Pancreatin - instructions for use, analogs, reviews and release forms (tablets 100 mg, 25 units and 30 units, dragees, forte) for the treatment of pancreatitis in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Pancreatin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Pancreatin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Pancreatin in the presence of existing structural analogues. Use for the treatment of pancreatitis and other pancreatic and gastrointestinal diseases in adults, children, as well as during pregnancy and lactation.Composition of the preparation.

Pancreatin - Combined drug, the effect of which is due to the components that make up its composition. It has a proteolytic, amylolytic and lipolytic effect. Has a protective coating that does not dissolve before entering the small intestine, which protects the enzymes from the destructive effect of gastric juice. Promotes fast and complete digestion of food, eliminates symptoms that result from digestive disorders (feeling of heaviness and overflow of the stomach, flatulence, lack of air, shortness of breath due to the accumulation of gases in the intestines, diarrhea). Improves the process of digestion of food in children; stimulates the release of its own enzymes of the pancreas, stomach and small intestine, as well as bile. Bile extract acts choleretically, promotes fat emulsification, increases lipase activity, improves absorption of fats and fat-soluble Vitamins A, E, K. Hemicellulase is an enzyme that promotes the breakdown of plant fiber.

Composition

Pancreatin with enzymatic activity: proteolytic - 200 FIP units, amylolytic - 3500 FIP units, lipolytic - 4300 FIP units + auxiliary substances.

Pharmacokinetics

Pancreatic enzymes are released from the dosage form in the alkaline medium of the small intestine. protected from the action of gastric juice with an enteric-soluble coat. The maximum enzymatic activity of the drug is observed 30-45 minutes after oral administration.

Indications

• substitution therapy with exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, cystic fibrosis; flatulence, diarrhea of ​​non-infectious genesis;
• a violation of the assimilation of food (state after resection of the stomach and small intestine);
• to improve the digestion of food in individuals with normal gastrointestinal function in the event of errors in nutrition (eating fatty foods, large amounts of food, irregular meals) and in cases of malfunctioning, sedentary lifestyle, prolonged immobilization;
• Remkheld's syndrome (gascocardial syndrome);
• Preparation for X-ray examination and ultrasound examination of the abdominal cavity organs.

Forms of release

Tablets coated with a shell, soluble in the intestine 100 mg and 500 mg, 25 units and 30 units.

Tablets, covered with enterosoluble shell Forte.

The dragee is enteric-soluble.

Instructions for use and dosage

Inside, 1 dragee (an enteric-coated tablet) 3 times a day during or immediately after meals. Swallowed whole, can not chew. If necessary, single dose is increased 2 times. Duration of treatment - from several days (with digestion disorders due to inaccuracies in nutrition) to several months and years (if necessary, permanent replacement therapy).

Before the X-ray examination and ultrasound - 2 dragees 2-3 times a day for 2-3 days before the study.

Side effect

• allergic reactions (skin hyperemia, sneezing, lacrimation);
• diarrhea;
• nausea;
• abdominal pain (including intestinal colic);
• hyperuricemia;
• hyperuricosuria;
• irritation of the oral mucosa (in children).

Contraindications

• hypersensitivity;
• hyperbilirubinemia;
• acute pancreatitis;
• chronic pancreatitis (exacerbation);
• hepatitis;
• liver failure;
• hepatic coma or precoma;
• empyema of the gallbladder;
• cholelithiasis;
• mechanical jaundice;
• intestinal obstruction.

Application in pregnancy and lactation

Contraindicated in pregnancy.

Drug Interactions

Reduces the bioavailability of iron preparations

Increases the absorption of PASC, sulfonamides, antibiotics.

Cimetidine enhances the effect of the drug.

Antacids containing magnesium ions and / or calcium, reduce the effectiveness of the drug.

Analogues of the drug Pancreatin

Structural analogs for the active substance:

• Gastenorm forte;
• Gastenorm forte 10000;
• Creon 10000;
• Creon 25,000;
• Creon 40000;
• Mezim 20000;
• Mezi forte;
• Mezim forte 10000;
• Mikrazim;
• Pangrol 25,000;
• Pangrol 10000;
• PanziKam;
• Panzim Forte;
• Panzinorm 10000;
• Penzinorm forte 20000;
• Pancreatym;
• Pancreatin forte;
• Pancreatin-LekT;
• Pancrelipase;
• Pantcitrate;
• Penzital;
• Festal N;
• Enzistal-P;
• Hermitage.

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