Ketonal - instructions for use, reviews, analogs and formulations (tablets 100 mg and 150 mg, suppositories 100 mg, cream 5%, gel 2.5%, injections in ampoules, capsules Uno and Duo) medication for the treatment of pain in adults , children and pregnancy
In this article, you can read the instructions for using the drug Ketonal. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ketonal in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Ketonal analogs in the presence of existing structural analogs. Use for symptomatic treatment of inflammatory diseases and analgesia in adults, children, as well as during pregnancy and lactation.
Ketonal - a non-steroidal anti-inflammatory agent, a derivative of propionic acid. Has analgesic, anti-inflammatory and antipyretic effect. By inhibiting COX-1 and COX-2 and, in part, lipoxygenase, Ketoprofen inhibits the synthesis of prostaglandins and bradykinin, stabilizes the lysosomal membranes.
Ketoprofen (the active substance of the Ketonal preparation) does not adversely affect the condition of the articular cartilage.
Pharmacokinetics
When ingestion Ketonal easily absorbed from the digestive tract. Eating does not affect the bioavailability of ketoprofen. Ketoprofen penetrates well into the synovial fluid. Ketoprofen is mainly metabolized in the liver. About 80% of ketoprofen is excreted in the urine, mainly in the form of a conjugate with glucuronic acid (90%). About 10% is excreted unchanged through the intestine.
Indications
Symptomatic therapy of painful and inflammatory processes of various genesis, including:
- rheumatoid arthritis and periarthritis;
- ankylosing spondylitis (Bekhterev's disease);
- psoriatic arthritis;
- reactive arthritis (Reiter's syndrome);
- osteoarthrosis of different localization;
- tendonitis, bursitis;
- myalgia;
- neuralgia;
- radiculitis;
- injuries of the musculoskeletal system (incl.sports), bruises of muscles and ligaments, sprains of ligaments, ruptures of ligaments and tendons of muscles.
Forms of release
Tablets of 100 mg and 150 mg.
Candles for rectal administration 100 mg.
Cream or ointment for external use 5%.
Gel for external use 2.5%.
Capsules Ketonal Uno 200 mg.
Capsules Ketonal Duo 150 mg.
Solution for intravenous and intramuscular injection (injections in ampoules for injection) 50 mg / ml.
Instructions for use and dosing regimen
Tablets and capsules
Adults prescribe 1-2 capsules 2-3 times a day, or 1 tablet 2 times a day, or 1 tablet of prolonged action once a day. Capsules and tablets should be taken during or immediately after meals, without chewing, squeezed with enough water or milk (the volume of the liquid - not less than 100 ml).
Oral forms can be combined with the use of rectal suppositories or medicinal forms of Ketonal for external use (cream, gel).
The maximum daily dose (including when using different dosage forms) is 200 mg.
Ampoules
The solution is administered intramuscularly or intravenously. In / m injected to 100 mg 1-2 times a day. In / in the infusion of ketoprofen is carried out only in a hospital.
A short intravenous infusion: 100-200 mg, diluted in 100 ml of 0.9% sodium chloride solution, injected for 0.5-1 hour. Possible repeated administration after 8 hours.
Continuous intravenous infusion: 100-200 mg, diluted in 500 ml infusion solution (0.9% sodium chloride solution, lactate-containing Ringer's solution, 5% Dextrose solution), injected for 8 hours. Possible repeated administration after 8 hours.
Ketonal Uno and Duo
The standard dose of Ketonal Uno for adults and children over 15 years is 200 mg per day. Capsules should be taken during or after a meal, washed down with water or milk (the volume of the liquid should be at least 100 ml). A similar regimen for Ketonal Duo with a dosage of 150 mg in a single cuspule.
The maximum dose of ketoprofen is 200 mg per day.
Parenteral administration can be combined with the use of oral forms (capsules, tablets) or rectal suppositories. The maximum daily dose (including when using different dosage forms) is 200 mg.
Candles
Adults appoint 1 candle 1-2 times a day rectally.
Rectal suppositories can be used in combination with ketoprofen dosage forms for systemic or external use.The maximum daily dose of ketoprofen (including when using different dosage forms) is 200 mg.
Side effect
- dyspepsia (nausea, flatulence, diarrhea or constipation, vomiting, decreased or increased appetite);
- abdominal pain;
- stomatitis;
- dry mouth;
- ulceration of the mucosa of the gastrointestinal tract;
- abnormal liver function;
- exacerbation of Crohn's disease;
- bleeding from the gastrointestinal tract;
- headache;
- dizziness;
- drowsiness;
- fatigue;
- nervousness;
- nightmarish dreams;
- peripheral neuropathy;
- hallucinations;
- disorientation;
- noise in ears;
- change in taste;
- blurred vision;
- conjunctivitis;
- tachycardia;
- arterial hypertension;
- peripheral edema;
- reduction of platelet aggregation;
- anemia, thrombocytopenia, agranulocytosis, purpura;
- hematuria (with prolonged intake of NSAIDs and diuretics);
- itching;
- hives;
- rhinitis;
- bronchospasm;
- angioedema;
- anaphylactoid reactions;
- loose stools;
- hemoptysis;
- menometrorrhagia.
Contraindications
- peptic ulcer of the stomach and duodenum in the phase of exacerbation;
- NNC, Crohn's disease;
- hemophilia and other bleeding disorders;
- severe hepatic impairment;
- severe renal failure;
- uncompensated heart failure;
- Postoperative period after coronary artery bypass grafting;
- Gastrointestinal, cerebrovascular and other bleeding or suspicion of bleeding;
- chronic dyspepsia;
- 3 trimester of pregnancy;
- lactation (breastfeeding);
- children's age till 15 years;
- inflammatory diseases of the rectum;
- hypersensitivity to ketoprofen, acetylsalicylic acid or other NSAIDs;
- history of bronchial asthma, hives and rhinitis caused by taking acetylsalicylic acid or other NSAIDs.
Application in pregnancy and lactation
The use of Ketonal in the 3 trimester of pregnancy is contraindicated. The use of Ketonal in the first and second trimester of pregnancy is possible only if the potential benefit to the mother exceeds the risk to the fetus.
If Ketonal is needed during lactation, the question of stopping breastfeeding should be resolved.
special instructions
Patients with inflammatory bowel disease should not be prescribed Ketonal in the form of rectal suppositories.
With the long-term use of Ketonal, as well as other NSAIDs, regular monitoring of hematological parameters, liver function and kidney function is required, especially in elderly patients.
Ketoprofen should be administered with caution to patients with arterial hypertension and heart disease accompanied by fluid retention in the body, monitoring of blood pressure is recommended.
Ketonal can mask the symptoms of infectious diseases.
Impact on the ability to drive vehicles and manage mechanisms
Data on the negative effects of Ketonal in the recommended doses on the ability to drive and work with the mechanisms there.
However, patients who notice unusual effects when applying Ketonal should be careful when engaging in potentially dangerous activities that require increased concentration and speed of psychomotor reactions.
Drug Interactions
Ketoprofen reduces the effect of diuretics, antihypertensive agents.
Strengthens the effect of oral hypoglycemic drugs and some anticonvulsants (phenytoin).
When used simultaneously with other NSAIDs, salicylates, GCS and ethanol (alcohol), the risk of developing gastrointestinal bleeding increases.
With simultaneous use with anticoagulants, thrombolytic agents, antiplatelet agents, the risk of bleeding increases.
The risk of developing kidney dysfunction increases with simultaneous admission with diuretics or ACE inhibitors.
With simultaneous application increases the concentration of cardiac glycosides, blockers of slow calcium channels, lithium preparations, cyclosporine, methotrexate.
Ketonal can be combined with analgesics of central action.
Analogues of the drug Ketonal
Structural analogs for the active substance:
- Arketal Rompharm;
- Arthrosylen;
- Artrum;
- Bystrumgel;
- Bystrumcaps;
- VALUSAL;
- Ketoprofen;
- Ketoprofen Vramed;
- Ketoprofen MB;
- Ketoprofen Organic;
- Ketoprofen-Verte;
- Ketoprofen-ESCOM;
- Ketosphere;
- OCI;
- Oruvel;
- Profenide;
- Fastum;
- Fastum gel;
- Febrofide;
- Flamax forte;
- Flamax;
- Fleksen.
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