Clion - instructions for use, reviews, analogs and forms of release (tablets 250 mg and D 100 tablets or vaginal suppositories, injections in ampoules) drugs for treatment of thrush in adults, children and pregnancy

In this article, you can read the instructions for using the drug Clion. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Clion in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Clion in the presence of existing structural analogues. Use to treat thrush and other vaginitis in adults, children, as well as during pregnancy and lactation. The difference between the drugs Klion and Clion D 100.

Clion - antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of Metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The restored 5-nitro group of metronidazole interacts with the DNA of a cell of microorganisms, inhibiting the synthesis of nucleic acids, which leads to the death of microorganisms.

It is active against Trichomonas vaginalis, Entamoeba hystolitica, Gardnerella vaginalis, Giardia intestinalis, and obligate anaerobes Bacteroides spp. (including B. fragilis, B. ovatus, B. thetaiotaomicron, B. distasonis, B. vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some Gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). In combination with amoxicillin, it shows activity against Helicobacter pylori (amoxicillin suppresses the development of resistance to metronidazole (the active substance of Clion)).

Metronidazole is insensitive to aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against conventional aerobes.

Increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, stimulates reparative processes.

Composition

Metronidazole + auxiliary substances.

Clion D 100 additionally contains miconazole nitrate, which has an antifungal effect, this is the main difference between the two drugs.

Pharmacokinetics

When taking the drug, absorption is high. Bioavailability - not less than 80%. Has a high penetrating ability, reaching bactericidal concentrations in most tissues and body fluids, including. in the lungs, kidneys, liver, skin, cerebrospinal fluid, brain, bile, saliva, amniotic fluid, abscess cavity, vaginal secretions, seminal fluid, breast milk, penetrates the BBB and the placental barrier. It is excreted by the kidneys 60-80% (20% - unchanged), 6-15% is excreted through the intestine.

Indications

• protozoal infections: extraintestinal amoebiasis, incl. amoebic liver abscess, intestinal amoebiasis (amoebic dysentery), trichomoniasis (including trichomonas vaginitis, trichomoniasis urethritis), balantidiasis, giardiasis, cutaneous leishmaniasis;
• infections caused by Bacteroides spp. (including B. fragilis, B. ovatus, B. thetaiotaomicron, B. distasonis, B. vulgatus): infections of bones and joints, infections of the central nervous system (including meningitis, brain abscess), bacterial endocarditis, pneumonia , empyema and abscess of the lungs;
• infections caused by Clostridium spp.,Peptococcus spp., Peptostreptococcus spp .: infections of the abdominal cavity (peritonitis, abscess of the liver), infections of the pelvic organs (endometritis, abscess of the fallopian tubes and ovaries, vaginal vaginal infection after surgery), infections of the skin and soft tissues;
• pseudomembranous colitis (associated with the use of antibiotics);
• gastritis or duodenal ulcer associated with Helicobacter pylori;
• chronic alcoholism;
• prevention of postoperative complications (especially after interventions on the colon, near-rectal area, appendectomy, and also after gynecological operations);
• Radiation therapy of patients with tumors - as a radiosensitizer in cases where tumor resistance is caused by hypoxia in tumor cells;
• local treatment of mixed etiologies of vaginitis caused simultaneously by Trichomonas spp. and Candida spp (Clion D 100).

Forms of release

Tablets 250 mg.

Vaginal tablets (sometimes called candles) Klion D 100.

Solution for infusions (injections in ampoules).

Instructions for use and reception scheme

Pills

The drug is taken orally during or after a meal (with milk), without chewing.

Trichomoniasis: adults are prescribed 250 mg twice a day for 16 days or 400 mg twice a day for 5-8 days. Women need to additionally appoint Clion in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment or increase the dose to 0.75-1 g per day. Between the courses should be a break in 3-4 weeks with the conduct of repeated control laboratory tests.

An alternative scheme of therapy is the appointment of 2 g once to the patient and his sexual partner.

Children aged 2-5 years, the drug is prescribed at a dose of 250 mg per day, at the age of 5-10 years - 250-375 mg per day; over 10 years - 500 mg per day. The daily dose should be divided into 2 divided doses. The course of treatment is 10 days.

Giardiasis: adults are prescribed 500 mg twice a day for 5-7 days.

Children older than 8 years - 500 mg per day (in 2 doses), at the age of 5 to 8 years - 375 mg per day, at the age of 3 years and older - 250 mg per day; the daily dose should be divided into 2 divided doses; course of treatment - 5 days. The dose of the drug can be 15 mg / kg per day in 3 doses for 5 days.

Asymptomatic amebiasis (if cyst is detected): adults are prescribed in a daily dose of 1-1.5 g (500 mg 2-3 times a day) for 5-7 days.

Chronic amoebiasis: 1.5 g per day in 3 divided doses for 5-10 days.

Acute amoebic dysentery: 2.25 g per day in 3 divided doses before the symptoms stop.

Liver abscess: the maximum daily dose is 2.5 g in 1 or 2-3 doses for 3-5 days, in combination with antibiotics (tetracyclines) and as part of complex therapy.

Children from 3 years old - 1/4 of the adult dose, at the age of 3-7 years - 1/3 of the adult dose, at the age of 7-10 years - 1/2 dose of an adult.

Balantidiasis: 750 mg 3 times a day for 5-6 days.

Ulcerative stomatitis: adults are prescribed 500 mg twice a day for 3-5 days. Children in this case, the drug is not shown.

Pseudomembranous colitis: 500 mg 3-4 times a day.

For the eradication of Helicobacter pylori: 500 mg 3 times daily for 7 days (as part of combination therapy, for example, in combination with Amoxicillin 2.25 g per day).

Treatment of anaerobic infection: the maximum daily dose is 1.5-2 g.

Treatment of chronic alcoholism: appoint a dose of 500 mg per day for a period of up to 6 (not more) months.

For the prevention of infectious complications: 750-1500 mg per day in 3 doses 3-4 days before surgery, or once a dose of 1 g in the first day after the operation. 1-2 days after the operation (when already allowed ingestion) - 750 mg per day for 7 days.

Tablets or vaginal suppositories

Intravaginal.One vaginal tablet (previously moistened with water) is injected deep into the vagina in the evening before going to bed for 10 days in combination with taking Clion inside.

Side effect

• diarrhea;
• anorexia;
• nausea, vomiting;
• intestinal colic;
• constipation;
• dry mouth;
• metallic taste in the mouth;
• glossitis;
• stomatitis;
• dizziness;
• violation of coordination of movements;
• ataxia;
• confusion of consciousness;
• irritability;
• depression;
• increased excitability;
• weakness;
• insomnia;
• headache;
• convulsions;
• hallucinations;
• cystitis;
• urinary incontinence;
• staining the urine in a red-brown color;
• neutropenia, leukopenia;
• hives;
• skin rash;
• hyperemia of the skin;
• nasal congestion;
• fever;
• arthralgia;
• candidiasis.

Contraindications

• organic lesions of the central nervous system (including epilepsy);
• hepatic insufficiency (in case of prescribing the drug in high doses);
• leukopenia (including in the anamnesis);
• 1 trimester of pregnancy;
• lactation period (breastfeeding);
• children under 3 years of age (for a dosage form in the form of tablets);
• hypersensitivity to the components of the drug.

Application in pregnancy and lactation

The drug is contraindicated for use in the first trimester of pregnancy and during breastfeeding.

special instructions

During the period of treatment, alcohol use is contraindicated (it is possible to develop a disulfiram-like reaction: spasmodic abdominal pain, nausea, vomiting, headache, sudden rush of blood to the face).

With prolonged therapy, it is necessary to monitor the blood picture.

With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.

The appearance of ataxia, dizziness and any other deterioration in the neurological status of patients requires discontinuation of treatment.

Metronidazole is able to immobilize treponema, which leads to Nelson's false test.

In the treatment of trichomonas vaginitis in women and trichomoniasis in men, patients should abstain from sexual activity. It is necessary to simultaneously treat sexual partners. Treatment does not stop during menstruation. After trichomoniasis therapy, control tests should be performed for three consecutive cycles before and after menstruation.

After treatment of giardiasis, if symptoms persist,After 3-4 weeks, 3 feces were analyzed at intervals of several days (in some successfully treated patients lactose intolerance caused by invasion can persist for several weeks or months, recalling the symptoms of giardiasis).

Stains urine in a dark color.

Drug Interactions

Strengthens the effect of oral anticoagulants, which leads to an increase in prothrombin time.

Similarly to disulfiram, causes intolerance to ethanol. Simultaneous use with Disulfiram can lead to the development of various neurologic symptoms (the interval between appointments is at least 2 weeks).

Cimetidine inhibits metronidazole metabolism, which can lead to an increase in serum concentrations and an increased risk of adverse reactions.

Inducers of microsomal liver oxidation enzymes (phenytoin, phenobarbital) can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in the blood plasma.

With simultaneous administration with lithium preparations, an increase in plasma concentration in the plasma and the development of symptoms of intoxication are possible.

It is not recommended to use in combination with nondepolarizing muscle relaxants (vecuronium bromide).

Sulfonamides increase the antimicrobial effect of metronidazole.

Analogues of the drug Clion

Structural analogs for the active substance:

• Bacimex;
• Deflamon;
• Metrovagin;
• Metrogil;
• Metroxan;
• Metrolacker;
• Metron;
• Metronidazole;
• Metronidal;
• Metroseptol;
• Orvagil;
• Rosamet;
• Rosex;
• Siptrogyl;
• Tricho-PIN;
• Trichobrol;
• Trichopol;
• Trichosept;
• Flagel;
• Efloran.

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