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Ketonal - instructions for use, reviews, analogs and formulations (tablets 100 mg and 150 mg, suppositories 100 mg, cream 5%, gel 2.5%, injections in ampoules, capsules Uno and Duo) medication for the treatment of pain in adults , children and pregnancy

Ketonal - instructions for use, reviews, analogs and formulations (tablets 100 mg and 150 mg, suppositories 100 mg, cream 5%, gel 2.5%, injections in ampoules, capsules Uno and Duo) medication for the treatment of pain in adults , children and pregnancy

In this article, you can read the instructions for using the drug Ketonal. Presented are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Ketonal in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Ketonal analogs in the presence of existing structural analogs. Use for symptomatic treatment of inflammatory diseases and analgesia in adults, children, as well as during pregnancy and lactation.

 

Ketonal - a non-steroidal anti-inflammatory agent, a derivative of propionic acid. Has analgesic, anti-inflammatory and antipyretic effect. By inhibiting COX-1 and COX-2 and, in part, lipoxygenase, Ketoprofen inhibits the synthesis of prostaglandins and bradykinin, stabilizes the lysosomal membranes.

 

Ketoprofen (the active substance of the Ketonal preparation) does not adversely affect the condition of the articular cartilage.

 

Pharmacokinetics

 

When ingestion Ketonal easily absorbed from the digestive tract. Eating does not affect the bioavailability of ketoprofen. Ketoprofen penetrates well into the synovial fluid. Ketoprofen is mainly metabolized in the liver. About 80% of ketoprofen is excreted in the urine, mainly in the form of a conjugate with glucuronic acid (90%). About 10% is excreted unchanged through the intestine.

 

Indications

 

Symptomatic therapy of painful and inflammatory processes of various genesis, including:

  • rheumatoid arthritis and periarthritis;
  • ankylosing spondylitis (Bekhterev's disease);
  • psoriatic arthritis;
  • reactive arthritis (Reiter's syndrome);
  • osteoarthrosis of different localization;
  • tendonitis, bursitis;
  • myalgia;
  • neuralgia;
  • radiculitis;
  • injuries of the musculoskeletal system (incl.sports), bruises of muscles and ligaments, sprains of ligaments, ruptures of ligaments and tendons of muscles.

 

Forms of release

 

Tablets of 100 mg and 150 mg.

 

Candles for rectal administration 100 mg.

 

Cream or ointment for external use 5%.

 

Gel for external use 2.5%.

 

Capsules Ketonal Uno 200 mg.

 

Capsules Ketonal Duo 150 mg.

 

Solution for intravenous and intramuscular injection (injections in ampoules for injection) 50 mg / ml.

 

Instructions for use and dosing regimen

 

Tablets and capsules

 

Adults prescribe 1-2 capsules 2-3 times a day, or 1 tablet 2 times a day, or 1 tablet of prolonged action once a day. Capsules and tablets should be taken during or immediately after meals, without chewing, squeezed with enough water or milk (the volume of the liquid - not less than 100 ml).

 

Oral forms can be combined with the use of rectal suppositories or medicinal forms of Ketonal for external use (cream, gel).

 

The maximum daily dose (including when using different dosage forms) is 200 mg.

 

Ampoules

 

The solution is administered intramuscularly or intravenously. In / m injected to 100 mg 1-2 times a day. In / in the infusion of ketoprofen is carried out only in a hospital.

 

A short intravenous infusion: 100-200 mg, diluted in 100 ml of 0.9% sodium chloride solution, injected for 0.5-1 hour. Possible repeated administration after 8 hours.

 

Continuous intravenous infusion: 100-200 mg, diluted in 500 ml infusion solution (0.9% sodium chloride solution, lactate-containing Ringer's solution, 5% Dextrose solution), injected for 8 hours. Possible repeated administration after 8 hours.

 

Ketonal Uno and Duo

 

The standard dose of Ketonal Uno for adults and children over 15 years is 200 mg per day. Capsules should be taken during or after a meal, washed down with water or milk (the volume of the liquid should be at least 100 ml). A similar regimen for Ketonal Duo with a dosage of 150 mg in a single cuspule.

 

The maximum dose of ketoprofen is 200 mg per day.

 

Parenteral administration can be combined with the use of oral forms (capsules, tablets) or rectal suppositories. The maximum daily dose (including when using different dosage forms) is 200 mg.

 

Candles

 

Adults appoint 1 candle 1-2 times a day rectally.

 

Rectal suppositories can be used in combination with ketoprofen dosage forms for systemic or external use.The maximum daily dose of ketoprofen (including when using different dosage forms) is 200 mg.

 

Side effect

  • dyspepsia (nausea, flatulence, diarrhea or constipation, vomiting, decreased or increased appetite);
  • abdominal pain;
  • stomatitis;
  • dry mouth;
  • ulceration of the mucosa of the gastrointestinal tract;
  • abnormal liver function;
  • exacerbation of Crohn's disease;
  • bleeding from the gastrointestinal tract;
  • headache;
  • dizziness;
  • drowsiness;
  • fatigue;
  • nervousness;
  • nightmarish dreams;
  • peripheral neuropathy;
  • hallucinations;
  • disorientation;
  • noise in ears;
  • change in taste;
  • blurred vision;
  • conjunctivitis;
  • tachycardia;
  • arterial hypertension;
  • peripheral edema;
  • reduction of platelet aggregation;
  • anemia, thrombocytopenia, agranulocytosis, purpura;
  • hematuria (with prolonged intake of NSAIDs and diuretics);
  • itching;
  • hives;
  • rhinitis;
  • bronchospasm;
  • angioedema;
  • anaphylactoid reactions;
  • loose stools;
  • hemoptysis;
  • menometrorrhagia.

 

Contraindications

  • peptic ulcer of the stomach and duodenum in the phase of exacerbation;
  • NNC, Crohn's disease;
  • hemophilia and other bleeding disorders;
  • severe hepatic impairment;
  • severe renal failure;
  • uncompensated heart failure;
  • Postoperative period after coronary artery bypass grafting;
  • Gastrointestinal, cerebrovascular and other bleeding or suspicion of bleeding;
  • chronic dyspepsia;
  • 3 trimester of pregnancy;
  • lactation (breastfeeding);
  • children's age till 15 years;
  • inflammatory diseases of the rectum;
  • hypersensitivity to ketoprofen, acetylsalicylic acid or other NSAIDs;
  • history of bronchial asthma, hives and rhinitis caused by taking acetylsalicylic acid or other NSAIDs.

 

Application in pregnancy and lactation

 

The use of Ketonal in the 3 trimester of pregnancy is contraindicated. The use of Ketonal in the first and second trimester of pregnancy is possible only if the potential benefit to the mother exceeds the risk to the fetus.

 

If Ketonal is needed during lactation, the question of stopping breastfeeding should be resolved.

 

special instructions

 

Patients with inflammatory bowel disease should not be prescribed Ketonal in the form of rectal suppositories.

 

With the long-term use of Ketonal, as well as other NSAIDs, regular monitoring of hematological parameters, liver function and kidney function is required, especially in elderly patients.

 

Ketoprofen should be administered with caution to patients with arterial hypertension and heart disease accompanied by fluid retention in the body, monitoring of blood pressure is recommended.

 

Ketonal can mask the symptoms of infectious diseases.

 

Impact on the ability to drive vehicles and manage mechanisms

 

Data on the negative effects of Ketonal in the recommended doses on the ability to drive and work with the mechanisms there.

 

However, patients who notice unusual effects when applying Ketonal should be careful when engaging in potentially dangerous activities that require increased concentration and speed of psychomotor reactions.

 

Drug Interactions

 

Ketoprofen reduces the effect of diuretics, antihypertensive agents.

 

Strengthens the effect of oral hypoglycemic drugs and some anticonvulsants (phenytoin).

 

When used simultaneously with other NSAIDs, salicylates, GCS and ethanol (alcohol), the risk of developing gastrointestinal bleeding increases.

 

With simultaneous use with anticoagulants, thrombolytic agents, antiplatelet agents, the risk of bleeding increases.

 

The risk of developing kidney dysfunction increases with simultaneous admission with diuretics or ACE inhibitors.

 

With simultaneous application increases the concentration of cardiac glycosides, blockers of slow calcium channels, lithium preparations, cyclosporine, methotrexate.

 

Ketonal can be combined with analgesics of central action.

 

Analogues of the drug Ketonal

 

Structural analogs for the active substance:

  • Arketal Rompharm;
  • Arthrosylen;
  • Artrum;
  • Bystrumgel;
  • Bystrumcaps;
  • VALUSAL;
  • Ketoprofen;
  • Ketoprofen Vramed;
  • Ketoprofen MB;
  • Ketoprofen Organic;
  • Ketoprofen-Verte;
  • Ketoprofen-ESCOM;
  • Ketosphere;
  • OCI;
  • Oruvel;
  • Profenide;
  • Fastum;
  • Fastum gel;
  • Febrofide;
  • Flamax forte;
  • Flamax;
  • Fleksen.

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Other medicines:

Reviews (36):
Guests
ando
Somewhere a year ago, unsuccessfully turned her neck and how stuck, could not normally turn neither to tilt her head, such a strong pain was. The husband from the lumbago tunic usually Voltaren or Diclofenac and ran to the drugstore for injections, but there he was advised by the "good" pharmacists Ketonal cream, they said that it was as effective as injections (although more expensive). I smeared this medicine with a sick neck for a week. The effect is zero. Probably, it was simple that the pharmacists had a contract with these pharmacists and they injected this cream.

Then by the way I bruised my leg in winter and also tried to smear Ketonal - I did not feel the effect again. So for me this medicine does not exist now.
Guests
Irina Shcherbina
5 days ago, they had a complicated operation to remove the wisdom tooth, the tooth was inside the gum, so I had to cut the gum. They vydulblivali it for an hour, put a few stitches. After the operation, the pains are creepy, the floor of the face swollen, tried to drink Trimol, analgin, even ketones did not help (although I thought it was a similar drug).From this pain, it seemed, everything hurts: head, ears, neck))) Mother offered to drink ketonal, after 15 minutes. I even forgot about the pain. True, after 3-4 hours the pain resumed, suffered for a long time, drank one more. For the fifth day I am saving myself only with this drug, no more than 3 tablets a day. I think I will survive)))
Guests
Lydia
What can I say, the ketonal has helped me more than once with various inflammations and pains. So, recently decided to resort to it when pain in the knee (gonarthrosis) and in the hands of both hands (inflammation of the tendons) became intolerable and no physiotherapy and gels could cope. I bought a pack of 150 mg tablets, took it according to the instructions, on the 1st 1 time a day. The pains disappeared on the second day of admission. But on the third day there was a strong allergic reaction in the form of a rash on the skin, the drug had to be discontinued. As they say: "one heals, and the other maims."
Guests
viktor ivanovich
To whom, and from pain in my knees saves me. After taking the pill I feel like anew born, but it lasts for 20 hours then pain again. I will experiment, the benefit is the Internet.
Guests
Anastasia
It helps me! Ketorol in particular ... Often I suffer with teeth, but it is worth to drink one pill and everything ... I do not feel pain for 15 hours)))
Guests
Sania
I do not have medical education, but when my husband got a sharp pain in the lower back (unsuccessfully lifted the weight), I decided to make the injection "Ketonal" myself, although they write that it is impossible at home. Why? Here, today I'm going to do a second injection. How to be?
Administrators
admin
Sania, My opinion is this: if a person does not have medical education, then he can not be engaged in self-medication, this is fraught with consequences and I know them many times. I only know more than 5 problems on back problems (and this without specific problems).

Of course lumbulgia, which most often occurs after lifting weights, is successfully treated with Diclofenac, Ketonal and similar preparations. If you have already begun to be treated, then after the first injection your husband should feel better, it's like a differential test for inflammatory problems in the back.More than two shots without positive dynamics, I would not put, and if such problems were not before, you still have to see a doctor to check the status of organs and body systems.
Guests
Pavel Zubko
I immediately removed wisdom tooth 2 (the operation was difficult since at lower tooth roots joined to the ring and held to something kept, and the upper tooth grew in the maxillary cavity) and prescribed the drug. When the anesthesia was released, the hellish headache began. I thought I would. Nifiga, then the temperature to 38 rose. I drank this Ketonal, the effect did not immediately come, I did not notice the time, but in the end, I was cut down by 4-5 hours, I do not remember exactly. And when I woke up, I did not even feel edema, although it was pretty decent and the temperature, by the way, dropped =)
Guests
Venus
At me an osteochondrosis and a protrusion of a lumbar department of a vertebra. And even after all the procedures that the doctor prescribed me, my back hurts from time to time. And it turns out that I drink Ketonal. But what I noticed is that almost immediately after taking the medicine, I have nausea and vomiting. By the way and from a nyxis the same.Now I think - is it worth it ?! no
Administrators
admin
VenusI think it's not worth it. Obviously, the body responds with a negative reaction to the Ketonal drug, since regardless of the method of administration, a reaction is present. I advise you to look at similar medicines for the active substance - ketoprofen or the mechanism of analgesic action. Most likely, Ketonal does not suit you.
Guests
Tatyana
I quickly help ointment ketonal for pain in the hip joint. Analogues such as fast-fat, fastum-gel are useless ...
Guests
Galina
One year ago she underwent an operation on her spine - a tumor of the spinal cord. Have removed. Often the back hurts, especially on weather I am rescueed or saved only by ketonalom.
Guests
sergeant
I put the first injection today, I have sciatica, I give a strong back in the leg, the pain in my back is unbearable. After a nyxis, he regained his temper. Tomorrow I'll continue, we'll see.
Visitors
Dmitriy
I had an angina here. With a temperature of 40, as expected. Already I drink an antibiotic Augmentin. But still only the first day, so it did not let go yet. From painkillers paracetamol to terribly sore head, and not much sense ... And after intramuscular injection Ketonalom for six hours even forget that sick! Question: Can I?
Administrators
admin
Dmitriy, Prick Ketonala possible if a really bad stomach and allows as NSAID drugs of bad effect on the mucous membrane of the stomach and intestines. In the rest, follow the recommendations of the doctor and on antibiotics, angina should pass quickly. You can additionally rinse the herbs or any antiseptic solution, which you can find in our directory, it contributes to the mechanical purification of the tonsils of pus and air raids., Which facilitates and reduces the overall toxicity (headache, fever, body aches, etc. .).
Guests
Love
Ketonal perfectly removes postoperative pain. True, very terrible pobochki. But we have to resort to his help.Thank you for this ketonalu.
Guests
George Andreevich
I have coxarthrosis of 3 tbsp. Prostate cancer with metastases throughout the skeleton. Ketonal injection in m 100 ml 1-2 times a day, the pain stops. Also cream ketonal for problem spots also anesthetizes. I use it for a long time. Ketonal is better than tramadol.
Guests
maximova
Has drunk 1 tablet ketonalum, it became easier. But we'll see tomorrow what will happen to the dentist. Teeth ache badly, but the pain has passed, the ketonal has helped. I'll wait till morning ...
Guests
Lyudmila
Yesterday the doctor appointed me ketonal. After the first pill, the stomach ached terribly and diarrhea began.
Guests
salavat
In general, so. The day before yesterday, the roots of the upper front teeth, which were left after a concrete (!) Injury, ached. Everything was going to be removed, but so far, as always, the cock in one place has not pecked ... All night I did not sleep, I drank ketonal for the morning. Pain, and this is natural and the head, and throws a neck, passed the minutes in 15-20, immediately before dinner was cut out. At three o'clock after lunch I went to the hospital (ultracaine, syringe). To delete it is necessary 4 roots, have removed one, have told: tomorrow the second, then, type, in a day, etc.As if everything is normal, neat, nothing hurts. On the trail. The day was immediately removed by all three remaining. But, sorry, after - everything hurt heavily. He drank ketonechiku - everything went well after 15-20 minutes. And the question is - ketonal blood does not dilute the case, the blood still does not brake, although I regularly change gauze tampons? The pressure is 120-80, 130-90, there is a tonometer, checked it. Thank you in advance.
Administrators
admin
salavat, Ketonal can lead to violations of blood coagulability, although in your case it is not obvious, because from two tablets of medication this effect can hardly be earned. So it probably crits a lot, because the amount of intervention was decent - just three roots of the tooth were removed. If the blood does not stop the next day and continues to smear tampons, you should consult a dental surgeon, which removed the teeth repeatedly. Preparations for stopping bleeding in their arsenal are available.
Guests
Irina
Your message to the use of the drug Ketonal is not relevant, about advertising and philology - this is for you to other sites.
admin
Guests
Taras
Ketonal duo helps me with the rheumatoid arthritis of the knee, but it only lasts for a day and a half.
Guests
Anatoly Snezan
Ketorol and ketonal are often confused, and there are similar names. So, ketorol acts stronger against any toothache (many times checked!). Because of the different consequences ... Ketonal is quite different from the other list of ailments.
Guests
Tatyana
She dislocated her right arm, the surgeon prescribed Ketonal in tablets and gel. Reception 10 days. After 5 days there was dry mouth and pain in the lower abdomen after each meal. Now the second day I do not drink. I bought baktisubtil for restoration of intestinal flora.
Guests
Tanya
Ketorol is stronger than ketonal, and why is it not given in pharmacies without a prescription?
Administrators
admin
Tanya, Different active substances and if Ketonal is allowed for sale as an over-the-counter medicine, then Ketorol is sold only by prescription.
Guests
realist
I was looking for 4! month anesthetizing from a pinch of the sciatic nerve, could not walk. I tried ibuprofen, nimesulide and nise, ketans, diclofenac, then catena, pregabalin, sedalgin with codeine - nothing helped. I tried ketonal duo - a miracle, I can step on foot for a day and a half! And all the rest and injections of hormones including. did not help at all. So my teeth are teeth, but I'm almost normal now.
Guests
Irina
After taking Ketonal, severe abdominal pain began. It seems that everything hurts: the liver, kidneys, stomach - perish.
Guests
Alesya
My neck was inflamed. All pain went to shoulder shoulder and chest. In short, the whole left side hurts. The doctor prescribed a ketonal in pricks. After reading pobochki and testimonials, it became frightening.
Guests
Anatole
Chronic urethritis. Has registered the urologist of a candle (ketonal) and not only. After 3-4 receptions (at night), it became easier. After a course of 12 pieces, the inflammation passed, then of course again resumed, but in the moment it helped. crying
Guests
Anya
I was prescribed ketonal duo in tablets after excision of anal fissures, if it hurts. It hurts and continues to hurt periodically, because of what I had to buy it ... Wild stomach pain + nausea within 24 hours after taking the pill crying
Guests
Marina Samarina
Sometimes the desire to save leads to bad consequences. So I decided to buy an analog of Milgamma - Ketonal. Never in my life I have experienced a lot of drugs, but here everything is right away. Nausea and vomiting are the most unpleasant, the sensation is like poisoning, but after I stopped drinking those pills, everything went right away. Therefore, you should not always buy analogs, but rather trust trusted funds.
Administrators
admin
Marina SamarinaIn no way can Ketonal be regarded as an analog of Milgamma. Pharmacological groups of drugs have different and therapeutic effects are also different.
Visitors
Ketrin
After the accident, the son formed a huge hematoma around this place, from the bottom of the abdomen almost to the knees.They smeared ointment with doloben, bruises began to descend, and in 3 days on the inner side of the leg in the inguinal region a tight knob was formed. Several times the doctor pumped a liquid out of her with a syringe. But the cone did not decrease and prevents walking. Has advised to grease with ointment Ketonal. Yesterday he rubbed it four times during the day. Today I felt that the cone softened and it became easier to walk. Will not there be any pimples or allergies, not too much 4 times a day? The instructions about the ointment do not write anything.
Administrators
admin
KetrinWhen Ketonal ointment is used, absorption of the active substance is inward and its systemic effect on the human body is minimal. Therefore, the treatment recommended by the doctor can be continued.

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