Dicinon - instructions for use, analogs, reviews and release forms (tablets 250 mg, injections in ampoules for injections) drugs for the treatment of bleeding during surgery, menses, miscarriages in adults, children and pregnancy

In this article, you can read the instructions for using the drug Dicycin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Dicinone in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Dicinon in the presence of existing structural analogs. Use for the treatment and prevention of bleeding during surgery, menses, miscarriages in adults, children, as well as during pregnancy and lactation.

Dicycin haemostatic drug.The drug increases the formation of capillaries in the walls of mucopolysaccharides of large molecular weight and increases the stability of capillaries, normalizes their permeability in pathological processes, improves microcirculation. Has a hemostatic effect, which is due to activation of the formation of thromboplastin at the site of damage to small vessels. The drug stimulates the formation of the coagulation factor 3, normalizes the adhesion of platelets. The drug does not affect prothrombin time, does not possess hypercoagulable properties and does not contribute to the formation of blood clots.

After intravenous administration, the drug begins to act after 5-15 minutes; the maximum effect is observed after 1 hour, the duration of action is 4-6 hours.

Pharmacokinetics

After ingestion, the drug is quickly and almost completely absorbed. Etamsylate (the active ingredient of Dicycin) penetrates the placental barrier and is excreted in breast milk. About 72% of the administered dose is excreted by the kidneys within the first 24 hours in unchanged form.

Indications

Prevention and treatment of capillary bleeding of various etiologies:

• during and after surgery on all well-vascularized tissues in otorhinolaryngology, gynecology, obstetrics, urology, dentistry, ophthalmology and plastic surgery;
• hematuria, metrorrhagia, primary menorrhagia, menorrhagia in women with intrauterine contraceptives, epistaxis, bleeding gums;
• diabetic microangiopathy (hemorrhagic diabetic retinopathy, repeated haemorrhages in the retina, hemophthalmus);
• intracranial hemorrhage in newborns and premature infants.

Forms of release

Tablets 250 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection) 125 mg / ml.

Instructions for use and dosage

Pills

The optimal daily intake for adults is 10-20 mg / kg body weight, divided into 3-4 doses. In most cases, a single dose is 250-500 mg 3-4 times a day. In exceptional cases, a single dose can be increased to 750 mg 3-4 times a day.

With a menorrhagia, 750-1000 mg per day is prescribed starting from the 5th day of the expected menstruation to 5 days of the next menstrual cycle.

In the postoperative period, the drug is prescribed in a single dose of 250-500 mg every 6 hours until the risk of bleeding disappears.

Children are prescribed in a daily dose of 10-15 mg / kg in 3-4 divided doses.

Ampoules

The optimal daily dose for adults is 10-20 mg / kg, divided into 3-4 intramuscular or intravenous (slow) injections.

Adults during surgery are prophylactically administered intramuscularly or intramuscularly 250-500 mg per hour before surgery. During the operation, I / O injected 250-500 mg, the introduction of this dose can be repeated again. After the operation, 250-500 mg is administered every 6 hours until the risk of bleeding disappears.

For children, the daily dose is 10-15 mg / kg body weight, divided into 3-4 injections.

In neonatology: Dicinone is given in / m or IV (slowly) at a dose of 12.5 mg / kg (0.1 ml = 12.5 mg). Treatment should be started within the first 2 hours after birth.

If Dicinone is mixed with saline, it should be administered immediately.

Side effect

• headache;
• dizziness;
• paresthesia of the lower extremities;
• nausea;
• heartburn;
• severity in the epigastric region;
• allergic reactions;
• hyperemia of the facial skin;
• decrease in systolic blood pressure.

Contraindications

• acute porphyria;
• hemoblastosis in children (lymphoblastic and myeloblastic leukemia, osteosarcoma);
• thrombosis;
• thromboembolism;
• hypersensitivity to the drug components and sodium sulfite;
• hypersensitivity to sodium sulfite (solution for iv and / m administration).

Application in pregnancy and lactation

Use in pregnancy is possible only in cases where the potential benefit of therapy for the mother exceeds the possible risk to the fetus.

If it is necessary to prescribe the drug during lactation, the question of stopping breastfeeding should be solved.

special instructions

Before starting treatment, other causes of bleeding should be ruled out.

1 tablet Dicinone contains 60.5 mg of lactose (the maximum daily dose of lactose should not exceed 5 g). You should not prescribe the drug to patients with congenital glucose intolerance, lactase deficiency lapp (lactase deficiency in some nationalities of the North) or glucose-galactose malabsorption syndrome.

When the color of the solution appears for intramuscular and intravenous administration, it can not be used.

The solution for intravenous and intravenous administration is intended only for use in hospitals and clinics.

Solution for IM and / or injection can be applied topically: a sterile swab or gauze pad impregnated with a solution and applied to the wound (eg, skin graft, tooth extraction).

Impact on the ability to drive vehicles and manage mechanisms

No special precautions are required.

Drug Interactions

Introduction at a dose of 10 mg / kg body weight 1 hour prior to the administration of dextrans prevents their antiaggregant effect. Introduction Dicycin after the administration of dextran does not have a hemostatic effect.

Possible combination with aminocaproic acid and menadione sodium bisulfite.

Pharmaceutical interaction

Pharmaceutically incompatible (in one syringe) with other medicines.

Incompatible with sodium bicarbonate solution for injection and sodium lactate solution.

Analogues of the drug Dicinon

Structural analogs for the active substance:

• Etamsylate;
• Etamsilat-Ferein;
• Etamsilat-Eskom;
• Etamsylate injection 12.5%.

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