Phenazepam - instructions for use, analogs, reviews and release forms (tablets 0.5, 1 and 2.5 mg) drugs for the treatment of neuroses, psychoses and epilepsy in adults, children and pregnancy. Leave from pharmacies (prescription or not), the effect of alcohol
In this article, you can read the instructions for using the drug Phenazepam. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Phenazepam in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of phenazepam in the presence of existing structural analogues. Use for the treatment of neuroses, psychoses,epilepsy and other mental and psychosomatic disorders and diseases in adults, children, as well as during pregnancy and lactation. Terms of leave from pharmacies (prescription or not). Joint reception of alcohol.
Phenazepam - has a pronounced anxiolytic, anticonvulsant, central muscle relaxant and hypnotic action.
Amplifies the braking effect of GABA in the CNS by increasing the sensitivity of the GABA neurotransmitter-receptor as a result of stimulation of benzodiazepine receptors, reduces the excitability of subcortical brain structures inhibits polysynaptic spinal reflexes.
Pharmacokinetics
When ingestion the drug is absorbed well from the digestive tract. Metabolised in the liver. Isolation of the drug, mainly carried out through the kidneys.
Indications
- at various neurotic, psychotic neurosis, psychopathic and other conditions involving anxiety, fear, increased irritability, stress, emotional lability;
- with reactive psychoses;
- with hypochondriacelo-sensopathic syndrome (incl.resistant to the action of other tranquilizers);
- with autonomic dysfunction and sleep disorders;
- for the prevention of states of fear and emotional stress;
- as an anticonvulsant drug is used to treat patients with temporal and myoclonic epilepsy;
- in neurological practice, phenazepam is used to treat hyperkinesis and tics, muscle stiffness, vegetative lability.
Forms of release
Tablets 0.5 mg, 1 mg and 2.5 mg.
Solution for injection 1 mg / ml.
Instructions for use and dosing regimen
The drug is prescribed inside.
A single dose of phenazepam is usually 0.5-1 mg, and for sleep disorders, 0.25-0.5 mg for 20-30 minutes before sleep.
For the treatment of neurotic, psychopathic, neurosis-like and psychopathic-like conditions, the initial dose is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account the effectiveness and tolerability of the drug, the dose can be increased to 4-6 mg per day, morning and daytime dose is 0.5-1 mg, at night - 2.5 mg.
With severe agitation, fear, anxiety, treatment starts with a dose of 3 mg per day, rapidly increasing the dose to obtain a therapeutic effect.
In the treatment of epilepsy, the dose is 2-10 mg per day.
To treat alcohol withdrawal are prescribed in a dose of 2.5-5 mg per day.
In neurological practice in diseases with increased muscle tone, the drug is prescribed for 2-3 mg 1 or 2 times a day.
The average daily dose of Phenazepam is 1.5-5 mg, it is divided into 3 or 2 doses, usually 0.5-1 mg in the morning and in the afternoon and up to 2.5 mg at night. The maximum daily dose is 10 mg.
To avoid the development of drug dependence, with course treatment, the duration of the use of phenazepam, as well as other benzodiazepines is 2 weeks. But in some cases, the duration of treatment can be increased to 2 months. With the withdrawal of the drug, the dose is reduced gradually.
Side effect
- memory impairment, concentration of attention, coordination of movements (especially at high doses);
- drowsiness
- muscle weakness
- ataxia
- perhaps paradoxical arousal
- dizziness, headache
- dry mouth
- nausea
- diarrhea
- menstrual disorder
- decreased libido
- dysuria
- skin rash, itching.
With prolonged use, especially in high doses - addiction, drug dependence.
Contraindications
- myasthenia gravis;
- marked violations of the liver and kidneys;
- poisoning with tranquilizers, antipsychotic drugs (neuroleptics), sleeping pills, narcotic drugs, ethyl alcohol;
- children and adolescents under 18 years of age (safety and efficacy not identified);
- pregnancy;
- lactation period.
With care - the elderly.
Application in pregnancy and lactation
Contraindicated in pregnancy and lactation.
Use in children
Contraindicated in children and adolescents under the age of 18 years (safety and efficacy not determined). Children, especially young children, are very sensitive to the CNS depressing action of benzodiazepines.
special instructions
It is necessary to use the drug with caution in elderly and weakened patients.
The frequency and nature of side effects depend on the individual sensitivity, dose and duration of treatment. With decreasing doses or stopping the use of phenazepam, side effects disappear.
Like other benzodiazepines. has the ability to induce drug dependence in long-term admission in large doses (more than 4 mg per day). With a sudden discontinuation of reception can be a withdrawal syndrome (depression, irritability, insomnia, increased sweating), especially with prolonged admission (more than 8-12 weeks).
The drug enhances the effect of alcohol, so the use of alcohol during treatment with phenazepam is not recommended.
Impact on the ability to drive vehicles and manage mechanisms
Phenazepam is contraindicated during work by drivers of transport and other persons performing work requiring quick reactions and precise movements.
Drug Interactions
Phenazepam is compatible with other drugs causing oppression of the central nervous system (hypnotics, anticonvulsant, neuroleptic), but in complex application it is necessary to take into account the mutual enhancement of their action.
Reduces the effectiveness of levodopa in patients with Parkinsonism.
May increase the toxicity of zidovudine.
Inhibitors of microsomal oxidation increase the risk of toxic effects.
Increases the concentration of imipramine in the serum.
Hypotensive drugs can increase the severity of blood pressure lowering.
Conditions of leave from pharmacies
The drug is released by prescription.
Analogues of the drug Phenazepam
Structural analogs for the active substance:
- Tranquesipam;
- Fezaneff;
- Fesipam;
- Phenorelaxane;
- Elzepam.
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