Diphenhydramine - instructions for use, reviews, analogs and forms of release (tablets 50 mg, injections in ampoules for injections in the form of a solution) of the drug for the treatment of allergic attacks in adults, children and pregnancy

In this article, you can read the instructions for using the drug Dimedrol. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Diphenhydramine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of diphenhydramine in the presence of existing structural analogues. Use to treat allergic seizures and conditions in adults, children, as well as during pregnancy and lactation.

Dimedrol - blocker of H1-histamine receptors of the first generation. Action on the central nervous system is due to blockade of H3-histamine receptors in the brain and inhibition of central cholinergic structures. Removes spasm of smooth muscles (direct action), reduces permeability of capillaries, prevents and weakens allergic reactions, has local anesthetic, antiemetic, sedative effects, moderately blocks cholinergic receptors of vegetative ganglia, and has a hypnotic effect. Antagonism with histamine manifests itself in a greater degree in relation to local vascular reactions in inflammation and allergies than in systemic, ie. lowering blood pressure. However, with parenteral administration, patients with circulating blood volume deficiency may have lowered blood pressure and increased existing hypotension, due to ganglion blocking effects. In people with local brain damage and epilepsy activates (even in low doses) epileptic discharges on the electroencephalogram and can provoke an epileptic attack.

The action develops within a few minutes, the duration is up to 12 hours.

Pharmacokinetics

Penetrates through the blood-brain barrier.Metabolized mainly in the liver, in part - in the lungs and kidneys. Within a day is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Essential amounts are excreted in milk and can cause sedation in infants (a paradoxical reaction characterized by excessive excitability may be observed).

Indications

• anaphylactic and anaphylactoid reactions (in complex therapy);
• angioedema;
• allergic reactions (hives, hay fever, angioedema);
• allergic conjunctivitis;
• vasomotor rhinitis;
• hemorrhagic vasculitis;
• serum sickness;
• itching dermatoses;
• sleep disorders (monotherapy or in combination with sleeping pills);
• chorea;
• sea ​​and air sickness;
• vomiting of pregnant women;
• Meniere's syndrome;
• premedication.

Forms of release

Tablets 50 mg.

Solution for intravenous and intramuscular injection (injections in ampoules) 10 mg / ml.

Instructions for use and dosage

Ampoules

Intravenous or intramuscular.

For adults and children over 14 years of age, intravenously or intramuscularly, 1-5 ml (10-50 mg) of 1% solution (10 mg / ml) 1-3 times a day; the maximum daily dose is 200 mg.

For children aged 7 months to 12 months, 0.3-0.5 ml (3-5 mg), 1 to 3 years, 0.5-1 ml (5-10 mg), 4 to 6 years, 1-1.5 ml (10-15 mg), from 7 to 14 years of 1.5-3 ml (15-30 mg) if necessary every 6-8 hours.

Pills

Adults inside - 30-50 mg 1-3 times a day. The course of treatment is 10-15 days. As a hypnotic, 50 mg at bedtime.

When administered orally, single doses for children under 1 year of age - 2-5 mg; from 2 to 5 years - 5-15 mg; from 6 to 12 years - 15-30 mg.

Side effect

• drowsiness;
• weakness;
• decrease in the speed of psychomotor reaction;
• violations of coordination of movements;
• dizziness;
• tremor;
• irritability;
• euphoria;
• Excitation (especially in children);
• insomnia;
• dryness of the mucous membrane of the oral cavity, nose, bronchi (increased viscosity of sputum);
• Hemolytic anemia, thrombocytopenia, agranulocytosis;
• a decrease in blood pressure;
• tachycardia;
• extrasystole;
• violation of urination;
• hives;
• skin rash;
• itching.

Contraindications

• hypersensitivity to diphenhydramine;
• angle-closure glaucoma;
• hyperplasia of the prostate;
• peptic ulcer of stomach and duodenum complicated by stenosis;
• stenosis of the neck of the bladder;
• epilepsy;
• Children's age is up to 7 months.

Application in pregnancy and lactation

Take with caution during pregnancy and lactation.

special instructions

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions (driving a car, etc.).

During treatment with diphenhydramine (the active substance of the drug Dimedrol), you should avoid UV radiation and the use of ethanol (alcohol).

Not recommended for subcutaneous administration.

Drug Interactions

Strengthens the action of ethanol (alcohol) and drugs (LS), depressing the central nervous system.

Inhibitors of monoamine oxidase (MAO) increase the anticholinergic activity of diphenhydramine.

Antagonistic interaction is noted when co-administered with psychostimulants.

Reduces the effectiveness of apomorphine as a vomiting drug in the treatment of poisoning.

It enhances the anticholinergic effects of drugs with m-cholinoblocking activity.

Analogues of the drug Diphenhydramine

Structural analogs for the active substance:

• Allergen;
• Diphenhydramine boufus;
• Dimedrol-Vial;
• Dimedrol-UBF;
• Diphenhydramine injection 1%;
• Psylo-balm.

Analogues on the therapeutic effect (antihistamines):

• Aviomarine;
• Alerza;
• Alerpriv;
• Allergodyl;
• Allertec;
• Allergies;
• Astemizole;
• Bonin;
• Bronal;
• Histaglobin;
• Histafen;
• Gifast;
• Diazoline;
• Dinox;
• Zirtek;
• Zodak;
• Kestin;
• Claritin;
• Clemastine;
• Loratadine;
• Lotharen;
• Mebhydrogen;
• Parliamentary;
• Peritol;
• Pipolphen;
• Primalan;
• Suprastin;
• Tavegil;
• Telfast;
• Pheniramine maleate;
• Fenistil;
• Fenkarol;
• Chloropyramine;
• Cetirizine;
• Cetrin;
• Erespal;
• Erius;
• Erolin.

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