Tamsulosin - instructions for use, analogs, reviews and release forms (capsules 0.4 mg, with prolonged release of retard, tablets, granules or powder for suspension) drugs for the treatment of prostatic hyperplasia in men

In this article, you can read the instructions for using the drug Tamsulosin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of Tamsulosin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Tamsulosin in the presence of existing structural analogues.Use for the treatment of benign prostatic hyperplasia (BPH) and dysuric disorders (urinary disorders) in adult men.

Tamsulosin - blocker of alpha1-adrenergic receptors; a remedy for symptomatic treatment of benign prostatic hyperplasia.

Selectively blocks postsynaptic alpha-1A-adrenoreceptors of smooth muscles of the prostate gland, the neck of the bladder, the prostatic part of the urethra. As a result, the tone of the smooth muscles of these formations decreases, and the outflow of urine is facilitated. Simultaneously, the symptoms of obstruction and irritation associated with benign prostatic hyperplasia decrease. The therapeutic effect is manifested approximately 2 weeks after the start of treatment.

Significantly less pronounced in tamsulosin is the ability to block alpha-1B-adrenoreceptors of smooth muscle vessels, so the effect on systemic blood pressure is negligible.

No mutagenic activity was detected in a number of tests.

Composition

Tamsulosin hydrochloride + excipients.

Pharmacokinetics

After ingestion, tamsulosin is rapidly and almost completely absorbed from the digestive tract.After a single intake of 400 μg Cmax active substance in the plasma is achieved after 6 hours. Binding to plasma proteins - 99%. Tamsulosin is slowly metabolized in the liver with the formation of pharmacologically active metabolites, which retain high selectivity to alpha1A-adrenergic receptors. Most of the active substance is present in the blood in unchanged form. It is excreted by the kidneys, 9% - unchanged.

Indications

• benign prostatic hyperplasia (BPH);
• treatment of dysuric disorders.

Forms of release

Capsules with sustained release 0.4 mg retard.

Granules for the preparation of a suspension for oral administration.

The tablets of the prolonged action, covered with a cover of 0.4 mg.

Instructions for use and dosing regimen

Inside - 400 mcg once a day (after breakfast, washing down with enough water).

Side effect

• dizziness;
• orthostatic hypotension;
• a feeling of palpitations;
• headache;
• asthenia;
• retrograde ejaculation.

Contraindications

• hypersensitivity to tamsulosin.

Application in pregnancy and lactation

In women, the drug Tamsulosin is not used.

Use in children

Children are not used.

special instructions

With caution apply in patients prone to arterial hypotension, with severe violations of liver function.

When the first signs of orthostatic hypotension (dizziness, weakness), the patient is recommended to sit or lay down.

When surgical interventions for cataracts against the background of taking the drug may develop the syndrome of intraoperative instability of the iris (narrow pupil's syndrome), which must be taken into account by the surgeon in the preoperative preparation of the patient and the operation.

Before starting therapy with tamsulosin, the patient should be examined for other diseases that can cause the same symptoms as benign prostatic hyperplasia. Before the beginning of treatment and regularly during therapy, a digital rectal examination and, if required, the determination of a specific antigen of the prostate should be performed. In patients with impaired renal function, a change in the dosing regimen is not required.

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, it is necessary to refrain from engaging in potentially dangerous activities that require a high concentration of attention and speed of psychomotor reactions.

Drug Interactions

With the simultaneous use of tamsulosin with cimetidine, a slight increase in the concentration of tamsulosin in the blood plasma was noted, and with Furosemide a decrease in concentration was noted; with other alpha1-adrenoblockers - possibly a marked increase in the hypotensive effect.

Diclofenac and indirect anticoagulants slightly increase the rate of elimination of tamsulosin.

Diazepam, propranolol, trichloromethiazide, chloromadinone, amitriptyline, diclofenac, glibenclamide, Simvastatin and Warfarin do not change the free fraction of tamsulosin in human plasma. In turn, tamsulosin also does not change the free fractions of diazepam, propranolol, trichloromethiazide and chloromadinone.

In studies, no interaction was found at the level of hepatic metabolism with amitriptyline, salbutamol, glibenclamide, and finasteride.

Other alpha 1-adrenoblockers, acetylcholinesterase inhibitors, alprostadil,anesthetics, diuretics, levodopa, antidepressants, beta adrenoblockers, slow calcium channel blockers, muscle relaxants, nitrates and ethanol can increase the severity of the hypotensive effect.

Analogues of Tamsulosin

Structural analogs for the active substance:

• Hyperprost;
• Glansin;
• Duodart;
• Myctosin;
• Omnik Okas;
• Omnik;
• Omsulosin;
• Proflosin;
• Sonizine;
• Sounirid Duo;
• Tamzelin;
• Tamsulosin retard;
• Tamsulosin Sandoz;
• Tamsulosin Teva;
• Tamsulosin hydrochloride;
• Tamsulon;
• Tanise;
• Tanise K;
• Tulosin;
• Focussin.

Analogues on the therapeutic effect (drugs for the treatment of prostate hyperplasia):

• Avodart;
• Adenostop;
• Alfinal;
• Artesine;
• Afala;
• Vezielut;
• Viardot;
• Vitaprost;
• Vitaprost forte;
• Gentos;
• Dalfaz;
• Depostat;
• Doxazosin;
• Dutasteride;
• Grain;
• Indigal;
• Cardura;
• Kornam;
• Metovit;
• Omnik;
• Permikson;
• Polipressin;
• Proscar;
• They will prostate;
• Prostamine;
• Prostamol Uno;
• Prostaplant;
• Prosteride;
• Simpletons;
• Setegis;
• Sinestrol;
• Sonizine;
• Spem;
• Tadenan;
• Tonicardin;
• Trianol;
• Urorek;
• Finast;
• Finasteride;
• Haytrin;
• Cernilton.

Similar medicines:

Other medicines: