Proflosin - instructions for use, analogs, reviews and release forms (capsules or tablets 400 μg) drugs for the treatment of benign prostatic hyperplasia or BPH and urinary tract disorders in men. Composition and alcohol

In this article, you can read the instructions for using the drug Proflosin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Proflosin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Proflosin with available structural analogues. Use to treat benign prostatic hyperplasia orBPH and urinary dysfunction in men. Composition and interaction of the drug with alcohol.

Proflosin - blocker of alpha1-adrenergic receptors; a remedy for symptomatic treatment of benign prostatic hyperplasia.

Selectively blocks postsynaptic alpha-1A-adrenoreceptors of smooth muscles of the prostate gland, the neck of the bladder, the prostatic part of the urethra. As a result, the tone of the smooth muscles of these formations decreases, and the outflow of urine is facilitated. Simultaneously, the symptoms of obstruction and irritation associated with benign prostatic hyperplasia decrease. The therapeutic effect is manifested approximately 2 weeks after the start of treatment.

Proflosin's ability to block alpha-1B-adrenoreceptors of smooth muscle vessels is much less pronounced, therefore, the effect on systemic blood pressure is negligible.

Composition

Tamsulosin hydrochloride + excipients.

Pharmacokinetics

After ingestion, Proflosin is rapidly and almost completely absorbed from the digestive tract. After a single intake of 400 μg Cmax active substance in the plasma is achieved after 6 hours. Binding to plasma proteins - 99%.Tamsulosin is slowly metabolized in the liver with the formation of pharmacologically active metabolites, which retain high selectivity to alpha1A-adrenergic receptors. Most of the active substance is present in the blood in unchanged form. It is excreted by the kidneys, 9% - unchanged.

Indications

• benign prostatic hyperplasia (treatment of dysuric disorders or micturition disorders in men).

Forms of release

Capsules intestinal soluble prolonged action 400 mcg (sometimes mistakenly called pills).

Instructions for use and dosing regimen

Inside, 1 capsule 1 time per day after breakfast or first meal. The capsule should be swallowed whole, without chewing, squeezed with enough water. Capsule can not be divided into parts or broken, as this can affect the release rate of the active substance. Duration of use is not limited.

Side effect

• dizziness;
• headache;
• fainting;
• tachycardia;
• orthostatic hypotension;
• constipation, diarrhea;
• nausea, vomiting;
• violation of ejaculation;
• priapism;
• rash;
• itching;
• hives;
• angioedema;
• the development of atonic iris syndrome (narrow-pupil syndrome) during an operation to remove cataracts;
• asthenia;
• rhinitis.

Contraindications

• hypersensitivity to tamsulosin or other components of the drug;
• orthostatic hypotension (including in the anamnesis);
• severe hepatic insufficiency.

Application in pregnancy and lactation

The drug Proflosin is prescribed only to men.

special instructions

At the first signs of orthostatic hypotension (dizziness, weakness), the patient should be seated or laid.

Before starting therapy with Proflosin, patients should be excluded from the presence of diseases and conditions capable of causing symptoms similar to that of benign prostatic hyperplasia.

Before the start of treatment and regularly during therapy, a digital rectal examination and, if necessary, determination of the concentration of a specific prostatic antigen (PSA) should be performed.

In case of angioedema development, therapy with Proflosin should be stopped immediately. Repeated administration of the drug is contraindicated.With surgery for cataracts against the background of taking the drug, it is possible to develop a syndrome of atonic iris, which must be taken into account by the surgeon for preoperative preparation of the patient and during the operation.

With care use Proflosin in chronic renal failure (QC less than 10 ml / min); arterial hypotension.

Impact on the ability to drive a vehicle and other complex mechanisms

Care must be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions, due to the possible development of dizziness.

Drug Interactions

Tamsulosin does not interact with atenolol, enalapril, Nifedipine and theophylline.

Simultaneous intake of alcohol does not affect the absorption and pharmacokinetics of Proflosin.

With simultaneous use with cimetidine, a slight increase in the concentration of Tamsulosin in the blood plasma was noted; with Furosemide - a decrease in concentration, but this does not require a correction of the dose of the drug Proflosin, since the concentration of the drug remains within the normal range.

Diclofenac and Warfarin can increase the rate of excretion of tamsulosin.

Simultaneous appointment of Proflosin with other alpha1-adrenergic blockers may lead to a decrease in blood pressure.

Analogues of the drug Proflosin

Structural analogs for the active substance:

• Hyperprost;
• Glansin;
• Myctosin;
• Omnik;
• Omnik Okas;
• Omsulosin;
• Sonizine;
• Tamzelin;
• Tamsulosin;
• Tamsulosin hydrochloride;
• Tamsulon;
• Tanis Eras;
• Tanise K;
• Tulosin;
• Focussin.

Analogues on the curative effect (remedies for the treatment of benign prostatic hyperplasia or BPH):

• Avodart;
• Adenostop;
• Akineton;
• Alfinal;
• Artesine;
• Afala;
• Afalase;
• Vezielut;
• Viardot;
• Vitaprost;
• Vitaprost forte;
• Gentos;
• Glansin;
• Dalfaz;
• Dalfaz retard;
• Doxazosin;
• Grain;
• Indigal;
• Camyrin;
• Cardura;
• Kornam;
• Longidase;
• Metovit;
• Omnik;
• Omsulosin;
• Penester;
• Peponen;
• Permikson;
• Polipressin;
• They will prostate;
• Prostamine;
• Prostamol Uno;
• Prostaplant;
• Prosteride;
• Simpletons;
• Raveron;
• Serpens;
• Setegis;
• Cialis;
• Sinestrol;
• Sonizine;
• Sounirid Duo;
• Spem;
• Tadenan;
• Tamsulon;
• Tonicardin;
• Trianol;
• Tulosin;
• Urorek;
• Finasteride;
• Finast;
• Focussin;
• Haytrin;
• Cernilton.

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