Maxikold - instructions for use, analogs, testimonials and release forms (spray or Lore aerosol, tablets, powder for the preparation of Rino solution, suspension for children) for the treatment of cold symptoms in adults, children and pregnancy

In this article, you can read the instructions for using the drug Maxikold. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors specialists on the use of MaxiKold in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogs of Maksikold in the presence of existing structural analogs.Use to treat cold and flu symptoms (runny nose, sore throat, fever) in adults, children, as well as during pregnancy and lactation. Composition of the preparation.

Maxikold - Combined drug, has antipyretic and analgesic effect, is intended to relieve the symptoms of colds and flu. The effect of the drug is due to the properties of its constituent components.

Paracetamol is a non-narcotic analgesic, has antipyretic and analgesic effects due to cyclooxygenase blockade in the central nervous system and exposure to pain centers and thermoregulation. Reduces headache and muscle pain, fever.

Phenylephrine is an alpha1-adrenostimulant that has little effect on the cardiac beta-adrenoceptors; is not catecholamine. Causes narrowing of arterioles, due to which reduces edema and flushing of the mucous membrane of the nasal cavity, facilitates breathing through the nose.

Pheniramine has an antiallergic effect: it eliminates edema and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses, reduces runny nose and lacrimation

Ascorbic acid - increases the body's resistance to infections, replenishes the increased need for vitamin C for colds and flu.

Maxicold for children is a non-steroidal anti-inflammatory drug (NSAID), a derivative of phenylpropionic acid. Has anti-inflammatory, analgesic and antipyretic effect.

The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. The analgesic effect is caused both by peripheral (indirectly, through suppression of prostaglandin synthesis) and by the central mechanism (inhibition of the synthesis of prostaglandins in the central and peripheral nervous system). Suppresses the aggregation of platelets.

With external application has anti-inflammatory and analgesic effect. Reduces the morning stiffness, promotes an increase in the volume of movements in the joints.

Maxocold Lor is an antiseptic preparation for topical application.Has antimicrobial, antifungal, analgesic, enveloping and deodorizing action.

The antimicrobial effect of the Maxocold Lor drug is associated with the suppression of oxidative reactions of bacterial metabolism (hexathidine-thiamine antagonist). The drug has a broad spectrum of antibacterial and antifungal effects, in particular against Gram-positive bacteria and fungi of the genus Candida (Candida), however Maxocold Lor can also have an effect in the treatment of infections caused, for example, by Pseudomonas aeruginosa or Proteus spp (Proteus). At a concentration of 100 mg / ml, the drug suppresses most strains of bacteria. The development of stability was not observed. Maxicold Lor has a weak anesthetic effect on the mucosa.

Composition

Paracetamol + Phenylephrine hydrochloride + Ascorbic acid + excipients (Maxikold).

Paracetamol + Phenylephrine hydrochloride + Pheniramine maleate + ascorbic acid + excipients (Maxicold Reno).

Hexetidine + excipients (Maksikold Lor).

Ibuprofen + auxiliary substances (Maxikold for children).

Pharmacokinetics

Paracetamol: well absorbed in the intestine, TCmax - 0.5-2 h; communication with plasma proteins - 15%. Metabolised in the liver with the formation of both active and inactive metabolites. Primarily excreted by the kidneys in the form of metabolites - glucuronides and sulfates, 3% - unchanged.

Phenylephrine: after ingestion phenylephrine is poorly absorbed from the digestive tract. Metabolized with the participation of monoamine oxidase (MAO) in the intestinal wall and "first pass" through the liver. Bioavailability of phenylephrine is low.

Ascorbic acid: absorbed in the digestive tract (mainly in the jejunum). Easily penetrates into leukocytes, platelets, and then into all tissues; the greatest concentration is achieved in glandular organs, leukocytes, liver and lens of the eye; penetrates the placenta. Metabolised mainly in the liver in desoxyascorbic and then in oxaloacetic acid and ascorbate-2-sulfate. It is excreted by the kidneys, through the intestines, with sweat, breast milk in unchanged form and in the form of metabolites.

Hexetidine: after a single use, the local action of hexiethidine lasts 10-12 hours. The drug is not practically absorbed from the surface of the mucous membranes and does not have a systemic effect.After a single application of the active substance, its traces are found on the gingival mucosa for 65 hours. In the dental plaques, active concentrations are maintained for 10-14 hours after application.

Ibuprofen: when ingested almost completely absorbed from the digestive tract. Simultaneous food intake slows down the rate of absorption. Metabolised in the liver (90%). 80% of the dose is excreted in the urine mainly in the form of metabolites (70%), 10% - unchanged; 20% is excreted through the intestines in the form of metabolites.

Indications

Maxikold and Maxikold Reno

symptomatic treatment of infectious and inflammatory diseases (including influenza and other acute respiratory viral infections (ARVI)), accompanied by fever, chills, nasal congestion, headache, pain in the bones and muscles, in the throat and sinuses of the nose.

Maxikold Lor

infectious and inflammatory diseases of the oral cavity and pharynx (tonsillitis, including Plout-Vincent's angina, pharyngitis, stomatitis, aphthous ulcers of the oral cavity, glossitis, periodontitis, gingivitis, periodontitis, periodontitis, alveolitis), gum bleeding;
with ARI - as an auxiliary, as part of complex therapy;
fungal infections of the oral cavity, pharynx and larynx (thrush);
injuries and surgical interventions in the oral cavity, throat and larynx (both before and after their holding), incl. prevention of infection of the alveoli after extraction of the tooth;
as a means of oral hygiene to eliminate an unpleasant odor (deodorizing effect);
prevention of superinfections in decaying tumors of the oral cavity and larynx.

Maxikold for children

inflammatory-degenerative diseases of the joints and spine (including rheumatic and rheumatoid arthritis, ankylosing spondylitis, osteoarthrosis);
articular syndrome with exacerbation of gout;
psoriatic arthritis;
ankylosing spondylitis;
tendonitis;
bursitis;
radiculitis;
traumatic inflammation of soft tissues and musculoskeletal system;
neuralgia;
myalgia;
pain syndrome in infectious and inflammatory diseases of ENT organs, adnexitis;
algodismenorea;
headache and toothache;
fever in infectious and inflammatory diseases.

Forms of release

The tablets covered with a cover.

Powder for solution for oral administration (Maxikold Rino).

Spray or aerosol for topical application (Maksikold Lor).

Suspension for oral administration (Maxikold for children).

Instructions for use and dosing regimen

Pills

Inside, before meals or 1-2 hours after eating, squeezed large amounts of liquid.

Adults and children over 12 years of age (body weight over 40 kg): 1-2 tablets every 4-6 hours. The frequency of reception is no more than 4 times a day with an interval of at least 4 hours.

Children aged 9 to 12 years (body weight more than 30 kg): 1 tablet every 4-6 hours. The frequency of reception is no more than 4 times a day with an interval of at least 4 hours.

The drug is not recommended for more than 5 days as an anesthetic and 3 days as an antipyretic agent without consulting a doctor. If symptoms persist, consult a physician.

Do not exceed the indicated dose.

Powder Reno

The drug is taken orally. The contents of one packet should be dissolved in 1 glass of boiled hot water. Ready-made solution must be consumed in hot condition; you can add sugar to taste.

Repeated dose can be taken every 4 hours (no more than 3 doses in 24 hours).

Maxikold Reno can be used at any time of the day, but the best effect comes from taking the drug before going to bed, at night.

If there is no relief of symptoms within 3 days after starting the drug, the patient should consult a doctor.

Spray Lor

Apply topically, after a meal or in between meals.

With the help of spray treated affected areas in the mouth and throat. The frequency of application for adults and children over 3 years is 2-3 times a day. If necessary, more frequent use of the drug. The course of treatment is 5-7 days. For proper use of the drug, you must perform the following actions:

Remove the lid from the cylinder, install the nebulizer in the corresponding opening of the top of the cylinder.
When using for the first time, several short presses on the nebulizer must be made in advance (in order to ensure uniform dispersion of the contents of the cylinder).
Enter the required amount of the drug into the oral cavity by pressing the sprayer 3-4 times until it stops. During the introduction of the drug should hold your breath.
After use, remove the nebulizer, rinse it in running water and dry it at room temperature out of the reach of children.
Keep the nebulizer in the package with the product.

During the introduction, the balloon should be kept upright.

Suspension for children

Established individually, depending on the nosological form of the disease, the severity of clinical manifestations.When administered or rectally for adults, a single dose is 200-800 mg, the frequency of admission is 3-4 times a day; for children - 20-40 mg / kg per day in several receptions.

Apply externally for 2-3 weeks.

The maximum daily intake for adults with oral or rectal administration is 2.4 g.

Side effect

allergic reactions (skin rash, skin hyperemia, urticaria, angioedema, edema);
disorders of hematopoiesis (anemia, thrombocytopenia, methemoglobinemia);
headache;
nausea, vomiting;
angina pectoris;
bradycardia;
dyspnea;
increase or decrease in blood pressure;
palpitation;
tachycardia;
ventricular arrhythmia (especially when used in high doses);
irritability;
motor anxiety;
allergic reactions;
irritation of the mucosa of the gastrointestinal tract;
decreased capillary permeability (possibly deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).

Maxikold Reno

drowsiness;
violation of falling asleep;
increased excitability;
dizziness;
paresis of accommodation;
increased blood pressure;
nausea;
pain in the epigastric region;
dry mouth;
retention of urine;
allergic reactions;
anemia.

Suspension for children

nausea, vomiting;
anorexia;
a feeling of discomfort in the epigastrium;
diarrhea;
development of erosive and ulcerative gastrointestinal lesions;
bleeding from the digestive tract;
headache;
dizziness;
sleep disorders;
excitation;
visual impairment;
anemia, thrombocytopenia, agranulocytosis;
skin rash;
angioedema;
aseptic meningitis (more often in patients with autoimmune diseases);
bronchospastic syndrome;
hyperemia of the skin;
a burning sensation or tingling sensation.

Contraindications

marked renal / hepatic impairment;
hyperthyroidism (including thyrotoxicosis);
heart disease (pronounced stenosis of the aortic aorta, acute myocardial infarction, tachyarrhythmias);
arterial hypertension;
simultaneous administration of tricyclic antidepressants, beta-adrenoblockers, monoamine oxidase inhibitors, incl. in the period of 14 days after cancellation;
simultaneous administration of other paracetamol-containing drugs and agents to relieve the symptoms of "colds", flu and nasal congestion;
hyperplasia of the prostate;
angle-closure glaucoma;
children's age (up to 9 years, as well as children weighing less than 30 kg);
hypersensitivity to any component of the drug.

Maxikold Reno

severe hepatic impairment;
severe renal failure;
pregnancy;
lactation period (breastfeeding);
children's age till 12 years;
hypersensitivity to the components of the drug.

Maxikold Lor

atrophic pharyngitis;
children under 3 years;
hypersensitivity to the components of the drug.

Suspension for children

erosive and ulcerative lesions of the gastrointestinal tract in the phase of exacerbation;
diseases of the optic nerve;
"aspirin triad";
disorders of hematopoiesis;
marked impairment of renal and / or liver function;
3 trimester of pregnancy;
hypersensitivity to ibuprofen.

Application in pregnancy and lactation

Use with caution during pregnancy and lactation.

Maxikold Reno

The drug is contraindicated for use in pregnancy and lactation.

Maxikold Lor

There is no information about any adverse effects of hexaetidine in pregnancy and lactation. Before prescribing the drug to pregnant or lactating women, the physician should carefully weigh the benefits of treatment for the mother and the possible risk to the fetus andchild, given the lack of sufficient data on the penetration of the drug through the placenta and into breast milk.

Maxikold for children

Application in the 3 trimester of pregnancy is contraindicated. The use in 1 and 2 trimesters of pregnancy is justified only in those cases when the expected benefit for the mother exceeds the possible risk to the fetus.

Ibuprofen in small amounts excreted in breast milk. Use in the lactation period for pain and fever is possible. If you need long-term use or use in high doses (more than 800 mg per day), you should decide whether to stop breastfeeding.

Use in children

Contraindicated in children under 9 years old, and also with a body weight of less than 30 kg.

Maxikold Reno

The drug is contraindicated in children under 12 years of age.

Maxikold Lor

Contraindicated in children under 3 years. Children can use the drug from such an age when they do not resist the foreign object (spray) in the mouth when applying the spray and are able to hold their breath when injecting the drug.

Maxikold for children

Possible use of the drug in children.

special instructions

Before taking the drug, it is necessary to consult a doctor in case of concomitant use of metoclopramide, domperidone, colestyramine (because Metoclopramide and Domperidone increase, and colestyramin reduces the rate of absorption of paracetamol), anticoagulants (because concomitant use of Paracetamol in high doses increases the effect of anticoagulant medicinal products).

Acceptance of the drug distorts the results of laboratory tests evaluating the concentration of glucose and uric acid in the plasma.

When using the drug for more than 5-7 days, it is necessary to monitor the peripheral blood and the functional state of the liver.

The use of the drug during pregnancy is possible only according to the doctor's prescription.

To avoid toxic damage to the liver, the drug should not be combined with taking alcoholic beverages, as well as taking people with chronic alcoholism.

Impact on the ability to drive vehicles and manage mechanisms

The drug does not adversely affect the performance of potentially hazardous activities requiring special attention and rapid reactions.

Drug Interactions

The drug enhances the effects of monoamine oxidase inhibitors, sedatives, ethanol (alcohol).

The risk of hepatotoxic action of paracetamol increases with the simultaneous administration of ethanol, hepatotoxic drugs, inducers of microsomal oxidation enzymes in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants, etc.).

The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs (a decrease in the synthesis of procoagulant factors in the liver). Paracetamol reduces the effectiveness of uricosuric drugs.

Long-term use of barbiturates reduces the effectiveness of paracetamol. Metoclopramide and domperidone are increased, and colestramine reduces the rate of absorption of paracetamol. Inhibitors of microsomal oxidase enzymes (including cimetidine) reduce the risk of hepatotoxic effects of paracetamol.

Simultaneous administration of ethanol and paracetamol promotes the development of acute pancreatitis. Long-term combined use of paracetamol and non-steroidal anti-inflammatory drugs increases the risk of developing "analgesic" nephropathy and renal papillarynecrosis, the onset of the terminal stage of renal failure. Simultaneous long-term administration of paracetamol in high doses and salicylates increases the risk of developing kidney or bladder cancer. Diflunisal increases the plasma concentration of paracetamol by 50% - the risk of developing hepatotoxicity. Myelotoxic drugs increase the manifestation of hematotoxicity of paracetamol.

Phenylephrine reduces the hypotensive effect of diuretics and hypotensive drugs (including methyldopy, mekamilamin, guanadrel, guanetidine), reduces the antianginal effect of nitrates.

Phenothiazines, alpha-adrenoblockers (phentolamine), Furosemide and other diuretics reduce the hypertensive effect of phenyramine. Inhibitors of monoamine oxidase (including furazolidone, procarbazine, selegiline), oxytocin, ergot alkaloids, tricyclic antidepressants, methylphenidate, adrenostimulants increase the vasoconstrictive effect and arrhythmogenicity of phenylephrine, against the background of reserpine, hypertension is possible. Ergometrin, ergotamine, methylergometrine, oxytocin, doxapram increase the severity of the vasoconstrictor effect of phenyramine.

Inhalational anesthetics (incl.chloroform, enflurane, halothane, isoflurane, methoxyflurane) increase the risk of severe atrial and ventricular arrhythmias. Thyroid hormones increase (mutually) the effect of phenylephrine and the associated risk of coronary insufficiency (especially in coronary atherosclerosis).

Ascorbic acid increases the concentration in the blood of benzylpenicillin and tetracyclines, reduces the effectiveness of Heparin and indirect anticoagulants, increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body, reduces the therapeutic effect of antipsychotic drugs - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

With simultaneous use with acetylsalicylic acid, urinary excretion of ascorbic acid increases and the excretion of Acetylsalicylic acid decreases. Acetylsalicylic acid, oral contraceptives, fresh juices and alkaline drink reduce the absorption and absorption of ascorbic acid.

Ascorbic acid improves the absorption of iron in the intestine; increases the risk of developing crystalluria in the treatment of salicylates andsulfonamides short-acting, slows the excretion of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration in the blood of oral contraceptives, reduces the chronotropic effect of isoprenaline. With long-term use or use in high doses, it can interfere with the interaction of Disulfiram and ethanol, in high doses increases the excretion of mexiletine by the kidneys.

Drugs quinoline series, calcium chloride, salicylates, glucocorticoids with prolonged use deplete the stores of ascorbic acid. Barbiturates and primidon increase the excretion of ascorbic acid in the urine.

Analogues of the drug Maxikold

Structural analogs for the active substance:

Ajikold Hotmix;
Antigrippin-ARVI neo;
Influenza from the cold and flu;
Grippoflu extra for cold and flu;
Gripand HotActiv;
Gripand HotActive Max;
Coldrex;
Coldrex MaxGripp;
Coldrex Hotrem;
Coldrex Junior;
Coldrex Junior Hot Drink;
Lemsip Black Currant;
Maxikold Reno;
Neoflum 750;
Prostudox;
Stopgrispan;
Stopgripan forte;
TeraFlu from influenza and colds;
TeraFlu Extra Plus;
Feniprex C;
Flukoldex C.

Structural analogues of the drug Maxichold Lor according to the active ingredient:

Hexoral;
Hexetidine;
Stomatidin;
Stopangin.

Analogues on the pharmacological group (Anilids):

Aldolor;
Antigrippin;
Antigrippin maximum;
Antiflu;
Acetaminophen;
Brustan;
Grippostad;
Daleron;
Children's Panadol;
Children's Tylenol;
Children's Tylenol for colds;
Dolaren;
Ibuklin;
Influblock;
Influenza;
Caffetin;
Caged Flux Plus;
Coldrex;
Coldrex Knight;
Coldfri;
Coffedon;
Lupocet;
Maxikold Reno;
Meksavit;
Mexalen;
Migraine;
Migrenol;
Next;
Novalgin;
Nurofen;
Panadine;
Panadol;
Panoxen;
Paracetamol;
Pentalgin;
Perfalgan;
Pliwalgin;
Prostudox;
Rince;
Rinzasip;
Rinicold;
Solpadein;
Stopgrispan;
Tylenol;
Tylenol for infants;
Tylenol for the common cold;
TeraFlu;
Fastoric;
Febricet;
Femizol;
Fervex;
Fervex rhinitis;
Fluxcold;
Hyrumat;
Cefekon D;
Efferalgan;
Yunispaz.

If there are no analogues of the medication for the active substance, you can go to the links below for diseases, from which the corresponding drug helps, and to look at the available analogs for therapeutic effects.

Used for the treatment of diseases: infection, cold, orvi, Orz, flu, angina, tonsillitis, pharyngitis, stomatitis, gingivitis, pain, runny nose, thrush, temperature, a sore throat, rhinitis, heat, chills, fever, muscle pain, headache, neuralgia, myalgia, parodontosis, candidiasis, radiculitis