with diagnoses of hypertension, angina, stenosis, in the history of the disease there is an incident of pre-infarction. Accepts at this time, my mother, according to the appointment of a cardiologist, with hypertension, ischemic heart disease, it is already clear that in this case it is not in vain.

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