En DE FR ES PL
Tretinoin - instructions for use, analogs, reviews and release forms (cream, ointment or gel 0.05 g and 0.1 g, solution, capsules or tablets) of a drug for the treatment of acne or acne, promyelocytic leukemia in adults, children and in pregnancy . Composition

Tretinoin - instructions for use, analogs, reviews and release forms (cream, ointment or gel 0.05 g and 0.1 g, solution, capsules or tablets) of a drug for the treatment of acne or acne, promyelocytic leukemia in adults, children and in pregnancy . Composition

In this article, you can read the instructions for using the drug Tretinoin. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Tretinoin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tretinoin in the presence of existing structural analogues.Use to treat acne or acne, promyelocytic leukemia in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

 

Tretinoin - retinoid. Structurally close to vitamin A, it is a natural metabolite of retinol. When administered, inhibits the differentiation and growth of a clone of altered blood cells, including human myeloid leukemias. The mechanism of action in acute promyelocytic leukemia is probably due to damage caused by the binding of tretinoin to the nuclear receptors of retinoic acid.

 

With external application enhances the proliferation of cells in the papillary layer of the skin, reduces the adhesion of cells involved in the formation of vulgar acne. When treating open acne promotes smoothing of the skin surface without signs of inflammation. When treating closed acne promotes their transition to open acne or papules, which then heal without scarring after removing the keratinous plug. Prevents the formation of new acne.

 

Composition

 

Tretinoin + auxiliary substances.

 

Pharmacokinetics

 

Tretinoin is a natural metabolite of retinol, which is normally present in plasma.After ingestion, tretinoin is absorbed from the digestive tract. Concentration in plasma returns to the initial endogenous level 7-12 hours after administration of a single dose of 40 mg. The binding with plasma proteins is high. Do not cumulate. After ingestion of radioactivity-labeled tretinoin, about 60% is excreted in the urine and about 30% with feces. Metabolites are formed by oxidation and glucuronization. With prolonged use of tretinoin, a decrease in its concentration in the plasma is observed, which may be due to the induction of isoenzymes of the CYP system.

 

Indications

 

For oral administration:

  • acute promyelocytic leukemia (for induction of remission) both in patients who have not received previous therapy, and in relapses or refractoriness to standard therapy (daunomycin or cytarabine).

 

For external use:

  • Acne vulgaris or pimples (including with the formation of comedones, papules, pustules);
  • drained eels;
  • Favre-Rakusho disease (nodular cystic skin elastosis with comedones).

 

Forms of release

 

Cream 0.05 g and 0.1 g (sometimes mistakenly called ointment or gel).

 

Solution for external use.

 

Capsules 10 mg (sometimes mistakenly called pills).

 

Instructions for use and how to use them

 

Cream or solution

 

Locally. Once, in the evening, 30 minutes before bedtime, on absolutely dry skin (15 minutes after a mild cleansing with cosmetic milk or a soap substitute).

 

The solution is applied with the tips of the fingers. Cream (a small amount) is applied to the affected areas of the skin and is easily triturated until completely absorbed.

 

After each use, wash hands thoroughly.

 

Capsules

 

Inside. The daily dose is 45 mg / m2 in two divided doses. For adults, this equals about 8 capsules. For children, the same dose is recommended, unless severe toxic effects occur; in particular, the dose should be reduced if the child develops severe headaches.

 

Treatment should be continued from 30 to 90 days until a complete remission is achieved. After this, immediately go to the standard regimen of consolidating chemotherapy, for example, three courses of daunorubicin and cytarabine at intervals of 5-6 weeks.

 

Side effect

  • xeroderma;
  • rash;
  • cheilitis;
  • erythema;
  • itching;
  • increased sweating;
  • cellulite;
  • alopecia (baldness);
  • exfoliative dermatitis;
  • dryness of mucous membranes;
  • xerophthalmia;
  • dry mouth;
  • nausea, vomiting;
  • increased activity of liver transaminases;
  • stomach ache;
  • diarrhea, constipation;
  • bullous stomatitis;
  • dizziness;
  • impaired consciousness;
  • increased intracranial pressure (especially in children);
  • anxiety;
  • depression;
  • impaired vision and hearing;
  • increased concentration of triglycerides of plasma, cholesterol;
  • changes in body weight;
  • cough;
  • pleural effusion;
  • edema of the nasal mucosa;
  • dyspnea;
  • pharyngitis;
  • wheezing in the lungs;
  • breathy breathing;
  • arrhythmias;
  • pain in muscles and bones;
  • increased bleeding;
  • fever;
  • chills;
  • association of infections (including pneumonia, septicemia);
  • general weakness and drowsiness;
  • pain in the chest and back;
  • redness, burning sensation, skin peeling in the place of application;
  • the formation of blisters or crusts;
  • photosensitization.

 

The syndrome of retinoic acid: fever, dyspnea, dyspnea, acute respiratory distress syndrome, pulmonary infiltrate, hyperleukocytosis, arterial hypotension, pleural effusion, renal and hepatic insufficiency.

 

Contraindications

  • pregnancy;
  • cutaneous epithelium in the anamnesis (including in the family);
  • hypersensitivity to tretinoin;
  • acute inflammatory (incl.eczematous) skin lesions, wounds, burns - for external use.

 

Application in pregnancy and lactation

 

Tretinoin is contraindicated in pregnancy. Women of childbearing age should use effective methods of contraception at least 1 month before the start of treatment, during therapy and 1 month after the withdrawal of tretinoin. The application begins on the 2-3rd day of the normal menstrual cycle. For 2 weeks before the start of treatment, the absence of pregnancy should be confirmed by laboratory tests. Such tests should be carried out once a month.

 

If you need to ingest during lactation, breastfeeding should be discontinued.

 

Use in children

 

It should be refrained from the use in pediatric practice, because the safety and effectiveness of the use of Tretinoin in children are not defined.

 

special instructions

 

Inside Tretinoin can appoint only a doctor with experience in the treatment of hematological / oncological diseases.

 

To prevent retinoic acid syndrome with a significant increase in the number of white blood cells or the appearance of other signs of this syndrome, complete chemotherapy is prescribed in adequate doses.If the earliest symptoms occur, you should immediately begin treatment with dexamethasone.

 

For external use, try to avoid getting Tretinoin into the eyes, mouth, mucous membranes; In case of contact, wash immediately with water.

 

It is recommended to avoid sun exposure during treatment. With tanned skin, you can start treatment after weakening the tan.

 

In the first week of treatment, acne can be intensified.

 

Tretinoin can not be used simultaneously with drugs that cause desquamation of the skin, as well as with cosmetic and hygienic agents that cause dryness and irritation of the skin.

 

Drug Interactions

 

Tretinoin is metabolized in the liver with the participation of CYP450 isoenzymes. Therefore, with simultaneous use with drugs that affect these enzymes, the pharmacokinetic parameters can not be ruled out.

 

Tretinoin reduces the contraceptive effect of progesterones.

 

With simultaneous use with tetracyclines, an increase in intracranial pressure is possible.

 

At simultaneous application with vitamin A symptoms of hypervitaminosis are observed.

 

Analogues of the drug Tretinoin

 

Structural analogs for the active substance:

  • Weightoids;
  • Locacid;
  • Retin A.

 

Analogues on the curative effect (remedies for the treatment of acne or acne):

  • Aquazan;
  • Acnekutan;
  • Androkur;
  • Arthromax;
  • Basiron AC;
  • Bassado;
  • Bellune 35;
  • Betaspan Depot;
  • Betusil;
  • Biseptol;
  • Bonade;
  • Wilprafen solute;
  • Dalacin;
  • Delex Acne gel from acne;
  • Deleks Acne cleansing lotion;
  • Desquam;
  • Jess;
  • Jess Plus;
  • Diane 35;
  • Dimephosphone;
  • Differin;
  • Doxal;
  • Doxycycline;
  • Dr. Theiss Acne Cream for acne;
  • Dr. Theiss Acne Acne Lotion;
  • Yeast beer;
  • Genetten;
  • Mirror;
  • Zinerit;
  • Zitrolid forte;
  • Clenzite;
  • Klindovit;
  • Curious;
  • Kutis compositum;
  • Lei;
  • Purge of Puree;
  • Metrogil;
  • Metronidazole;
  • Microfolline;
  • Monoclin;
  • Piolizin;
  • Proderm;
  • Retinoic ointment 0.05 and 0.1%;
  • Roaccutane;
  • Rosamet;
  • Roxithromycin Lek;
  • Silhouettes;
  • Skinoren;
  • Streptonitol;
  • Sudokrem;
  • Chloe;
  • Zinctal;
  • Cytale;
  • Eplan;
  • Erica 35;
  • Unidox Solutab;
  • Yarina Plus.

Similar medicines:

Other medicines:

Reviews (0):

Rules for publishing reviews and visitor questions