Cinarizine - instructions for use, reviews, analogs and formulations (tablets 25 mg) of the drug for the treatment of vascular disorders in adults, children (including infants and newborns) and in pregnancy
In this article, you can read the instructions for using the drug Cinnarizine. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Cinnarizine in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cinnarizine in the presence of existing structural analogues. Use to treat vascular disorders (strokes and encephalopathies) in adults, children (including infants and newborns), as well as during pregnancy and lactation.
Cinnarizine - a selective blocker of "slow" calcium channels, reduces the entry of calcium ions into cells and reduces their concentration in the depot of plasmolemmas, reduces the tone of the smooth muscles of arterioles, strengthens the vasodilating effect of carbon dioxide. Directly affecting the smooth muscles of blood vessels, reduces their response to biogenic vasoconstrictor substances (adrenaline and norepinephrine). It has a vasodilating effect (especially with respect to cerebral vessels), without having a significant effect on blood pressure. It shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system.
Effective in patients with latent insufficiency of cerebral circulation, initial atherosclerosis of cerebral vessels and chronic diseases of cerebral vessels with postinsultaneous focal symptoms. In patients with impaired peripheral circulation improves blood supply to organs and tissues (including myocardium), enhances postischemic vasodilation. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces the viscosity of the blood. Increases muscle resistance to hypoxia.
Pharmacokinetics
It is excreted in the form of metabolites: 1/3 - kidney, 2/3 - intestine.
Indications
- the period of convalescence after a previous ischemic and hemorrhagic stroke, craniocerebral trauma;
- encephalopathy;
- labyrinthine disorders (including for maintenance therapy for dizziness, tinnitus, nystagmus, nausea, vomiting of a labyrinthine origin);
- migraine, (prevention of seizures);
- Meniere's disease;
- sea and air sickness (prevention);
- violation of peripheral circulation (prevention and treatment) - obliterating endarteritis, obliterating thromboangiitis, Raynaud's disease, diabetic angiopathy, thrombophlebitis, trophic disorders, trophic and varicose ulcers, pregangrenous conditions, paresthesia, night spasms and cold extremities.
Forms of release
Tablets 25 mg.
Other forms of a pure preparation Cinnarizine whether be nyxes in ampoules, capsules, etc. does not occur, it is possible that these medications are fakes.
Instructions for use and dosage
Inside, after eating. For violations of the cerebral circulation - 25-50 mg 3 times a day; with violations of peripheral circulation - 50-75 mg 3 times a day; with labyrinthine disorders - 25 mg 3 times a day; in marine andair illness, before the upcoming trip to adults - 25 mg, if necessary, dose reception is repeated after 6 hours. Children are prescribed half the dose for adults. The maximum daily dose should not exceed 225 mg.
With high sensitivity to the drug, treatment starts with 1/2 dose, increasing it gradually. The course of treatment is from several weeks to several months.
Side effect
- drowsiness;
- increased fatigue;
- headache;
- extrapyramidal disorders (limb tremor and increased muscle tone, hypokinesia);
- depression;
- dry mouth;
- pain in the epigastric region;
- dyspepsia;
- cholestatic jaundice;
- increased sweating;
- red flat lichen (extremely rare);
- skin rash;
- a decrease in blood pressure;
- increase in body weight.
Contraindications
- pregnancy;
- lactation period;
- Children under 12 years of age (use of the drug in infants and infants is contraindicated);
- hypersensitivity to the drug.
Application in pregnancy and lactation
Contraindicated during pregnancy and lactation.
Use in children
Contraindicated in children under 12 years.
special instructions
At the beginning of treatment should refrain from taking ethanol (alcohol).
In connection with the presence of antihistamine effect, cinnarizine can affect the result of the study in the case of anti-doping control of athletes (false positive result), and also neutralize positive reactions in conducting skin diagnostic tests (4 days before the study treatment should be canceled).
With prolonged use, it is recommended that a check examination of liver function, kidney function, and peripheral blood picture is recommended.
Women who take cinnarizine are not recommended breast-feeding. Patients with Parkinson's disease should be appointed only in cases where the benefits from his appointment exceed the possible risk of deterioration.
Impact on the ability to drive vehicles and manage mechanisms
During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
Drug Interactions
Pharmaceutical: Chemical incompatibility is not known.
Pharmacodynamic: Strengthens the effect of alcohol, sedatives and antidepressant drugs.At simultaneous application with nootropic, antihypertensive and vasodilating agents strengthens their effect, and with simultaneous application with drugs prescribed for arterial hypotension - reduces their effect.
Analogues of the drug Cinnarizine
Structural analogs for the active substance:
- Vertizine;
- Vertizin Forte;
- Stugeron;
- Cinedal;
- Cinnarizin Sopharma;
- Cinnaron;
- Cinnasan.
In combination with Piracetam (enhancing nootropic action):
- Combbitropyl;
- NooCam;
- Omaron;
- Piracesine;
- Fezam.
Analogues on the effect (nootropic effect):
- Amylonosar;
- Aminalon;
- Ampasse;
- Anvifen;
- Bilobil;
- Gamalon;
- Glaser;
- Gliatilin;
- Glycine;
- Gopantam;
- Hopantenic acid;
- Delecite;
- Demanol;
- Idebenon;
- Intelland;
- Cortexin;
- Lucetsam;
- Mexipridol;
- Memotropized;
- Minisem;
- Nootropil;
- Noocetam;
- Pantogam;
- Piraben;
- Piracetam;
- Semax;
- Tenoten;
- Fenibut;
- Phenotropil;
- Cerebrosolate;
- Cerebrolysin;
- Encephalabol.
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