Cortexin - instructions for use, analogs, reviews and release forms (injections in injections (lyophilizate) 5 mg and 10 mg) drug for the treatment of encephalopathy in adults, children (including newborns) and pregnancy
In this article, you can read the instructions for using the drug Cortexin. There are reviews of visitors to the site - consumers of this medication, as well as opinions of doctors of specialists on the use of Cortexin in their practice. A big request is to actively add their feedback on the drug: the medicine helped or did not help get rid of the disease, which were observed complications and side effects, possibly not declared by the manufacturer in the annotation. Analogues of Cortexin in the presence of existing structural analogues.Use for the treatment of encephalopathies and cerebral circulation disorders in adults, children (including newborns), as well as during pregnancy and lactation.
Cortexin - Nootropic preparation.
Contains a complex of low molecular weight water-soluble polypeptide fractions with a molecular weight of no more than 10 000 Da, isolated from the cerebral cortex of cattle or pigs not older than 12 months of age. It penetrates through the BBB directly to the nerve cells. The drug has nootropic, neuroprotective, antioxidant and tissue-specific effects.
Nootropic action
Improves the higher functions of the brain, learning and memory processes, concentration of attention, stability under various stresses.
Neuroprotective action
Protects neurons from damage by various endogenous neurotoxic factors (glutamate, calcium ions, free radicals), reduces the toxic effects of psychotropic substances.
Antioxidant action
It inhibits lipid peroxidation in neurons, increases the survival of neurons in conditions of oxidative stress and hypoxia.
Tissue-specific effect
It activates the metabolism of neurons of the central and peripheral nervous system, reparative processes, contributes to the improvement of the functions of the cerebral cortex and the general tone of the nervous system.
Pharmacokinetics
The complex composition of Cortexin, the active substance of which is a complex of polypeptide fractions, does not allow the usual pharmacokinetic analysis of individual components.
Indications
In the complex therapy of the following conditions and diseases:
- disorders of cerebral circulation;
- craniocerebral trauma and its consequences;
- encephalopathy of various genesis;
- Cognitive impairment (including memory disorders and thinking);
- acute and chronic encephalitis and encephalomyelitis;
- epilepsy;
- asthenic conditions;
- supra-segmental vegetative disorders (vegetative-vascular dystonia);
- decreased ability to learn;
- delay of psychomotor and speech development in children;
- critical conditions of newborns with perinatal damages of the nervous system;
- various forms of infantile cerebral palsy.
Forms of release
Lyophilizate for solution for intramuscular injection (injections in ampoules for injection) 5 mg and 10 mg.
There are no other forms of release, including tablets or capsules. Perhaps this is a fake.
Instructions for use and dosage
The drug is administered intramuscularly.
Children with a body weight of less than 20 kg of the drug administered at a dose of 0.5 mg / kg of body weight, with children weighing more than 20 kg - at a dose of 10 mg per day for 10 days.
If necessary, repeat the course in 3-6 months.
Rules for the preparation of solution
The contents of the vial are dissolved in 1-2 ml of 0.5% solution of procaine (novocaine), water for injection or 0.9% sodium chloride solution.
Side effect
- individual hypersensitivity to the components of the drug.
Contraindications
- pregnancy;
- lactation period (breastfeeding);
- individual intolerance of the drug.
Application in pregnancy and lactation
The drug is contraindicated for use in pregnancy due to lack of data from clinical studies.
If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped (due to the lack of data from clinical trials).
Drug Interactions
Drug interaction of the drug Cortexin is not described.
Analogues of the drug Cortexin
Structural analogues of the active substance of the drug Cortexin has not. However, there is a large class of drugs of nootropics with a similar mechanism of action. Preparations of this type are:
- Aminalon;
- Ampasse;
- Bilobil;
- Gamma-aminobutyric acid;
- Glycine;
- Glutamic acid;
- Hopantenic acid;
- Idebenon;
- Lucetsam;
- Nootropil;
- Pantogam;
- Piracetam;
- Semax;
- Tenoten;
- Tenoten for children;
- Fenibut;
- Phenotropil;
- Holilitil;
- Cebrilysin;
- Ceraxon;
- Cerebramine;
- Cerebrial;
- Cerebrosolate;
- Cerebrolysin;
- Encephabol;
- The escotrope.
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