Zhenala - instructions for use, reviews, analogs and forms of release (tablets 10 mg) drugs for emergency postcoital contraception (after intercourse) in women. Composition of hormonal contraceptive and side effects

In this article, you can read the instructions for using the drug Zhenala. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of experts on the use of Genal in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Genalais in the presence of existing structural analogues. Use for emergency postcoital contraception (after intercourse) in women,as well as during pregnancy and lactation. Composition of the hormonal contraceptive.

Zhenala - a synthetic steroidal anti-progestagenic drug. It blocks the action of Progesterone at the level of receptors, does not possess gestagenic activity. Antagonism with glucocorticosteroids (GCS) was noted due to competition at the level of communication with receptors.

Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choroidectid cells, increasing the sensitivity of the myometrium to the prostaglandins. As a result of the action of the drug desquamation of the decidual membrane occurs and excretion of the fetal egg. It causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.

Composition

Mifepristone + excipients.

Pharmacokinetics

After a single oral intake, Cmax is achieved after 1.3 hours. Absolute bioavailability is 69%. In blood plasma, Mifepristone binds 98% to proteins: albumin and acid alpha-1 glycoprotein. After the distribution phase, the excretion first occurs slowly, the concentration decreases 2 times between 12-72 hours, then more rapidly.

Indications

• emergency (postcoital) contraception within 72 hours after sexual intercourse without previous use of contraceptives or methods, and also in case of their unsuccessful application (including error in using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).

Forms of release

Tablets 10 mg.

There are no other medicinal forms, whether they are vaginal suppositories or douching.

Instructions for use and how to use them

Take 1 tablet inside 2 hours before or 2 hours after ingestion (the next 72 hours after unprotected sexual intercourse), regardless of the phase of the menstrual cycle.

Side effect

• bloody discharge from the genital tract;
• discomfort and pain in the lower abdomen;
• exacerbation of inflammatory diseases of the uterus and appendages;
• nausea, vomiting;
• diarrhea;
• headache;
• dizziness;
• weakness;
• hyperthermia;
• hives.

Contraindications

• acute or chronic renal and / or liver failure;
• long-term therapy with glucocorticosteroid agents;
• porphyria;
• anemia;
• violations of hemostasis (including the previous treatment with anticoagulants);
• presence of severe extragenital pathology;
• adrenal insufficiency;
• pregnancy;
• lactation period;
• the presence in the anamnesis of hypersensitivity to mifepristone and / or accessory components.

Application in pregnancy and lactation

The drug Genelle can not be used during pregnancy. Breastfeeding should be discontinued for 14 days after taking the drug.

Use in children

Not noted.

Application in elderly patients

Not applicable.

special instructions

The drug does not protect against sexually transmitted diseases and AIDS.

It is not recommended to use the drug as a planned, permanent contraception after each sexual intercourse, as well as monthly.

After applying as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual acts are not recommended without the use of contraceptives. With further sexual intercourse, a barrier method of contraception should be used.

If you delay the cycle time of menstruation after using the drug Zhenala, you should consult a doctor to diagnose a possible pregnancy.

The dose of 10 mg is not enough to cause abortion, so before its further use, a highly sensitive pregnancy test should be carried out, ensuring that the drug is used only in the absence of pregnancy. In the case of pregnancy, despite the use of the drug, it is recommended that it be interrupted by a medical or surgical method. If the patient decides to keep the pregnancy, it is impossible to completely exclude the risk to the health of the unborn child.

The drug is released by prescription.

Impact on the ability to drive vehicles and manage mechanisms

The effect of the drug on the ability to drive and work with machinery has not been noted.

Drug Interactions

Use of non-steroidal anti-inflammatory drugs (NSAIDs) should be avoided within 8-12 days after taking the drug.

Analogues of the drug Zhenala

Structural analogs for the active substance:

• Agesta;
• Ginepristone;
• Gynestrel;
• Miropristone;
• Mifegin;
• Mifeprex;
• Mifepristone;
• Mythophian;
• Pencrofton.

Analogues for the pharmacological group (contraceptives):

• Antotevin;
• Belara;
• Bellune 35;
• Benatex;
• Bonade;
• Gestarella;
• Gynecotheque;
• Demulen;
• Jess;
• Jess Plus;
• Diane 35;
• Dimia;
• Evra;
• Janine;
• Genetten;
• Zoeli;
• Clira;
• Contraceptin T;
• Lactineth;
• Lei;
• Lindineth 20;
• Lyndyneth 30;
• Loveston;
• Logest;
• Marvelon;
• Mersilon;
• Midian;
• Microinon;
• Microlus;
• Miniziston;
• Mirell;
• Mirena;
• Modell;
• NovaRing;
• Novinet;
• Non Ovlon;
• Norkolut;
• Norplant;
• Ovidon;
• Oralcon;
• Postinor;
• Regulon;
• Rigevidone;
• Silestus;
• Silhouettes;
• Synphase;
• Sterilin;
• Three regol;
• Trigestrel;
• Trikwilar;
• Pharmatex;
• Femoden;
• Chloe;
• Egestenol;
• Exluent;
• Erica 35;
• Escapel;
• Eskinor F;
• Yarina;
• Yarina Plus.

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