Elzepam - instructions for use, reviews, analogs and forms of release (tablets 0.5 mg and 1 mg, injections in ampoules for injection in solution) drugs for the treatment of neuroses, psychoses, insomnia, epilepsy in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Elzepam. Comments of visitors of the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Elzepam in their practice are presented. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Elzepam in the presence of existing structural analogues.Use to treat neuroses, psychoses, insomnia, epilepsy in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Elzepam - A tranquilizer (anxiolytic). It is a derivative of benzodiazepine.

Has a pronounced anxiolytic, hypnotic, sedative, as well as anticonvulsant and central muscle relaxant action. Has a depressing effect on the central nervous system, which is realized mainly in the thalamus, hypothalamus and limbic system. Enhances the inhibitory effect of GABA, which is one of the main mediators of pre- and postsynaptic inhibition of nerve impulse transmission in the central nervous system.

The mechanism of action of Elzepam is determined by the stimulation of the benzodiazepine receptors of the supramolecular GABA-benzodiazepine-chloronophore compounding complex, leading to the activation of the GABA receptor, which causes a decrease in the excitability of the subcortical structures of the brain, inhibition of polysynaptic spinal reflexes.

Composition

Bromodihydrochlorophenylbenzodiazepine + auxiliary substances.

Pharmacokinetics

Widely distributed in the body. Metabolised in the liver. Excretion of the drug is mainly carried out with urine in the form of metabolites.

Indications

• neurotic, neurotic, psychopathic, psychopathic and other conditions, accompanied by anxiety, fear, increased irritability, tension, emotional lability;
• reactive psychoses;
• hypochondriacal-senesthetic syndrome (including resistant to the action of other tranquilizers);
• in the complex therapy of alcohol withdrawal syndrome;
• autonomic dysfunction;
• sleep disorders (insomnia);
• for the prevention of states of fear and emotional stress;
• temporal and myoclonic epilepsy (as an anticonvulsant);
• in neurological practice - for the treatment of hyperkinesis and tics, rigidity of muscles, vegetative lability.

Forms of release

Tablets 0.5 mg and 1 mg.

Solution for intravenous and intramuscular injection (injections in ampoules for injection).

Instructions for use and dosage

Pills

Inside.

A single dose is usually 0.5-1 mg, with sleep disorders - 0.5 mg for 20-30 minutes before sleep.

With neurotic, neurosis-like disorders, hypochondriacelo-sensopathic syndrome, 0.5-1 mg 2-3 times a day.After 2-4 days, taking into account the effectiveness and tolerability of the drug, the dose can be increased to 4-6 mg per day, morning and daytime doses are 0.5-1 mg, at night - 2.5 mg.

With severe anxiety, treatment starts with a dose of 3 mg per day, rapidly increasing the dose to obtain a therapeutic effect.

In the complex treatment of alcohol withdrawal symptoms are prescribed in a dose of 2.5-6 mg per day.

As an auxiliary for the treatment of patients with temporal and myoclonic epilepsy, the dose is 2-10 mg per day.

With increased muscle tone, hyperkinesia and rigidity in the CNS lesion, the drug is prescribed 2-3 mg once or twice a day. The maximum daily dose is 10 mg.

To avoid the development of drug dependence, with course treatment, the duration of the drug, as well as other benzodiazepines, is 2 weeks. In some cases, the duration of treatment can be increased to 2 months.

Ampoules

Elzepam is prescribed intramuscularly or intravenously (either struino or drip (as a dropper)).

A single dose is usually 0.5-1 mg. In cases of sleep disorders, the drug is prescribed in a dose of 0.5-1 mg 1 time per day before bedtime.

For the relief of anxiety, anxiety, psychomotor agitation, as well as in vegetative paroxysms and psychotic conditions, Elzepam is used in / m or IV, an initial dose of 0.5-1 mg (0.5-1 ml 0.1% solution), an average daily dose of 3-5 mg (3-5 ml 0.1% solution), in severe cases - up to 7-9 mg.

With epileptic status and serial epileptic seizures, the drug is administered in / m or IV, starting at a dose of 0.5 mg.

For the treatment of alcohol withdrawal, the drug is given in / m or IV in a dose of 2.5-5 mg per day.

In neurological practice with diseases with increased muscle tone, the drug is given in / m 0.5 mg 1 or 2 times a day.

For preoperative preparation - iv injection of 3-4 mg (3-4 ml of 0.1% solution) is slowly introduced.

The average daily dose of Elzepam is 1.5-5 mg. The maximum daily dose is 10 mg.

After achieving a sustainable therapeutic effect, it is advisable to switch to oral dosage forms of the drug.

To avoid the development of drug dependence, with course treatment, the duration of the use of Elzepam, like other benzodiazepines, is 2 weeks. But in some cases, the duration of treatment can be increased to 3-4 weeks.

With the withdrawal of the drug, the dose is reduced gradually.

Side effect

• drowsiness;
• feeling tired;
• dizziness;
• violation of concentration of attention;
• ataxia;
• disorientation;
• slowing of mental and motor reactions;
• confusion of consciousness;
• headache;
• euphoria;
• depression;
• tremor;
• decreased memory;
• disorders of coordination of movements (especially at high doses);
• decreased mood;
• dystonic extrapyramidal reactions (uncontrolled movements, including the eye);
• asthenia;
• myasthenia gravis;
• dysarthria;
• convulsions (in patients with epilepsy);
• paradoxical reactions (outbreaks of aggression, psychomotor agitation, fear, suicidal tendencies, muscle spasm, hallucinations, anxiety, sleep disturbance);
• leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, unusual fatigue or weakness), anemia, thrombocytopenia;
• dry mouth or drooling;
• heartburn;
• nausea, vomiting;
• decreased appetite;
• constipation or diarrhea;
• impaired liver function;
• increased activity of hepatic transaminases and alkaline phosphatase;
• jaundice;
• urinary incontinence;
• retention of urine;
• impaired renal function;
• decreased or increased libido;
• dysmenorrhea;
• skin rash;
• itching;
• influence on the fetus during pregnancy (teratogenicity (especially in the first trimester),depression of the central nervous system, impaired breathing and suppression of the sucking reflex in newborns whose mothers used the drug);
• addiction, drug dependence;
• lowering blood pressure;
• impaired vision (diplopia);
• decreased body weight;
• tachycardia;
• phlebitis or venous thrombosis (redness, swelling, or pain at the injection site).

With a sharp decrease in dose or discontinuation of reception - withdrawal syndrome (sleep disturbance, dysphoric reactions, spasm of smooth muscles of internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting, tremor, perceptual disorders, including hyperaemia, paresthesia , photophobia, tachycardia, convulsions, psychotic reactions).

The frequency and nature of side effects depend on the individual sensitivity, dose and duration of treatment. With reduced doses or discontinuation of reception side effects disappear.

Contraindications

• hypersensitivity to the components of the drug, as well as to other benzodiazepine derivatives;
• coma;
• shock;
• myasthenia gravis;
• closed angle glaucoma (acute attack or predisposition);
• acute alcohol poisoning (with a weakening of vital functions), narcotic analgesics and hypnotics;
• severe chronic obstructive pulmonary disease (possibly increased respiratory failure);
• acute respiratory failure;
• severe depression (suicidal tendencies may manifest);
• age under 18 years (safety and efficacy not established);
• deficiency of lactase;
• lactose intolerance, glucose-galactose malabsorption.

Carefully

• hepatic and / or renal insufficiency;
• cerebral and spinal ataxia;
• drug dependence in history;
• propensity to abuse psychoactive drugs (drug addiction);
• hyperkinesis;
• organic diseases of the brain;
• psychosis (paradoxical reactions are possible);
• hypoproteinemia;
• nighttime apnea (established or suspected);
• elderly age.

Application in pregnancy and lactation

The drug is contraindicated for use in the first trimester of pregnancy and lactation. The use of the drug in the 2nd and 3rd trimester of pregnancy is possible only for life indications.

It is known that Elzepam has a toxic effect on the fetus and increases the risk of developing congenital malformations when applied in the first trimester of pregnancy. Admission to therapeutic doses at a later time of pregnancy can cause depression of the newborn's central nervous system. Continuous use during pregnancy can lead to physical dependence with the development of the syndrome of "cancellation" in a newborn.

Children, especially at a young age, are very sensitive to the CNS depressing action of benzodiazepines. Use immediately before childbirth or during childbirth can cause a respiratory depression in the newborn, a decrease in muscle tone, hypotension, hypothermia, and a weak act of sucking ("sluggish child" syndrome).

Use in children

Contraindicated in children and adolescents under the age of 18 years.

Application in elderly patients

With caution should prescribe the drug to elderly patients

special instructions

In renal / hepatic insufficiency and long-term treatment, control over the picture of peripheral blood and hepatic enzymes is necessary.

The frequency and nature of side effects depend on the individual sensitivity, dose and duration of treatment.With reduced doses or discontinuation of the drug, side effects tend to disappear.

Like other benzodiazepines, Elzepam has the ability to induce drug dependence in long-term admission in large doses (more than 4 mg per day).

With a sudden discontinuation of reception may be a withdrawal syndrome (depression, irritability, insomnia, increased sweating, etc.), especially with long-term admission (more than 8-12 weeks).

The use immediately before childbirth or during childbirth can cause a respiratory depression, a decrease in muscle tone, a decrease in blood pressure, hypothermia, and a weak act of sucking in the newborn ("sluggish child" syndrome). The drug enhances the effect of alcohol, so the use of alcoholic beverages during treatment with the drug is contraindicated.

The drug enhances the effect of alcohol, so the use of alcohol during treatment with Elzepam is not recommended.

Influence on the ability to drive vehicles, work with mechanisms

When taking the drug is prohibited to drive vehicles and engage in other activities that require increased concentration and speed of psychomotor reactions.

Drug Interactions

Compatible with other drugs that cause depression of the central nervous system (hypnotics, anticonvulsants, neuroleptics, etc.), however, in complex application it is necessary to take into account the mutual enhancement of their action.

Reduces the effectiveness of levodopa.

Elzepam may increase the toxicity of zidovudine.

Inhibitors of microsomal liver enzymes increase the risk of toxic effects and reduce efficacy.

Elzepam increases the concentration of imipramine in the blood serum.

Hypotensive drugs can increase the severity of lowering blood pressure. Simultaneous use with clozapine may cause respiratory depression.

Against the background of simultaneous with Elzepam administration of clozapine, an increase in respiratory depression is possible.

Analogues of the drug Elzepam

Structural analogs for the active substance:

• Bromodihydrochlorophenylbenzodiazepine;
• Tranquesipam;
• Fezaneff;
• Fesipam;
• Phenazepam;
• Fenzitate;
• Phenorelaxane.

Analogues on the pharmacological group (anxiolytics):

• Adaptol;
• Alzolam;
• Alprazolam;
• Alprox;
• Anvifen;
• Apaurin;
• Atarax;
• Afobazol;
• Bromazep;
• Bromazepam;
• Bromide;
• Valium Rosh;
• Hydroxysine;
• Grandaxin;
• Dabigatran;
• Diazepabene;
• Diazepam;
• Diazepec;
• Diamidazepam;
• Diapam;
• Zolomax;
• Ipronal;
• Kassadan;
• Xanax;
• Xanax retard;
• Lexotan;
• Librax;
• Lorazepam;
• Laurafen;
• Mebicar;
• Mebiks;
• Mezapam;
• Mexiprim;
• Mexicin;
• Merlit;
• Miolastane;
• Napoton;
• Neurophasole;
• Neurol;
• Nobrethum;
• Nozepam;
• Noophen;
• Oxazepam;
• Pradax;
• Relanium;
• Relium;
• Seduxen;
• Sibazon;
• Stresam;
• Tazepam;
• Tenoten;
• Tenoten for children;
• Tofizopam;
• Tranquesipam;
• Tranxen;
• Fesipam;
• Phenazepam;
• Fenzitate;
• Fenibut;
• Helex;
• Chlosepide;
• Elenium.

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