Effezel - instructions for use, analogs, reviews and release forms (gel, ointment or cream for external use) drugs for the treatment of acne or acne, acne in adults, children and pregnancy. Composition

In this article, you can read the instructions for using the drug Effezel. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of physicians specialists on the use of Effezela in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Effezela in the presence of existing structural analogs. Use to treat acne or acne, acne in adults, children, as well as during pregnancy and lactation. Composition of nonhormonal drug.

Effezel - contains in its composition two active substances with different, but complementary, mechanisms of action.

Adapalene is a chemically stable naphthoic acid derivative with retinoid-like action. Adapalene acts pathogenetically with acne vulgaris: it is a strong modulator of the processes of cell differentiation and keratinization, and also has an anti-inflammatory effect. The mechanism of action of the drug is based on the binding of adapalene to specific nuclear receptors of retinoic acid. Current data suggest that, with topical application, adapalene normalizes the process of differentiation of epithelial cells of follicles, thereby reducing the formation of micro-comedones. Adapalen inhibits the chemotactic (directional) and chemokinetic (arbitrary) responses of human polymorphonuclear leukocytes, and also inhibits the metabolism of arachidonic acid and the formation of inflammatory mediators. According to in vitro studies, adapalene oppresses AP-1 factors, as well as the expression of toll-like receptors-2. Thus, it can be said that under the influence of adapalene, the cellular-mediated inflammatory component of acne is reduced.

Benzoyl peroxide has an antimicrobial effect, in particular with respect to Propionibacterium acnes present in the sebaceous hair follicle with acne. Has exfoliating and keratolytic action. Has a sebostatic effect, preventing excessive production of sebum accompanying acne.

Composition

Adapalene + Benzoyl peroxide + excipients.

Pharmacokinetics

Pharmacokinetic properties of the drug Effezzel are similar to the pharmacokinetics of the drug Differin (adapalene) 0.1% gel for external use. Penetration of benzoyl peroxide through the skin is low. It is completely converted to benzoic acid, which is quickly eliminated from the body.

Indications

local treatment of acne with comedones (acne or acne), papules and pustules.

Forms of release

Gel for external use (sometimes mistakenly called ointment or cream).

Instructions for use and how to use them

Apply a thin film with the fingertips to the entire affected surface 1 time per day in the evening on a clean and dry skin, avoiding contact with the eyes and mucous lips.

The therapeutic effect develops after 1-4 weeks of treatment.The duration of treatment should be determined by the doctor on the basis of the clinical condition of the patient.

In case of signs of skin irritation, the use of non-medigens with moisturizing effect is recommended, the number of applications can be reduced (for example, every other day), the treatment can be temporarily suspended until signs of irritation disappear or completely discontinued.

Side effect

dry skin;
irritable contact dermatitis;
burning and irritation of the skin;
itching;
sunburn;
allergic contact dermatitis.

In case of development of skin irritation, its intensity is usually mild or moderate, with local symptoms of tolerance (redness, dryness, flaking and burning) that reach a peak during the first week of treatment, and then spontaneously leave.

Contraindications

hypersensitivity or allergic reactions to active ingredients or any of the ingredients of the drug.

Application in pregnancy and lactation

Data on the local use of Effexel in pregnant women is not enough. However, several available data collected from patients who received the drug in the early stages of pregnancy, do not indicate any of its negative effects.

Studies of the combination of adapalene and benzoyl peroxide on animals in which the drug was fed to the animals orally showed toxic effects on the reproductive system at high system exposure.

Due to the limitations of the available data, as well as due to the possible weak penetration of adapalene through the skin, Effezzel should not be used during pregnancy. In case of pregnancy, treatment should be discontinued.

Investigations of the penetration of the drug into the milk of animals or humans after the ephemezel has not been applied. Since the systemic exposure of Effexel in lactating women is negligible, there is no expectation of any impact on breast-fed infants.

Effezel can be used during breastfeeding. Avoid contact of the newborn with the drug, applying the drug to the breast when used during breastfeeding.

Use in children

The safety and efficacy of the drug has not been investigated in children younger than 12 years.

special instructions

Do not apply Effegel gel to injuries resulting from injuries (cuts or abrasions) or eczematically altered skin.

Avoid contact with eyes, mouth, nostrils and other mucous membranes. In case of contact with eyes, rinse immediately with warm water.

The preparation contains propylene glycol (E1520), which can cause skin irritation. If suspicion of increased sensitivity to any of the ingredients of the drug, Effexel should be discontinued.

Does not contain hormones and hormone-like substances.

Excessive exposure to sunlight or UV radiation should be avoided.

Avoid contact with any colored materials (including hair and dyed fabrics), as this can lead to discoloration or discoloration.

Drug Interactions

There have been no studies of interaction with other drugs.

Based on the experience of using adapalene and benzoyl peroxide, interactions with other drugs have not been identified.

However, do not use other retinoids or benzoyl peroxide, or drugs with a similar mechanism of action. Care should be taken when applying cosmetic products with exfoliating,irritating or drying effect due to the possible additional irritating effect.

Absorption of adapalene through the skin is low, so the development of interaction with systemic drugs is unlikely.

Penetration of benzoyl peroxide through the skin is low, it is completely metabolized to benzoic acid, which is rapidly eliminated from the body. In this regard, the development of interaction of benzoic acid with systemic drugs is unlikely.

Analogues of the drug Effezel

Effehzel does not have structural analogs for the active substance. The drug contains a unique combination of active ingredients.

Analogues on the curative effect (remedies for the treatment of acne or acne):

Adaclin;
Adapalen;
Adolen;
Aquazan;
Acnekutan;
Androkur;
Arthromax;
Basiron AC;
Bassado;
Bellune 35;
Betaspan Depot;
Betula Charm;
Betusil;
Bonade;
Wilprafen;
Wilprafen solute;
Delex Acne gel from acne;
Deleks Acne cleansing lotion;
Desquam;
Jess;
Jess Plus;
Diane 35;
Dimephosphone;
Differin;
Doxal;
Doxycycline;
Dr. Theiss Acne Cream for acne;
Dr. Theiss Acne Acne Lotion;
Yeast beer;
Genetten;
Mirror;
Zinerit;
Zitrolid forte;
Clenzite;
Cylinder C;
Curious;
Kutis compositum;
Lei;
Purge of Puree;
Metronidazole;
Microfolline;
Monoclin;
Piolizin;
Proderm;
Retinoic ointment;
Roaccutane;
Rosamet;
Roxithromycin;
Silhouettes;
Skinoren;
Streptonitol;
Sudokrem;
Chloe;
Zinctal;
Cytale;
Eplan;
Erica 35;
Unidox Solutab;
Yarina;
Yarina Plus.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: blackheads, acne, acne