Ambrobene - instructions for use, analogs, reviews and release forms (30 mg tablets, inhalation and injection solution, 75 mg retard capsules, syrup) for cough treatment in adults, children and during pregnancy
In this article, you can read the instructions for using the drug Ambroben. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ambrobene in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues Ambrobene in the presence of existing structural analogues. Use for the treatment of dry cough, liquefaction and excretion of viscous sputum in bronchitis, pneumonia in adults, children,as well as during pregnancy and lactation.
Ambroben - mucolytic and expectorant drug.
Ambroxol (descendant substance Ambrobene) - an active metabolite of Bromhexine improves the rheological properties of sputum, reduces its viscosity and adhesive properties, contributing to its removal from the respiratory tract.
Ambrobene stimulates the activity of serous cells of the glands of the bronchial membrane, the production of enzymes that break bonds between polysaccharides of sputum, the formation of surfactant and directly the activity of the cilia of the bronchi, preventing their coalescence.
After oral administration, the therapeutic effect occurs after 30 minutes and persists for 6-12 hours (depending on the dose taken).
With parenteral administration, the action of the drug occurs rapidly and lasts for 6-10 hours.
Pharmacokinetics
With parenteral administration Ambrobene quickly penetrates into the tissues. The highest concentration is found in the lungs. Ambroxol penetrates through the BBB and placental barrier, excreted in breast milk. About 90% of ambroxol is excreted in the urine: 90% in the form of metabolites and 10% in unchanged form.
Indications
All forms of the drug are used for diseases of the respiratory tract with the release of viscous sputum and the difficulty of its divergence:
- acute and chronic bronchitis;
- pneumonia;
- bronchial asthma;
- bronchiectatic disease;
- as part of complex therapy to stimulate the synthesis of surfactant for respiratory distress syndrome in premature infants and newborns (injection solution).
Forms of release
Tablets 30 mg.
Solution for ingestion and inhalation.
Capsules retard 75 mg.
Syrup (child form of the drug).
Solution for injections (injections in ampoules).
Instructions for use and dosage
The drug should be taken orally after a meal with enough liquid (a glass of water, tea or juice).
Pills
Tablets for adults and children over the age of 12 years in the first 2-3 days prescribed 1 tablet 3 times a day (90 mg per day). Subsequently, they switch to a 2-time dose of the drug 1/2 tablet a day (30 mg per day).
Children aged 6 to 12 years in the first 2-3 days prescribed 1/2 tablet 2-3 per day (30-45 mg per day). Subsequently, they switch to a two-time dose of 1 tablet per day (30 mg per day).
Capsules retard
Capsules retard adults and children over the age of 12 years appoint 1 capsule per day (75 mg per day).
Syrup
The syrup should be taken with a measuring cup: 1 ml of syrup contains 3 mg of ambroxol.
Children under 2 years of age are prescribed a drug of 2.5 ml syrup 2 times a day (15 mg per day).
Children aged 2 to 6 years are prescribed a drug of 2.5 ml syrup 3 times a day (22.5 mg per day).
Children aged 6 to 12 years are prescribed a drug of 5 ml of syrup 2-3 times a day (30-45 mg per day).
Adults and children over the age of 12 years during the first days of 10 ml of syrup 3 times a day (90 mg per day). In the subsequent 10 ml of syrup 2 times a day (60 mg per day).
Ambrobene in the form of a syrup is the most convenient dosage form for the treatment of patients of childhood.
Solution for ingestion and inhalation
Solution for ingestion and inhalation should be taken with a measuring cup: 1 ml of the solution contains 7.5 mg of ambroxol.
Children under the age of 2 years are prescribed a drug of 1 ml of solution 2 times a day (15 mg per day).
Children aged 2 to 6 years are prescribed a drug of 1 ml of solution 3 times a day (22.5 mg per day).
Children aged 6 to 12 years are prescribed a drug of 2 ml of solution 2-3 times a day (30-45 mg per day).
Adults and adolescents in the first 2-3 days prescribe 4 ml of solution 3 times a day (90 mg per day). In the following days - 4 ml 2 times a day (60 mg per day).
When using Ambrobene in the form of inhalations use any modern equipment (except for steam inhalations). Before inhalation, the drug should be mixed with 0.9% sodium chloride solution (for optimal humidification, it can be diluted 1: 1) and heated to body temperature. Inhalation should be carried out in the mode of normal breathing, so as not to provoke coughing tremors.
Patients with bronchial asthma should be treated with bronchodilators to avoid nonspecific irritation of the respiratory tract and their spasm before inhaling ambroxol.
Children under the age of 2 years are inhaled 1 ml of solution 1-2 times a day (7.5-15 mg per day).
Children aged 2 to 6 years inhaled 2 ml of the solution 1-2 times a day (15-30 mg per day).
Adults and children over the age of 6 years are inhaled 2-3 ml of the solution 1-2 times a day (15-45 mg per day).
Injection
The solution for injections should be administered intravenously (slowly by jet or drip). As a solvent, 0.9% sodium chloride solution, 5% Dextrose solution, Ringer-Lock solution or other basic solution with a pH not higher than 6.3 are used.
Children usually prescribe the drug in a daily dose at the rate of 1.2-1.6 mg / kg body weight.
Children under the age of 2 years are prescribed 1 ml (1/2 ampoules) 2 times a day (15 mg per day).
Children aged 2 to 6 years are prescribed 1 ml (1/2 ampoules) 3 times a day (22.5 mg per day).
Children over the age of 6 years are prescribed 2 ml (1 ampoule) 2-3 times a day (30-45 mg per day).
Adults appoint 1 ampoule 2-3 times a day (30-45 mg per day). In severe cases, the dose can be increased to 2 ampoules 2-3 times a day (60-90 mg per day).
With respiratory distress syndrome in newborns and premature babies, the daily dose of the drug is 30 mg and, as a rule, is divided into 4 separate injections.
Injections stop after the disappearance of acute manifestations of the disease and go on to enter into other medicinal forms Ambrobene.
Treatment of children under the age of 2 years should only be carried out under the supervision of a doctor.
During the use of the drug is a plentiful drink.
The duration of the course of treatment depends on the features of the course of the disease. It is not recommended to use the drug without medical appointment for more than 4-5 days.
Side effect
- salivation;
- gastralgia;
- nausea, vomiting;
- diarrhea, constipation;
- dry mouth and respiratory tract;
- rhinorrhea;
- skin rash;
- angioedema of the face;
- impaired breathing;
- temperature reaction with chill;
- contact dermatitis;
- anaphylactic shock;
- weakness;
- headache;
- with intravenous administration - intense headaches, fatigue and heaviness in the legs, numbness, increased blood pressure, shortness of breath, hyperthermia, chills.
Contraindications
- peptic ulcer of the stomach and duodenum;
- epileptic syndrome;
- children under the age of 6 years (for tablets, retard capsules, injection solutions);
- children under the age of 12 years (for retard capsules);
- hypersensitivity to the components of the drug.
Application in pregnancy and lactation
Since there is still no reliable data on the adverse effects of ambroxol on the fetus and the newborn, Ambrobene during pregnancy, especially in the first trimester, and during breastfeeding is possible only if the intended benefit to the mother exceeds the potential risk to the fetus.
Drug Interactions
Simultaneous use of Ambrobene with drugs that have antitussive activity (for example, containing codeine), is not recommended because of the difficulty of excretion of sputum from the bronchi against the background of a decrease in cough.
Simultaneous use of Ambrobene with antibiotics (including amoxicillin, cefuroxime, erythromycin, doxycycline) improves the flow of antibiotics into the pulmonary pathways. Such interaction with Doxycycline is widely used for therapeutic purposes.
Do not use Ambrobene for injections with solutions having a pH above 6.3.
Analogues of the drug Ambrobene
Structural analogs for the active substance:
- AmbroGEXAL;
- Ambroxol;
- Ambroxol Vramed;
- Ambroxol retard;
- Ambroxol-Verte;
- Ambroxol-Vial;
- Ambroxol-Richter;
- Ambroxol-Teva;
- Ambroxol-Hemofarm;
- Ambrolan;
- Ambrosan;
- Ambrosol;
- Bronoxoxol;
- Bronchorus;
- Dephlegmine;
- Bronchovern drops;
- Lazolangin;
- Lazolvan;
- Medox;
- Mucobron;
- Neo-Bronhol;
- Remebroks;
- Suprima-kof;
- Fervex from coughing;
- Flavamed;
- Haliksol.
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